Superfund Research Program

Staci L. Simonich

Oregon State University
Department of Environmental Toxicology
1141 Ag. Life Sciences Building
Corvallis, Oregon 97331
Phone: 541-737-9194
Fax: 541-737-0497
Email: staci.simonich@oregonstate.edu

Projects

• Oregon State University: Identification of Remediation Technologies and Conditions that Minimize Formation of Hazardous PAH Breakdown Products at Superfund Sites (2009-2025)

Research Briefs

• 319 - Analyzing Chemicals and Genes Yields Novel Insight into PAH Behavior

Hazardous Waste Sites

American Creosote Works Superfund Site

• Oregon State University: Identification of Remediation Technologies and Conditions that Minimize Formation of Hazardous PAH Breakdown Products at Superfund Sites

Portland Harbor

• Oregon State University: Identification of Remediation Technologies and Conditions that Minimize Formation of Hazardous PAH Breakdown Products at Superfund Sites

St. Maries Creosote Superfund Site

• Oregon State University: Identification of Remediation Technologies and Conditions that Minimize Formation of Hazardous PAH Breakdown Products at Superfund Sites

Wyckoff Co./Eagle Harbor

• Oregon State University: Identification of Remediation Technologies and Conditions that Minimize Formation of Hazardous PAH Breakdown Products at Superfund Sites

Publications

2022

• Titaley IA, Trine LS, Wang T, Duberg D, Davis EL, Engwall M, Simonich SL, Larsson M. 2022. Extensive chemical and bioassay analysis of polycyclic aromatic compounds in a creosote-contaminated superfund soil following steam enhanced extraction. Environ Pollut 312:120014. doi:10.1016/j.envpol.2022.120014 PMID:36007793

2021

• Kramer AL, Dorn SE, Perez A, Roper C, Titaley IA, Cayton K, Cook RP, Cheong H, Simonich SL. 2021. Assessing the oxidative potential of PAHs in ambient PM2.5 using the DTT consumption assay. Environ Pollut 285:117411. doi:10.1016/j.envpol.2021.117411 PMID:34051568
• St Mary L, Trine LS, Roper C, Wiley J, Simonich SL, McCoustra M, Henry TB. 2021. Time-related alteration of aqueous-phase anthracene and phenanthrene photoproducts in the presence of TiO(2) nanoparticles. Environ Sci Technol 55:3727-3735. doi:10.1021/acs.est.0c07488 PMID:33651588

2020

• Kramer AL, Campbell L, Donatuto J, Heidt M, Kile ML, Simonich SL. 2020. Impact of local and regional sources of PAHs on tribal reservation air quality in the US Pacific Northwest. Sci Total Environ 710:136412. doi:10.1016/j.scitotenv.2019.136412 PMID:31927295 PMCID:PMC7923342
• Roper C, Perez A, Barrett D, Hystad P, Simonich SL, Tanguay RL. 2020. Workflow for comparison of chemical and biological metrics of filter collected PM2.5. Atmos Environ (1994) 226:doi:10.1016/j.atmosenv.2020.117379 PMID:32313426 PMCID:PMC7170255
• Titaley IA, Simonich SL, Larsson M. 2020. Recent advances in the study of the remediation of polycyclic aromatic compound (PAC)-contaminated soils: Transformation products, toxicity, and bioavailability analyses. Environ Sci Technol Lett 7:873-882. doi:10.1021/acs.estlett.0c00677

