Superfund Research Program

Jonathan A. Doorn

University of Iowa
115 South Grand Ave
S328 College of Pharmacy
Iowa City, Iowa 52242-1112
Phone: 319-335-8834
Email: jonathan-doorn@uiowa.edu

Projects

• University of Iowa: Airborne PCBs and their Metabolites: Risk Factors for Adverse Neurodevelopmental Outcomes in Adolescence (2020-2025)
• University of Iowa: Research Experience & Training Coordination Core (2006-2025)

Publications

2024

• Paranjape N, Strack S, Lehmler H, Doorn JA. 2024. Astrocyte mitochondria are a sensitive target of PCB52 and its human-relevant metabolites. ACS Chem Neurosci 15(15):2729-2740. doi:10.1021/acschemneuro.4c00116 PMID:38953493 PMCID:11311133

2023

• Bullert AJ, Li X, Chunyun Z, Lee K, Pulliam CF, Cagle B, Doorn JA, Klingelhutz AJ, Robertson LW, Lehmler H. 2023. Disposition and metabolomic effects of 2,2',5,5'-tetrachlorobiphenyl in female rats following intraperitoneal exposure. Environ Toxicol Pharmacol 102:104245. doi:10.1016/j.etap.2023.104245 PMID:37572994
• Paranjape N, Dean LE, Martinez A, Tjalkens RB, Lehmler H, Doorn JA. 2023. Structure-activity relationship of lower chlorinated biphenyls and their human-relevant metabolites for astrocyte toxicity. Chem Res Toxicol 36(6):971-981. doi:10.1021/acs.chemrestox.3c00095 PMID:37279407 PMCID:PMC10283044

2021

• Bullert AJ, Doorn JA, Stevens HE, Lehmler H. 2021. The effects of polychlorinated biphenyl exposure during adolescence on the nervous system: A comprehensive review. Chem Res Toxicol 34(9):doi:10.1021/acs.chemrestox.1c00226 PMID:34491731 PMCID:PMC8456429

2019

• Uwimana E, Cagle B, Yeung C, Li X, Patterson EV, Doorn JA, Lehmler H. 2019. Atropselective oxidation of 2,2 ,3,3 ,4,6 -hexachlorobiphenyl (PCB 132) to hydroxylated metabolites by human liver microsomes and its implications for pcb 132 neurotoxicity. Toxicology 171:406-420. doi:10.1093/toxsci/kfz150 PMID:31268529 PMCID:PMC6760323

2018

• Enayah SH, Vanle BC, Fuortes LJ, Doorn JA, Ludewig G. 2018. PCB95 and PCB153 change dopamine levels and turn-over in PC12 cells. Toxicology 394:93-101. doi:10.1016/j.tox.2017.12.003 PMID:29233657 PMCID:PMC5756734
• Rodriguez EA, Vanle BC, Doorn JA, Lehmler H, Robertson LW, Duffel MW. 2018. Hydroxylated and sulfated metabolites of commonly observed airborne polychlorinated biphenyls display selective uptake and toxicity in N27, SH-SY5Y, and HepG2 cells. Environ Toxicol Pharmacol 62:69-78. doi:10.1016/j.etap.2018.06.010 PMID:29986280 PMCID:PMC609219

2016

• Anderson DG, Florang V, Schamp J, Buettner GR, Doorn JA. 2016. Antioxidant-mediated modulation of protein reactivity for 3,4-dihydroxyphenylacetaldehyde, a toxic dopamine metabolite. Chem Res Toxicol 29(7):1098-1107. doi:10.1021/acs.chemrestox.5b00528 PMID:27268734 PMCID:PMC5248556

2011

• Anderson DG, Mariappan S, Buettner GR, Doorn JA. 2011. Oxidation of 3,4-dihydroxyphenylacetaldehyde, a toxic dopaminergic metabolite, to a semiquinone radical and an ortho-quinone. J Biol Chem 286:26978-26986. doi:10.1074/jbc.M111.249532 PMID:21642436 PMCID:PMC3143656