Superfund Research Program
James Zach Hilt
University of Kentucky
177 F. Paul Anderson Tower
Lexington, Kentucky 40506-0503
Phone: 859-257-9844
Email: zach.hilt@uky.edu
Projects
- Bluegrass Advanced Materials, LLC: Development of Smart Flocculants for the Treatment of PFAS Contaminated Water (Phase I: September 2020 - February 2021)
- Bluegrass Advanced Materials, LLC: Development of Smart Flocculants for the Treatment of PFAS Contaminated Water (Phase II: May 2024 - April 2026)
- University of Kentucky: Biomimetic Magnetic Nanocomposites as a Platform Technology for the Capture and Sensing of PCBs (2014-2019)
- University of Kentucky: Research Experience and Training Coordination Core (2000-2025)
- University of Kentucky: Responsive Membranes and Advanced Materials for Sensing and Remediation of Halo-Organics (2020-2025)
Patents
Hazardous Waste Sites
Rockwell International Site
- University of Kentucky: Biomimetic Magnetic Nanocomposites as a Platform Technology for the Capture and Sensing of PCBs
Publications
2023
- Gutierrez AM, Dziubla TD, Hilt JZ. 2023. The impact of solution ionic strength, hardness, and pH on the sorption efficiency of polychlorinated biphenyls in magnetic nanocomposite microparticle (MNM) gels. Gels 9(4):344. doi:10.3390/gels9040344 PMID:37102956 PMCID:PMC1013771
- Klaus MV, Gutierrez AM, Hilt JZ. 2023. Development of poly(acrylamide)-based hydrogel composites with powdered activated carbon for controlled sorption of PFOA and PFOS in aqueous systems. Polymers 15(22):4384. doi:10.3390/polym15224384 PMID:38006108 PMCID:PMC10675425
- Paul P, Nicholson M, Hilt JZ. 2023. Magnetic nanocomposites for the remote activation of sulfate radicals for the removal of rhodamine B. Nanomaterials 13(7):1151. doi:10.3390/nano13071151 PMID:37049245 PMCID:PMC1009711
2022
- Baldridge KC, Edmonds K, Dziubla TD, Hilt JZ, Dutch RE, Bhattacharyya D. 2022. Demonstration of hollow fiber membrane-based enclosed space air remediation for capture of an aerosolized synthetic SARS-CoV-2 mimic and pseudovirus particles. ACS ES&T Eng 2(2):doi:10.1021/acsestengg.1c00369
- Frazar EM, Smith A, Dziubla TD, Hilt JZ. 2022. Thermoresponsive cationic polymers: PFAS binding performance under variable pH, temperature and comonomer composition. Gels 8(10):668. doi:10.3390/gels8100668 PMID:36286169 PMCID:PMC9602350
- Gutierrez AM, Leniz-Pizarro F, Wang X, Dziubla TD, Hilt JZ. 2022. Effect of atom transfer radical polymerization reaction time on PCB binding capacities of styrene-CMA/QMA core-shell iron oxide nanoparticles. Mater Sci Eng B-Adv Funct Solid-State Mater 277:115577. doi:10.1016/j.mseb.2021.115577
- Paul P, Edmonds K, Baldridge KC, Bhattacharyya D, Dziubla TD, Dutch RE, Hilt JZ. 2022. Enhanced inactivation of pseudoparticles containing SARS-CoV-2 protein using magnetic nanoparticles and an alternating magnetic field. ACS Appl Bio Mater doi:10.1021/acsabm.2c00522 PMID:36314574
2021
- Gutierrez AM, Frazar EM, Klaus MV, Paul P, Hilt JZ. 2021. Hydrogels and hydrogel nanocomposites: Enhancing healthcare through human and environmental treatment. Adv Healthc Mater doi:10.1002/adhm.202101820 PMID:34811960
- Savage DT, Briot N, Hilt JZ, Dziubla TD. 2021. On the swelling behavior of poly(N-Isopropylacrylamide) hydrogels exposed to perfluoroalkyl acids. J Polym Sci A Polym Chem 59(4):289-299. doi:10.1002/pol.20200805 PMID:34859243 PMCID:PMC8631585
- Savage DT, Hilt JZ, Dziubla TD. 2021. Assessing the perfluoroalkyl acid-induced swelling of Forster resonance energy transfer-capable poly(N-isopropylacrylamide) microgels. Soft Matter 10:doi:10.1039/d1sm00985k PMID:34661226 PMCID:PMC8889493
- Savage DT, Hilt JZ, Dziubla TD. 2021. Leveraging the thermoresponsiveness of fluorinated poly(N-isopropylacrylamide) copolymers as a sensing tool for perfluorooctane sulfonate. Analyst doi:10.1039/d1an00144b PMID:33928975
- Savage DT, Hilt JZ, Dziubla TD. 2021. Leveraging the thermoresponsiveness of fluorinated poly(N-isopropylacrylamide) copolymers as a sensing tool for perfluorooctane sulfonate. Analyst 11:doi:10.1039/D1AN00144B
- Shah RA, Runge T, Ostertag TW, Tang S, Dziubla TD, Hilt JZ. 2021. Development of temperature-responsive polymeric gels with physical crosslinking due to intermolecular pi-pi interactions. Polym Int
2020
