Superfund Research Program

Xueshu Li

University of Iowa
UI Research Park 221 IREH
Iowa City, Iowa 52242-5000
Phone: 319-335-4981
Email: xueshu-li@uiowa.edu

Projects

• University of Iowa: Research Support Core: Synthesis Core (2006-2025)

Publications

2024

• Griffin J, Li X, Lehmler H, Holland EB. 2024. Predicted versus observed activity of PCB mixtures toward the ryanodine receptor. Neurotoxicology 100:25-34. doi:10.1016/j.neuro.2023.12.003 PMID:38065417 PMCID:10842331

2023

• Behan-Bush RM, Liszewski JN, Schrodt MV, Vats B, Li X, Lehmler H, Klingelhutz AJ, Ankrum J. 2023. Toxicity impacts on human adipose mesenchymal stem/stronal cells acutely exposed to aroclor and non-aroclor mixtures of polychorinated biphenyl. Environ Sci Technol 57(4):1731-1742. doi:10.1021/acs.est.2c07281 PMID:36651682 PMCID:PMC9893815
• Bullert AJ, Li X, Chunyun Z, Lee K, Pulliam CF, Cagle B, Doorn JA, Klingelhutz AJ, Robertson LW, Lehmler H. 2023. Disposition and metabolomic effects of 2,2',5,5'-tetrachlorobiphenyl in female rats following intraperitoneal exposure. Environ Toxicol Pharmacol 102:104245. doi:10.1016/j.etap.2023.104245 PMID:37572994
• Li X, Bullert AJ, Han W, Yang W, Zhang Q, Ding X, Lehmler H. 2023. Enantiomeric fractions reveal differences in the atroposelective disposition of 2,2',3,5',6-pentachlorobiphenyl (PCB 95) in wildtype, cyp2abfgs-null, and CYP2A6-humanized mice. Chem Res Toxicol doi:10.1021/acs.chemrestox.3c00128 PMID:37467352
• Mouat JS, Li X, Neier K, Zhu Y, Mordaunt CE, La Merrill MA, Lehmler H, Jones MP, Lein PJ, Schmidt RJ, LaSalle J. 2023. Networks of placental DNA methylation correlate with maternal serum PCB concentrations and child neurodevelopment. Environ Res 220:115227. doi:10.1016/j.envres.2023.115227 PMID:36608759
• Wang H, Bullert AJ, Li X, Stevens HE, Klingelhutz AJ, Ankrum J, Adamcakova-Dodd A, Thorne PS, Lehmler H. 2023. Use of a polymeric implant system to assess the neurotoxicity of subacute exposure to 2,2',5,5'-tetrachlorobiphenyl-4-ol, a human metabolite of PCB 52, in male adolescent rats. Toxicology 500:153677. doi:10.1016/j.tox.2023.153677 PMID:37995827 PMCID:PMC10757425
• Zhang C, Li X, Stietz KP, Sethi S, Yang W, Marek RF, Ding X, Lein PJ, Hornbuckle KC, Lehmler H. 2023. Rebuttal to correspondence on "machine learning-assisted identification and quantification of hydroxylated metabolites of polychlorinated biphenyls in animal samples". Environ Sci Technol 57(15):6251-6252. doi:10.1021/acs.est.3c01659 PMID:37017328

