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Person Details: Craig J. McClain

Superfund Research Program

Craig J. McClain

University of Louisville
505 S. Hancock St
CTR Bldg Rm 503
Louisville, Kentucky 40202-0000
Phone: 502-852-6128




  • Warner J, Hardesty JE, Song Y, Floyd A, Deng Z, Jebet A, He L, Zhang XH, McClain CJ, Hammock BD, Warner D, Kirpich IA. 2024. Hepatic transcriptome and its regulation following soluble epoxide hydrolase inhibition in alcohol-associated liver disease. Am J Pathol 194(1):71-84. doi:10.1016/j.ajpath.2023.09.016 PMID:37925018 PMCID:10768534


  • Wahlang B, Gao H, Rai SN, Keith RJ, McClain CJ, Srivastava S, Cave MC, Bhatnagar A. 2023. Associations between residential volatile organic compound exposures and liver injury markers: The role of biological sex and race. Environ Res 221:115228. doi:10.1016/j.envres.2023.115228 PMID:36610539 PMCID:PMC9957966


  • Wahlang B, Gripshover T, Gao H, Krivokhizhina T, Keith RJ, Sithu ID, Rai SN, Bhatnagar A, McClain CJ, Srivastava S, Cave MC. 2022. Associations between residential exposure to volatile organic compounds and liver injury markers. Toxicol Sci 185(1):doi:10.1093/toxsci/kfab119 PMID:34668566 PMCID:PMC8714366


  • Guardiola JJ, Hardesty JE, Beier JI, Prough RA, McClain CJ, Cave MC. 2021. Plasma metabolomics analysis of polyvinyl chloride workers identifies altered processes and candidate biomarkers for hepatic hemangiosarcoma and its development. Int J Mol Sci 22:doi:10.3390/ijms22105093 PMID:34065028 PMCID:PMC8150673


  • Donde H, Ghare S, Joshi-Barve S, Zhang J, Vadhanam MV, Gobejishvili L, Lorkiewicz P, Srivastava S, McClain CJ, Barve S. 2020. Tributyrin Inhibits Ethanol-Induced Epigenetic Repression of CPT-1A and Attenuates Hepatic Steatosis and Injury. Cell Mol Gastroenterol Hepatol 9:569-585. doi:10.1016/j.jcmgh.2019.10.005 PMID:31654770 PMCID:PMC7078548
  • Rai SN, Qian C, Pan J, McClain CJ, McClain M, Eichenberger MR, Galandiuk S. 2020. Statistical issues and group classification in plasma microRNA studies with data application. Evol Bioinform 16:9. doi:10.1177/1176934320913338 PMID:32313420 PMCID:PMC7157974


  • Vatsalya V, Kong M, Gobejishvili L, Chen W, Srivastava S, Barve S, McClain CJ, Joshi-Barve S. 2019. Urinary acrolein metabolite levels in severe acute alcoholic hepatitis patients. Am J Physiol Gastrointest Liver Physiol 316(1):G115-G122. doi:10.1152/ajpgi.00209.2018 PMID:30234998
  • Wahlang B, Appana S, Falkner KC, McClain CJ, Brock GN, Cave MC. 2019. Insecticide and metal exposures are associated with a surrogate biomarker for non-alcoholic fatty liver disease in the National Health and Nutritional Examination Survey 2003-2004. Environ Sci Pollut Res Int 6(4):265-276. doi:10.1007/s11356-019-07066-x PMID:31873887


  • Clair HB, Pinkston CM, Rai SN, Pavuk M, Dutton ND, Brock GN, Prough RA, Falkner KC, McClain CJ, Cave MC. 2018. Liver disease in a residential cohort with elevated polychlorinated biphenyl exposures. Toxicol Sci 164:39-49. doi:10.1093/toxsci/kfy076 PMID:29684222 PMCID:PMC6016643


  • Salman KN, Stuart MA, Schmidt J, Borges T, McClain CJ, Robinson FR, Li M, Robertson LW. 2014. The effects of 3,3',4,4'-tetrabromobiphenyl on rats fed diets containing a constant level of copper and varying levels of molybdenum. Environ Sci Pollut Res Int 21(10):6400-6409. doi:10.1007/s11356-013-1638-5 PMID:23532536 PMCID:PMC3732555


  • Hennig B, Ormsbee LE, McClain CJ, Watkins BA, Blumberg B, Bachas LG, Sanderson W, Suk WA. 2012. Nutrition can modulate the toxicity of environmental pollutants: implications in risk assessment and human health. Environ Health Perspect 120(6):771-774. doi:10.1289/ehp.1104712 PMID:22357258 PMCID:PMC3385446


  • Hennig B, Ettinger AS, Jandacek RJ, Koo S, McClain CJ, Seifried H, Silverstone AE, Watkins B, Suk WA. 2007. Using nutrition for intervention and prevention against environmental chemical toxicity and associated diseases. Environ Health Perspect 115(4):493-495. PMID:17450213


  • Hennig B, Toborek M, McClain CJ. 2001. High-energy diets, fatty acids and endothelial cell function: implications for atherosclerosis. J Am Coll Nutr 20(2):97-105. PMID:11349944


  • Young VM, Toborek M, Yang F, McClain CJ, Hennig B. 1998. Effect of linoleic acid on endothelial cell inflammatory mediators. Metabolism 47:566-572. PMID:9591748


  • Connell P, Young VM, Toborek M, Cohen DA, Barve S, McClain CJ, Hennig B. 1997. Zinc attenuates tumor necrosis factor-mediated activation of transcription factors in endothelial cells. J Am Coll Nutr 16(5):411-417. PMID:9322188


  • Hennig B, Toborek M, Joshi-Barve S, Barger SW, Barve S, Mattson MP, McClain CJ. 1996. Linoleic acid activates NF-ÇB and induces NF-ÇB-dependent transcription in cultured endothelial cells. Am J Clin Nutr 63(3):322-328. PMID:8602587
  • Hennig B, Toborek M, McClain CJ. 1996. Antiatherogenic properties of zinc: implications in endothelial cell metabolism. J Nutr 12:711-717. PMID:8936496
  • Hennig B, Toborek M, McClain CJ, Diana JN. 1996. Nutritional implications in vascular endothelial cell metabolism. J Am Coll Nutr 15(4):345-358. PMID:8829090
  • Toborek M, Barger SW, Mattson MP, Barve S, McClain CJ, Hennig B. 1996. Linoleic acid and TNF-a cross-amplify oxidative injury and dysfunction of endothelial cells. J Lipid Res 37:123-135. PMID:8820108


  • Clair J, Talwalkar R, McClain CJ, Hennig B. 1995. Selective removal of zinc from cell culture media. Journal of Trace Elements and Experimental Medicine 7:143-151.
  • McClain CJ, Morris P, Hennig B. 1995. Zinc and endothelial function. J Nutr 11:117-120. PMID:7749257
  • Ramasamy S, Lipke DW, McClain CJ, Hennig B. 1995. Tumor necrosis factor reduces proteoglycan synthesis in cultured endothelial cells. Journal of Cellular Physiology 162:119-126. PMID:7814444
  • Toborek M, Barger SW, Mattson MP, McClain CJ, Hennig B. 1995. Role of glutathione redox cycle in TNF-alpha-mediated endothelial cell dysfunction. Atherosclerosis 117(2):179-188. PMID:8801863
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