Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

National Institute of Environmental Health Sciences

Use this QR code to view the newest version of this document
Use this QR code to view the newest version of this document

Your Environment. Your Health.

Person Details: Jun Yang

Superfund Research Program

Jun Yang

University of California-Davis
Department of Entomology
90 Briggs Hall
One Shields Avenue
Davis, California 95616
Phone: 530-752-5109
Fax: 530-752-1537
Email: junyang@ucdavis.edu

Projects

Publications

2023

  • Atone J, Wagner KM, Koike S, Yang J, Hwang SH, Hammock BD. 2023. Inhibition of soluble epoxide hydrolase reduces paraquat neurotoxicity in rodents. Environ Toxicol Pharmacol 98:104070. doi:10.1016/j.etap.2023.104070 PMID:36682504 PMCID:PMC9992278
  • Oh YT, Yang J, Morriseau C, He Q, Hammock BD, Youn JH. 2023. Effects of individual circulating FFAs on plasma and hepatic FFA epoxides, diols, and epoxide-diol ratios as indices of soluble epoxide hydrolase activity. Int J Mol Sci 24(13):10760. doi:10.3390/ijms241310760 PMID:37445935 PMCID:PMC10341844
  • Oh YT, Yang J, Stefanovski D, Hammock BD, Youn JH. 2023. Determinants of meal-induce changes in circulating FFA epoxides, diols, and diol-to-epoxide ratios as indices of soluble epoxide hydrolase activity. Int J Mol Sci 24(24):17351. doi:10.3390/ijms242417351 PMID:38139180 PMCID:PMC10743433
  • Thai PN, Ren L, Xu W, Overton J, Timofeyev V, Nader CE, Haddad MJ, Yang J, Gomes AV, Hammock BD, Chiamvimonvat N, Sirish P. 2023. Chronic diclofenac exposure increases mitochondrial oxidative stress, inflammatory mediators, and cardiac dysfunction. Cardiovasc Drugs Ther 37(1):25-37. doi:10.1007/s10557-021-07253-4 PMID:34499283 PMCID:PMC8904649
  • Wang W, Wagner KM, Wagner YM, Singh N, Yang J, He Q, Morisseau C, Hammock BD. 2023. Soluble epoxide hydrolase contributes to cell senescence and ER stress in aging mice colon. Int J Mol Sci 24(5):4570. doi:10.3390/ijms24054570 PMID:36901999 PMCID:PMC1000356
  • Wang Y, Morisseau C, Takamura A, Wan D, Li D, Sidoli S, Yang J, Wolan DW, Hammock BD, Kitamura S. 2023. PROTAC-mediated selective degradation of cytosolic soluble epoxide hydrolase enhances ER stress reduction. ACS Chem Biol doi:10.1021/acschembio.3c00017 PMID:36947831

2022

  • Wan D, Morisseau C, Hammock BD, Yang J. 2022. A fast and selective approach for profiling vicinal diols using liquid chromatography-post column derivatization-double precursor ion scanning mass spectrometry. Molecules 27(1):283. doi:10.3390/molecules27010283 PMID:35011515 PMCID:PMC8747065

2021

  • Jamieson KL, Darwesh AM, Sosnowski DK, Zhang H, Shah S, Zhabyeyev P, Yang J, Hammock BD, Edin ML, Zeldin DC, Oudit GY, Kassiri Z, Seubert JM. 2021. Soluble epoxide hydrolase in aged female mice and human explanted hearts following ischemic injury. Int J Mol Sci 22:doi:10.3390/ijms22041691 PMID:33567578
  • McReynolds C, Cortes-Puch I, Hammock BD, Shih P, Hammock BG, Yang J, Khan IH, Ravindran R. 2021. Plasma linoleate diols are potential biomarkers for severe COVID-19 infections. Front Physiol doi:10.3389/fphys.2021.663869 PMID:33868029 PMCID:PMC8047414
  • Mello A, Hsu M, Koike S, Chu B, Cheng J, Yang J, Morisseau C, Torok NJ, Hammock BD, Haj FG. 2021. Soluble epoxide hydrolase hepatic deficiency ameliorates alcohol-associated liver disease. Cell Mol Gastroenterol Hepatol 11:815-830. doi:10.1016/j.jcmgh.2020.10.002 PMID:33068774 PMCID:PMC7851189
  • Morisseau C, Kodani SD, Kamita SG, Yang J, Lee KS, Hammock BD. 2021. Relative importance of soluble and microsomal epoxide hydrolases for the hydrolysis of epoxy-fatty acids in human tissues. Int J Mol Sci 22:doi:10.3390/ijms22094993 PMID:34066758 PMCID:PMC8125816
  • Ravindran R, McReynolds C, Yang J, Hammock BD, Ikram A, Ali A, Bashir A, Zohra T, Chang W, Hartigan-O'Connor DJ, Rashidi HH, Khan IH. 2021. Immune response dynamics in COVID-19 patients to SARS-CoV-2 and other human coronaviruses. PLoS One 16:e0254367. doi:10.1371/journal.pone.0254367 PMID:34242356
  • Tiwari S, Yang J, Morisseau C, Durbin-Johnson BP, Hammock BD, Gomes AV. 2021. Ibuprofen alters epoxide hydrolase activity and epoxy-oxylipin metabolites associated with different metabolic pathways in murine livers. Sci Rep 11:7042. doi:10.1038/s41598-021-86284-1 PMID:33782432 PMCID:PMC8007717
  • Wagner KM, Yang J, Morisseau C, Hammock BD. 2021. Soluble epoxide hydrolase deletion limits high-fat diet-induced inflammation. Front Pharmacol 12:778470. doi:10.3389/fphar.2021.778470 PMID:34975481 PMCID:PMC8719166
  • Yang Y, Xu X, Wu H, Yang J, Chen J, Morisseau C, Hammock BD, Bettaieb A, Zhao L. 2021. Differential effects of 17,18-EEQ and 19,20-EDP combined with soluble epoxide hydrolase inhibitor t-TUCB on diet-induced obesity in mice. Int J Mol Sci 22(15):8267. doi:10.3390/ijms22158267 PMID:34361032 PMCID:PMC8347952