2022

• Li X, Hefti MM, Marek RF, Hornbuckle KC, Wang K, Lehmler H. 2022. Assessment of polychlorinated biphenyls and their hydroxylated metabolites in postmortem human brain samples: Age and brain region differences. Environ Sci Technol 56(13):9515-9526. doi:10.1021/acs.est.2c00581 PMID:35658127 PMCID:PMC9260965
• Li X, Lim JJ, Wang K, Prasad B, Bhatt D, Cui JY, Lehmler H. 2022. The disposition of polychlorinated biphenyls (PCBs) differs between germ-free and conventional mice. Environ Toxicol Pharmacol 92:103854. doi:10.1016/j.etap.2022.103854 PMID:35331926 PMCID:PMC9090986
• Saktrakulkla P, Li X, Martinez A, Lehmler H, Hornbuckle KC. 2022. Hydroxylated polychlorinated biphenyls are emerging legacy pollutants in contaminated sediments. Environ Sci Technol 56:2269-2278. doi:10.1021/acs.est.1c04780 PMID:35107261 PMCID:PMC8851693
• Yaghoobi B, Miller GW, Holland EB, Li X, Harvey D, Li S, Lehmler H, Pessah IN, Lein PJ. 2022. Ryanodine receptor-active non-dioxin-like polychlorinated biphenyls cause neurobehavioral deficits in larval zebrafish. Front Toxicol 4:947795. doi:10.3389/ftox.2022.947795 PMID:36278027 PMCID:PMC9582434
• Zhang C, Li X, Flor S, Ruiz P, Kruve A, Ludewig G, Lehmler H. 2022. Metabolism of 3-chlorobiphenyl (PCB 2) in a human-relevant cell line: evidence of dechlorinated metabolites. Environ Sci Technol 56(17):12460-12472. doi:10.1021/acs.est.2c03687 PMID:35994059 PMCID:PMC9573771
• Zhang C, Li X, Stietz KP, Sethi S, Yang W, Marek RF, Ding X, Lein PJ, Hornbuckle KC, Joachim-Lehmler H. 2022. Machine learning-assisted identification and quantification of hydroxylated metabolites of polychlorinated biphenyls in animal samples. Environ Sci Technol 56(18):13169-13178. doi:10.1021/acs.est.2c02027 PMID:36047920

2021

• Li X, Liu Y, Martin JW, Cui JY, Lehmler H. 2021. Nontarget analysis reveals gut microbiome-dependent differences in the fecal PCB metabolite profiles of germ-free and conventional mice. Environ Pollut doi:10.1016/j.envpol.2020.115726 PMID:33032095 PMCID:PMC7746632

2020

• Dhakal RC, Li X, Parkin S, Lehmler H. 2020. Synthesis of mono- and dimethoxylated polychlorinated biphenyl derivatives starting from fluoroarene derivatives. Environ Sci Pollut Res Int 27:8905-8925. doi:10.1007/s11356-019-07133-3
• Grimm FA, Klaren WD, Li X, Lehmler H, Karmakar M, Robertson LW, Chiu WA, Rusyn I. 2020. Cardiovascular effects of polychlorinated biphenyls and their major metabolites. Environ Health Perspect 128:77008. doi:10.1289/EHP7030 PMID:32701041 PMCID:PMC7377239
• Li X, Zhang C, Wang K, Lehmler H. 2020. Fatty liver and impaired hepatic metabolism alter the congener-specific distribution of polychlorinated biphenyls (PCBs) in mice with a liver-specific deletion of cytochrome P450 reductase. Environ Pollut 266:115233. doi:10.1016/j.envpol.2020.115233 PMID:32712482 PMCID:PMC7492420
• Lim JJ, Li X, Lehmler H, Wang D, Gu H, Cui JY. 2020. Gut microbiome critically impacts PCB-induced changes in metabolic fingerprints and the hepatic transcriptome in mice. Toxicol Sci 177:168-187. doi:10.1093/toxsci/kfaa090 PMID:32544245 PMCID:PMC7553702