2019

• Kramer AL, Suski KJ, Bell DM, Zelenyuk A, Simonich SL. 2019. Formation of polycyclic aromatic hydrocarbon oxidation products in alpha-pinene secondary organic aerosol particles formed through ozonolysis. Environ Sci Technol 53(12):6669-6677. doi:10.1021/acs.est.9b01732 PMID:31125204
• Roper C, Santiago-Delgado L, Barrett D, Simonich SL, Tanguay RL. 2019. PM2.5 filter extraction methods: Implications for chemical and toxicological analyses. Environ Sci Technol 53:434-442. doi:10.1021/acs.est.8b04308 PMID:30507171
• Titaley IA, Walden DM, Dorn SE, Ogba OM, Simonich SL, Cheong H. 2019. Evaluating computational and structural approaches to predict transformation products of polycyclic aromatic hydrocarbons. Environ Sci Technol 53(3):1595-1607. doi:10.1021/acs.est.8b05198 PMID:30571095
• Trine LS, Davis EL, Roper C, Truong L, Tanguay RL, Simonich SL. 2019. Formation of PAH derivatives and increased developmental toxicity during steam enhanced extraction remediation of creosote contaminated Superfund soil. Environ Sci Technol 53(8):4460-4469. doi:10.1021/acs.est.8b07231 PMID:30957485

2018

• Geier MC, Chlebowski A, Truong L, Simonich SL, Anderson KA, Tanguay RL. 2018. Comparative developmental toxicity of a comprehensive suite of polycyclic aromatic hydrocarbons. Arch Toxicol 92(2):571-586. doi:10.1007/s00204-017-2068-9 PMID:29094189 PMCID:PMC5820187
• Roper C, Simonich SL, Tanguay RL. 2018. Development of a high-throughput in vivo screening platform for particulate matter exposures. Environ Pollut 235:993-1005. doi:10.1016/j.envpol.2018.01.025 PMID:29751403 PMCID:PMC5951187
• Titaley IA, Ogba OM, Chibwe L, Hoh E, Cheong H, Simonich SL. 2018. Automating data analysis for two-dimensional gas chromatography/time-of-flight mass spectrometry non-targeted analysis of comparative samples. J Chromatogr A 1541:57-62. doi:10.1016/j.chroma.2018.02.016 PMID:29448996

2017

• Chibwe L, Davie-Martin C, Aitken MD, Hoh E, Simonich SL. 2017. Identification of polar transformation products and high molecular weight polycyclic aromatic hydrocarbons (PAHs) in contaminated soil following bioremediation. Sci Total Environ 599-600:1099-1107. doi:10.1016/j.scitotenv.2017.04.190 PMID:28511355
• Chibwe L, Titaley IA, Hoh E, Simonich SL. 2017. Integrated framework for identifying toxic transformation products in complex environmental mixtures. Environ Sci Technol Lett 4(2):32-43. doi:10.1021/acs.estlett.6b00455
• Chlebowski A, Garcia GR, La Du JK, Bisson WH, Simonich SL, Tanguay RL. 2017. Mechanistic investigations into the developmental toxicity of nitrated and heterocyclic PAHs. Toxicol Sci 157(1):246-259. doi:10.1093/toxsci/kfx035 PMID:28186253 PMCID:PMC5414855
• Chlebowski A, La Du JK, Truong L, Simonich SL, Tanguay RL. 2017. Investigating the application of a nitroreductase-expressing transgenic zebrafish line for high-throughput toxicity testing. Toxicol Rep 4:202-210. doi:10.1016/j.toxrep.2017.04.005 PMID:28758069 PMCID:PMC5527975
• Davie-Martin C, Stratton KG, Teeguarden J, Waters KM, Simonich SL. 2017. Implications of bioremediation of polycyclic aromatic hydrocarbon contaminated soils for human health and cancer risk. Environ Sci Technol 51:9458-9468. doi:10.1021/acs.est.7b02956 PMID:28836766
• Schrlau J, Kramer AL, Chlebowski A, Truong L, Tanguay RL, Simonich SL, Semprini L. 2017. Formation of developmentally toxic phenanthrene metabolite mixtures by mycobacterium sp ELW1. Environ Sci Technol 51:8569-8578. doi:10.1021/acs.est.7b01377 PMID:28727453
• Shrivastava M, Lou S, Zelenyuk A, Easter RC, Corley RA, Thrall BD, Rasch PJ, Fast JD, Simonich SL, Shen H, Tao S. 2017. Global long-range transport and lung cancer risk from polycyclic aromatic hydrocarbons shielded by coatings of organic aerosol. Proc Natl Acad Sci U S A 114(6):1246-1251. doi:10.1073/pnas.1618475114 PMID:28115713 PMCID:PMC5307436
• Zelenyuk A, Imre DG, Wilson J, Bell DM, Suski KJ, Shrivastava M, Josef B, Alexander ML, Kramer AL, Simonich SL. 2017. The effect of gas-phase polycyclic aromatic hydrocarbons on the formation and properties of biogenic secondary organic aerosol particles. Faraday Discuss 200:143-164. doi:10.1039/c7fd00032d PMID:28581016

