Superfund Research Program
Ian A. Blair
University of Pennsylvania
Perelman School of Medicine
Department of Systems Pharmacology and Translational Therapeutics
854 BRB II/III, 421 Curie Blvd
Philadelphia, Pennsylvania 19104-6160
Phone: 215-573-9880
Fax: 215-573-9889
Email: ianblair@upenn.edu
Projects
- University of Pennsylvania: Administrative Core (2014-2020)
- University of Pennsylvania: Biomarkers of Asbestos Exposure (2014-2020)
Patents
Publications
2020
- Borgmann-Winter KE, Wang K, Bandyopadhyay S, Torshizi AD, Blair IA, Hahn C. 2020. The proteome and its dynamics: A missing piece for integrative multi-omics in schizophrenia. Schizophr Res 217:148-161. doi:10.1016/j.schres.2019.07.025 PMID:31416743
2019
- Weng L, Wang Q, Yu S, Yang X, Lynch DR, Mesaros C, Blair IA. 2019. Evaluation of antibodies for western blot analysis of frataxin protein isoforms. J Immunol Methods 474:doi:10.1016/j.jim.2019.07.001 PMID:31279523 PMCID:PMC6829029
2018
- Friedman ES, Bittinger K, Esipova TV, Hou L, Chau L, Jiang J, Mesaros C, Lund PJ, Liang X, FitzGerald GA, Goulian M, Lee D, Garcia BA, Blair IA, Vinogradov SA, Wu GD. 2018. Microbes vs. chemistry in the origin of the anaerobic gut lumen. Proc Natl Acad Sci U S A 4170-4175:115. doi:10.1073/pnas.1718635115 PMID:29610310 PMCID:PMC5910840
- Guo L, Wang Q, Weng L, Hauser LA, Strawser CJ, Mesaros C, Lynch DR, Blair IA. 2018. Characterization of a new N-terminally acetylated extra-mitochondrial isoform of frataxin in human erythrocytes. Sci Rep 8(1):17043. doi:10.1038/s41598-018-35346-y PMID:30451920 PMCID:PMC6242848
- Guo L, Wang Q, Weng L, Hauser LA, Strawser CJ, Rocha AG, Dancis A, Mesaros C, Lynch DR, Blair IA. 2018. Liquid chromatography-high resolution mass spectrometry analysis of platelet frataxin as a protein biomarker for the rare disease Friedreich's ataxia. Anal Chem 90:2216-2223. doi:10.1021/acs.analchem.7b04590 PMID:29272104 PMCID:PMC5817373
- Mazaleuskaya LL, Salamatipour A, Sarantopoulou D, Weng L, FitzGerald GA, Blair IA, Mesaros C. 2018. Analysis of HETEs in human whole blood by chiral UHPLC-ECAPCI/HRMS. J Lipid Res 59:564-575. doi:10.1194/jlr.D081414 PMID:29301865 PMCID:PMC5832923
- Weng L, Guo L, Vachani A, Mesaros C, Blair IA. 2018. Quantification of serum high mobility group box 1 by liquid chromatography/high-resolution mass spectrometry: Implications for its role in immunity, inflammation, and cancer. Anal Chem 90:7552-7560. doi:10.1021/acs.analchem.8b01175 PMID:29791130
2017
- Blair IA, Wang Q, Guo L, Weng L, Salimatipour A, Hwang W, Lynch DR, Mesaros C. 2017. Systems pharmacology approach to the study of mitochondrial dysfunction. Abstr Pap Am Chem Soc 254:2.
- Huang J, Liu Y, Vitale S, Penning TM, Whitehead A, Blair IA, Vachani A, Clapper M, Muscat JE, Lazarus P, Scheet P, Moore JH, Chen Y. 2017. On meta- and mega-analyses for gene-environment interactions. Genet Epidemiol 41:876-886. doi:10.1002/gepi.22085 PMID:29110346
- Mesaros C, Arroyo AD, Blair IA, Snyder NW. 2017. Coenzyme A thioester formation of 11-and 15-oxo-eicosatetraenoic acid. Prostaglandins Other Lipid Mediat 130:1-7. doi:10.1016/j.prostaglandins.2017.02.004 PMID:28238887 PMCID:PMC5446925
- Mesaros C, Blair IA, Weng L. 2017. Biomarkers of response to asbestos exposure. Chapter 12 in: Asbestos and Mesothelioma. Springer International Publishing, pp.259-277.
