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Person Details: Donna D. Zhang

Superfund Research Program

Donna D. Zhang

University of Arizona
PO Box 210207
Pharmacy, Rm. 421
Tucson, Arizona 85721
Phone: 520-626-9918





  • Dodson M, Dai W, Anandhan A, Schmidlin CJ, Liu P, Wilson NC, Wei Y, Kitamura N, Galligan JJ, Ooi A, Chapman E, Zhang DD. 2022. CHML is an NRF2 target gene that regulates mTOR function. Mol Oncol 16:1714-1727. doi:10.1002/1878-0261.13194 PMID:35184380 PMCID:PMC9019883
  • Li H, Fan X, Wu X, Han W, Amistadi M, Liu P, Zhang DD, Chorover J, Ding X, Zhang Q. 2022. Differential effects of arsenic in drinking water on mouse hepatic and intestinal heme oxygenase-1 expression. Antioxidants (Basel) 11(9):1835. doi:10.3390/antiox11091835 PMID:36139908 PMCID:PMC9495312
  • Liu P, Anandhan A, Chen J, Shakya A, Dodson M, Ooi A, Chapman E, White E, Garcia JG, Zhang DD. 2022. Decreased autophagosome biogenesis, reduced NRF2, and enhanced ferroptotic cell death are underlying molecular mechanisms of non-alcoholic fatty liver disease. Redox Biol 59:102570. doi:10.1016/j.redox.2022.102570 PMID:36495698 PMCID:PMC9731892
  • Schiro G, Liu P, Dodson M, Zhang DD, Ghishan FK, Barberan A, Kiela PR. 2022. Interactions between arsenic exposure, high-fat diet and NRF2 shape the complex responses in the murine gut microbiome and hepatic metabolism. Front Microbiomes 1:doi:10.3389/frmbi.2022.1041188





  • Dodson M, de la Vega MR, Harder B, Castro-Portuguez R, Rodrigues SD, Wong PK, Chapman E, Zhang DD. 2018. Low-level arsenic causes proteotoxic stress and not oxidative stress. Toxicol Appl Pharmacol 341:106-113. doi:10.1016/j.taap.2018.01.014 PMID:29408041 PMCID:PMC5929483
  • Dodson M, Liu P, Jiang T, Ambrose AJ, Luo G, de la Vega MR, Cholanians AB, Wong PK, Chapman E, Zhang DD. 2018. Increased O-GlcNAcylation of SNAP29 drives arsenic-induced autophagic dysfunction. Mol Cell Biol 38(11):e00595-17. doi:10.1128/MCB.00595-17 PMID:29507186 PMCID:PMC5954189
  • Liu P, de la Vega MR, Sammani S, Mascarenhas JB, Kerins M, Dodson M, Sun X, Wang T, Ooi A, Garcia JG, Zhang DD. 2018. RPA1 binding to NRF2 switches ARE-dependent transcriptional activation to ARE-NRE-dependent repression. Proc Natl Acad Sci U S A 115(44):E10352-E10361. doi:10.1073/pnas.1812125115 PMID:30309964 PMCID:PMC6217430


  • Bao L, Wu J, Dodson M, de la Vega MR, Ning Y, Zhang Z, Yao M, Zhang DD, Xu C, Yi X. 2017. ABCF2, an Nrf2 target gene, contributes to cisplatin resistance in ovarian cancer cells. Mol Carcinog 56(6):1543-1553. doi:10.1002/mc.22615 PMID:28112439 PMCID:PMC5509336


  • Tao S, Zheng Y, Lau A, Jaramillo MC, Chau BT, Lantz RC, Wong PK, Wondrak GT, Zhang DD. 2013. Tanshinone I activates the Nrf2-dependent antioxidant response and protects against As(III)-induced lung inflammation in vitro and in vivo. Antioxid Redox Signal 19(14):1647-1661. doi:10.1089/ars.2012.5117 PMID:23394605 PMCID:PMC3809600


  • Zheng Y, Tao S, Lian F, Chau BT, Chen J, Sun G, Fang D, Lantz RC, Zhang DD. 2012. Sulforaphane prevents pulmonary damage in response to inhaled arsenic by activating the Nrf2-defense response. Toxicol Appl Pharmacol 265(3):292-299. doi:10.1016/j.taap.2012.08.028 PMID:22975029 PMCID:PMC3725323


  • Wang X, Sun Z, Chen W, Eblin KE, Gandolfi A, Zhang DD. 2007. Nrf2 protects human bladder urothelial cells from arsenite and monomethylarsonous acid toxicity. Toxicol Appl Pharmacol 225(2):206-13. PMID:17765279
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