2020

  • Fishbein A, Wang W, Yang H, Yang J, Hallisey V, Deng J, Verheul S, Hwang SH, Gartung A, Wang Y, Bielenberg DR, Huang S, Kieran MW, Hammock BD, Panigrahy D. 2020. Resolution of eicosanoid/cytokine storm prevents carcinogen and inflammation-initiated hepatocellular cancer progression. Proc Natl Acad Sci U S A 117:21576-21587. doi:10.1073/pnas.2007412117 PMID:32801214 PMCID:PMC7474612
  • Grinan-Ferre C, Codony S, Pujol E, Yang J, Leiva R, Escolano C, Puigoriol-Illamola D, Companys-Alemany J, Corpas R, Sanfeliu C, Perez B, Loza MI, Brea J, Morisseau C, Hammock BD, Vazquez S, Pallas M, Galdeano C. 2020. Pharmacological inhibition of soluble epoxide hydrolase as a new therapy for Alzheimer's Disease. Neurotherapeutics doi:10.1007/s13311-020-00854-1 PMID:32488482
  • Huerta-Yepez S, Tirado-Rodriguez A, Montecillo-Aguado M, Yang J, Hammock BD, Hankinson O. 2020. Aryl Hydrocarbon Receptor-Dependent inductions of omega-3 and omega-6 polyunsaturated fatty acid metabolism act inversely on tumor progression. Sci Rep 10:17. doi:10.1038/s41598-020-64146-6 PMID:32398692 PMCID:PMC7217871
  • Lee KS, Ng JC, Yang J, Hwang SH, Morisseau C, Wagner KM, Hammock BD. 2020. Preparation and evaluation of soluble epoxide hydrolase inhibitors with improved physical properties and potencies for treating diabetic neuropathic pain. Bioorg Med Chem 28:doi:10.1016/j.bmc.2020.115735 PMID:33007552
  • Sirish P, Thai PN, Lee JH, Yang J, Zhang X, Ren L, Li N, Timofeyev V, Lee KS, Nader CE, Rowland DJ, Yechikov S, Ganaga S, Young JN, Lieu DK, Yamoah EN, Hammock BD, Chiamvimonvat N. 2020. Suppression of inflammation and fibrosis using soluble epoxide hydrolase inhibitors enhances cardiac stem cell-based therapy. Stem Cells Transl Med doi:10.1002/sctm.20-0143 PMID:32790136
  • Spath J, Nording M, Lindberg R, Brodin T, Jansson S, Yang J, Wan D, Hammock BD, Fick J. 2020. Novel metabolomic method to assess the effect-based removal efficiency of advanced wastewater treatment techniques. Environ Chem 17:1-5. doi:10.1071/en19270
  • Wang Y, Yang J, Wang W, Sanidad KZ, Cinelli MA, Wan D, Hee-Hwang S, Kim D, Lee KS, Xiao H, Hammock BD, Zhang G. 2020. Soluble epoxide hydrolase is an endogenous regulator of obesity-induced intestinal barrier dysfunction and bacterial translocation. Proc Natl Acad Sci U S A 117:8431-8436. doi:10.1073/pnas.1916189117 PMID:32220957 PMCID:PMC7165420
  • Xie M, Yang J, Zhang J, Sherman HL, Zhang Z, Minter LM, Hammock BD, Park Y, Zhang G. 2020. Effects of linoleic acid-rich diet on plasma profiles of eicosanoids and development of colitis in Il-10(-/-) mice. J Agric Food Chem 68:7641-7647. doi:10.1021/acs.jafc.0c03024 PMID:32594738

