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Your Environment. Your Health.

Person Details: Lisa Smeester

Superfund Research Program

Lisa Smeester

University of North Carolina-Chapel Hill
Gillings School of Global Public Health
344B Rosenau - CB 7431
Chapel Hill, North Carolina
Phone: 919-843-8471



  • Freedman AN, Eaves LA, Rager JE, Gavino-Lopez N, Smeester L, Bangma J, Santos HP, Joseph RM, Kuban KC, O'Shea TM, Fry RC. 2022. The placenta epigenome-brain axis: placental epigenomic and transcriptomic responses that preprogram cognitive impairment. Epigenomics 14(15):897-911. doi:10.2217/epi-2022-0061 PMID:36073148


  • Clark J, Avula V, Ring C, Eaves LA, Howard T, Santos HP, Smeester L, Bangma J, O'Shea TM, Fry RC, Rager JE. 2021. Comparing the predictivity of human placental gene, microRNA, and CpG methylation signatures in relation to perinatal outcomes. Toxicol Sci 183(2):269-284. doi:10.1093/toxsci/kfab089 PMID:34255065 PMCID:PMC8478332
  • Clark J, Eaves LA, Gaona AR, Santos HP, Smeester L, Bangma J, Rager JE, O'Shea TM, Fry RC. 2021. Pre-pregnancy BMI-associated miRNA and mRNA expression signatures in the placenta highlight a sexually-dimorphic response to maternal underweight status. Sci Rep 11(1):15743. doi:10.1038/s41598-021-95051-1 PMID:34344912 PMCID:PMC8333418


  • Eaves LA, Nguyen HT, Rager JE, Sexton K, Howard T, Smeester L, Freedman AN, Aagaard KM, Shope C, Lefer B, Flynn JH, Erickson MH, Fry RC, Vizuete W. 2020. Identifying the Transcriptional Response of Cancer and Inflammation-Related Genes in Lung Cells in Relation to Ambient Air Chemical Mixtures. Environ Sci Technol 1380713816.
  • Eaves LA, Nguyen HT, Rager JE, Sexton K, Howard T, Smeester L, Freedman AN, Aagaard KM, Shope C, Lefer B, Flynn JH, Erickson MH, Fry RC, Vizuete W. 2020. Identifying the transcriptional response of cancer and inflammation-related genes in lung cells in relation to ambient air chemical mixtures in Houston, Texas. Environ Sci Technol 54:13807-13816. doi:10.1021/acs.est.0c02250 PMID:33064461 PMCID:PMC7757424
  • Eaves LA, Phookphan P, Rager JE, Bangma J, Santos H, Smeester L, O'Shea TM, Fry RC. 2020. A role for microRNAs in the epigenetic control of sexually dimorphic gene expression in the human placenta. Epigenomics 12:doi:10.2217/epi-2020-0062 PMID:32901510
  • Payton A, Clark J, Eaves LA, Santos H, Smeester L, Bangma J, O'Shea TM, Fry RC, Rager JE. 2020. Placental genomic and epigenomic signatures associated with infant birth weight highlight mechanisms involved in collagen and growth factor signaling. Reprod Toxicol 96:221-230. doi:10.1016/j.reprotox.2020.07.007 PMID:32721520 PMCID:PMC7855285


  • Johnson J, Robinson S, Smeester L, Fry RC, Boggess K, Vora NL. 2019. Ubiquitous identification of inorganic arsenic in a cohort of second trimester amniotic fluid in women with preterm and term births. Reprod Toxicol 87:97-99. doi:10.1016/j.reprotox.2019.05.061 PMID:31128209


  • Meakin C, Martin EM, Santos H, Mokrova I, Kuban K, O'Shea TM, Joseph RM, Smeester L, Fry RC. 2018. Placental CpG methylation of HPA-axis genes is associated with cognitive impairment at age 10 among children born extremely preterm. Horm Behav 101:29-35. doi:10.1016/j.yhbeh.2018.02.007 PMID:29477804
  • Smeester L, Fry RC. 2018. Long-Term Health Effects and Underlying Biological Mechanisms of Developmental Exposure to Arsenic. Curr Environ Health Rep 5(1):134-144. doi:10.1007/s40572-018-0184-1 PMID:29411302
  • Tilley SK, Martin EM, Smeester L, Joseph RM, Kuban KC, Heeren T, Dammann OU, O'Shea TM, Fry RC. 2018. Placental CpG methylation of infants born extremely preterm predicts cognitive impairment later in life. PLoS One 13:16. doi:10.1371/journal.pone.0193271 PMID:29513726 PMCID:PMC5841757


