Skip Navigation

Person Details: Scott Boitano

Superfund Research Program

Scott Boitano

University of Arizona
Department of Physiology
P.O. Box 245051
Tucson, Arizona 85724
Phone: 520-626-2105






  • Moy JK, Khoutorsky A, Asiedu MN, Black BJ, Kuhn JL, Barragan-Iglesias P, Megat S, Burton MD, Burgos-Vega CC, Melemedjian OK, Boitano S, Vagner J, Gkogkas CG, Pancrazio JJ, Mogil JS, Dussor G, Sonenberg N, Price TJ. 2017. The MNK-eIF4E signaling axis contributes to injury-induced Nociceptive plasticity and the development of chronic pain. J Neurosci Res 37:7481-7499. doi:10.1523/JNEUROSCI.0220-17.2017 PMID:28674170 PMCID:PMC5546114 (accepted for publication)
  • Polley DJ, Mihara K, Ramachandran R, Vliagoftis H, Renaux B, Saifeddine M, Daines MO, Boitano S, Hollenberg M. 2017. Cockroach allergen serine proteinases: Isolation, sequencing and signalling via proteinase-activated receptor-2. Clinical and Experimental Allergy 47:946-960. doi:10.1111/cea.12921 PMID:28317204 PMCID:PMC5501740 (accepted for publication)



  • Boitano S, Hoffman J, Flynn AN, Asiedu MN, Tillu DV, Zhang Z, Sherwood CL, Rivas CM, DeFea KA, Vagner J, Price TJ. 2015. The novel PAR2 ligand C391 blocks multiple PAR2 signalling pathways in vitro and in vivo. Br J Pharmacol 172(18):4535-4545. doi:10.1111/bph.13238 PMID:26140338 PMCID:PMC4562513


  • Boitano S, Hoffman J, Tillu DV, Asiedu MN, Zhang Z, Sherwood CL, Wang Y, Dong X, Price TJ, Vagner J. 2014. Development and evaluation of small peptidomimetic ligands to protease-activated receptor-2 (PAR2) through the use of lipid tethering. PLoS One 9(6):e99140. doi:10.1371/journal.pone.0099140 PMID:24927179 PMCID:PMC4057235
  • Burgess JL, Kurzius-Spencer M, Poplin GS, Littau S, Kopplin MJ, Sturup S, Boitano S, Lantz RC. 2014. Environmental arsenic exposure, selenium and sputum alpha-1 antitrypsin. J Expo Sci Environ Epidemiol 24(2):150-155. doi:10.1038/jes.2013.35 PMID:23838883 PMCID:PMC4019207
  • Sherwood CL, Daines MO, Price TJ, Vagner J, Boitano S. 2014. A highly potent agonist to protease-activated receptor-2 reveals apical activation of the airway epithelium resulting in Ca2+-regulated ion conductance. Am J Physiol Cell Physiol 307(8):C718-C726. doi:10.1152/ajpcell.00257.2014 PMID:25143347 PMCID:PMC4199996



  • Hoffman J, Flynn AN, Tillu DV, Zhang Z, Patek R, Price TJ, Vagner J, Boitano S. 2012. Lanthanide labeling of a potent protease activated receptor-2 agonist for time-resolved fluorescence analysis. Bioconjug Chem 23(10):2098-2104. doi:10.1021/bc300300q PMID:22994402 PMCID:PMC3556274
  • Sierra-Alvarez R, Boitano S, Field JA, Otero-Gonzalez L. 2012. Application and validation of an impedance-based real time cell analyzer to measure the toxicity of nanoparticles impacting human bronchial epithelial cells. Environ Sci Technol 46:10271-8. doi:10.1021/es301599f PMID:22916708


  • Boitano S, Flynn AN, Schulz SM, Hoffman J, Price TJ, Vagner J. 2011. Potent agonists of the protease activated receptor 2 (PAR(2)). J Med Chem 54(5):1308-1313. doi:10.1021/jm1013049 PMID:21294569 PMCID:PMC3069554
  • Flynn AN, Tillu DV, Asiedu MN, Hoffman J, Vagner J, Price TJ, Boitano S. 2011. The protease-activated receptor-2-specific agonists 2-aminothiazol-4-yl-LIGRL-NH2 and 6-aminonicotinyl-LIGRL-NH2 stimulate multiple signaling pathways to induce physiological responses in vitro and in vivo. J Biol Chem 286:19076-19088. doi:10.1074/jbc.M110.185264 PMID:21467041 PMCID:PMC3099721
  • Ramanathan S, Mazzalupo S, Boitano S, Montfort WR. 2011. Thrombospondin-1 and angiotensin II inhibit soluble guanylyl cyclase through an increase in intracellular calcium concentration. Biochemistry 50:7787-7799. doi:10.1021/bi201060c PMID:21823650 PMCID:PMC3168727
  • Sherwood CL, Lantz RC, Burgess JL, Boitano S. 2011. Arsenic alters ATP-dependent Ca2+ signaling in human airway epithelial cell wound response. Toxicol Sci 121:191-206. doi:10.1093/toxsci/kfr044 PMID:21357385 PMCID:PMC3080191



  • Lantz RC, Lynch BJ, Boitano S, Poplin GS, Littau S, Tsaprailis G, Burgess JL. 2007. Pulmonary biomarkers based on alterations in protein expression after exposure to arsenic. Environ Health Perspect 115(4):586-91. PMID:17450228
to Top