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Person Details: Fawaz G. Haj

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Superfund Research Program

Fawaz G. Haj

University of California-Davis
One Shields Ave
Davis, California 95616-5270
Phone: 530-752-3214
Email: fghaj@ucdavis.edu

Projects

Patents

Publications

2023

  • Hsu M, Ito Y, Singh JP, Hsu S, Wells A, Jen K, Meng T, Haj FG. 2023. Protein tyrosine phosphatase 1B is a regulator of alpha-actinin4 in the glomerular podocyte. Biochim Biophys Acta 1871(1):119590. doi:10.1016/j.bbamcr.2023.119590 PMID:37730132

2022

  • Hsu M, Ito Y, Afkarian M, Haj FG. 2022. Deficiency of the Src homology phosphatase 2 in podocytes is associated with renoprotective effects in mice under hyperglycemia. Cellular and Molecular Life Sciences 79(10):516. doi:10.1007/s00018-022-04517-6 PMID:36102977

2021

  • Koike S, Hsu M, Bettaieb A, Chu B, Matsumoto N, Morisseau C, Havel PJ, Huising MO, Hammock BD, Haj FG. 2021. Genetic deficiency or pharmacological inhibition of soluble epoxide hydrolase ameliorates high fat diet-induced pancreatic beta-cell dysfunction and loss. Free Radic Biol Med 172:48-57. doi:10.1016/j.freeradbiomed.2021.05.029 PMID:34038767
  • Mello A, Hsu M, Koike S, Chu B, Cheng J, Yang J, Morisseau C, Torok NJ, Hammock BD, Haj FG. 2021. Soluble epoxide hydrolase hepatic deficiency ameliorates alcohol-associated liver disease. Cell Mol Gastroenterol Hepatol 11:815-830. doi:10.1016/j.jcmgh.2020.10.002 PMID:33068774 PMCID:PMC7851189

2020

2019

  • Bailey KA, Moreno E, Haj FG, Simon SI, Passerini AG. 2019. Mechanoregulation of p38 activity enhances endoplasmic reticulum stress-mediated inflammation by arterial endothelium. FASEB J 33:12888-12899. doi:10.1096/fj.201900236R PMID:31499005 PMCID:PMC6902662
  • Li Q, Kailemia M, Merleev A, Xu G, Serie D, Danan L, Haj FG, Maverakis E, Lebrilla CB. 2019. Site-Specific Glycosylation Quantitation of 50 Serum Glycoproteins Enhanced by Predictive Glycopeptidomics for Improved Disease Biomarker Discovery. Anal Chem 91:5433-5445. doi:10.1021/acs.analchem.9b00776
  • Perez S, Finamor I, Marti-Andres P, Pereda J, Campos A, Domingues R, Haj FG, Sabater L, de-Madaria E, Sastre J. 2019. Role of obesity in the release of extracellular nucleosomes in acute pancreatitis: a clinical and experimental study. Int J Obes 43:158-168. doi:10.1038/s41366-018-0073-6 PMID:29717278

2018

  • Napimoga MH, Trindade-da-Silva C, Demasi AP, Martinez EF, Macedo CG, Abdalla HB, Bettaieb A, Haj FG, Clemente-Napimoga JT, Hammock BD. 2018. Soluble epoxide hydrolase inhibitor promotes immunomodulation to inhibit bone resorption. J Periodontal Res doi:10.1111/jre.12559 PMID:29851077

