Superfund Research Program

Lisa Truong

Oregon State University
28645 Highway 34
Corvallis, Oregon 97333-0000
Phone: 425-445-8182
Email: lisa.truong@oregonstate.edu

Projects

• Oregon State University: Predicting the Toxicity of Complex PAH Mixtures (2009-2025)

Publications

2023

• Gosline S, Kim DN, Pande P, Thomas DG, Truong L, Hoffman PD, Barton ML, Loftus J, Moran A, Hampton S, Dowson S, Franklin L, Degnan D, Anderson LN, Thessen AE, Tanguay RL, Anderson KA, Waters KM. 2023. The Superfund Research Program Analytics Portal: linking environmental chemical exposure to biological phenotypes. Sci Data 10(1):151. doi:10.1038/s41597-023-02021-5 PMID:36944655 PMCID:PMC1003089
• Rericha Y, Simonich MT, Truong L, Tanguay RL. 2023. Review of the zebrafish as a model to investigate per- and polyfluoroalkyl substances toxicity. Toxicol Sci doi:10.1093/toxsci/kfad051 PMID:37220906 PMCID:PMC10375317

2022

• Rericha Y, Truong L, Leong C, Cao D, Field JA, Tanguay RL. 2022. Dietary perfluorohexanoic acid (PFHxA) exposures in juvenile zebrafish produce subtle behavioral effects across generations. Toxics 10(7):372. doi:10.3390/toxics10070372 PMID:35878277 PMCID:PMC9319656
• Rivera BN, Ghetu CC, Chang Y, Truong L, Tanguay RL, Anderson KA, Tilton SC. 2022. Leveraging multiple data streams for prioritization of mixtures for hazard characterization. Toxics 10(11):651. doi:10.3390/toxics10110651 PMID:36355943
• Thunga P, Truong L, Rericha Y, La Du JK, Morshead M, Tanguay RL, Reif DM. 2022. Utilizing a population-genetic framework to test for gene-environment interactions between zebrafish behavior and chemical exposure. Toxics 10(12):769. doi:10.3390/toxics10120769 PMID:36548602 PMCID:PMC9781692
• Truong L, Rericha Y, Thunga P, Marvel S, Wallis DJ, Simonich MT, Field JA, Cao D, Reif DM, Tanguay RL. 2022. Systematic developmental toxicity assessment of a structurally diverse library of PFAS in zebrafish. J Hazard Mater doi:10.1016/j.jhazmat.2022.128615 PMID:35263707 PMCID:PMC8970529
• Wallis DJ, Du JL, Thunga P, Elson D, Truong L, Kolluri SK, Tanguay RL, Reif DM. 2022. Leveraging a high-throughput screening method to identify mechanisms of individual susceptibility differences in a genetically diverse zebrafish model. Front Toxicol 4:846221. doi:10.3389/ftox.2022.846221 PMID:35573279 PMCID:PMC9098949

2021

• Dasgupta S, Dunham CL, Truong L, Simonich MT, Sullivan CM, Tanguay RL. 2021. Phenotypically anchored mRNA and miRNA expression profiling in zebrafish reveals flame retardant chemical toxicity networks. Front Cell Dev Biol 9:663032. doi:10.3389/fcell.2021.663032 PMID:33898466 PMCID:PMC8063052
• Green AJ, Mohlenkamp MJ, Das J, Chaudhari M, Truong L, Tanguay RL, Reif DM. 2021. Leveraging high-throughput screening data, deep neural networks, and conditional generative adversarial networks to advance predictive toxicology. PLoS Comput Biol 17(7):e1009135. doi:10.1371/journal.pcbi.1009135 PMID:34214078 PMCID:PMC8301607
• Guan X, Truong L, Lomnicki S, Tanguay RL, Cormier SA. 2021. Developmental hazard of environmentally persistent free radicals and protective effect of TEMPOL in zebrafish model. Toxics 9:doi:10.3390/toxics9010012 PMID:33467068 PMCID:PMC7829864
• Shankar P, Dashner-Titus EJ, Truong L, Hayward K, Hudson LG, Tanguay RL. 2021. Developmental toxicity in zebrafish (Danio rerio) exposed to uranium: A comparison with lead, cadmium, and iron. Environ Pollut 269:116097. doi:10.1016/j.envpol.2020.116097 PMID:33246768 PMCID:PMC7785642
• Thunga P, Truong L, Tanguay RL, Reif DM. 2021. Concurrent evaluation of mortality and behavioral responses: a fast and efficient testing approach for high-throughput chemical hazard identification. Front Toxicol 3:670496. doi:10.3389/ftox.2021.670496 PMID:35295121 PMCID:PMC8915815
• Wallis DJ, Truong L, La Du JK, Tanguay RL, Reif DM. 2021. Uncovering evidence for endocrine-disrupting chemicals that elicit differential susceptibility through gene-environment interactions. Toxics doi:10.3390/toxics9040077 PMID:33917455 PMCID:PMC8067468