2016

• Chen S, Wang J, Wang T, Mai B, Simonich SL. 2016. Seasonal variations and source apportionment of complex polycyclic aromatic hydrocarbon mixtures in particulate matter in an electronic waste and urban area in South China. Sci Total Environ 573:115-122. doi:10.1016/j.scitotenv.2016.08.101 PMID:27552735
• Chlebowski A, Tanguay RL, Simonich SL. 2016. Quantitation and prediction of sorptive losses during toxicity testing of polycyclic aromatic hydrocarbon (PAH) and nitrated PAH (NPAH) using polystyrene 96-well plates. Neurotoxicol Teratol 57:30-38. doi:10.1016/j.ntt.2016.05.001 PMID:27170619
• Rohlman D, Frey G, Kile ML, Harper B, Harris S, Motorykin O, Simonich SL, Harding A. 2016. Communicating results of a dietary exposure study following consumption of traditionally smoked salmon. Environ Justice 9(3):85-92. doi:10.1089/env.2016.0006 PMID:28804531 PMCID:PMC4981151
• Teeguarden J, Tan Y, Edwards SW, Leonard JA, Anderson KA, Corley RA, Harding A, Kile ML, Simonich SL, Stone D, Tanguay RL, Waters KM, Harper SL, Williams DE. 2016. Expanding on successful concepts, models, and organization. Environ Sci Technol 50(17):8921-8922. doi:10.1021/acs.est.6b03027 PMID:27509267
• Teeguarden J, Tan Y, Edwards SW, Leonard JA, Anderson KA, Corley RA, Kile ML, Simonich SL, Stone D, Tanguay RL, Waters KM, Harper SL, Williams DE. 2016. Completing the link between exposure science and toxicology for improved environmental health decision making: the aggregate exposure pathway framework. Environ Sci Technol 50(9):4579-4586. doi:10.1021/acs.est.5b05311 PMID:26759916 PMCID:PMC4854780
• Titaley IA, Chlebowski A, Truong L, Tanguay RL, Simonich SL. 2016. Identification and toxicological evaluation of unsubstituted PAHs and novel PAH derivatives in pavement sealcoat products. Environ Sci Technol 3(6):234-242. doi:10.1021/acs.estlett.6b00116
• Titaley IA, Chlebowski A, Truong L, Tanguay RL, Simonich SL. 2016. Response to correspondence on identification and toxicological evaluation of unsubstituted PAHs and novel PAH derivatives in pavement sealcoat products. Environ Sci Technol Lett 3(11):406-408.
• Truong L, Bugel SM, Chlebowski A, Usenko CY, Simonich MT, Simonich SL, Tanguay RL. 2016. Optimizing multi-dimensional high throughput screening using zebrafish. Reprod Toxicol 65:139-147. doi:10.1016/j.reprotox.2016.05.015 PMID:27453428 PMCID:PMC5067206