- Gutierrez AM, Bhandari R, Weng J, Stromberg AJ, Dziubla TD, Hilt JZ. 2020. Synthesis of magnetic nanocomposite microparticles for binding of chlorinated organics in contaminated water sources. J Appl Polym Sci 137(37):49109. doi:10.1002/app.49109 PMID:34305166 PMCID:PMC8300995
- Shah RA, Frazar EM, Hilt JZ. 2020. Recent developments in stimuli responsive nanomaterials and their bionanotechnology applications. Curr Opin Chem Eng 30:103-111. doi:10.1016/j.coche.2020.08.007 PMID:34307003 PMCID:PMC8300877
- Shah RA, Ostertag TW, Tang S, Dziubla TD, Hilt JZ. 2020. Development of biphenyl monomers and associated crosslinked polymers with intramolecular pi-pi interactions. J Appl Polym Sci 12:doi:10.1002/app.50257
2019
- Ahmad I, Weng J, Stromberg AJ, Hilt JZ, Dziubla TD. 2019. Fluorescence based detection of polychlorinated biphenyls (PCBs) in water using hydrophobic interactions. Analyst 144(2):677-684. doi:10.1039/c8an00867a PMID:30511719 PMCID:PMC6331228
- Frazar EM, Shah RA, Dziubla TD, Hilt JZ. 2019. Multifunctional temperature-responsive polymers as advanced biomaterials and beyond. J Appl Polym Sci doi:10.1002/app.48770
- Gutierrez AM, Bhandari R, Weng J, Stromberg AJ, Dziubla TD, Hilt JZ. 2019. Novel magnetic core-shell nanoparticles for the removal of polychlorinated biphenyls from contaminated water sources. Mater Chem Phys 223:68-74. doi:10.1016/j.matchemphys.2018.10.045 PMID:31452560 PMCID:PMC6710019
- Savage DT, Hilt JZ, Dziubla TD. 2019. In vitro methods for assessing nanoparticle toxicity. In: Nanotoxicity. Humana Press, New York, NY. pp.1-29.
2018
- Gupta P, Thompson B, Wahlang B, Jordan CT, Hilt JZ, Hennig B, Dziubla TD. 2018. The environmental pollutant, polychlorinated biphenyls, and cardiovascular disease: a potential target for antioxidant nanotherapeutics. Drug Deliv Transl Res 8(3):740-759. doi:10.1007/s13346-017-0429-9 PMID:28975503 PMCID:PMC5882597
2017
- Gupta P, Lacerda C, Patil VS, Biswal D, Wattamwar P, Hilt JZ, Dziubla TD. 2017. Degradation of poly(beta-amino ester) hydrogels in alcohols through transesterification: a method to conjugate drugs to hydrogel matrices. J Polym Sci A Polym Chem 55(12):2019–2026. PMID:29398778
- Gutierrez AM, Dziubla TD, Hilt JZ. 2017. Recent advances on iron oxide magnetic nanoparticles as sorbents of organic pollutants in water and wastewater treatment. Rev Environ Health 32(1-2):111-117. doi:10.1515/reveh-2016-0063 PMID:28231068
- Patil VS, Gutierrez AM, Sunkara M, Morris AJ, Hilt JZ, Kalika DS, Dziubla TD. 2017. Curcumin acrylation for biological and environmental applications. J Nat Prod 80:1964-1971. doi:10.1021/acs.jnatprod.6b00951 PMID:28661687
- Tang S, Bhandari R, Delaney SP, Munson EJ, Dziubla TD, Hilt JZ. 2017. Synthesis and characterization of thermally responsive N-isopropylacrylamide hydrogels copolymerized with novel hydrophobic polyphenolic crosslinkers. Mater Today Commun 10:46-53. PMID:28989952 PMCID:PMC562875
- Tang S, Floy M, Bhandari R, Dziubla TD, Hilt JZ. 2017. Development of novel N-isopropylacrylamide (NIPAAm) based hydrogels with varying content of chrysin multiacrylate. Gels 3(4):40. doi:10.3390/gels3040040 PMID:29805968 PMCID:PMC5967267
- Tang S, Floy M, Bhandari R, Sunkara M, Morris AJ, Dziubla TD, Hilt JZ. 2017. Synthesis and characterization of thermoresponsive hydrogels based on N-isopropylacrylamide crosslinked with 4,4’-dihydroxybiphenyl diacrylate. ACS Omega 2(12):8723-8729. doi:10.1021/acsomega.7b01247 PMID:29302630 PMCID:PMC5748278
2016
- Dziubla TD, Hilt JZ, Bhandari R, Gupta P. 2016. Single step synthesis, characterization and applications of curcumin functionalized iron oxide magnetic nanoparticles. Mater Sci Eng C Mater Biol Appl 67:59-64. doi:10.1016/j.msec.2016.04.093 PMID:27287099
2014
- Petriello MC, Newsome B, Dziubla TD, Hilt JZ, Bhattacharyya D, Hennig B. 2014. Modulation of persistent organic pollutant toxicity through nutritional intervention: emerging opportunities in biomedicine and environmental remediation. Sci Total Environ 491-492:11-16. doi:10.1016/j.scitotenv.2014.01.109 PMID:24530186 PMCID:PMC4077968
2013
- Xiao L, Isner AB, Hilt JZ, Bhattacharyya D. 2013. Temperature responsive hydrogel with reactive nanoparticles. J Appl Polym Sci 128(3):1804-1814. doi:10.1002/app.38335
2012
- Knecht LD, Ali N, Wei Y, Hilt JZ, Daunert S. 2012. Nanoparticle-mediated remote control of enzymatic activity. ACS Nano 6(10):9079-9086. doi:10.1021/nn303308v PMID:22989219 PMCID:PMC4127402