Superfund Research Program
Kurt J. Varner
Louisiana State University
LSU Health Sciences Center
1901 Perdido St.
New Orleans, Louisiana 70112
Phone: 504-568-4742
Email: kvarne@lsuhsc.edu
Projects
- Louisiana State University: Combustion-Generated EPFRs: Assessing Cardiovascular Risks of Exposure (2011-2025)
- Louisiana State University: Combustion-Generated Ultrafine Particles: Cardiovascular and Cardiac Effects (ARRA Funded) (2009-2011)
- Louisiana State University: Environmentally Persistent Free Radicals Alter Pulmonary Immunologic Homeostasis (2011-2018)
Publications
2023
- Noël A, Harmon AC, Subramanian B, Perveen Z, Aryal A, Legendre K, Zaman H, Paulsen DB, Varner KJ, Dugas TR, Penn A. 2023. Adjuvant effect of inhaled particulate matter containing free radicals following house-dust mite induction of asthma in mice. Inhal Toxicol 35:333-349. doi:10.1080/08958378.2023.2289024 PMID:38060410 PMCID:10903547
2021
- Harmon AC, Noel A, Subramanian B, Perveen Z, Jennings MH, Chen Y, Penn A, Legendre K, Paulsen DB, Varner KJ, Dugas TR. 2021. Inhalation of particulate matter containing free radicals leads to decreased vascular responsiveness associated with an altered pulmonary function. Am J Physiol Heart Circ Physiol 321(4):H667-H683. doi:10.1152/ajpheart.00725.2020 PMID:34415187
2020
- Dugas TR, Varner KJ. 2020. Cardiovascular Toxicology. Chapter 15 in: An Introduction to Interdisciplinary Toxicology: From Molecules to Man. Elsevier,
2017
- Chuang GC, Xia H, Mahne S, Varner KJ. 2017. Environmentally persistent free radicals cause apoptosis in HL-1 cardiomyocytes. Cardiovasc Toxicol 17(2):140-149. doi:10.1007/s12012-016-9367-x PMID:27052339 PMCID:PMC5053829
2015
- Burn B, Varner KJ. 2015. Environmentally persistent free radicals compromise left ventricular function during ischemia/reperfusion injury. Am J Physiol Heart Circ Physiol 308(9):H998-H1006. doi:10.1152/ajpheart.00891.2014 PMID:25681431 PMCID:PMC4551132
2014
- Burn B, Varner KJ. 2014. Radical-containing ultrafine particulate matter exacerbates cardiac functional decline induced by ischemia-reperfusion injury. Society of Toxicology
- Chuang GC, Varner KJ. 2014. Radical-containing ultrafine particulate matter suppresses cardiomyocyte NRF-2 signaling. Society of Toxicology
- Lomnicki S, Gullett BK, Stoger T, Kennedy I, Diaz J, Dugas TR, Varner KJ, Carlin DJ, Dellinger B, Cormier SA. 2014. Combustion by-products and their health effects--combustion engineering and global health in the 21st century: issues and challenges. Int J Toxicol 33(1):3-13. doi:10.1177/1091581813519686 PMID:24434722 PMCID:PMC3944372
2013
- Kelley MA, Hebert VY, Thibeaux TM, Orchard MA, Hasan F, Cormier SA, Thevenot PT, Lomnicki S, Varner KJ, Dellinger B, Latimer BM, Dugas TR. 2013. Model combustion-generated particulate matter containing persistent free radicals redox cycle to produce reactive oxygen species. Chem Res Toxicol 26(12):1862-1871. doi:10.1021/tx400227s PMID:24224526 PMCID:PMC4112599
2012
- Mahne S, Chuang GC, Pankey E, Kiruri LW, Kadowitz PJ, Dellinger B, Varner KJ. 2012. Environmentally persistent free radicals decrease cardiac function and increase pulmonary artery pressure. Am J Physiol Heart Circ Physiol 303:H1135-H1142. doi:10.1152/ajpheart.00545.2012 PMID:22942180 PMCID:PMC3517644
2011
- Lord K, Moll D, Lindsey JK, Mahne S, Raman G, Dugas TR, Cormier SA, Troxlair D, Lomnicki S, Dellinger B, Varner KJ. 2011. Environmentally persistent free radicals decrease cardiac function before and after ischemia/reperfusion injury in vivo. J Recept Signal Transduct Res 31(2):157-167. doi:10.3109/10799893.2011.555767 PMID:21385100 PMCID:PMC3152960 (Completed with ARRA Funds)