2019

  • Brown AL, de Smith AJ, Gant VU, Yang W, Scheurer ME, Walsh KM, Chernus JM, Kallsen NA, Peyton SA, Davies GE, Ehli EA, Winick N, Heerema NA, Carroll AJ, Borowitz MJ, Wood BL, Carroll WL, Raetz EA, Feingold E, Devidas M, Barcellos L, Hansen HM, Morimoto L, Kang AY, Smirnov I, Healy J, Laverdiere C, Sinnett D, Taub JW, Birch JM, Thompson P, Spector LG, Pombo-de-Oliveira MS, DeWan AT, Mullighan CG, Hunger SP, Pui C, Loh ML, Zwick ME, Metayer C, Ma X, Mueller BA, Sherman SL, Wiemels JL, Relling MV, Yang J, Lupo PJ, Rabin KR. 2019. Inherited genetic susceptibility to acute lymphoblastic leukemia in Down syndrome. Blood 134:1227-1237. PMID:31350265
  • Deol P, Yang J, Morisseau C, Hammock BD, Sladek FM. 2019. Dimethyl sulfoxide decreases levels of oxylipin diols in mouse liver. Front Pharmacol 10:580. doi:10.3389/fphar.2019.00580 PMID:31191316 PMCID:PMC6548860
  • Dileepan M, Rastle-Simpson S, Greenberg Y, Wijesinghe D, Kumar N, Yang J, Hwang SH, Hammock BD, Sriramarao P, Rao S. 2019. Effect Of Dual sEH/COX-2 Inhibition on Allergen-Induced Airway Inflammation. Front Pharmacol 10:1118. doi:10.3389/fphar.2019.01118 PMID:31611798 PMCID:PMC6777353
  • Gartung A, Yang J, Sukhatme VP, Bielenberg DR, Fernandes D, Chang J, Schmidt BA, Hee-Hwang S, Zurakowski D, Huang S, Kieran MW, Hammock BD, Panigrahy D. 2019. Suppression of chemotherapy-induced cytokine/lipid mediator surge and ovarian cancer by a dual COX-2/sEH inhibitor. Proc Natl Acad Sci U S A 116:1698-1703. doi:10.1073/pnas.1803999116 PMID:30647111 PMCID:PMC6358686
  • Lee KS, Yang J, Niu J, Ng CJ, Wagner KM, Dong H, Kodani SD, Wan D, Morisseau C, Hammock BD. 2019. Drug-target residence time affects in vivo target occupancy through multiple pathways. ACS Cent Sci 5:1614-1624. doi:10.1021/acscentsci.9b00770 PMID:31572788 PMCID:PMC6764161
  • Ma M, Ren Q, Yang J, Zhang K, Xiong Z, Ishima T, Pu Y, Hwang SH, Toyoshima M, Iwayama Y, Hisano Y, Yoshikawa T, Hammock BD, Hashimoto K. 2019. Key role of soluble epoxide hydrolase in the neurodevelopmental disorders of offspring after maternal immune activation. Proc Natl Acad Sci U S A 116(14):7083-7088. doi:10.1073/pnas.1819234116 PMID:30890645 PMCID:PMC6452650
  • McReynolds C, Hee-Hwang S, Yang J, Wan D, Wagner KM, Morisseau C, Li D, Schmidt WK, Hammock BD. 2019. Pharmaceutical effects of inhibiting the soluble epoxide hydrolase in canine osteoarthritis. Front Pharmacol 10:12. doi:10.3389/fphar.2019.00533 PMID:31214021 PMCID:PMC6554663
  • Otoki Y, Metherel AH, Pedersen TL, Yang J, Hammock BD, Bazinet RP, Newman JW, Taha AY. 2019. Acute hypercapnia/ischemia alters the esterification of arachidonic acid and docosahexaenoic acid epoxide metabolites in rat brain neutral lipids. Lipids 55(1):7-22. doi:10.1002/lipd.12197
  • Panigrahy D, Gartung A, Yang J, Yang H, Gilligan MM, Sulciner ML, Bhasin SS, Bielenberg DR, Chang J, Schmidt BA, Piwowarski J, Fishbein A, Soler-Ferran D, Sparks MA, Staffa SJ, Sukhatme V, Hammock BD, Kieran MW, Huang S, Bhasin M, Serhan CN, Sukhatme VP. 2019. Preoperative stimulation of resolution and inflammation blockade eradicates micrometastases. J Clin Invest 129(7):2964-2979. doi:10.1172/JCI127282 PMID:31205032 PMCID:PMC6597207
  • Shen Y, Peng W, Chen Q, Hammock BD, Liu J, Li D, Yang J, Ding J, Wang X. 2019. Anti-inflammatory treatment with a soluble epoxide hydrolase inhibitor attenuates seizures and epilepsy-associated depression in the LiCl-pilocarpine post-status epilepticus rat model. Brain Behav Immun 81:535-544. doi:10.1016/j.bbi.2019.07.014 PMID:31306773 PMCID:PMC6873816
  • Wan D, Yang J, McReynolds C, Barnych B, Wagner KM, Morisseau C, Hee-Hwang S, Sun J, Blocher R, Hammock BD. 2019. In vitro and in vivo metabolism of a potent inhibitor of soluble epoxide hydrolase, 1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea. Front Pharmacol 10:464. doi:10.3389/fphar.2019.00464 PMID:31143115 PMCID:PMC6520522
  • Wang K, Vasylieva N, Wan D, Eads DA, Yang J, Tretten T, Barnych B, Li J, Li QX, Gee SJ, Hammock BD, Xu T. 2019. Quantitative detection of fipronil and fipronil-sulfone in sera of black-tailed prairie dogs and rats after oral exposure to fipronil by camel single-domain antibody-based immunoassays. Anal Chem 91:1532-1540. doi:10.1021/acs.analchem.8b04653
  • Yang J, Bruun DA, Wang C, Wan D, McReynolds C, Phu K, Inceoglu B, Lein PJ, Hammock BD. 2019. Lipidomes of brain from rats acutely intoxicated with diisopropylfluorophosphate identifies potential therapeutic targets. Toxicol Appl Pharmacol 382:114749. doi:10.1016/j.taap.2019.114749 PMID:31521729 PMCID:PMC6957308

