Superfund Research Program
Bernard W. Futscher
University of Arizona
Arizona Cancer Center
1515 N. Campbell Avenue
Tucson, Arizona 85724
Phone: 520-626-4646
Email: bfutscher@azcc.arizona.edu
Projects
- University of Arizona: Epigenomic Actions of Environmental Arsenicals (2010-2015)
Publications
2015
- Vrba L, Garbe JC, Stampfer MR, Futscher BW. 2015. A lincRNA connected to cell mortality and epigenetically-silenced in most common human cancers. Epigenetics 10(11):1074-1083. doi:10.1080/15592294.2015.1106673 PMID:26646903 PMCID:PMC4844203
2014
- Severson PL, Vrba L, Stampfer MR, Futscher BW. 2014. Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells. Mutat Res 775-776:48-54. doi:10.1016/j.mrgentox.2014.10.011 PMID:25435355 PMCID:PMC4250937
- Vorrink SU, Severson PL, Kulak MV, Futscher BW, Domann FE. 2014. Hypoxia perturbs aryl hydrocarbon receptor signaling and CYP1A1 expression induced by PCB 126 in human skin and liver-derived cell lines. Toxicol Appl Pharmacol 274(3):408-416. doi:10.1016/j.taap.2013.12.002 PMID:24355420 PMCID:PMC3919493
2013
- Severson PL, Tokar EJ, Vrba L, Waalkes MP, Futscher BW. 2013. Coordinate H3K9 and DNA methylation silencing of ZNFs in toxicant-induced malignant transformation. Epigenetics 8(10):1080–1088. doi:10.4161/epi.25926 PMID:23974009 PMCID:PMC3891689
- Zhao F, Severson PL, Pacheco S, Futscher BW, Klimecki WT. 2013. Arsenic exposure induces the Warburg effect in cultured human cells. Toxicol Appl Pharmacol 271(1):72-77. doi:10.1016/j.taap.2013.04.020 PMID:23648393 PMCID:PMC3714307
2012
- Futscher BW. 2012. Epigenetic Changes during Cell Transformation. Chapter 9 in: Epigenetic Alterations in Oncogenesis. Springer, New York, NY. pp.179-194.
- Severson PL, Tokar EJ, Vrba L, Waalkes MP, Futscher BW. 2012. Agglomerates of aberrant DNA methylation are associated with toxicant-induced malignant transformation. Epigenetics 7(11):1238-1248. doi:10.4161/epi.22163 PMID:22976526 PMCID:PMC3499325
2011
- States JC, Barchowsky A, Cartwright IL, Reichard JF, Futscher BW, Lantz RC. 2011. Arsenic toxicology: translating between experimental models and human pathology. Environ Health Perspect 119:1356-1363. doi:10.1289/ehp.1103441 PMID:21684831 PMCID:PMC3230447
2010
- Wnek SM, Jensen TJ, Severson PL, Futscher BW, Gandolfi A. 2010. Monomethylarsonous acid produces irreversible events resulting in malignant transformation of a human bladder cell line following 12 weeks of low-level exposure. Toxicol Sci 116(1):44-57. doi:10.1093/toxsci/kfq106 PMID:20375083 PMCID:PMC2886861
2009
- Eblin KE, Jensen TJ, Wnek SM, Buffington SE, Futscher BW, Gandolfi A. 2009. Reactive oxygen species regulate properties of transformation in UROtsa cells exposed to monomethylarsonous acid by modulating MAPK signaling. Toxicology 255(1-2):107-114. doi:10.1016/j.tox.2008.10.007 PMID:19014992 PMCID:PMC2665711
- Jensen TJ, Wozniak RJ, Eblin KE, Gandolfi A, Futscher BW, Wnek SM. 2009. Epigenetic mediated transcriptional activation of WNT5A participates in arsenical-associated malignant transformation. Toxicol Appl Pharmacol 235(1):39-46. doi:10.1016/j.taap.2008.10.013 PMID:19061910 PMCID:PMC4438681
2008
- Eblin KE, Hau AM, Jensen TJ, Gandolfi A, Futscher BW. 2008. The role of reactive oxygen species in arsenite and monomethylarsonous acid-induced signal transduction in human bladder cells: acute studies. Toxicology 250(1):47-54. doi:10.1016/j.tox.2008.05.018 PMID:18588940 PMCID:PMC2567114