Superfund Research Program

Ke Jian Liu

University of New Mexico
2703 Frontier NE
Suite 220
Albuquerque, New Mexico 87131-0000
Phone: 505-272-9546
Email: kliu@salud.unm.edu

Projects

• University of New Mexico: Mechanisms of Immune Dysregulation Produced by Uranium, Arsenic and Metal Mixtures (2017-2022)

Publications

2024

• Speer RM, Yu H, Zhou X, Nandi S, Alexandrov LB, Guo Y, Hudson LG, Liu K. 2024. Arsenic and UVR co-exposure results in unique gene expression profile identifying key co-carcinogenic mechanisms. Toxicol Appl Pharmacol 482:116773. doi:10.1016/j.taap.2023.116773 PMID:38036231

2023

• Medina S, Zhang H, Santos-Medina LV, Yee ZA, Martin KJ, Wan G, Bolt AM, Zhou X, Styblo M, Liu K. 2023. Arsenite methyltransferase is an important mediator of hematoxicity induced by arsenic in drinking water. Water (Basel) 15(3):448. doi:10.3390/w15030448 PMID:36936034 PMCID:PMC1001945

2022

• Cooper KL, Volk L, Dominguez DR, Duran AD, Liu K, Hudson LG. 2022. Contribution of NADPH oxidase to the retention of UVR-induced DNA damage by arsenic. Toxicol Appl Pharmacol 434:115799. doi:10.1016/j.taap.2021.115799 PMID:34798142
• Medina S, Zhang H, Santos-Medina LV, Wan G, Bolt AM, Zhou X, Burchiel SW, Liu K. 2022. Arsenic impairs the lineage commitment of hematopoietic progenitor cells through the attenuation of GATA-2 DNA binding activity. Toxicol Appl Pharmacol 452:116193. doi:10.1016/j.taap.2022.116193 PMID:35961411 PMCID:PMC9583771

2021

• Duan M, Speer RM, Ulibarri J, Liu K, Mao P. 2021. Transcription-coupled nucleotide excision repair: New insights revealed by genomic approaches. DNA Repair (Amst) 103:103126. doi:10.1016/j.dnarep.2021.103126 PMID:33894524 PMCID:PMC8205993
• Medina S, Bolt AM, Zhou X, Wan G, Xu H, Lauer FT, Liu K, Burchiel SW. 2021. Arsenite and monomethylarsonous acid disrupt erythropoiesis through combined effects on differentiation and survival pathways in early erythroid progenitors. Toxicol Lett 350:111-120. doi:10.1016/j.toxlet.2021.07.008 PMID:34274428 PMCID:PMC8487637
• Medina S, Zhou X, Lauer FT, Zhang H, Liu K, Lewis JL, Burchiel SW. 2021. Modulation of PARP activity by Monomethylarsonous (MMA +3) acid and uranium in mouse thymus. Toxicol Appl Pharmacol 411:115362. doi:10.1016/j.taap.2020.115362 PMID:33279514 PMCID:PMC7855914
• Speer RM, Toyoda JH, Croom-Perez TJ, Liu K, Wise Sr. JP. 2021. Particulate hexavalent chromium inhibits E2F1 leading to reduced RAD51 nuclear foci formation in human lung cells. Toxicol Sci 181(1):35-46. doi:10.1093/toxsci/kfab019 PMID:33677506 PMCID:PMC8081024
• Zhou X, Speer RM, Volk L, Hudson LG, Liu K. 2021. Arsenic co-carcinogenesis: Inhibition of DNA repair and interaction with zinc finger proteins. Semin Cancer Biol 76:86-98. doi:10.1016/j.semcancer.2021.05.009 PMID:33984503 PMCID:PMC8578584
• Zhou X, Xue B, Medina S, Burchiel SW, Liu K. 2021. Uranium directly interacts with the DNA repair protein poly (ADP-ribose) polymerase 1. Toxicol Appl Pharmacol 410:115360. doi:10.1016/j.taap.2020.115360 PMID:33279515 PMCID:PMC7775282

2020

• Medina S, Lauer FT, Castillo EF, Bolt AM, Ali AS, Liu K, Burchiel SW. 2020. Exposures to uranium and arsenic alter intraepithelial and innate immune cells in the small intestine of male and female mice. Toxicol Appl Pharmacol 403:doi:10.1016/j.taap.2020.115155 PMID:32710956
• Zhou X, Medina S, Bolt AM, Zhang H, Wan G, Xu H, Lauer FT, Wang S, Burchiel SW, Liu K. 2020. Inhibition of red blood cell development by arsenic-induced disruption of GATA-1. Sci Rep 10(1):19055. doi:10.1038/s41598-020-76118-x PMID:33149232 PMCID:PMC7643154

2019

• Bolt AM, Medina S, Lauer FT, Liu K, Burchiel SW. 2019. Minimal uranium immunotoxicity following a 60-day drinking water exposure to uranyl acetate in male and female C57BL/6J mice. Toxicol Appl Pharmacol 372:33-39. doi:10.1016/j.taap.2019.04.003 PMID:30978399

2018

• Bolt AM, Medina S, Lauer FT, Xu H, Ali AS, Liu K, Burchiel SW. 2018. Minimal uranium accumulation in lymphoid tissues following an oral 60-day uranyl acetate exposure in male and female C57BL/6J mice. PLoS One 13(10):e0205211. doi:10.1371/journal.pone.0205211 PMID:30356336 PMCID:PMC6200214
• Dashner-Titus EJ, Hoover JH, Li L, Lee J, Du R, Liu K, Traber MG, Ho E, Lewis JL, Hudson LG. 2018. Metal exposure and oxidative stress markers in pregnant Navajo Birth Cohort Study participants. Free Radic Biol Med 124:484-492. doi:10.1016/j.freeradbiomed.2018.04.579 PMID:29723666 PMCID:PMC6381929

2014

• Burchiel SW, Lauer FT, Beswick EJ, Gandolfi A, Parvez F, Liu K, Hudson LG. 2014. Differential susceptibility of human peripheral blood T cells to suppression by environmental levels of sodium arsenite and monomethylarsonous acid. PLoS One 9:8. doi:10.1371/journal.pone.0109192 PMID:25271956 PMCID:PMC4182801
• Ezeh PC, Lauer FT, MacKenzie D, McClain S, Liu K, Hudson LG, Gandolfi A, Burchiel SW. 2014. Arsenite selectively inhibits mouse bone marrow lymphoid progenitor cell development in vivo and in vitro and suppresses humoral immunity in vivo. PLoS One 9(4):e93920. doi:10.1371/journal.pone.0093920 PMID:24714590 PMCID:PMC3979857
• Zhou X, Sun X, Mobarak C, Gandolfi A, Burchiel SW, Hudson LG, Liu K. 2014. Differential binding of monomethylarsonous acid compared to arsenite and arsenic trioxide with zinc finger peptides and proteins. Chem Res Toxicol 27(4):690-698. doi:10.1021/tx500022j PMID:24611629 PMCID:PMC3998772