  • Bommarito P, Martin EM, Smeester L, Palys T, Baker E, Karagas MR, Fry RC. 2017. Fetal-sex dependent genomic responses in the circulating lymphocytes of arsenic-exposed pregnant women in New Hampshire. Reprod Toxicol 73:184-195. doi:10.1016/j.reprotox.2017.07.023 PMID:28793237
  • Laine JE, Bailey KA, Olshan A, Smeester L, Drobna Z, Styblo M, Douillet C, Garcia-Vargas G, Rubio-Andrade M, Pathmasiri W, McRitchie S, Sumner SJ, Fry RC. 2017. Neonatal metabolomic profiles related to prenatal arsenic exposure. Environ Sci Technol 51(1):625-633. doi:10.1021/acs.est.6b04374 PMID:27997141
  • Martin EM, Smeester L, Bommarito P, Grace MR, Boggess K, Kuban K, Karagas MR, Marsit CJ, O'Shea TM, Fry RC. 2017. Sexual epigenetic dimorphism in the human placenta: implications for susceptibility during the prenatal period. Epigenomics 9(3):267-278. doi:10.2217/epi-2016-0132 PMID:28234023 PMCID:PMC5331919
  • Smeester L, Bommarito P, Martin EM, Recio-Vega R, Gonzalez-Cortes, Olivas-Calderon E, Lantz RC, Fry RC. 2017. Chronic early childhood exposure to arsenic is associated with a TNF-mediated proteomic signaling response. Environ Toxicol Pharmacol 52:183-187. doi:10.1016/j.etap.2017.04.007 PMID:28433805
  • Smeester L, Martin EM, Cable P, Bodnar WM, Boggess K, Vora NL, Fry RC. 2017. Toxic metals in amniotic fluid and altered gene expression in cell‐free fetal RNA. Prenat Diagn 37(13):1364-1366. doi:10.1002/pd.5183 PMID:29111618 PMCID:PMC5766286
  • Tomlinson MS, Bommarito P, Martin EM, Smeester L, Fichorova RN, Onderdonk AB, Kuban KC, O'Shea TM, Fry RC. 2017. Microorganisms in the human placenta are associated with altered CpG methylation of immune and inflammation-related genes. PLoS One 12:13. doi:10.1371/journal.pone.0188664 PMID:29240761 PMCID:PMC5730116
  • Vora NL, Smeester L, Boggess K, Fry RC. 2017. Investigating the role of fetal gene expression in preterm birth. Reprod Sci 24:824-828. doi:10.1177/1933719116670038 PMID:27678095


  • Brooks SA, Martin EM, Smeester L, Grace MR, Boggess K, Fry RC. 2016. miRNAs as common regulators of the transforming growth factor (TGF)-β pathway in the preeclamptic placenta and cadmium-treated trophoblasts: Links between the environment, the epigenome and preeclampsia. Food Chem Toxicol 98(PtA):50-57. doi:10.1016/j.fct.2016.06.023 PMID:27375191 PMCID:PMC5156314
  • Drobna Z, Martin EM, Kim K, Smeester L, Bommarito P, Rubio-Andrade M, Garcia-Vargas GG, Styblo M, Zou F, Fry RC. 2016. Analysis of maternal polymorphisms in arsenic (+3 oxidation state)-methyltransferase AS3MT and fetal sex in relation to arsenic metabolism and infant birth outcomes: Implications for risk analysis. Reprod Toxicol 61:28-38. doi:10.1016/j.reprotox.2016.02.017 PMID:26928318 PMCID:PMC4970429
  • Vora NL, Smeester L, Boggess K, Fry RC. 2016. Increased fetal inflammatory gene expression in cell-free fetal RNA is associated with earlier gestational age at birth. Journal of Women's Health 25:977-978.


  • Laine JE, Bailey KA, Rubio-Andrade M, Olshan A, Smeester L, Drobna Z, Herring AH, Styblo M, Garcia-Vargas GG, Fry RC. 2015. Maternal arsenic exposure, arsenic methylation efficiency, and birth outcomes in the Biomarkers of Exposure to ARsenic (BEAR) pregnancy cohort in Mexico. Environ Health Perspect 123(2):186-192. doi:10.1289/ehp.1307476 PMID:25325819 PMCID:PMC4314242
  • Martin EA, Ray PD, Smeester L, Grace MR, Boggess K, Fry RC. 2015. Epigenetics and preeclampsia: defining functional epimutations in the preeclamptic placenta related to the TGF-β pathway. PLoS One 10(10):e0141294. doi:10.1371/journal.pone.0141294 PMID:26510177 PMCID:PMC4624949
  • Rager JE, Tilley SK, Tulenko SE, Smeester L, Ray PD, Yosim A, Currier JM, Ishida MC, del Carmen Gonzalez-Horta M, Sanchez-Ramirez B, Ballinas-Casarrubias L, Gutierrez-Torres DS, Drobna Z, Del Razo LM, Garcia-Vargas GG, Kim WY, Zhou Y, Wright FA, Styblo M, Fry RC. 2015. Identification of novel gene targets and putative regulators of arsenic-associated DNA methylation in human urothelial cells and bladder cancer. Chem Res Toxicol 28(6):1144-1155. doi:10.1021/tx500393y PMID:26039340 PMCID:PMC4748849
  • Rojas D, Rager JE, Smeester L, Bailey KA, Drobna Z, Rubio-Andrade M, Styblo M, Garcia-Vargas GG, Fry RC. 2015. Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci 143(1):97-106. doi:10.1093/toxsci/kfu210 PMID:25304211 PMCID:PMC4274382


  • Bailey KA, Laine JE, Rager JE, Sebastian E, Olshan A, Smeester L, Drobna Z, Styblo M, Rubio-Andrade M, Garcia-Vargas GG, Fry RC. 2014. Prenatal arsenic exposure and shifts in the newborn proteome: interindividual differences in tumor necrosis factor (TNF)-responsive signaling. Toxicol Sci 139(2):328-337. doi:10.1093/toxsci/kfu053 PMID:24675094 PMCID:PMC4031624
  • Smeester L, Yosim A, Nye MD, Hoyo C, Murphy SK, Fry RC. 2014. Imprinted genes and the environment: links to the toxic metals arsenic, cadmium, lead and mercury. Genes (Basel) 5(2):477-496. doi:10.3390/genes5020477 PMID:24921406 PMCID:PMC4094944


  • Sanders AP, Smeester L, Rojas D, DeBussycher T, Wu MC, Wright FA, Zhou Y, Laine JE, Rager JE, Swamy GK, Ashley-Koch A, Miranda ML, Fry RC. 2013. Cadmium exposure and the epigenome: Exposure-associated patterns of DNA methylation in leukocytes from mother-baby pairs. Epigenetics 9(2):29-38. doi:10.4161/epi.26798 PMID:24169490 PMCID:PMC3962531
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