2018

  • Cinelli MA, Yang J, Scharmen A, Woodman J, Karchalla LM, Lee KS. 2018. Enzymatic synthesis and chemical inversion provide both enantiomers of bioactive epoxydocosapentaenoic acids. J Lipid Res 59:2237-2252. doi:10.1194/jlr.D089136 PMID:30209076 PMCID:PMC6210906
  • Harris TR, Kodani SD, Rand AA, Yang J, Imai DM, Hwang SH, Hammock BD. 2018. Celecoxib does not protect against fibrosis and inflammation in a carbon tetrachloride-induced model of liver injury. Mol Pharmacol 94:834-841. doi:10.1124/mol.118.111831 PMID:29844231 PMCID:PMC6022802
  • Hennebelle M, Metherel AH, Kitson AP, Otoki Y, Yang J, Lee KS, Hammock BD, Bazinet RP, Taha AY. 2018. Brain oxylipin concentrations following hypercapnia/ischemia: effects of brain dissection and dissection time. J Lipid Res 60:671-682. doi:10.1194/jlr.D084228 PMID:30463986 PMCID:PMC6399504
  • Ren Q, Ma M, Yang J, Nonaka R, Yamaguchi A, Ishikawa K, Kobayashi K, Murayama S, Hwang SH, Saiki S, Akamatsu W, Hattori N, Hammock BD, Hashimoto K. 2018. Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson's disease. Proc Natl Acad Sci U S A 115:E5815-E5823. doi:10.1073/pnas.1802179115 PMID:29735655 PMCID:PMC6016799
  • Taha AY, Hennebelle M, Yang J, Zamora D, Rapoport SI, Hammock BD, Ramsden CE. 2018. Regulation of rat plasma and cerebral cortex oxylipin concentrations with increasing levels of dietary linoleic acid. Prostaglandins Leukot Essent Fatty Acids 138:71-80. doi:10.1016/j.plefa.2016.05.004 PMID:27282298 PMCID:PMC5106341
  • Wang F, zhang H, Ma A, Yu W, Zimmermann M, Yang J, Hwang SH, Zhu D, Lin T, Malfatti MA, Turteltaub KW, Henderson PT, Airhart S, Hammock BD, Yuan J, de Vere White RW, Pan C. 2018. COX-2/sEH dual inhibitor PTUPB potentiates the antitumor efficacy of cisplatin. Mol Cancer Ther 17:474-483. doi:10.1158/1535-7163.MCT-16-0818 PMID:29284644 PMCID:PMC5824635
  • Wang W, Yang J, Zhang J, Wang Y, Hee-Hwang S, Qi W, Wan D, Kim D, Sun J, Sanidad KZ, Yang H, Park Y, Liu J, Zhao X, Zheng X, Liu Z, Hammock BD, Zhang G. 2018. Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation. Proc Natl Acad Sci U S A 115:5283-5288. doi:10.1073/pnas.1721711115 PMID:29717038 PMCID:PMC5960306

