Superfund Research Program
Scott Boitano
University of Arizona
Department of Physiology
P.O. Box 245051
Tucson, Arizona 85724
Phone: 520-626-2105
Email: sboitano@email.arizona.edu
Projects
- University of Arizona: Role of NRF2 in the Pulmonary Response to Inhaled Mine Tailing Dust (2017-2020)
- University of Arizona: Toxicological Impact of Mine Tailings Dust on Lung Epithelial Barrier Function (2005-2020)
Publications
2019
- Witten M, Chau BT, Saez AE, Boitano S, Lantz RC. 2019. Early life inhalation exposure to mine tailings dust affects lung development. Toxicol Appl Pharmacol 365:124-132. doi:10.1016/j.taap.2019.01.009 PMID:30641074 PMCID:PMC6349506
2018
- Zeng C, Nguyen C, Boitano S, Field JA, Shadman F, Sierra-Alvarez R. 2018. Cerium dioxide (CeO2) nanoparticles decrease arsenite (As(III)) cytotoxicity to 16HBE14o- human bronchial epithelial cells. Environ Res 164:452-458. doi:10.1016/j.envres.2018.03.007 PMID:29574255 PMCID:PMC6240918
2017
- Moy JK, Khoutorsky A, Asiedu MN, Black BJ, Kuhn JL, Barragan-Iglesias P, Megat S, Burton MD, Burgos-Vega CC, Melemedjian OK, Boitano S, Vagner J, Gkogkas CG, Pancrazio JJ, Mogil JS, Dussor G, Sonenberg N, Price TJ. 2017. The MNK-eIF4E signaling axis contributes to injury-induced Nociceptive plasticity and the development of chronic pain. J Neurosci Res 37:7481-7499. doi:10.1523/JNEUROSCI.0220-17.2017 PMID:28674170 PMCID:PMC5546114 (accepted for publication)
- Polley DJ, Mihara K, Ramachandran R, Vliagoftis H, Renaux B, Saifeddine M, Daines MO, Boitano S, Hollenberg M. 2017. Cockroach allergen serine proteinases: Isolation, sequencing and signalling via proteinase-activated receptor-2. Clinical and Experimental Allergy 47:946-960. doi:10.1111/cea.12921 PMID:28317204 PMCID:PMC5501740 (accepted for publication)
2016
- Sherwood CL, Boitano S. 2016. Airway epithelial cell exposure to distinct e-cigarette liquid flavorings reveals toxicity thresholds and activation of CFTR by the chocolate flavoring 2,5-dimethypyrazine. Respir Res 17(1):57. doi:10.1186/s12931-016-0369-9 PMID:27184162 PMCID:PMC4869201
2015
- Boitano S, Hoffman J, Flynn AN, Asiedu MN, Tillu DV, Zhang Z, Sherwood CL, Rivas CM, DeFea KA, Vagner J, Price TJ. 2015. The novel PAR2 ligand C391 blocks multiple PAR2 signalling pathways in vitro and in vivo. Br J Pharmacol 172(18):4535-4545. doi:10.1111/bph.13238 PMID:26140338 PMCID:PMC4562513
2014
- Boitano S, Hoffman J, Tillu DV, Asiedu MN, Zhang Z, Sherwood CL, Wang Y, Dong X, Price TJ, Vagner J. 2014. Development and evaluation of small peptidomimetic ligands to protease-activated receptor-2 (PAR2) through the use of lipid tethering. PLoS One 9(6):e99140. doi:10.1371/journal.pone.0099140 PMID:24927179 PMCID:PMC4057235
- Burgess JL, Kurzius-Spencer M, Poplin GS, Littau S, Kopplin MJ, Sturup S, Boitano S, Lantz RC. 2014. Environmental arsenic exposure, selenium and sputum alpha-1 antitrypsin. J Expo Sci Environ Epidemiol 24(2):150-155. doi:10.1038/jes.2013.35 PMID:23838883 PMCID:PMC4019207
- Sherwood CL, Daines MO, Price TJ, Vagner J, Boitano S. 2014. A highly potent agonist to protease-activated receptor-2 reveals apical activation of the airway epithelium resulting in Ca2+-regulated ion conductance. Am J Physiol Cell Physiol 307(8):C718-C726. doi:10.1152/ajpcell.00257.2014 PMID:25143347 PMCID:PMC4199996