- Patel CJ, Kerr J, Thomas DC, Mukherjee B, Ritz B, Chatterjee N, Jankowska M, Madan JC, Karagas MR, McAllister KA, Mechanic LM, Fallin MD, Ladd-Acosta C, Blair IA, Teitelbaum SL, Amos CI. 2017. Opportunities and challenges for environmental exposure assessment in population-based studies. Cancer Epidemiol Biomarkers Prev 26:1370-1380. doi:10.1158/1055-9965.epi-17-0459 PMID:28710076 PMCID:PMC5581729
- Xu R, Mesaros C, Weng L, Snyder NW, Vachani A, Blair IA, Hwang W. 2017. Comparison of statistical methods for detection of serum lipid biomarkers for mesothelioma and asbestos exposure. Biomark Med 11:547-556. doi:10.2217/bmm-2017-0087 PMID:28534416 PMCID:PMC5619144
2016
- Frey AJ, Wang Q, Busch C, Feldman D, Bottalico L, Mesaros C, Blair IA, Vachani A, Snyder NW. 2016. Validation of highly sensitive simultaneous targeted and untargeted analysis of keto-steroids by Girard P derivatization and stable isotope dilution-liquid chromatography-high resolution mass spectrometry. Steroids 116:60-66. doi:10.1016/j.steroids.2016.10.003 PMID:27743906 PMCID:PMC5127713
- Guo L, Worth AJ, Mesaros C, Snyder NW, Glickson JD, Blair IA. 2016. Diisopropylethylamine/hexafluoroisopropanol-mediated ion-pairing ultra-high-performance liquid chromatography/mass spectrometry for phosphate and carboxylate metabolite analysis: utility for studying cellular metabolism. Rapid Commun Mass Spectrom 30(16):1835-1845. doi:10.1002/rcm.7667 PMID:27476658 PMCID:PMC4970762
- Mesaros C, Blair IA. 2016. Mass spectrometry-based approaches to targeted quantitative proteomics in cardiovascular disease. Clin Proteomics 13:20. doi:10.1186/s12014-016-9121-1 PMID:27713681 PMCID:PMC5050566
- Vazquez-Medina J, Dodia C, Weng L, Mesaros C, Blair IA, Feinstein SI, Chatterjee S, Fisher AB. 2016. The phospholipase A2 activity of peroxiredoxin 6 modulates NADPH oxidase 2 activation via lysophosphatidic acid receptor signaling in the pulmonary endothelium and alveolar macrophages. FASEB J 30(8):2885-2898. doi:10.1096/fj.201500146R PMID:27178323 PMCID:PMC4970605
2015
- Mesaros C, Worth AJ, Snyder NW, Christofidou-Solomidou M, Vachani A, Albelda SM, Blair IA. 2015. Bioanalytical techniques for detecting biomarkers of response to human asbestos exposure. Bioanalysis 7(9):1157-1173. doi:10.4155/bio.15.53 PMID:26039812 PMCID:PMC4487641
- Snyder NW, Mesaros C, Blair IA. 2015. Translational metabolomics in cancer research. Biomark Med 9(9):821-834. doi:10.2217/bmm.15.52 PMID:26329905 PMCID:PMC4718447
- Snyder NW, Tombline G, Worth AJ, Parry RC, Silvers JA, Gillespie KP, Basu SS, Millen J, Goldfarb DS, Blair IA. 2015. Production of stable isotope-labeled acyl-coenzyme A thioesters by yeast stable isotope labeling by essential nutrients in cell culture. Anal Biochem 474:59-65. doi:10.1016/j.ab.2014.12.014 PMID:25572876 PMCID:PMC4413507