2020

• Dasgupta S, Wang G, Simonich MT, Zhang T, Truong L, Liu H, Tanguay RL. 2020. Impacts of high dose 3.5 GHz cellphone radiofrequency on zebrafish embryonic development. PLoS One 15(7):e0235869. doi:10.1371/journal.pone.0235869 PMID:32645106 PMCID:PMC7347199
• Shen Q, Truong L, Simonich MT, Huang C, Tanguay RL, Dong Q. 2020. Rapid well-plate assays for motor and social behaviors in larval zebrafish. Behav Brain Res 391:10. doi:10.1016/j.bbr.2020.112625 PMID:32428631 PMCID:PMC7341899
• Thessen AE, Grondin CJ, Kulkarni RD, Brander SM, Truong L, Vasilevsky NA, Callahan TJ, Chan LE, Westra B, Willis M, Rothenberg SE, Jarabek AM, Burgoon LD, Korrick SA, Haendel MA. 2020. Community approaches for integrating environmental exposures into human models of disease. Environ Health Perspect 128(12):125002. doi:10.1289/EHP7215 PMID:33369481 PMCID:PMC7769179
• Truong L, Marvel S, Reif DM, Thomas DG, Pande P, Dasgupta S, Simonich MT, Waters KM, Tanguay RL. 2020. The multi-dimensional embryonic zebrafish platform predicts flame retardant bioactivity. Reprod Toxicol 96:359-369. doi:10.1016/j.reprotox.2020.08.007 PMID:32827657 PMCID:PMC7892636
• Wilson LB, Truong L, Simonich MT, Tanguay RL. 2020. Systematic Assessment of Exposure Variations on Observed Bioactivity in Zebrafish Chemical Screening. Toxics 8:doi:10.3390/toxics8040087 PMID:33066419 PMCID:PMC7712973

2019

• Hagstrom D, Truong L, Zhang S, Tanguay RL, Collins ES. 2019. Comparative analysis of zebrafish and planarian model systems for developmental neurotoxicity screens using an 87-compound library. Toxicol Sci 167(1):15-25. doi:10.1093/toxsci/kfy180 PMID:30011007 PMCID:PMC6317421
• Shankar P, Geier MC, Truong L, McClure RS, Pande P, Waters KM, Tanguay RL. 2019. Coupling genome-wide transcriptomics and developmental toxicity profiles in zebrafish to characterize polycyclic aromatic hydrocarbon (PAH) hazard. Int J Mol Sci 20:2570. doi:10.3390/ijms20102570 PMID:31130617 PMCID:PMC6566387
• Thomas DG, Shankaran H, Truong L, Tanguay RL, Waters KM. 2019. Time-dependent behavioral data from zebrafish reveals novel signatures of chemical toxicity using point of departure analysis. Comput Toxicol 9:50-60. doi:10.1016/j.comtox.2018.11.001 PMID:31485548 PMCID:PMC6726397
• Trine LS, Davis EL, Roper C, Truong L, Tanguay RL, Simonich SL. 2019. Formation of PAH derivatives and increased developmental toxicity during steam enhanced extraction remediation of creosote contaminated Superfund soil. Environ Sci Technol 53(8):4460-4469. doi:10.1021/acs.est.8b07231 PMID:30957485

