Superfund Research Program

Donna D. Zhang

University of Arizona
PO Box 210207
Pharmacy, Rm. 421
Tucson, Arizona 85721
Phone: 520-626-9918
Email: dzhang@pharmacy.arizona.edu

Projects

• University of Arizona: Administrative Core (2000-2025)
• University of Arizona: Diabetogenic Mine Tailings: Mechanistic Link Between Arsenic, NRF2, Autophagy, and Diabetes (2020-2025)
• University of Arizona: Research Experience and Training Coordination Core (1995-2025)
• University of Arizona: Role of NRF2 in the Pulmonary Response to Inhaled Mine Tailing Dust (2017-2020)
• University of Arizona: Toxicological Impact of Mine Tailings Dust on Lung Epithelial Barrier Function (2005-2020)

Publications

2023

• Anandhan A, Dodson M, Shakya A, Chen J, Liu P, Wei Y, Tan H, Wang Q, Jiang Z, Yang K, Garcia JG, Chambers SK, Chapman E, Ooi A, Yang-Hartwich Y, Stockwell BR, Zhang DD. 2023. NRF2 controls iron homeostasis and ferroptosis through HERC2 and VAMP8. Sci Adv 9(5):doi:10.1126/sciadv.ade9585 PMID:36724221 PMCID:PMC9891695
• Shakya A, Mckee NW, Dodson M, Chapman E, Zhang DD. 2023. Anti-ferroptotic effects of Nrf2: beyond the antioxidant response. Mol Cells 46(3):165-175. doi:10.14348/molcells.2023.0005 PMID:36994475 PMCID:PMC10070163

2022

• Dodson M, Dai W, Anandhan A, Schmidlin CJ, Liu P, Wilson NC, Wei Y, Kitamura N, Galligan JJ, Ooi A, Chapman E, Zhang DD. 2022. CHML is an NRF2 target gene that regulates mTOR function. Mol Oncol 16:1714-1727. doi:10.1002/1878-0261.13194 PMID:35184380 PMCID:PMC9019883
• Li H, Fan X, Wu X, Han W, Amistadi M, Liu P, Zhang DD, Chorover J, Ding X, Zhang Q. 2022. Differential effects of arsenic in drinking water on mouse hepatic and intestinal heme oxygenase-1 expression. Antioxidants (Basel) 11(9):1835. doi:10.3390/antiox11091835 PMID:36139908 PMCID:PMC9495312
• Liu P, Anandhan A, Chen J, Shakya A, Dodson M, Ooi A, Chapman E, White E, Garcia JG, Zhang DD. 2022. Decreased autophagosome biogenesis, reduced NRF2, and enhanced ferroptotic cell death are underlying molecular mechanisms of non-alcoholic fatty liver disease. Redox Biol 59:102570. doi:10.1016/j.redox.2022.102570 PMID:36495698 PMCID:PMC9731892
• Schiro G, Liu P, Dodson M, Zhang DD, Ghishan FK, Barberan A, Kiela PR. 2022. Interactions between arsenic exposure, high-fat diet and NRF2 shape the complex responses in the murine gut microbiome and hepatic metabolism. Front Microbiomes 1:doi:10.3389/frmbi.2022.1041188

2021

• Dodson M, Anandhan A, Zhang DD, Madhavan L. 2021. An NRF2 perspective on stem cells and aging. Front Aging 2:690686. doi:10.3389/fragi.2021.690686 PMID:36213179 PMCID:PMC9536878
• Liu P, Dodson M, Li H, Schmidlin C, Shakya A, Wei Y, Garcia JG, Chapman E, Kiela PR, Zhang Q, White E, Ding X, Ooi A, Zhang DD. 2021. Non-canonical NRF2 activation promotes a pro-diabetic shift in hepatic glucose metabolism. Mol Metab 51:101243. doi:10.1016/j.molmet.2021.101243 PMID:33933676 PMCID:PMC8164084
• Liu P, Luo G, Dodson M, Schmidlin C, Wei Y, Kerimoglu B, Ooi A, Chapman E, Garcia JG, Zhang DD. 2021. The NRF2-LOC344887 signaling axis suppresses pulmonary fibrosis. Redox Biol 38:101766. doi:10.1016/j.redox.2020.101766 PMID:33126057 PMCID:PMC7573654
• Schmidlin C, Shakya A, Dodson M, Chapman E, Zhang DD. 2021. The intricacies of NRF2 regulation in cancer. Semin Cancer Biol 76:110-119. doi:10.1016/j.semcancer.2021.05.016 PMID:34020028 PMCID:PMC8599504
• Schmidlin C, Tian W, Dodson M, Chapman E, Zhang DD. 2021. FAM129B-dependent activation of NRF2 promotes an invasive phenotype in BRAF mutant melanoma cells. Mol Carcinog doi:10.1002/mc.23295 PMID:33684228 PMCID:PMC8189631

2020

• Anandhan A, Dodson M, Schmidlin C, Liu P, Zhang DD. 2020. Breakdown of an ironclad defense system: The critical role of NRF2 in mediating ferroptosis. Cell Chem Biol 27:436-447. doi:10.1016/j.chembiol.2020.03.011 PMID:32275864
• Liu P, Dodson M, Fang D, Chapman E, Zhang DD. 2020. NRF2 negatively regulates primary ciliogenesis and hedgehog signaling. PLoS Biol 18(2):doi:10.1371/journal.pbio.3000620 PMID:32053600 PMCID:PMC7043785
• Schmidlin C, de la Vega MR, Perer J, Zhang DD, Wondrak GT. 2020. Activation of NRF2 by topical apocarotenoid treatment mitigates radiation-induced dermatitis. Redox Biol 37:101714. doi:10.1016/j.redox.2020.101714 PMID:32927319 PMCID:PMC7494798
• Schmidlin CJ, Zeng T, Liu P, Wei Y, Dodson M, Chapman E, Zhang DD. 2020. Chronic arsenic exposure enhances metastatic potential via NRF2-mediated upregulation of SOX9. Toxicol Appl Pharmacol 402:12. doi:10.1016/j.taap.2020.115138 PMID:32682831