2017

  • Bettaieb A, Koike S, Chahed S, Bachaalany S, Hashoush N, Graham J, Fatima H, Havel PJ, Gruzdev A, Zeldin DC, Hammock BD, Haj FG, Zhao Y. 2017. Podocyte-specific soluble exposide hydrolase deficiency in mice attenuates acute kidney injury. FEBS J 284(13):1970-1986. doi:10.1111/febs.14100 PMID:28485854 PMCID:PMC5515292
  • Bettaieb A, Koike S, Hsu M, Ito Y, Chahed S, Bachaalany S, Gruzdev A, Calvo-Rubio M, Lee KS, Inceoglu B, Imig JD, Villalba JM, Zeldin DC, Hammock BD, Haj FG. 2017. Soluble epoxide hydrolase in podocytes is a significant contributor to renal function under hyperglycemia. Biochim Biophys Acta 1861:2758-2765. doi:10.1016/j.bbagen.2017.07.021 PMID:28757338
  • Inceoglu B, Bettaieb A, Haj FG, Gomes AV, Hammock BD. 2017. Modulation of mitochondrial dysfunction and endoplasmic reticulum stress are key mechanisms for the wide-ranging actions of epoxy fatty acids and soluble epoxide hydrolase inhibitors. Prostaglandins Other Lipid Mediat 133:68-78. doi:10.1016/j.prostaglandins.2017.08.003 PMID:28847566 PMCID:PMC5584617
  • Trindade-da-Silva C, Bettaieb A, Napimoga M, Stephen Lee KS, Inceoglu B, Ueira-Vieira C, Bruun DA, Goswami SK, Haj FG, Hammock BD. 2017. Soluble epoxide hydrolase pharmacological inhibition decreases alveolar bone loss by modulating host inflammatory response, RANK-related signaling, endoplasmic reticulum stress, and apoptosis. J Pharmacol Exp Ther 361(3):408-416. doi:10.1124/jpet.116.238113 PMID:28356494 PMCID:PMC5443319

2016

  • Sirish P, Li N, Timofeyev V, Zhang X, Wang L, Yang J, Lee KS, Bettaieb A, Ma S, Lee JH, Su D, Lau V, Myers R, Lieu DK, Lopez JE, Young JN, Yamoah EN, Haj FG, Ripplinger C, Hammock BD, Chiamvimonvat N. 2016. Molecular mechanisms and new treatment paradigm for atrial fibrillation. Circ Arrhythm Electrophysiol 9(5):e003721-e003740. doi:10.1161/CIRCEP.115.003721 PMID:27162031 PMCID:PMC4869994

2015

  • Bettaieb A, Chahed S, Bachaalany S, Griffey S, Hammock BD, Haj FG. 2015. Soluble epoxide hydrolase pharmacological inhibition ameliorates experimental acute pancreatitis in mice. Mol Pharmacol 88(2):281-290. doi:10.1124/mol.114.097501 PMID:25993999 PMCID:PMC4518092
  • Harris TR, Bettaieb A, Kodani SD, Dong H, Myers R, Chiamvimonvat N, Haj FG, Hammock BD. 2015. Inhibition of soluble epoxide hydrolase attenuates hepatic fibrosis and endoplasmic reticulum stress induced by carbon tetrachloride in mice. Toxicol Appl Pharmacol 286(2):102-111. doi:10.1016/j.taap.2015.03.022 PMID:25827057 PMCID:PMC4458210
  • Inceoglu B, Bettaieb A, Trindade da Silva CA, Lee KS, Haj FG, Hammock BD. 2015. Endoplasmic reticulum stress in the peripheral nervous system is a significant driver of neuropathic pain. Proc Natl Acad Sci U S A 112(29):9082-9087. doi:10.1073/pnas.1510137112 PMID:26150506 PMCID:PMC4517273

2014

2013

  • Bettaieb A, Nagata N, AbouBechara D, Chahed S, Morisseau C, Hammock BD, Haj FG. 2013. Soluble epoxide hydrolase deficiency or inhibition attenuates diet-induced endoplasmic reticulum stress in liver and adipose tissue. J Biol Chem 288:14189-14199. doi:10.1074/jbc.M113.458414 PMID:23576437 PMCID:PMC3656275

2012

  • Inceoglu B, Wagner KM, Yang J, Bettaieb A, Schebb N, Hwang SH, Morisseau C, Haj FG, Hammock BD. 2012. Acute augmentation of epoxygenated fatty acid levels rapidly reduces pain-related behavior in a rat model of Type I Diabetes. Proc Natl Acad Sci U S A 109(28):11390-11395. doi:10.1073/pnas.1208708109 PMID:22733772 PMCID:PMC3396532

2011

  • Luria A, Bettaieb A, Xi Y, Shieh G, Liu H, Inoue H, Tsai H, Imig JD, Haj FG, Hammock BD. 2011. Soluble epoxide hydrolase deficiency alters pancreatic islet size and improves glucose homeostasis in a model of insulin resistance. Proc Natl Acad Sci U S A 108(22):9038-9043. doi:10.1073/pnas.1103482108 PMID:21571638 PMCID:PMC3107315
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