Superfund Research Program

Aloysius J. Klingelhutz

University of Iowa
3-612 Bowen Science Building
51 Newton Rd
Iowa City, Iowa 52242
Phone: 319-335-7788
Email: al-klingelhutz@uiowa.edu

Projects

• University of Iowa: The Role of Airborne PCBs in Adipogenesis, Adipose Function, and Metabolic Syndrome (2020-2025)

Publications

2023

• Behan-Bush RM, Liszewski JN, Schrodt MV, Vats B, Li X, Lehmler H, Klingelhutz AJ, Ankrum J. 2023. Toxicity impacts on human adipose mesenchymal stem/stronal cells acutely exposed to aroclor and non-aroclor mixtures of polychorinated biphenyl. Environ Sci Technol 57(4):1731-1742. doi:10.1021/acs.est.2c07281 PMID:36651682 PMCID:PMC9893815
• Bullert AJ, Li X, Chunyun Z, Lee K, Pulliam CF, Cagle B, Doorn JA, Klingelhutz AJ, Robertson LW, Lehmler H. 2023. Disposition and metabolomic effects of 2,2',5,5'-tetrachlorobiphenyl in female rats following intraperitoneal exposure. Environ Toxicol Pharmacol 102:104245. doi:10.1016/j.etap.2023.104245 PMID:37572994
• El-Hattab MY, Sinclair N, Liszewski JN, Schrodt MV, Herrmann J, Klingelhutz AJ, Sander EA, Ankrum J. 2023. Native adiponectin plays a role in the adipocyte-mediated conversion of fibroblasts to myofibroblasts. J R Soc Interface 20(202):20230004. doi:10.1098/rsif.2023.0004 PMID:37132228 PMCID:PMC1015492
• Gourronc FA, Chimenti MS, Lehmler H, Ankrum J, Klingelhutz AJ. 2023. Hydroxylation markedly alters how the polychlorinated biphenyl (PCB) congener, PCB52, affects gene expression in human preadipocytes. Toxicol Vitro 89:105568. doi:10.1016/j.tiv.2023.105568 PMID:36804509 PMCID:PMC10081964
• Gourronc FA, Chimenti MS, Lehmler H, Ankrum J, Klingelhutz AJ. 2023. Updating Dataset of transcriptomic changes that occur in human preadipocytes over a 3-day course of exposure to 3,3',4,4',5-pentachlorobiphenyl (PCB126) with additional data on exposure to 2,2',5,5'-tetrachlorobiphenyl (PCB52) or its 4-hydroxy metabolite (4-OH-PCB52). Data Brief 49:109415. doi:10.1016/j.dib.2023.109415 PMID:37520642 PMCID:PMC10375549
• Wang H, Bullert AJ, Li X, Stevens HE, Klingelhutz AJ, Ankrum J, Adamcakova-Dodd A, Thorne PS, Lehmler H. 2023. Use of a polymeric implant system to assess the neurotoxicity of subacute exposure to 2,2',5,5'-tetrachlorobiphenyl-4-ol, a human metabolite of PCB 52, in male adolescent rats. Toxicology 500:153677. doi:10.1016/j.tox.2023.153677 PMID:37995827 PMCID:PMC10757425

2022

• Gourronc FA, Helm BK, Robertson LW, Chimenti MS, Joachim-Lehmler H, Ankrum J, Klingelhutz AJ. 2022. Transcriptome sequencing of 3,3',4,4',5-Pentachlorobiphenyl (PCB126)-treated human preadipocytes demonstrates progressive changes in pathways associated with inflammation and diabetes. Toxicol Vitro 83:105396. doi:10.1016/j.tiv.2022.105396 PMID:35618242 PMCID:PMC9423686
• Gourronc FA, Helm BK, Robertson LW, Chimenti MS, Lehmler H, Ankrum J, Klingelhutz AJ. 2022. Dataset of transcriptomic changes that occur in human preadipocytes over a 3-day course of exposure to 3,3',4,4',5-Pentachlorobiphenyl (PCB126). Data Brief 45:108571. doi:10.1016/j.dib.2022.108571 PMID:36131953 PMCID:PMC9483567

2019

• Gourronc FA, Perdew GH, Robertson LW, Klingelhutz AJ. 2019. PCB126 blocks the thermogenic beiging response of adipocytes. Environ Sci Pollut Res Int 27:doi:10.1007/s11356-019-06663-0 PMID:31721030 PMCID:PMC7098842

2018

• Gourronc FA, Robertson LW, Klingelhutz AJ. 2018. A delayed proinflammatory response of human preadipocytes to PCB126 is dependent on the aryl hydrocarbon receptor. Environ Sci Pollut Res Int 25:16481-16492. doi:10.1007/s11356-017-9676-z PMID:28699004 PMCID:PMC5764822

2016

• Gadupudi GS, Klaren WD, Olivier AK, Klingelhutz AJ, Robertson LW. 2016. PCB126-induced disruption in gluconeogenesis and fatty acid oxidation precedes fatty liver in male rats. Toxicol Sci 149(1):98-110. doi:10.1093/toxsci/kfv215 PMID:26396156 PMCID:PMC4731404
• Gadupudi GS, Klingelhutz AJ, Robertson LW. 2016. Diminished phosphorylation of CREB is a key event in the dysregulation of gluconeogenesis and glycogenolysis in PCB126 hepatotoxicity. Chem Res Toxicol 29(9):1504-1509. doi:10.1021/acs.chemrestox.6b00172 PMID:27509375

2015

• Gadupudi GS, Gourronc FA, Ludewig G, Robertson LW, Klingelhutz AJ. 2015. PCB126 inhibits adipogenesis of human preadipocytes. Toxicol In Vitro 29(1):132-141. doi:10.1016/j.tiv.2014.09.015 PMID:25304490 PMCID:PMC4250299

2011

• Senthilkumar PK, Klingelhutz AJ, Jacobus JA, Lehmler H, Robertson LW, Ludewig G. 2011. Airborne polychlorinated biphenyls (PCBs) reduce telomerase activity and shorten telomere length in immortal human skin keratinocytes (HaCat). Toxicol Lett 204:64-70. doi:10.1016/j.toxlet.2011.04.012 PMID:21530622 PMCID:PMC3109099

2008

• Jacobus JA, Flor S, Klingelhutz AJ, Robertson LW, Ludewig G. 2008. 2-(4'-Chlorophenyl)-1,4-benxoquinone increases the frequency of micronuclei and shortens telomeres. Environ Toxicol Pharmacol 25(2):267-272. doi:10.1016/j.etap.2007.10.022 PMID:18438462 PMCID:PMC2346440