2018

• Balik-Meisner M, Truong L, Scholl EH, La Du JK, Tanguay RL, Reif DM. 2018. Elucidating gene-by-environment interactions associated with differential susceptibility to chemical exposure. Environ Health Perspect 126:8. doi:10.1289/ehp2662 PMID:29968567
• Balik-Meisner M, Truong L, Scholl EH, Tanguay RL, Reif DM. 2018. Population genetic diversity in zebrafish lines. Mamm Genome 1-11. doi:10.1007/s00335-018-9735-x PMID:29368091
• Garcia GR, Bugel SM, Truong L, Spagnoli S, Tanguay RL. 2018. AHR2 required for normal behavioral responses and proper development of the skeletal and reproductive systems in zebrafish. PLoS One 13(3):e0193484. doi:10.1371/journal.pone.0193484 PMID:29494622 PMCID:PMC5832240
• Garcia GR, Shankar P, Dunham CL, Garcia A, La Du JK, Truong L, Tilton SC, Tanguay RL. 2018. Signaling events downstream of AHR activation that contribute to toxic responses: The functional role of an AHR-dependent long noncoding RNA (slincR) using the zebrafish model. Environ Health Perspect 126(11):117002. doi:10.1289/EHP3281 PMID:30398377 PMCID:PMC6371766
• Geier MC, Chlebowski A, Truong L, Simonich SL, Anderson KA, Tanguay RL. 2018. Comparative developmental toxicity of a comprehensive suite of polycyclic aromatic hydrocarbons. Arch Toxicol 92(2):571-586. doi:10.1007/s00204-017-2068-9 PMID:29094189 PMCID:PMC5820187
• Geier MC, Minick DJ, Truong L, Tilton SC, Pande P, Anderson KA, Teeguardan J, Tanguay RL. 2018. Systematic developmental neurotoxicity assessment of a representative PAH Superfund mixture using zebrafish. Toxicol Appl Pharmacol 354:115-125. doi:10.1016/j.taap.2018.03.029 PMID:29630969 PMCID:PMC6087484
• Weinhouse C, Truong L, Meyer JN, Allard P. 2018. Caenorhabditis elegans as an emerging model system in environmental epigenetics. Environ Mol Mutagen 59:560-575. doi:10.1002/em.22203 PMID:30091255 PMCID:PMC6113102

2017

• Chlebowski A, La Du JK, Truong L, Simonich SL, Tanguay RL. 2017. Investigating the application of a nitroreductase-expressing transgenic zebrafish line for high-throughput toxicity testing. Toxicol Rep 4:202-210. doi:10.1016/j.toxrep.2017.04.005 PMID:28758069 PMCID:PMC5527975
• Knecht AL, Truong L, Marvel S, Reif DM, Garcia A, Lu C, Simonich MT, Teeguarden J, Tanguay RL. 2017. Transgenerational inheritance of neurobehavioral and physiological deficits from developmental exposure to benzo[a]pyrene in zebrafish. Toxicol Appl Pharmacol 329:148-157. doi:10.1016/j.taap.2017.05.033 PMID:28583304 PMCID:PMC5539966
• Knecht AL, Truong L, Simonich MT, Tanguay RL. 2017. Developmental benzo[a]pyrene (B[a]P) exposure impacts larval behavior and impairs adult learning in zebrafish. Neurotoxicol Teratol 59:27-34. doi:10.1016/j.ntt.2016.10.006 PMID:27989697 PMCID:PMC5235990
• Schrlau J, Kramer AL, Chlebowski A, Truong L, Tanguay RL, Simonich SL, Semprini L. 2017. Formation of developmentally toxic phenanthrene metabolite mixtures by mycobacterium sp ELW1. Environ Sci Technol 51:8569-8578. doi:10.1021/acs.est.7b01377 PMID:28727453
• Truong L, Tanguay RL. 2017. Evaluation of embryotoxicity using the zebrafish model. Methods Mol Biol 1641:325-333. doi:10.1007/978-1-4939-7172-5_18 PMID:28748473
• Zhang G, Roell K, Truong L, Tanguay RL, Reif DM. 2017. A data-driven weighting scheme for multivariate phenotypic endpoints recapitulates zebrafish developmental cascades. Toxicol Appl Pharmacol 314:109-117. doi:10.1016/j.taap.2016.11.010 PMID:27884602 PMCID:PMC5224523
• Zhang G, Truong L, Tanguay RL, Reif DM. 2017. A new statistical approach to characterize chemical-elicited behavioral effects in high-throughput studies using zebrafish. PLoS One 12(1):e0169408. doi:10.1371/journal.pone.0169408 PMID:28099482 PMCID:PMC5242475
• Zhang G, Truong L, Tanguay RL, Reif DM. 2017. Integrating morphological and behavioral phenotypes in developing zebrafish. In: The rights and wrongs of zebrafish: behavioral phenotyping of zebrafish. Springer International Publishing, pp.259-272.