2015

• Chibwe L, Geier MC, Nakamura J, Tanguay RL, Aitken MD, Simonich SL. 2015. Aerobic bioremediation of PAH contaminated soil results in increased genotoxicity and developmental toxicity. Environ Sci Technol 49(23):13889-13898. doi:10.1021/acs.est.5b00499 PMID:26200254 PMCID:PMC4666737
• Lafontaine S, Schrlau J, Butler J, Jia Y, Harper B, Harris S, Bramer LM, Waters KM, Harding A, Simonich SL. 2015. Relative influence of trans-Pacific and regional atmospheric transport of PAHs in the Pacific Northwest, US. Environ Sci Technol 49(23):13807-13816. doi:10.1021/acs.est.5b00800 PMID:26151337 PMCID:PMC4666789
• Motorykin O, Santiago-Delgado L, Rohlman D, Schrlau J, Harper B, Harris S, Harding A, Kile ML, Simonich SL. 2015. Metabolism and excretion rates of parent and hydroxy-PAHs in urine collected after consumption of traditionally smoked salmon for Native American volunteers. Sci Total Environ 514:170-177. doi:10.1016/j.scitotenv.2015.01.083 PMID:25659315 PMCID:PMC4361301
• Motorykin O, Schrlau J, Jia Y, Harper B, Harris S, Harding A, Stone D, Kile ML, Sudakin D, Simonich SL. 2015. Determination of parent and hydroxy PAHs in personal PM and urine samples collected during Native American fish smoking activities. Sci Total Environ 505:694-703. doi:10.1016/j.scitotenv.2014.10.051 PMID:25461072 PMCID:PMC4261013

2014

• Jariyasopit N, McIntosh M, Zimmermann K, Arey J, Atkinson R, Cheong H, Carter RG, Yu T, Dashwood RH, Simonich SL. 2014. Novel nitro-PAH formation from heterogeneous reactions of PAHs with NO2, NO3/N2O5, and OH radicals: prediction, laboratory studies, and mutagenicity. Environ Sci Technol 48(1):412-419. doi:10.1021/es4043808 PMID:24350894 PMCID:PMC4125200
• Jariyasopit N, Zimmermann K, Schrlau J, Arey J, Atkinson R, Yu T, Dashwood RH, Tao S, Simonich SL. 2014. Heterogeneous reactions of particulate matter-bound PAHs and NPAHs with NO3/N2O5, OH radicals, and O3 under simulated long-range atmospheric transport conditions: reactivity and mutagenicity. Environ Sci Technol 48(17):10155-10164. doi:10.1021/es5015407 PMID:25119270 PMCID:PMC4152393

2013

• Manzano C, Hoh E, Simonich SL. 2013. Quantification of complex polycyclic aromatic hydrocarbon mixtures in standard reference materials using comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry. J Chromatogr A 1307:172-179. doi:10.1016/j.chroma.2013.07.093 PMID:23932031 PMCID:PMC4153360
• Motorykin O, Matzke MM, Waters KM, Simonich SL. 2013. Association of carcinogenic polycyclic aromatic hydrocarbon emissions and smoking with lung cancer mortality rates on a global scale. Environ Sci Technol 47(7):3410-3416. doi:10.1021/es305295d PMID:23472838 PMCID:PMC3634325
• Rochman CM, Manzano C, Hentschel BT, Simonich SL, Hoh E. 2013. Polystyrene plastic: a source and sink for polycyclic aromatic hydrocarbons in the marine environment. Environ Sci Technol 47(24):13976-13984. doi:10.1021/es403605f PMID:24341360 PMCID:PMC4140420
• Zimmermann K, Jariyasopit N, Simonich SL, Tao S, Atkinson R, Arey J. 2013. Formation of nitro-PAHs from the heterogeneous reaction of ambient particle-bound PAHs with N sub 2 sub O sub 5 sub NO sub 3 sub NO sub 2 sub. Environ Sci Technol 47(15):8434-8442. doi:10.1021/es401789x PMID:23865889 PMCID:PMC4167764