2019

• Li X, Wu X, Kelly KM, Veng-Pedersen P, Lehmler H. 2019. Toxicokinetics of chiral PCB 136 and its hydroxylated metabolites in mice with a liver-specific deletion of cytochrome P450 reductase. Chem Res Toxicol 32:727-736. doi:10.1021/acs.chemrestox.8b00389 PMID:30729780 PMCID:PMC6465157
• Sethi S, Morgan RK, Feng W, Lin Y, Li X, Luna C, Koch M, Bansal R, Duffel MW, Puschner B, Zoeller RT, Lehmler H, Pessah IN, Lein PJ. 2019. Comparative analyses of the 12 most abundant PCB congeners detected in human maternal serum for activity at the thyroid hormone receptor and ryanodine receptor. Environ Sci Technol 53:3948-3958. doi:10.1021/acs.est.9b00535 PMID:30821444 PMCID:PMC6457253
• Uwimana E, Cagle B, Yeung C, Li X, Patterson EV, Doorn JA, Lehmler H. 2019. Atropselective oxidation of 2,2 ,3,3 ,4,6 -hexachlorobiphenyl (PCB 132) to hydroxylated metabolites by human liver microsomes and its implications for pcb 132 neurotoxicity. Toxicology 171:406-420. doi:10.1093/toxsci/kfz150 PMID:31268529 PMCID:PMC6760323
• Uwimana E, Ruiz P, Li X, Lehmler H. 2019. Human CYP2A6, CYP2B6, and CYP2E1 atropselectively metabolize polychlorinated biphenyls to hydroxylated metabolites. Environ Sci Technol 53(4):2114-2123. doi:10.1021/acs.est.8b05250 PMID:30576102 PMCID:PMC6380921

2018

• Alam S, Carter GS, Krager KJ, Li X, Lehmler H, Aykin-Burns N. 2018. PCB11 metabolite, 3,3-dichlorobiphenyl-4-ol, exposure alters the expression of genes governing fatty acid metabolism in the absence of functional sirtuin 3: examining the contribution of MnSOD. Antioxidants (Basel) 7(9):121. doi:10.3390/antiox7090121 PMID:30223548
• Cheng SL, Li X, Lehmler H, Phillips B, Shen D, Cui JY. 2018. Gut microbiota modulates interactions between polychlorinated biphenyls and bile acid homeostasis. Toxicol Sci 166:269-287. doi:10.1093/toxsci/kfy208 PMID:30496569 PMCID:PMC6260149
• Gadupudi GS, Elser BA, Sandgruber FA, Li X, Gibson-Corley KN, Robertson LW. 2018. PCB126 inhibits the activation of AMPK-CREB signal transduction required for energy sensing in liver. Toxicol Sci 163:440-453. doi:10.1093/toxsci/kfy041 PMID:29474705 PMCID:PMC5974782
• Li X, Holland EB, Feng W, Zheng J, Dong Y, Pessah IN, Duffel MW, Robertson LW, Lehmler H. 2018. Authentication of synthetic environmental contaminants and their (bio)transformation products in toxicology: polychlorinated biphenyls as an example. Environ Sci Pollut Res Int 25(17):1-14. doi:10.1007/s11356-017-1162-0 PMID:29322390 PMCID:PMC6015536
• Li X, Parkin S, Lehmler H. 2018. Absolute configuration of 2,2',3,3',6-pentachlorinatedbiphenyl (PCB 84) atropisomers. Environ Sci Pollut Res Int 25:16402-16410. doi:10.1007/s11356-017-9259-z PMID:28537024 PMCID:PMC5823790
• Liu Y, Richardson ES, Derocher AE, Lunn NJ, Lehmler H, Li X, Zhang Y, Cui JY, Cheng L, Martin JW. 2018. Hundreds of unrecognized halogenated contaminants discovered in polar bear serum. Angew Chem Int Ed Engl 57:16401-16406. doi:10.1002/anie.201809906 PMID:30376612
• Pencikova K, Svrzkova L, Strapacova S, Neca J, Bartonkova I, Dvorak Z, Hyzdalova M, Pivnicka J, Palkova L, Lehmler H, Li X, Vondracek J, Machala M. 2018. In vitro profiling of toxic effects of prominent environmental lower-chlorinated PCB congeners linked with endocrine disruption and tumor promotion. Environ Pollut 237:473-486. doi:10.1016/j.envpol.2018.02.067 PMID:29518658 PMCID:PMC5908724
• Uwimana E, Li X, Lehmler H. 2018. Human liver microsomes atropselectively metabolize 2,2 ',3,4 ',6-pentachlorobiphenyl (PCB 91) to a 1,2-shift product as the major metabolite. Environ Sci Technol 52:6000-6008. doi:10.1021/acs.est.8b00612 PMID:29659268 PMCID:PMC5966832