2017

  • Fischer GJ, Bacon W, Yang J, Palmer JM, Dagenais T, Hammock BD, Keller NP. 2017. Lipoxygenase activity accelerates programmed spore germination in aspergillus fumigatus. Front Microbiol 8:831. doi:10.3389/fmicb.2017.00831 PMID:28536571 PMCID:PMC5422543
  • Goswami SK, Rand A, Wan DB, Yang J, Inceoglu B, Thomas M, Morisseau C, Yang G, Hammock BD. 2017. Pharmacological inhibition of soluble epoxide hydrolase or genetic deletion reduces diclofenac-induced gastric ulcers. Life Sciences 180:114-122. doi:10.1016/j.lfs.2017.05.018 PMID:28522175 PMCID:PMC5659729
  • Hennebelle M, Zhang Z, Metherel AH, Kitson AP, Otoki Y, Richardson CE, Yang J, Lee KS, Hammock BD, Zhang L, Bazinet RP, Taha AY. 2017. Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission. Sci Rep 7:4342. doi:10.1038/s41598-017-02914-7 PMID:28659576 PMCID:PMC5489485
  • Lee KS, Henriksen NM, Ng CJ, Yang J, Jia W, Morisseau C, Andaya A, Gilson MK, Hammock BD. 2017. Probing the orientation of inhibitor and epoxy-eicosatrienoic acid binding in the active site of soluble epoxide hydrolase. Arch Biochem Biophys 613:1-11. doi:10.1016/j.abb.2016.10.017 PMID:27983948 PMCID:PMC5172606
  • Richardson CE, Hennebelle M, Otoki Y, Zamora D, Yang J, Hammock BD, Taha AY. 2017. Lipidomic analysis of oxidized fatty acids in plant and algae oils. J Agric Food Chem 65(9):1941-1951. doi:10.1021/acs.jafc.6b05559 PMID:28157307
  • Wagner KM, Gilda JE, Yang J, Wan D, Morisseau C, Gomes AV, Hammock BD. 2017. Soluble epoxide hydrolase inhibition alleviates neuropathy in Akita (Ins2 Akita) mice. Behav Brain Res 326:69-76. doi:10.1016/j.bbr.2017.02.048 PMID:28259677 PMCID:PMC5409858
  • Wan D, Yang J, Barnych B, Hwang SH, Lee KS, Cui Y, Niu J, Watsky MA, Hammock BD. 2017. A new sensitive LC/MS/MS analysis of vitamin D metabolites using a click derivatizatization reagent, 2-nitrosopyridine. J Lipid Res 58(4):798-808. doi:10.1194/jlr.D073536 PMID:28148721 PMCID:PMC5392736
  • Wang W, Yang J, Qi W, Yang H, Wang C, Tan B, Hammock BD, Park Y, Kim D, Zhang G. 2017. Lipidomic profiling of high-fat diet-induced obesity in mice: importance of cytochrome P450-derived fatty acid epoxides. Obesity (Silver Spring) 25(1):132-140. doi:10.1002/oby.21692 PMID:27891824 PMCID:PMC5182168
  • Yang J, Oh YT, Wan D, Watanabe RM, Hammock BD, Youn JH. 2017. Postprandial effect to decrease soluble epoxide hydrolase activity: roles of insulin and gut microbiota. J Nutr Biochem 49:8-14. doi:10.1016/j.jnutbio.2017.07.006 PMID:28863368

2016

  • Akintoye E, Wu JH, Hou T, Song X, Yang J, Hammock BD, Mozaffarian D. 2016. Effect of fish oil on monoepoxides derived from fatty acids during cardiac surgery. J Lipid Res 57(3):492-498. doi:10.1194/jlr.P062398 PMID:26749073 PMCID:PMC4766998
  • Goswami SK, Wan D, Yang J, Trindade da Silva CA, Morisseau C, Kodani SD, Yang G, Inceoglu B, Hammock BD. 2016. Anti-ulcer efficacy of soluble epoxide hydrolase inhibitor TPPU on diclofenac-induced intestinal ulcers. J Pharmacol Exp Ther 357(3):529-536. doi:10.1124/jpet.116.232108 PMID:26989141 PMCID:PMC4885505
  • Ren Q, Ma M, Ishima T, Morisseau C, Yang J, Wagner KM, Zhang J, Yao W, Dong C, Han M, Hammock BD, Hashimoto K. 2016. Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress. Proc Natl Acad Sci U S A 113(13):E1944-E1952. doi:10.1073/pnas.1601532113 PMID:26976569 PMCID:PMC4822604
  • Sirish P, Li N, Timofeyev V, Zhang X, Wang L, Yang J, Lee KS, Bettaieb A, Ma S, Lee JH, Su D, Lau V, Myers R, Lieu DK, Lopez JE, Young JN, Yamoah EN, Haj FG, Ripplinger C, Hammock BD, Chiamvimonvat N. 2016. Molecular mechanisms and new treatment paradigm for atrial fibrillation. Circ Arrhythm Electrophysiol 9(5):e003721-e003740. doi:10.1161/CIRCEP.115.003721 PMID:27162031 PMCID:PMC4869994
  • Ulu A, Inceoglu B, Yang J, Singh V, Vito S, Wulff H, Hammock BD. 2016. Inhibition of soluble epoxide hydrolase as a novel approach to high dose diazepam induced hypotension. J Clin Toxicol 6(3):1000300. doi:10.4172/2161-0495.1000300 PMID:28255523 PMCID:PMC5328659
  • Wagner KM, Lee KS, Yang J, Hammock BD. 2016. Epoxy fatty acids mediate analgesia in murine diabetic neuropathy. Eur J Pain 21:456-465. doi:10.1002/ejp.939 PMID:27634339 PMCID:PMC5300894
  • Xu J, Morisseau C, Yang J, Lee KS, Kamita SG, Hammock BD. 2016. Ingestion of the epoxide hydrolase inhibitor AUDA modulates immune responses of the mosquito, Culex quinquefasciatus during blood feeding. Insect Biochem Mol Biol 76:62-69. doi:10.1016/j.ibmb.2016.06.011 PMID:27369469 PMCID:PMC5010450