2012

• Ding J, Zhong J, Yang Y, Li B, Shen G, Su Y, Wang C, Li W, Shen H, Wang B, Wang R, Huang Y, Zhang Y, Cao H, Zhu Y, Simonich SL, Tao S. 2012. Occurrence and exposure to polycyclic aromatic hydrocarbons and their derivatives in a rural Chinese home through biomass fuelled cooking. Environ Pollut 169:160-166. doi:10.1016/j.envpol.2011.10.008 PMID:22209516 PMCID:PMC3645489
• Manzano C, Hoh E, Simonich SL. 2012. Improved separation of complex polycyclic aromatic hydrocarbon mixtures using novel column combinations in GCxGC/ToF-MS. Environ Sci Technol 46:7677-7684. doi:10.1021/es301790h PMID:22769970 PMCID:PMC3423902
• Shen G, Tao S, Wei S, Zhang Y, Wang R, Wang B, Li W, Shen H, Huang Y, Chen Y, Chen H, Yang Y, Wang W, Wang X, Liu W, Simonich SL. 2012. Emissions of parent, nitro, and oxygenated polycyclic aromatic hydrocarbons from residential wood combustion in rural China. Environ Sci Technol 46(15):8123-8130. doi:10.1021/es301146v PMID:22765266 PMCID:PMC3415380
• Shen G, Tao S, Wei S, Zhang Y, Wang R, Wang B, Li W, Shen H, Huang Y, Chen Y, Chen H, Yang Y, Wang W, Wei W, Wang X, Liu W, Wang X, Simonich SL. 2012. Reductions in emissions of carbonaceous particulate matter and polycyclic aromatic hydrocarbons from combustion of biomass pellets in comparison with raw fuel burning. Environ Sci Technol 46(11):6409-6416. doi:10.1021/es300369d PMID:22568759 PMCID:PMC3377013
• Shen G, Tao S, Wei S, Zhang Y, Wang R, Wang B, Li W, Shen H, Huang Y, Wang W, Wang X, Simonich SL. 2012. Retene emission from residential solid fuels in China and evaluation of retene as a unique marker for soft wood combustion. Environ Sci Technol 46(8):4666-4672. doi:10.1021/es300144m PMID:22452486 PMCID:PMC3352239
• Wang J, Chen S, Tian M, Zheng X, Gonzales L, Ohura T, Mai B, Simonich SL. 2012. Inhalation cancer risk associated with exposure to complex polycyclic aromatic hydrocarbon mixtures in an electronic waste and urban area in South China. Environ Sci Technol 46(17):9745-9752. doi:10.1021/es302272a PMID:22913732 PMCID:PMC3433645
• Zhong J, Ding J, Su Y, Shen G, Yang Y, Wang C, Simonich SL, Cao H, Zhu Y, Tao S. 2012. Carbonaceous particulate matter air pollution and human exposure from indoor biomass burning practices. Environ Eng Sci 29(11):1038-1045. doi:10.1089/ees.2011.0543