2013
- Flynn AN, Hoffman J, Tillu DV, Sherwood CL, Zhang Z, Patek R, Asiedu MN, Vagner J, Price TJ, Boitano S. 2013. Development of highly potent protease-activated receptor 2 agonists via synthetic lipid tethering. FASEB J 27(4):1498-1510. doi:10.1096/fj.12-217323 PMID:23292071 PMCID:PMC3606532
- Sherwood CL, Lantz RC, Boitano S. 2013. Chronic arsenic exposure in nanomolar concentrations compromises wound response and intercellular signaling in airway epithelial cells. Toxicol Sci 132:222-234. doi:10.1093/toxsci/kfs331 PMID:23204110 PMCID:PMC3576008
- Sherwood CL, Liguori AE, Olsen CE, Lantz RC, Burgess JL, Boitano S. 2013. Arsenic compromises conducting airway epithelial barrier properties in primary mouse and immortalized human cell cultures. PLoS One 8(12):e82970. doi:10.1371/journal.pone.0082970 PMID:24349408 PMCID:PMC3857810
2012
- Hoffman J, Flynn AN, Tillu DV, Zhang Z, Patek R, Price TJ, Vagner J, Boitano S. 2012. Lanthanide labeling of a potent protease activated receptor-2 agonist for time-resolved fluorescence analysis. Bioconjug Chem 23(10):2098-2104. doi:10.1021/bc300300q PMID:22994402 PMCID:PMC3556274
- Sierra-Alvarez R, Boitano S, Field JA, Otero-Gonzalez L. 2012. Application and validation of an impedance-based real time cell analyzer to measure the toxicity of nanoparticles impacting human bronchial epithelial cells. Environ Sci Technol 46:10271-8. doi:10.1021/es301599f PMID:22916708
2011
- Boitano S, Flynn AN, Schulz SM, Hoffman J, Price TJ, Vagner J. 2011. Potent agonists of the protease activated receptor 2 (PAR(2)). J Med Chem 54(5):1308-1313. doi:10.1021/jm1013049 PMID:21294569 PMCID:PMC3069554
- Flynn AN, Tillu DV, Asiedu MN, Hoffman J, Vagner J, Price TJ, Boitano S. 2011. The protease-activated receptor-2-specific agonists 2-aminothiazol-4-yl-LIGRL-NH2 and 6-aminonicotinyl-LIGRL-NH2 stimulate multiple signaling pathways to induce physiological responses in vitro and in vivo. J Biol Chem 286:19076-19088. doi:10.1074/jbc.M110.185264 PMID:21467041 PMCID:PMC3099721
- Ramanathan S, Mazzalupo S, Boitano S, Montfort WR. 2011. Thrombospondin-1 and angiotensin II inhibit soluble guanylyl cyclase through an increase in intracellular calcium concentration. Biochemistry 50:7787-7799. doi:10.1021/bi201060c PMID:21823650 PMCID:PMC3168727
- Sherwood CL, Lantz RC, Burgess JL, Boitano S. 2011. Arsenic alters ATP-dependent Ca2+ signaling in human airway epithelial cell wound response. Toxicol Sci 121:191-206. doi:10.1093/toxsci/kfr044 PMID:21357385 PMCID:PMC3080191
2008
- Caldwell P, Thome PA, Johnson PD, Boitano S, Runyan RB, Selmin O. 2008. Trichloroethylene disrupts cardiac gene expression and calcium homeostasis in rat myocytes. Toxicol Sci 104(1):135-143. doi:10.1093/toxsci/kfn078 PMID:18411232 PMCID:PMC4001797
2007
- Lantz RC, Lynch BJ, Boitano S, Poplin GS, Littau S, Tsaprailis G, Burgess JL. 2007. Pulmonary biomarkers based on alterations in protein expression after exposure to arsenic. Environ Health Perspect 115(4):586-91. PMID:17450228