Superfund Research Program

Daniel K. Nomura

University of California-Berkeley
Nutritional Science and Toxicology Department
2151 Berkeley Way, Room 312G
Berkeley, California 94704
Phone: 510-643-7258
Email: dnomura@berkeley.edu

Projects

• University of California-Berkeley: Genomics and Analytical Chemistry (2006-2017)
• University of California-Berkeley: Mapping Proteome-Wide Reactivity of Superfund Chemicals Using Chemoproteomic Platforms (2017-2022)
• University of California-Berkeley: Oxidative Remediation of Superfund Contaminants (2006-2022)

Research Briefs

• 253 - Mapping Protein Targets of Environmental Chemicals Using Chemoproteomic Platforms

Publications

2022

• Page AC, Scholz SO, Keenan KN, Spradlin JN, Belcher BP, Brittain SM, Tallarico JA, McKenna JM, Schirle M, Nomura DK, Toste FD. 2022. Photo-Brook rearrangement of acyl silanes as a strategy for photoaffinity probe design. Chem Sci 13:doi:10.1039/d2sc00426g

2021

• Boike L, Cioffi AG, Majewski FC, Co J, Henning NJ, Jones MD, Liu G, McKenna JM, Tallarico JA, Schirle M, Nomura DK. 2021. Discovery of a functional covalent ligand targeting an intrinsically disordered cysteine within MYC. Cell Chem Biol 28(1):4-13.e17. doi:10.1016/j.chembiol.2020.09.001 PMID:32966806 PMCID:PMC7854864

2020

• Isobe Y, Okumura M, McGregor LM, Brittain SM, Jones MD, Liang X, White R, Forrester W, McKenna JM, Tallarico JA, Schirle M, Maimone T, Nomura DK. 2020. Manumycin polyketides act as molecular glues between UBR7 and P53. Nat Chem Biol 16:1189-1198. doi:10.1038/s41589-020-0557-2 PMID:32572277 PMCID:PMC7572527

2019

• Berdan C, Ho R, Lehtola H, To M, Hu X, Huffman T, Petri Y, Altobelli C, Demeulenaere S, Olzmann J, Maimone T, Nomura DK. 2019. Parthenolide covalently targets and inhibits focal adhesion kinase in breast cancer cells. Cell Chem Biol 26(7):1027-1035. doi:10.1016/j.chembiol.2019.03.016 PMID:31080076 PMCID:PMC6756182
• Bersuker K, Hendricks JM, Li Z, Magtanong L, Ford B, Tang PH, Roberts MA, Tong B, Maimone T, Zoncu R, Bassik MC, Nomura DK, Dixon SJ, Olzmann J. 2019. The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature 575:688-692. doi:10.1038/s41586-019-1705-2 PMID:31634900 PMCID:PMC6883167

2018

• Counihan JL, Wiggenhorn AL, Anderson KE, Nomura DK. 2018. Chemoproteomics-enabled covalent ligand screening reveals ALDH3A1 as a lung cancer therapy target. ACS Chem Biol 13(8):1970-1977. doi:10.1021/acschembio.8b00381 PMID:30004670 PMCID:PMC6389507
• Prasse C, Ford B, Nomura DK, Sedlak DL. 2018. Unexpected transformation of dissolved phenols to toxic dicarbonyls by hydroxyl radicals and UV light. Proc Natl Acad Sci U S A 115:2311-2316. doi:10.1073/pnas.1715821115 PMID:29463747 PMCID:PMC5877969

2017

• Counihan JL, Duckering M, Dalvie ED, Ku WM, Bateman LA, Fisher KJ, Nomura DK. 2017. Chemoproteomic profiling of acetanilide herbicides reveals their role in inhibiting fatty acid oxidation. ACS Chem Biol 12(3):635-642. doi:10.1021/acschembio.6b01001 PMID:28094496 PMCID:PMC6376971

2016

• Counihan JL, Ford B, Nomura DK. 2016. Mapping proteome-wide interactions of reactive chemicals using chemoproteomic platforms. Curr Opin Chem Biol 30:68-76. doi:10.1016/j.cbpa.2015.11.007 PMID:26647369 PMCID:PMC4731263

2015

• Medina-Cleghorn D, Bateman LA, Ford B, Heslin A, Fisher KJ, Dalvie ED, Nomura DK. 2015. Mapping proteome-wide targets of environmental chemicals using reactivity-based chemoproteomic platforms. Chem Biol 22(10):1394-1405. doi:10.1016/j.chembiol.2015.09.008 PMID:26496688 PMCID:PMC4621755

2014

• Cai X, Perttula K, Pajouh S, Hubbard AE, Nomura DK, Rappaport SM. 2014. Untargeted lipidomic profiling of human plasma reveals differences due to race, gender and smoking status. Metabolomics 4:131. doi:10.4172/2153-0769.1000131
• Medina-Cleghorn D, Heslin A, Morris PJ, Mulvihill MM, Nomura DK. 2014. Multidimensional profiling platforms reveal metabolic dysregulation caused by organophosphorus pesticides. ACS Chem Biol 9(2):423-432. doi:10.1021/cb400796c PMID:24205821 PMCID:PMC4042408
• Medina-Cleghorn D, Nomura DK. 2014. Exploring metabolic pathways and regulation through functional chemoproteomic and metabolomic platforms. Chem Biol 21(9):1171-1184. doi:10.1016/j.chembiol.2014.07.007 PMID:25237861 PMCID:PMC4171689
• Morris PJ, Medina-Cleghorn D, Heslin A, King SM, Orr J, Mulvihill MM, Krauss RM, Nomura DK. 2014. Organophosphorus flame retardants inhibit specific liver carboxylesterases and cause serum hypertriglyceridemia. ACS Chem Biol 9(5):1097-1103. doi:10.1021/cb500014r PMID:24597639 PMCID:PMC4027947