2017

• Holland EB, Feng W, Zheng J, Dong Y, Li X, Lehmler H, Pessah IN. 2017. An extended structure-activity relationship of nondioxin-like PCBs evaluates and supports modeling predictions and identifies picomolar potency of PCB 202 towards ryanodine receptors. Toxicol Sci 155(1):170-181. doi:10.1093/toxsci/kfw189 PMID:27655348 PMCID:PMC5216651
• Schroer HW, Langenfeld KL, Li X, Lehmler H, Just CL. 2017. Biotransformation of 2,4-dinitroanisole by a fungal Penicillium sp. Biodegradation 28(1):95-109. doi:10.1007/s10532-016-9780-7 PMID:27913891
• Schroer HW, Li X, Lehmler H, Just CL. 2017. Metabolism and photolysis of 2,4-Dinitroanisole in Arabidopsis. Environ Sci Technol 51:13714-13722. doi:10.1021/acs.est.7b04220 PMID:29131608
• Sethi S, Keil KP, Chen H, Hayakawa K, Li X, Lin Y, Lehmler H, Puschner B, Lein PJ. 2017. Detection of 3,3 '-dichlorobiphenyl in human maternal plasma and its effects on axonal and dendritic growth in primary rat neurons. Toxicol Sci 158(2):401-411. doi:10.1093/toxsci/kfx100 PMID:28510766 PMCID:PMC5837364
• Uwimana E, Maiers A, Li X, Lehmler H. 2017. Microsomal metabolism of prochiral polychlorinated biphenyls results in the enantioselective formation of chiral metabolites. Environ Sci Technol 51(3):1820-1829. doi:10.1021/acs.est.6b05387 PMID:28038482 PMCID:PMC5300040

2016

• Rodriguez EA, Li X, Lehmler H, Robertson LW, Duffel MW. 2016. Sulfation of lower chlorinated polychlorinated biphenyls increases their affinity for the major drug-binding sites of human serum albumin. Environ Sci Technol 50(10):5320-5327. doi:10.1021/acs.est.6b00484 PMID:27116425 PMCID:PMC4883002
• Uwimana E, Li X, Lehmler H. 2016. 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) is atropselectively metabolized to para-hydroxylated metabolites by human liver microsomes. Chem Res Toxicol 29(12):2108-2110. doi:10.1021/acs.chemrestox.6b00371 PMID:27989147 PMCID:PMC5175585

2014

• Li X, Parkin S, Lehmler H. 2014. 2,4-Di-chloro-1-iodo-6-nitro-benzene. Acta Crystallogr B 70(Pt5):o607. doi:10.1107/S1600536814008733 PMID:24860400 PMCID:PMC4011245

2013

• Lehmler H, He X, Li X, Duffel MW, Parkin S. 2013. Effective synthesis of sulfate metabolites of chlorinated phenols. Chemosphere 93(9):1965-1971. doi:10.1016/j.chemosphere.2013.06.087 PMID:23906814 PMCID:PMC3815985

2008

• Kania-Korwel I, Zhao H, Norstrom K, Li X, Hornbuckle KC, Lehmler H. 2008. Simultaneous extraction and clean-up of polychlorinated biphenyls and their metabolites from small tissue samples using pressurized liquid extraction. J Chromatogr A 1214(1-2):37-46. doi:10.1016/j.chroma.2008.10.089 PMID:19019378 PMCID:PMC2648864