2015

  • Berthelot CC, Kamita SG, Sacchi R, Yang J, Nording ML, Georgi K, Karbowski CH, German JB, Weiss RH, Hogg RJ, Hammock BD, Zivkovic AM. 2015. Changes in PTGS1 and ALOX12 gene expression in peripheral blood mononuclear cells are associated with changes in arachidonic acid, oxylipins, and oxylipin/fatty acid ratios in response to omega-3 fatty acid supplementation. PLoS One 10(12):e0144996. doi:10.1371/journal.pone.0144996 PMID:26672987 PMCID:PMC4681469
  • Cui Y, Li D, Morisseau C, Dong J, Yang J, Wan D, Rossotti MA, Gee SJ, Gonzalez-Sapienza GG, Hammock BD. 2015. Heavy chain single-domain antibodies to detect native human soluble epoxide hydrolase. Anal Bioanal Chem 407(24):7275-7283. doi:10.1007/s00216-015-8889-6 PMID:26229025 PMCID:PMC4573264
  • Fahrmann J, Grapov D, Yang J, Hammock BD, Fiehn O, Bell GI, Hara M. 2015. Systemic alterations in the metabolome of diabetic NOD mice delineate increased oxidative stress accompanied by reduced inflammation and hypertriglyceremia. Am J Physiol Endocrinol Metab 308(11):E978-E989. doi:10.1152/ajpendo.00019.2015 PMID:25852003 PMCID:PMC4451288
  • Goswami SK, Inceoglu B, Yang J, Wan D, Kodani SD, Trindade da Silva CA, Morisseau C, Hammock BD. 2015. Omeprazole increases the efficacy of a soluble epoxide hydrolase inhibitor in a PGE₂ induced pain model. Toxicol Appl Pharmacol 289(3):419-427. doi:10.1016/j.taap.2015.10.018 PMID:26522832 PMCID:PMC4666679
  • Nording M, Yang J, Hoang L, Zamora V, Uyeminami DL, Espiritu I, Pinkerton KE, Hammock BD, Luria A. 2015. Bioactive lipid profiling reveals drug target engagement of a soluble epoxide hydrolase inhibitor in a murine model of tobacco smoke exposure. Metabolomics 1:doi:10.7243/2059-0008-1-1 PMID:27076918 PMCID:PMC4827720
  • Shihadih DS, Harris TR, Yang J, Merzlikin O, Lee KS, Hammock BD, Morisseau C. 2015. Identification of potent inhibitors of the chicken soluble epoxide hydrolase. Bioorg Med Chem Lett 25(2):276-279. doi:10.1016/j.bmcl.2014.11.053 PMID:25479771 PMCID:PMC4277729
  • Wang J, Majkova Z, Bever C, Yang J, Gee SJ, Li J, Xu T, Hammock BD. 2015. One-step immunoassay for tetrabromobisphenol a using a camelid single domain antibody-alkaline phosphatase fusion protein. Anal Chem 87(9):4741-4748. doi:10.1021/ac504735p PMID:25849972 PMCID:PMC4476793
  • Xu J, Morisseau C, Yang J, Mamatha DM, Hammock BD. 2015. Epoxide hydrolase activities and epoxy fatty acids in the mosquito Culex quinquefasciatus. Insect Biochem Mol Biol 59:41-49. doi:10.1016/j.ibmb.2015.02.004 PMID:25686802 PMCID:PMC4387068
  • Yang J, Bratt J, Franzi L, Liu J, Zhang G, Zeki AA, Vogel CF, Williams K, Dong H, Lin Y, Hwang SH, Kenyon NJ, Hammock BD. 2015. Soluble epoxide hydrolase inhibitor attenuates inflammation and airway hyperresponsiveness in mice. Am J Respir Cell Mol Biol 52(1):46-55. doi:10.1165/rcmb.2013-0440OC PMID:24922186 PMCID:PMC4370250

