Superfund Research Program

Alicia M. Bolt

University of New Mexico
1 University of New Mexico
MSC 09 5360
Albuquerque, New Mexico 87131
Email: ambolt@salud.unm.edu

Projects

• University of New Mexico: Inhaled Mine-Site Derived Metal Particulate Matter Drives Pulmonary and Systemic Immune Dysregulation (2022-2027)

Publications

• Hoover JH, Bolt AM, Burchiel SW, Cerrato JM, Dashner-Titus EJ, Erdei E, Hayek EE, Hudson LG, Gonzalez-Estrella J, Luo L, MacKenzie D, Medina S, Schilz JR, Velasco CA, Zychowski KE, Lewis JL. A transdisciplinary approach for studying uranium mobility, exposure, and human health impacts on tribal lands in the southwest, United States. In: Practical Applications of Medical Geology. Springer,

2023

• Medina S, Zhang H, Santos-Medina LV, Yee ZA, Martin KJ, Wan G, Bolt AM, Zhou X, Styblo M, Liu K. 2023. Arsenite methyltransferase is an important mediator of hematoxicity induced by arsenic in drinking water. Water (Basel) 15(3):448. doi:10.3390/w15030448 PMID:36936034 PMCID:PMC1001945

2022

• Medina S, Zhang H, Santos-Medina LV, Wan G, Bolt AM, Zhou X, Burchiel SW, Liu K. 2022. Arsenic impairs the lineage commitment of hematopoietic progenitor cells through the attenuation of GATA-2 DNA binding activity. Toxicol Appl Pharmacol 452:116193. doi:10.1016/j.taap.2022.116193 PMID:35961411 PMCID:PMC9583771
• Schilz JR, Dashner-Titus EJ, Simmons KA, Erdei E, Bolt AM, MacKenzie D, Hudson LG. 2022. The immunotoxicity of natural and depleted uranium: From cells to people. Toxicol Appl Pharmacol 454:116252. doi:10.1016/j.taap.2022.116252 PMID:36152676
• Scieszka D, Hunter R, Begay J, Bitsui M, Lin Y, Galewsky J, Morishita M, Klaver Z, Wagner JG, Harkema JR, Herbert G, Lucas S, McVeigh C, Bolt AM, Bleske B, Canal CG, Mostovenko E, Ottens AK, Gu H, Campen M, Noor S. 2022. Neuroinflammatory and neurometabolomic consequences from inhaled wildfire smoke-derived particulate matter in the western United States. Toxicol Sci 186(1):doi:10.1093/toxsci/kfab147 PMID:34865172 PMCID:PMC8883349

2021

• Medina S, Bolt AM, Zhou X, Wan G, Xu H, Lauer FT, Liu K, Burchiel SW. 2021. Arsenite and monomethylarsonous acid disrupt erythropoiesis through combined effects on differentiation and survival pathways in early erythroid progenitors. Toxicol Lett 350:111-120. doi:10.1016/j.toxlet.2021.07.008 PMID:34274428 PMCID:PMC8487637

2020

• Medina S, Lauer FT, Castillo EF, Bolt AM, Ali AS, Liu K, Burchiel SW. 2020. Exposures to uranium and arsenic alter intraepithelial and innate immune cells in the small intestine of male and female mice. Toxicol Appl Pharmacol 403:doi:10.1016/j.taap.2020.115155 PMID:32710956
• Zhou X, Medina S, Bolt AM, Zhang H, Wan G, Xu H, Lauer FT, Wang S, Burchiel SW, Liu K. 2020. Inhibition of red blood cell development by arsenic-induced disruption of GATA-1. Sci Rep 10(1):19055. doi:10.1038/s41598-020-76118-x PMID:33149232 PMCID:PMC7643154

2019

• Bolt AM, Medina S, Lauer FT, Liu K, Burchiel SW. 2019. Minimal uranium immunotoxicity following a 60-day drinking water exposure to uranyl acetate in male and female C57BL/6J mice. Toxicol Appl Pharmacol 372:33-39. doi:10.1016/j.taap.2019.04.003 PMID:30978399

2018

• Bolt AM, Medina S, Lauer FT, Xu H, Ali AS, Liu K, Burchiel SW. 2018. Minimal uranium accumulation in lymphoid tissues following an oral 60-day uranyl acetate exposure in male and female C57BL/6J mice. PLoS One 13(10):e0205211. doi:10.1371/journal.pone.0205211 PMID:30356336 PMCID:PMC6200214

2012

• Bolt AM, Klimecki WT. 2012. Autophagy in toxicology: self-consumption in times of stress and plenty. J Appl Toxicol doi:10.1002/jat.1787 PMID:22334383 PMCID:PMC3572937
• Bolt AM, Zhao F, Pacheco S, Klimecki WT. 2012. Arsenite-induced autophagy is associated with proteotoxicity in human lymphoblastoid cells. Toxicol Appl Pharmacol 264(2):255-261. doi:10.1016/j.taap.2012.08.006 PMID:22959463 PMCID:PMC3462290

2010

• Bolt AM, Byrd RM, Klimecki WT. 2010. Autophagy is the predominant process induced by arsenite in human lymphoblastoid cell lines. Toxicol Appl Pharmacol 244(3):366-373. doi:10.1016/j.taap.2010.01.019 PMID:20153345 PMCID:PMC2849852
• Bolt AM, Douglas R, Klimecki WT. 2010. Arsenite exposure in human lymphoblastoid cell lines induces autophagy and coordinated induction of lysosomal genes. Toxicol Lett 199(2):153-159. doi:10.1016/j.toxlet.2010.08.017 PMID:20816728 PMCID:PMC2956852