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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Person Details: Jordan N. Smith

Superfund Research Program

Jordan N. Smith

Pacific Northwest National Laboratory
Chemical Biology and Exposure Science
PO Box 999, MSIN J4-02
Richland, Washington 99352
Phone: 509-371-6801
Fax: 509-371-6978
Email: jordan.smith@pnnl.gov

Projects

Publications

2023

  • Maier ML, Siddens LK, Pennington JM, Uesugi S, Tilton SC, Vertel EA, Anderson KA, Tidwell LG, Ognibene T, Turteltaub KW, Smith JN, Williams DE. 2023. Benzo[a]pyrene toxicokinetics in humans following dietary supplementation with 3,3'-diindolylmethane (DIM) or brussels sprouts. Toxicol Appl Pharmacol 460:116377. doi:10.1016/j.taap.2023.116377 PMID:36642108 PMCID:PMC9946811
  • Vermillion Maier ML, Siddens LK, Pennington J, Uesugi S, Labut EM, Vertel EA, Anderson KA, Tidwell LG, Tilton SC, Ognibene T, Turteltaub KW, Smith JN, Williams DE. 2023. Impact of phenanthrene co-administration on the toxicokinetics of benzo[a]pyrene in humans. UPLC-accelerator mass spectrometry following oral microdosing. Chem Biol Interact 382:110608. doi:10.1016/j.cbi.2023.110608

2022

  • Garcia WL, Miller CJ, Lomas GX, Gaither KA, Tyrrell KJ, Smith JN, Brandvold KR, Wright AT. 2022. Profiling how the gut microbiome modulates host xenobiotic metabolism in response to benzo[a]pyrene and 1-nitropyrene exposure. Chem Res Toxicol 35(4):585-596. doi:10.1021/acs.chemrestox.1c00360
  • Pande P, Madeen E, Williams DE, Crowell SR, Ognibene T, Turteltaub KW, Corley RA, Smith JN. 2022. Translating dosimetry of Dibenzo[def,p]chrysene (DBC) and metabolites across dose and species using physiologically based pharmacokinetic (PBPK) modeling. Toxicol Appl Pharmacol 438:doi:10.1016/j.taap.2021.115830 PMID:34933053 PMCID:PMC9264404
  • Smith JN, Gaither KA, Pande P. 2022. Competitive metabolism of polycyclic aromatic hydrocarbons (PAHs): An assessment using in vitro metabolism and physiologically based pharmacokinetic (PBPK) modeling. Int J Environ Res Public Health 19(14):8266. doi:10.3390/ijerph19148266 PMID:35886113 PMCID:PMC9323266
  • Vermillion Maier ML, Siddens LK, Pennington JM, Uesugi S, Anderson KA, Tidwell LG, Tilton SC, Ognibene T, Turteltaub KW, Smith JN, Williams DE. 2022. Benzo a pyrene (BaP) metabolites predominant in human plasma following escalating oral micro-dosing with C-14 -BaP. Environ Int 159:doi:10.1016/j.envint.2021.107045 PMID:34920278 PMCID:PMC8791557

2021

  • Stoddard EG, Nag S, Martin J, Tyrrell KJ, Gibbins T, Anderson KA, Shukla AK, Corley RA, Wright AT, Smith JN. 2021. Exposure to an environmental mixture of polycyclic aromatic hydrocarbons induces hepatic cytochrome P450 enzymes in mice. Chem Res Toxicol 34(9):2145-2156. doi:10.1021/acs.chemrestox.1c00235 PMID:34472326
  • Vermillion Maier ML, Siddens LK, Uesugi S, Choi J, Leonard SW, Pennington J, Tilton SC, Smith JN, Ho E, Chow S, Nguyen BD, Kolluri SK, Williams DE. 2021. 3,3'-diindolylmethane (BioResponse DIM) exhibits significant metabolism following oral dosing in humans. Drug Metab Dispos 49(8):doi:10.1124/dmd.120.000346 PMID:34035125 PMCID:PMC8407664 (ahead of print)
  • Zhao Y, Ruan X, Song Y, Smith JN, Vasylieva N, Hammock BD, Lin Y, Du D. 2021. Smartphone-based dual-channel immunochromatographic test strip with polymer quantum dot labels for simultaneous detection of cypermethrin and 3-phenoxybenzoic acid. Anal Chem 93:PMID:34591463

2019

  • Madeen E, Siddens LK, Uesugi S, McQuistan TJ, Corley RA, Smith JN, Waters KM, Tilton SC, Anderson KA, Ognibene T, Turteltaub KW, Williams DE. 2019. Toxicokinetics of benzo[a]pyrene in humans: Extensive metabolism as determined by UPLC-accelerator mass spectrometry following oral micro-dosing. Toxicol Appl Pharmacol 364:97-105. doi:10.1016/j.taap.2018.12.010 PMID:30582946 PMCID:PMC6369707
  • Stoddard EG, Nag S, Martin J, Killinger BJ, Corley RA, Smith JN, Wright AT. 2019. Benzo[a]pyrene induction of glutathione S-transferases: an activity-based protein profiling investigation. Chem Res Toxicol 32(6):1259-1267. doi:10.1021/acs.chemrestox.9b00069 PMID:30938511

2018

  • Hummel JM, Madeen E, Siddens LK, Uesugi S, McQuistan TJ, Anderson KA, Turteltaub KW, Ognibene T, Bench G, Krueger SK, Harris S, Smith JN, Tilton SC, Baird WM, Williams DE. 2018. Pharmacokinetics of [(14)C]-Benzo[a]pyrene (BaP) in humans: Impact of Co-Administration of smoked salmon and BaP dietary restriction. Food Chem Toxicol 115:136-147. doi:10.1016/j.fct.2018.03.003 PMID:29518434 PMCID:PMC5935529
  • Stoddard EG, Volk RF, Carson JP, Ljungberg CM, Murphree TA, Smith JN, Sadler NC, Shukla AK, Ansong C, Wright AT. 2018. Multifunctional activity-based protein profiling of the developing lung. J Proteome Res 17:2623-2634. doi:10.1021/acs.jproteome.8b00086 PMID:29972024

2017

  • Smith JN, Mehinagic D, Nag S, Crowell SR, Corley RA. 2017. In vitro metabolism of benzo[a]pyrene-7,8-dihydrodiol and dibenzo[def,p]chrysene-11,12 diol in rodent and human hepatic microsomes. Toxicol Lett 269:23-32. doi:10.1016/j.toxlet.2017.01.008 PMID:28119020
  • Stoddard EG, Killinger BJ, Nair RN, Sadler NC, Volk RF, Purvine SO, Shukla AK, Smith JN, Wright AT. 2017. Activity-based probes for Isoenzyme- and site-specific functional characterization of Glutathione S-Transferases. J Am Chem Soc 139(45):16032-16035. doi:10.1021/jacs.7b07378 PMID:29068682

2016

  • Sadler NC, Nandhikonda P, Webb-Robertson B, Ansong C, Anderson LN, Smith JN, Corley RA, Wright AT. 2016. Hepatic cytochrome P450 activity, abundance, and expression throughout human development. Drug Metab Dispos 44(7):984-991. doi:10.1124/dmd.115.068593 PMID:27084891 PMCID:PMC4931891
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