2019

• Dodson M, Castro-Portuguez R, Zhang DD. 2019. NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis. Redox Biol 23:101107. doi:10.1016/j.redox.2019.101107 PMID:30692038 PMCID:PMC6859567
• Dodson M, de la Vega MR, Cholanians AB, Schmidlin CJ, Chapman E, Zhang DD. 2019. Modulating NRF2 in disease: timing is everything. Annu Rev Pharmacol Toxicol 59:555-575. doi:10.1146/annurev-pharmtox-010818-021856 PMID:30256716 PMCID:PMC6538038
• Kerins M, Liu P, Tian W, Mannheim W, Zhang DD, Ooi A. 2019. Genome-wide CRISPR screen reveals autophagy disruption as the convergence mechanism that regulates the NRF2 transcription factor. Mol Cell Biol 39(13):e00037-19. doi:10.1128/MCB.00037-19 PMID:31010806 PMCID:PMC6580702
• Liu P, de la Vega MR, Dodson M, Yue F, Shi B, Fang D, Chapman E, Liu L, Zhang DD. 2019. Spermidine confers liver protection by enhancing NRF2 signaling through a MAP1S-mediated noncanonical mechanism. Hepatology 70(1):372-388. doi:10.1002/hep.30616 PMID:30873635 PMCID:PMC6597327
• Pengfei L, Kerins M, Tian W, Neupane D, Zhang DD, Ooi A. 2019. Differential and overlapping targets of the transcriptional regulators NRF1, NRF2, and NRF3 in human cells. J Biol Chem 294:18131-18149. doi:10.1074/jbc.RA119.009591 PMID:31628195 PMCID:PMC6885608
• Schmidlin C, Dodson M, Zhang DD. 2019. Filtering through the role of NRF2 in kidney disease. Archives of Pharmacal Research doi:10.1007/s12272-019-01177-2 PMID:31372933
• Schmidlin CJ, Dodson M, Madhavan L, Zhang DD. 2019. Redox regulation by NRF2 in aging and disease. Free Radic Biol Med 134:702-707. doi:10.1016/j.freeradbiomed.2019.01.016 PMID:30654017 PMCID:PMC6588470

2018

• Dodson M, de la Vega MR, Harder B, Castro-Portuguez R, Rodrigues SD, Wong PK, Chapman E, Zhang DD. 2018. Low-level arsenic causes proteotoxic stress and not oxidative stress. Toxicol Appl Pharmacol 341:106-113. doi:10.1016/j.taap.2018.01.014 PMID:29408041 PMCID:PMC5929483
• Dodson M, Liu P, Jiang T, Ambrose AJ, Luo G, de la Vega MR, Cholanians AB, Wong PK, Chapman E, Zhang DD. 2018. Increased O-GlcNAcylation of SNAP29 drives arsenic-induced autophagic dysfunction. Mol Cell Biol 38(11):e00595-17. doi:10.1128/MCB.00595-17 PMID:29507186 PMCID:PMC5954189
• Liu P, de la Vega MR, Sammani S, Mascarenhas JB, Kerins M, Dodson M, Sun X, Wang T, Ooi A, Garcia JG, Zhang DD. 2018. RPA1 binding to NRF2 switches ARE-dependent transcriptional activation to ARE-NRE-dependent repression. Proc Natl Acad Sci U S A 115(44):E10352-E10361. doi:10.1073/pnas.1812125115 PMID:30309964 PMCID:PMC6217430

2017

• Bao L, Wu J, Dodson M, de la Vega MR, Ning Y, Zhang Z, Yao M, Zhang DD, Xu C, Yi X. 2017. ABCF2, an Nrf2 target gene, contributes to cisplatin resistance in ovarian cancer cells. Mol Carcinog 56(6):1543-1553. doi:10.1002/mc.22615 PMID:28112439 PMCID:PMC5509336

2013

• Tao S, Zheng Y, Lau A, Jaramillo MC, Chau BT, Lantz RC, Wong PK, Wondrak GT, Zhang DD. 2013. Tanshinone I activates the Nrf2-dependent antioxidant response and protects against As(III)-induced lung inflammation in vitro and in vivo. Antioxid Redox Signal 19(14):1647-1661. doi:10.1089/ars.2012.5117 PMID:23394605 PMCID:PMC3809600

2012

• Zheng Y, Tao S, Lian F, Chau BT, Chen J, Sun G, Fang D, Lantz RC, Zhang DD. 2012. Sulforaphane prevents pulmonary damage in response to inhaled arsenic by activating the Nrf2-defense response. Toxicol Appl Pharmacol 265(3):292-299. doi:10.1016/j.taap.2012.08.028 PMID:22975029 PMCID:PMC3725323

2007

• Wang X, Sun Z, Chen W, Eblin KE, Gandolfi A, Zhang DD. 2007. Nrf2 protects human bladder urothelial cells from arsenite and monomethylarsonous acid toxicity. Toxicol Appl Pharmacol 225(2):206-13. PMID:17765279