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Person Details: Wayne L. Backes

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Superfund Research Program

Wayne L. Backes

LSU Health Sciences Center - New Orleans
1901 Perdido St. P7-1
New Orleans, Louisiana 70112
Phone: 504-568-6557
Email: wbacke@lsuhsc.edu

Projects

Publications

2023

  • Connick J, Reed JR, Cawley GF, Saha A, Backes WL. 2023. Functional characterization of CYP1 enzymes: Complex formation, membrane localization and function. J Inorg Biochem 247:112325. doi:10.1016/j.jinorgbio.2023.112325 PMID:37479567
  • Reed JR, Guidry JJ, Eyer M, Backes WL. 2023. The influence of lipid microdomain heterogeneity on protein-protein interactions: Proteomic analysis of co-immunoprecipitated binding partners of P450 1A2 and P450 3A in rate liver microsomes. Drug Metab Dispos 51(9):1196-1206. doi:10.1124/dmd.123.001287 PMID:37349115 PMCID:PMC10449098

2022

  • Reed JR, Guidry JJ, Backes WL. 2022. Proteomic and bioinformatics analysis of membrane lipid domains after Brij 98 solubilization of uninduced and phenobarbital-induced rat liver microsomes: Defining the membrane localization of the P450 enzyme system. Drug Metab Dispos 50(4):374-385. doi:10.1124/dmd.121.000752 PMID:35094979

2021

2019

  • Connick J, Reed JR, Backes WL. 2019. Physical interactions between heme oxygenase 1 and the cytochromes P450 in the endoplasmic reticulum membrane. FASEB J 33:
  • Fuchs R, Reed R, Backes WL. 2019. The effect of cholesterol depletion on the localization of CYP2D6. FASEB J 33:
  • Saha A, Connick J, Reed JR, Backes WL. 2019. Identifying the regions involved in the interactions between CYP1A2 and CYP2B4. FASEB J 33:

2018

  • Connick J, Reed JR, Backes WL. 2018. Characterization of interactions among CYP1A2, CYP2B4, and NADPH-cytochrome P450 reductase: Identifications of specific protein complexes. Drug Metab Dispos 46:197-203. doi:10.1124/dmd.117.078642 PMID:29233819 PMCID:PMC5797933
  • Harmon AC, Hebert VY, Cormier SA, Subramanian B, Reed JR, Backes WL, Dugas TR. 2018. Particulate matter containing environmentally persistent free radicals induces AhR-dependent cytokine and reactive oxygen species production in human bronchial epithelial cells. PLoS One 13:18. doi:10.1371/journal.pone.0205412 PMID:30308017 PMCID:PMC6181347

2017

2016

  • Brignac-Huber LM, Park J, Reed JR, Backes WL. 2016. Cytochrome P450 organization and function are modulated by endoplasmic reticulum phospholipid heterogeneity. Drug Metab Dispos 44(12):1859-1866. doi:10.1124/dmd.115.068981 PMID:27233287 PMCID:PMC5118634
  • Reed JR, Backes WL. 2016. The functional effects of physical interactions involving cytochromes P450: putative mechanisms of action and the extent of these effects in biological membranes. J Mol Biol 48(3):453-469. doi:10.1080/03602532.2016.1221961 PMID:27500687 PMCID:PMC5108515
  • Scott EE, Wolf CR, Otyepka M, Humphreys SC, Reed JR, Henderson CJ, McLaughlin LA, Paloncyova M, Navratilova V, Berka K, Anzenbacher P, Dahal UP, Barnaba C, Brozik JA, Jones JP, Estrada DF, Laurence JS, Park J, Backes WL. 2016. The role of protein-protein and protein-membrane interactions on P450 function. Drug Metab Dispos 44(4):576-590. doi:10.1124/dmd.115.068569 PMID:26851242 PMCID:PMC4810767

2015

2014

2013

  • Park J, Reed JR, Brignac-Huber LM, Cawley GF, Eyer M, Backes WL. 2013. Organization of cytochrome P450 system components in the endoplasmic reticulum. FASEB J 892.3:
  • Reed JR, Cawley GF, Backes WL. 2013. Interactions between cytochromes P450 2B4 (CYP2B4) and 1A2 (CYP1A2) lead to alterations in toluene disposition and P450 uncoupling. Biochemistry 52(23):4003-4013. doi:10.1021/bi400422a PMID:23675771 PMCID:PMC3750074

2012

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