2014

  • Bettaieb A, Chahed S, Tabet G, Yang J, Morisseau C, Griffey S, Hammock BD, Haj FG. 2014. Effects of soluble epoxide hydrolase deficiency on acute pancreatitis in mice. PLoS One 9(11):e113019. doi:10.1371/journal.pone.0113019 PMID:25402489 PMCID:PMC4234494
  • Charles RL, Rudyk O, Prysyazhna O, Kamynina A, Yang J, Morisseau C, Hammock BD, Freeman BA, Eaton P. 2014. Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase. Proc Natl Acad Sci U S A 111(22):8167-8172. doi:10.1073/pnas.1402965111 PMID:24843165 PMCID:PMC4050620
  • Kim J, Imig JD, Yang J, Hammock BD, Padanilam BJ. 2014. Inhibition of soluble epoxide hydrolase prevents renal interstitial fibrosis and inflammation. Am J Physiol Renal Physiol 307(8):F971-F980. doi:10.1152/ajprenal.00256.2014 PMID:25164080 PMCID:PMC4200297
  • Lee KS, Liu J, Wagner KM, Pakhomova S, Dong H, Morisseau C, Fu SH, Yang J, Wang P, Ulu A, Mate CA, Nguyen LV, Hwang SH, Edin ML, Mara AA, Wulff H, Newcomer ME, Zeldin DC, Hammock BD. 2014. Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy. J Med Chem 57(16):7016-7030. doi:10.1021/jm500694p PMID:25079952 PMCID:PMC4148150
  • Morisseau C, Wecksler AT, Deng C, Dong H, Yang J, Lee KS, Kodani SD, Hammock BD. 2014. Effect of soluble epoxide hydrolase polymorphism on substrate and inhibitor selectivity and dimer formation. J Lipid Res 55(6):1131-1138. doi:10.1194/jlr.M049718 PMID:24771868 PMCID:PMC4031944
  • Ono E, Dutile S, Kazani S, Weschsler ME, Yang J, Hammock BD, Douda DN, Tabet Y, Khaddaj-Mallat R, Sirois M, Sirois C, Rizcallah E, Rousseau E, Martin R, Sutherland E, Castro M, Jarjour NN, Israel E, Levy BD. 2014. Lipoxin generation is related to soluble epoxide hydrolase activity in severe asthma. Am J Respir Crit Care Med 190(8):886-897. doi:10.1164/rccm.201403-0544OC PMID:25162465 PMCID:PMC4299578
  • Schebb N, Ostermann AI, Yang J, Hammock BD, Hahn A, Schuchardt J. 2014. Comparison of the effects of long-chain omega-3 fatty acid supplementation on plasma levels of free and esterified oxylipins. Prostaglandins Other Lipid Mediat 113-115:21-29. doi:10.1016/j.prostaglandins.2014.05.002 PMID:24880049 PMCID:PMC4247815
  • Schuchardt J, Schneider I, Willenberg I, Yang J, Hammock BD, Hahn A, Schebb N. 2014. Increase of EPA-derived hydroxy, epoxy and dihydroxy fatty acid levels in human plasma after a single dose of long-chain omega-3 PUFA. Prostaglandins Other Lipid Mediat 109-111:23-31. doi:10.1016/j.prostaglandins.2014.03.001 PMID:24667634 PMCID:PMC4172375
  • Ulu A, Lee S, Miyabe C, Yang J, Hammock BG, Dong H, Hammock BD. 2014. An omega-3 epoxide of docosahexaenoic acid lowers blood pressure in angiotensin-II-dependent hypertension. J Cardiovasc Pharmacol 64(1):87-99. doi:10.1097/FJC.0000000000000094 PMID:24691274 PMCID:PMC4092041
  • Wagner KM, Yang J, Inceoglu B, Hammock BD. 2014. Soluble epoxide hydrolase inhibition is antinociceptive in a mouse model of diabetic neuropathy. J Pain 15(9):907-914. doi:10.1016/j.jpain.2014.05.008 PMID:24924124 PMCID:PMC4150748
  • Wang J, Bever C, Majkova Z, Dechant JE, Yang J, Gee SJ, Xu T, Hammock BD. 2014. Heterologous antigen selection of camelid heavy chain single domain antibodies against tetrabromobisphenol A. Anal Chem 86(16):8296-8302. doi:10.1021/ac5017437 PMID:25068372 PMCID:PMC4139172
  • Zhang G, Panigrahy D, Hwang SH, Yang J, Mahakian LM, Wettersten HI, Liu J, Wang Y, Ingham ES, Tam S, Kieran MW, Weiss RH, Ferrara KW, Hammock BD. 2014. Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis. Proc Natl Acad Sci U S A 111(30):11127-11132. doi:10.1073/pnas.1410432111 PMID:25024195 PMCID:PMC4121808