2011

• Jia Y, Stone D, Wang W, Schrlau J, Tao S, Simonich SL. 2011. Estimated reduction in cancer risk due to PAH exposures if source control measures during the 2008 Beijing Olympics were sustained. Environ Health Perspect 119:815-820. doi:10.1289/ehp.1003100 PMID:21632310 PMCID:PMC3114816 (Completed with ARRA Funds)
• Madeen EP, Larkin A, Siddens LK, Krueger SK, Lohr CV, Anderson KA, Simonich SL, Williams DE, Baird WM. 2011. Transplacental exposure to individual environmental carcinogens or mixtures, and dietary intervention as a chemoprevention strategy. In: Superfund Research Program Annual Meeting Oct. 24-25. Lexington, KY.
• Schrlau J, Geiser L, Hageman KJ, Landers D, Simonich SL. 2011. Comparison of lichen, conifer needles, passive air sampling devices, and snowpack as passive sampling media to measure semi-volatile organic compounds in remote atmospheres. Environ Sci Technol 45:10354-10361. doi:10.1021/es202418f PMID:22087860 PMCID:PMC3245801
• Simonich SL, Motorykin O, Jariyasopit N. 2011. PAH intermediates: links between the atmosphere and biological systems. Chem Biol Interact 192(1-2):26-29. doi:10.1016/j.cbi.2010.09.013 PMID:20849837 PMCID:PMC3010443 (Completed with ARRA Funds)
• Wang W, Jariyasopit N, Schrlau J, Jia Y, Tao S, Yu T, Dashwood RH, Zhang W, Wang X, Simonich SL. 2011. Concentration and photochemistry of PAHs, NPAHs, and OPAHs and toxicity of PM2.5 during the Beijing Olympic Games. Environ Sci Technol 45:6887-6895. doi:10.1021/es201443z PMID:21766847 PMCID:PMC3155004 (Completed with ARRA Funds)
• Wang W, Simonich SL, Giri B, Chang Y, Zhang Y, Jia Y, Tao S, Wang R, Wang B, Cao J, Lu X. 2011. Atmospheric concentrations and air-soil gas exchange of polycyclic aromatic hydrocarbons (PAHs) in remote, rural village and urban areas of Beijing-Tianjin region, North China. Sci Total Environ 409:2942-2950. doi:10.1016/j.scitotenv.2011.04.021 PMID:21669328 PMCID:PMC3718390 (Completed with ARRA Funds)
• Wang W, Simonich SL, Giri B, Xue M, Zhao J, Chen S, Shen H, Shen G, Wang R, Cao J, Tao S. 2011. Spatial distribution and seasonal variation of atmospheric bulk deposition of polycyclic aromatic hydrocarbons in Beijing-Tianjin region, North China. Environ Pollut 159(1):287-293. doi:10.1016/j.envpol.2010.08.029 PMID:20888097 PMCID:PMC3719861 (Completed with ARRA Funds)
• Wang W, Simonich SL, Wang W, Giri B, Zhao J, Xue M, Cao J, Lu X, Tao S. 2011. Atmospheric polycyclic aromatic hydrocarbon concentrations and gas/particle partitioning at background, rural village, and urban sites in the North China Plain. Atmos Res 99(2):197-206. doi:10.1016/j.atmosres.2010.10.002
• Zhang Y, Tao S, Ma J, Simonich SL. 2011. Transpacific transport of benzo[a]pyrene emitted from Asia. Atmos Chem Phys 11:11993-12006. doi:10.5194/acp-11-11993-2011

2010

• Layshock JA, Simonich SL, Anderson KA. 2010. Effect of dibenzopyrene measurement on assessing air quality in Beijing air and possible implications for human health. J Environ Monit 12:2290-2298. doi:10.1039/C0EM00057D PMID:20967364 PMCID:PMC4157367
• Siddens LK, Castro DJ, Larkin A, Simonich SL, Arlt VM, Phillips DH, Löhr C, Krueger SK, Williams DE, Baird WM, Swanson HI. 2010. Skin and transplacental carcinogenesis in mice following application of individual polycyclic aromatic hydrocarbons (PAHs) and environmental mixtures. In: Biological Radical Intermediates VIII Proceedings. Barcelona, Spain.
• Usenko S, Hageman KJ, Schrlau J, Geiser L, Campbell D, Appleby P, Landers D, Simonich SL. 2010. Sources and deposition of polycyclic aromatic hydrocarbons to western U.S. national parks. Environ Sci Technol 44(12):4512-4518. doi:10.1021/es903844n PMID:20465303 PMCID:PMC2898559 (Completed with ARRA Funds)
• Wang W, Simonich SL, Xue M, Zhao J, Zhang N, Wang R, Cao J, Tao S. 2010. Concentrations, sources and spatial distribution of polycyclic aromatic hydrocarbons in soils from Beijing, Tianjin and surrounding areas, North China. Environ Pollut 158(5):1245-1251. doi:10.1016/j.envpol.2010.01.021 PMID:20199833 PMCID:PMC3718396 (Completed with ARRA Funds)

2009

• Wang W, Primbs T, Tao S, Simonich SL. 2009. Atmospheric particulate matter pollution during the 2008 Beijing Olympics. Environ Sci Technol 43(14):5314-5320. doi:10.1021/es9007504 PMID:19708359 PMCID:PMC2739612 (Completed with ARRA Funds)

2008

• Zeng XY, Simonich SL, Robrock KR, Korytar P, Alvarez-Cohen L, Barofsky DF. 2008. Development and validation of a congener specific photodegradation model for PBDEs. Environ Toxicol Chem 27(12):2427-2435. PMID:18613751