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Person Details: Xihong Lin

Superfund Research Program

Xihong Lin

Harvard School of Public Health
Biostatistics, Bldg 2-451
655 Huntington Dr.
Boston, Massachusetts 02115
Phone: 617-432-2914
Fax: 617-432-5619




  • Sun R, Shi A, Lin X. 2023. Differences in set-based tests for sparse alternatives when testing sets of outcomes compared to sets of explanatory factors in genetic association studies. Biostatistics 25(1):171-187. doi:10.1093/biostatistics/kxac036 PMID:36000269 PMCID:10724113
  • Zhou H, Arapoglou T, Li X, Li Z, Zheng X, Moore JE, Asok A, Kumar S, Blue EE, Buyske S, Cox NJ, Felsenfeld A, Gerstein M, Kenny E, Li B, Matise T, Philippakis A, Rehm HL, Sofia HJ, Snyder G, Weng Z, Neale BM, Sunyaev SR, Lin X. 2023. FAVOR: functional annotation of variants online resource and annotator for variation across the human genome. Nucleic Acids Res 51:1300-1311. doi:10.1093/nar/gkac966 PMID:36350676 PMCID:9825437



  • Chen S, Lin X. 2020. Analysis in case-control sequencing association studies with different sequencing depths. Biostatistics 21:577-593. doi:10.1093/biostatistics/kxy073 PMID:30590456 PMCID:PMC7308042
  • Li X, Li Z, Zhou H, Gaynor S, Liu Y, Chen H, Sun R, Dey R, Arnett D, Aslibekyan S, Ballantyne CM, Bielak LF, Blangero J, Boerwinkle E, Bowden DW, Broome JG, Conomos MP, Correa A, Cupples A, Curran JE, Freedman BI, Guo X, Hindy G, Irvin MR, Kardia SL, Kathiresan S, Khan AT, Kooperberg CL, Laurie CC, Liu XS, Mahaney MC, Manichaikul AW, Martin LW, Mathias RA, McGarvey ST, Mitchell BD, Montasser ME, Moore JE, O'Connell JR, Palmer ND, Pampana A, Peralta JM, Peyser PA, Psaty BM, Redline S, Rice KM, Rich SS, Smith JA, Tiwari HK, Tsai MY, Vasan RS, Wang F, Weeks DE, Weng Z, Wilson JG, Yanek LR, Neale BM, Sunyaev SR, Abecasis GR, Rotter JI, Willer CJ, Peloso GM, Natarajan P, Lin X. 2020. Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale. Nat Genet 52:969-983. doi:10.1038/s41588-020-0676-4 PMID:32839606 PMCID:PMC7483769
  • Sun R, Xu M, Li X, Gaynor S, Zhou H, Li Z, Bosse Y, Lam S, Tsao M, Tardon A, Chen C, Doherty JA, Goodman G, Bojesen SE, Landi MT, Johansson M, Field JK, Bickeboller H, Wichmann H, Risch A, Rennert G, Arnold S, Wu X, Melander O, Brunnstrom H, Le Marchand L, Liu G, Andrew AS, Duell EJ, Kiemeney LA, Shen H, Haugen A, Johansson M, Grankvist K, Caporaso N, Woll P, Dawn Teare M, Scelo G, Hong Y, Yuan J, Lazarus P, Schabath MB, Aldrich MC, Albanes D, Mak R, Barbie D, Brennan P, Hung RJ, Amos CI, Christiani DC, Lin X. 2020. Integration of multiomic annotation data to prioritize and characterize inflammation and immune-related risk variants in squamous cell lung cancer. Genet Epidemiol doi:10.1002/gepi.22358 PMID:32924180


  • Sun R, Wang Z, Henn BC, Su L, Lu Q, Lin X, Wright RO, Bellinger DC, Kile ML, Mazumdar M, Tellez-Rojo MM, Schnaas L, Christiani DC. 2018. Identification of novel loci associated with infant cognitive ability. Mol Psychiatry PMID:30120420


  • Sun R, Carroll RJ, Christiani DC, Lin X. 2017. Testing for gene-environment interaction under exposure misspecification. Biometrics doi:10.1111/biom.12813 PMID:29120492
  • Wang Z, Henn BC, Wang C, Wei Y, Li S, Sun R, Chen H, Wagner PJ, Lu Q, Lin X, Wright RO, Bellinger DC, Kile ML, Mazumdar M, Tellez-Rojo M, Schnaas L, Christiani DC. 2017. Genome-wide gene by lead exposure interaction analysis identifies UNC5D as a candidate gene for neurodevelopment. Environ Health 16:81. doi:10.1186/s12940-017-0288-3 PMID:28754176 PMCID:PMC5534076



  • Seow W, Pan W, Kile ML, Tong L, Baccarelli A, Quamruzzaman Q, Rahman M, Mostofa G, Rakibuz-Zaman M, Ahsan H, Lin X, Christiani DC, Kibriya MG. 2015. A distinct and replicable variant of the squamous cell carcinoma gene inositol polyphosphate-5-phosphatase modifies the susceptibility of arsenic-associated skin lesions in Bangladesh. Cancer 121(13):2222-2229. doi:10.1002/cncr.29291 PMID:25759212 PMCID:PMC4565788
  • Wang C, Zhan X, Liang L, Abecasis GR, Lin X. 2015. Improved ancestry estimation for both genotyping and sequencing data using projection procrustes analysis and genotype imputation. Am J Hum Genet 96(6):926-937. doi:10.1016/j.ajhg.2015.04.018 PMID:26027497 PMCID:PMC4457959


  • Fan T, Fang SC, Cavallari JM, Barnett IJ, Wang Z, Su L, Byun H, Lin X, Baccarelli A, Christiani DC. 2014. Heart rate variability and DNA methylation levels are altered after short-term metal fume exposure among occupational welders: a repeated-measures panel study. BMC Public Health 14:1279. doi:10.1186/1471-2458-14-1279 PMID:25512264 PMCID:PMC4302115
  • Lee S, Abecasis GR, Boehnke M, Lin X. 2014. Rare-variant association analysis: study designs and statistical tests. Am J Hum Genet 95(1):5-23. doi:10.1016/j.ajhg.2014.06.009 PMID:24995866 PMCID:PMC4085641
  • Seow W, Kile ML, Baccarelli A, Pan W, Byun H, Mostofa G, Quamruzzaman Q, Rahman M, Lin X, Christiani DC. 2014. Epigenome-wide DNA methylation changes with development of arsenic-induced skin lesions in Bangladesh: a case-control follow-up study. Environ Mol Mutagen 55(6):449-456. doi:10.1002/em.21860 PMID:24677489 PMCID:PMC4082746





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