2013

  • Gardell AM, Yang J, Sacchi R, Fangue NA, Hammock BD, Kültz D. 2013. Tilapia (Oreochromis mossambicus) brain cells respond to hyperosmotic challenge by inducing myo-inositol biosynthesis. J Exp Biol 216(24):4615-4625. doi:10.1242/jeb.088906 PMID:24072790 PMCID:PMC3851147
  • Inceoglu B, Zolkowska D, Yoo H, Wagner KM, Yang J, Hackett E, Hwang SH, Lee KS, Rogawski MA, Morisseau C, Hammock BD. 2013. Epoxy fatty acids and inhibition of the soluble epoxide hydrolase selectively modulate GABA mediated neurotransmission to delay onset of seizures. PLoS One 8(12):doi:10.1371/journal.pone.0080922 PMID:24349022 PMCID:PMC3862847
  • Lee KS, Morisseau C, Yang J, Wang P, Hwang SH, Hammock BD. 2013. Forster resonance energy transfer competitive displacement assay for human soluble epoxide hydrolase. Anal Biochem 434(2):259-268. doi:10.1016/j.ab.2012.11.015 PMID:23219719 PMCID:PMC3632402
  • Lundstrom SL, Yang J, Brannan JD, Haeggstrom JZ, Nair P, O'Byrne P, Dahlen SE, Wheelock CE. 2013. Lipid mediator serum profiles in asthmatics significantly shift following dietary supplementation with omega-3 fatty acids. Mol Nutr Food Res 57(8):1378-1789. doi:10.1002/mnfr.201200827 PMID:23824870 PMCID:PMC3943463
  • Nording ML, Yang J, Georgi K, Karbowski CH, German JB, Weiss RH, Hogg RJ, Trygg J, Hammock BD, Zivkovic AM. 2013. Individual variation in lipidomic profiles of healthy subjects in response to omega-3 Fatty acids. PLoS One 8:e76575. doi:10.1371/journal.pone.0076575 PMID:24204640 PMCID:PMC3811983
  • Panigrahy D, Kalish BT, Huang S, Bielenberg DR, Le HD, Yang J, Edin ML, Lee CR, Benny O, Mudge DK, Butterfield CE, Mammoto A, Mammoto T, Inceoglu B, Jenkins RL, Simpson MA, Akino T, Lih FB, Tomer KB, Ingber DE, Hammock BD, Falck JR, Manthati VL, Kaipainen A, D'Amore PA, Puder M, Zeldin DC, Kieran MW. 2013. Epoxyeicosanoids promote organ and tissue regeneration. Proc Natl Acad Sci U S A 110(33):13528-13533. doi:10.1073/pnas.1311565110 PMID:23898174 PMCID:PMC3746918
  • Van Bogaert I, Zhang G, Yang J, Liu J, Ye Y, Soetaert W, Hammock BD. 2013. Preparation of 20- HETE using multifunctional enzyme type 2-negative Starmerella bombicola. J Lipid Res 54(11):3215-3219. doi:10.1194/jlr.D042226 PMID:23966667 PMCID:PMC3793626
  • Wagner KM, Inceoglu B, Dong H, Yang J, Hwang SH, Jones PD, Morisseau C, Hammock BD. 2013. Comparative efficacy of 3 soluble epoxide hydrolase inhibitors in rat neuropathic and inflammatory pain models. Eur J Pharmacol 700(1-3):93-101. doi:10.1016/j.ejphar.2012.12.015 PMID:23276668 PMCID:PMC3578047
  • Yang J, Solaimani P, Dong H, Hammock BD, Hankinson O. 2013. Treatment of mice with 2,3,7,8-Tetrachlorodibenzo-p-dioxin markedly increases the levels of a number of cytochrome P450 metabolites of omega-3 polyunsaturated fatty acids in the liver and lung. Toxicol Sci 38(6):833-836. PMID:24213002 PMCID:PMC4068614
  • Zhang G, Panigrahy D, Mahakian LM, Yang J, Liu J, Lee KS, Wettersten HI, Ulu A, Hu X, Tam S, Hwang SH, Ingham ES, Kieran MW, Weiss RH, Ferrara KW, Hammock BD. 2013. Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis. Proc Natl Acad Sci U S A 110(16):6530-6535. doi:10.1073/pnas.1304321110 PMID:23553837 PMCID:PMC3631682

2012

2011

2010

  • Liu J, Li N, Yang J, Li N, Qiu H, Ai D, Chiamvimonvat N, Zhu Y, Hammock BD. 2010. Metabolic profiling of murine plasma reveals an unexpected biomarker in rofecoxib-mediated cardiovascular events. Proc Natl Acad Sci U S A 107(39):17017-17022. doi:10.1073/pnas.1011278107 PMID:20837537 PMCID:PMC2947894
  • Nording ML, Yang J, Hegedus CM, Bhushan A, Kenyon NJ, Davis CE, Hammock BD. 2010. Endogenous levels of five fatty acid metabolites in exhaled breath condensate to monitor asthma by high-performance liquid chromatography: Electrospray tandem mass spectrometry. IEEE/ACM Trans Comput Biol Bioinform 10(1):123-130. doi:10.1109/JSEN.2009.2035736 PMID:21103452 PMCID:PMC2981865
  • Tsai H, Hwang SH, Morisseau C, Yang J, Jones PD, Kasagami T, Kim I, Hammock BD. 2010. Pharmacokinetic screening of soluble epoxide hydrolase inhibitors in dogs. European Journal of Pharmaceutical Sciences 40(3):222-238. doi:10.1016/j.ejps.2010.03.018 PMID:20359531 PMCID:PMC3285443

2009

  • Ai D, Pang W, Li N, Xu M, Jones PD, Yang J, Zhang Y, Chiamvimonvat N, Shyy JY, Hammock BD, Zhu Y. 2009. Soluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophy. Proc Natl Acad Sci U S A 106(2):564-569. doi:10.1073/pnas.0811022106 PMID:19126686 PMCID:PMC2626743
  • Li N, Liu J, Timofeyev V, Qiu H, Hwang SH, Tuteja D, Lu L, Yang J, Mochida H, Low R, Hammock BD, Chiamvimonvat N. 2009. Beneficial effects of soluble epoxide hydrolase inhibitors in myocardial infarction model: Insight gained using metabolomic approaches. J Mol Cell Cardiol 47(6):835-845. doi:10.1016/j.yjmcc.2009.08.017 PMID:19716829 PMCID:PMC3290524
  • Luria A, Morisseau C, Tsai H, Yang J, Inceoglu B, De Taeye B, Wiest MM, German JB, Hammock BD, Watkins SM. 2009. Alteration in plasma testosterone levels in male mice lacking soluble epoxide hydrolase. Am J Physiol Endocrinol Metab 297(2):E375-E383. doi:10.1152/ajpendo.00131.2009 PMID:19458064 PMCID:PMC2724109
  • Yang J, Schmelzer KR, Georgi K, Hammock BD. 2009. Quantitative profiling method for oxylipin metabolome by liquid chromatography electrospray ionization tandem mass spectrometry. Anal Chem 81(19):8085-8093. doi:10.1021/ac901282n PMID:19715299 PMCID:PMC3290520
Back
to Top