2016

• Reif DM, Truong L, Mandrell D, Marvel S, Zhang G, Tanguay RL. 2016. High-throughput characterization of chemical-associated embryonic behavioral changes predicts teratogenic outcomes. Arch Toxicol 90(6):1459-1470. doi:10.1007/s00204-015-1554-1 PMID:26126630 PMCID:PMC4701642
• Titaley IA, Chlebowski A, Truong L, Tanguay RL, Simonich SL. 2016. Identification and toxicological evaluation of unsubstituted PAHs and novel PAH derivatives in pavement sealcoat products. Environ Sci Technol 3(6):234-242. doi:10.1021/acs.estlett.6b00116
• Titaley IA, Chlebowski A, Truong L, Tanguay RL, Simonich SL. 2016. Response to correspondence on identification and toxicological evaluation of unsubstituted PAHs and novel PAH derivatives in pavement sealcoat products. Environ Sci Technol Lett 3(11):406-408.
• Truong L, Bugel SM, Chlebowski A, Usenko CY, Simonich MT, Simonich SL, Tanguay RL. 2016. Optimizing multi-dimensional high throughput screening using zebrafish. Reprod Toxicol 65:139-147. doi:10.1016/j.reprotox.2016.05.015 PMID:27453428 PMCID:PMC5067206
• Truong L, Simonich MT, Tanguay RL. 2016. Better, faster, cheaper: getting the most out of high-throughput screening with zebrafish. Methods Mol Biol 1473:89-98. doi:10.1007/978-1-4939-6346-1_10 PMID:27518627
• Zhang G, Marvel S, Truong L, Tanguay RL, Reif DM. 2016. Aggregate entropy scoring for quantifying activity across endpoints with irregular correlation structure. Reprod Toxicol 62:92-99. doi:10.1016/j.reprotox.2016.04.012 PMID:27132190 PMCID:PMC4905797

2014

• Truong L, Mandrell D, Mandrell R, Simonich MT, Tanguay RL. 2014. A rapid throughput approach identifies cognitive deficits in adult zebrafish from developmental exposure to polybrominated flame retardants. Neurotoxicology 43:134-142. doi:10.1016/j.neuro.2014.03.005 PMID:24674958 PMCID:PMC4134748
• Truong L, Reif DM, St Mary L, Geier MC, Truong HD, Tanguay RL. 2014. Multidimensional in vivo hazard assessment using zebrafish. Toxicol Sci 137(1):212-233. doi:10.1093/toxsci/kft235 PMID:24136191 PMCID:PMC3871932

2013

• Adenuga A, Truong L, Tanguay RL, Remcho V. 2013. Preparation of water-soluble carbon nanotubes and assessment of their biological activity in embryonic zebrafish. Int J Biomed Nanosci Nanotechnol 3(1/2):38-51. doi:10.1504/IJBNN.2013.054514 PMID:25750663 PMCID:PMC4349379
• Knecht AL, Goodale BC, Truong L, Simonich MT, Swanson AJ, Matzke MM, Anderson KA, Waters KM, Tanguay RL. 2013. Comparative developmental toxicity of environmentally relevant oxygenated PAHs. Toxicol Appl Pharmacol 271(2):266-275. doi:10.1016/j.taap.2013.05.006 PMID:23684558 PMCID:PMC3976560
• Truong L, Tilton SC, Zaikova T, Richman E, Waters KM, Hutchison JE, Tanguay RL. 2013. Surface functionalities of gold nanoparticles impact embryonic gene expression responses. Nanotechnology 7:192-201. doi:10.3109/17435390.2011.648225 PMID:22263968 PMCID:PMC3399027

2012

• Chen J, Huang C, Truong L, La Du JK, Tilton SC, Waters KM, Lin K, Tanguay RL, Dong Q. 2012. Early life stage trimethyltin exposure induces ADP-ribosylation factor expression and perturbs the vascular system in zebrafish. Toxicology 302:129-139. doi:10.1016/j.tox.2012.09.004 PMID:23000284 PMCID:PMC3511642
• Mandrell D, Truong L, Jephson C, Sarker MR, Moore A, Lang C, Simonich MT, Tanguay RL. 2012. Automated zebrafish chorion removal and single embryo placement: optimizing throughput of zebrafish developmental toxicity screens. J Lab Autom 17(1):66-74. doi:10.1177/2211068211432197 PMID:22357610 PMCID:PMC3327291