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Your Environment. Your Health.

Person Details: Weihsueh A. Chiu

Superfund Research Program

Weihsueh A. Chiu

Texas A&M University
4458 TAMU
College Station, Texas 77846-4458
Phone: 979-845-4106
Email: wchiu@cvm.tamu.edu

Projects

Research Briefs

Publications

2024

  • Chiu WA. 2024. Invited perspective: Uneven progress addressing population variability in human health risk assessment. Environ Health Perspect 132(3):31305. doi:10.1289/ehp13461 PMID:38498339 PMCID:10947099
  • Ford L, Lin H, Tsai H, Zhou Y, Wright FA, Sedykh A, Shah R, Chiu WA, Rusyn I. 2024. Hazard and risk characterization of 56 structurally diverse PFAS using a targeted battery of broad coverage assays using six human cell types. Toxicology 503:153763. doi:10.1016/j.tox.2024.153763 PMID:38423244
  • Lin H, Rusyn I, Chiu WA. 2024. Assessing proarrhythmic potential of environmental chemicals using a high throughput in vitro-in silico model with human induced pluripotent stem cell-derived cardiomyocytes. ALTEX 41(1):37-49. doi:10.14573/altex.2306231 PMID:37921411
  • Lu E, Ford L, Chen Z, Burnett SD, Rusyn I, Chiu WA. 2024. Evaluating scientific confidence in the concordance of in vitro and in vivo protective points of departure. Regul Toxicol Pharmacol 148:105596. doi:10.1016/j.yrtph.2024.105596 PMID:38447894

2023

  • Anderson MJ, Valdiviezo A, Conway MH, Farrell C, Andringa RK, Janik A, Chiu WA, Rusyn I, Hamer SA. 2023. Imidacloprid exposure is detectable in over one third of wild bird samples from diverse Texas ecoregions. Sci Total Environ 876:162723. doi:10.1016/j.scitotenv.2023.162723 PMID:36907393
  • Aurisano N, Jolliet O, Chiu WA, Judson RR, Jang S, Unnikrishnan A, Kosnik MB, Fantke P. 2023. Probabilistic points of departure and reference doses for characterizing human noncancer and developmental/reproductive effects for 10,145 cheimcals. Environ Health Perspect 131(3):37016. doi:10.1289/EHP11524 PMID:36989077 PMCID:PMC1005622
  • Cordova AC, Dodds J, Tsai H, Lloyd D, Roman-Hubers AT, Wright FA, Chiu WA, McDonald TJ, Zhu R, Newman G, Rusyn I. 2023. Application of ion mobility spectrometry-mass spectrometry for compositional characterization and fingerprinting of a library of diverse crude oil samples. Environ Toxicol Chem doi:10.1002/etc.5727 PMID:37530422
  • Cordova AC, Ford L, Valdiviezo A, Roman-Hubers AT, McDonald TJ, Chiu WA, Rusyn I. 2023. Dosing methods to enable cell-based in vitro testing of complex substances: a case study with a PAH mixture. Toxics 11(1):19. doi:10.3390/toxics11010019 PMID:36668745 PMCID:PMC9866728
  • Cuomo D, Nitcher M, Barba E, Feinberg AP, Rusyn I, Chiu WA, Threadgill DW. 2023. Refining risk estimates for lead in drinking water based on the impact of genetics and diet on blood lead levels using the Collaborative Cross mouse population. Toxicol Sci doi:10.1093/toxsci/kfad054 PMID:37243727 PMCID:PMC10375319
  • Jang S, Shao K, Chiu WA. 2023. Beyond the cancer slope factor: Broad application of Bayesian and probabilistic approaches for cancer dose-response assessment. Environ Int 175:107959. doi:10.1016/j.envint.2023.107959 PMID:37182419
  • Lee R, Tao Z, Prybutok S, Jang S, Dalaijamts C, Chiu WA, Newman G. 2023. Unseen risk: Mapping contamination hazards to enhance risk perception in Galena Park, Texas. Clim Risk Manag 41:100532. doi:10.1016/j.crm.2023.100532
  • Lewis PT, Chiu WA, Nasser E, Proville J, Barone A, Danforth C, Kim B, Prozzi J, Craft ES. 2023. Characterizing vulnerabilities to climate change across the United States. Environ Int 172:107772. doi:10.1016/j.envint.2023.107772 PMID:36731185 PMCID:PMC10214772
  • Lin H, Chiu WA. 2023. Development of physiologically-based gut absorption model for probabilistic prediction of environmental chemical bioavailability. ALTEX 40(3):471-484. doi:10.14573/altex.2210031 PMID:37158362
  • Lu E, Grimm FA, Rusyn I, Saeger SD, De Boevre M, Chiu WA. 2023. Advancing probabilistic risk assessment by integrating human biomonitoring, new approach methods, and Bayesian modeling: A case study with the mycotoxin deoxynivalenol. Environ Int 182:108326. doi:10.1016/j.envint.2023.108326 PMID:38000237
  • Lynch MT, Lay CR, Sokolinski S, Antezana A, Ghio C, Chiu WA, Rogers RD. 2023. Community-facing toxicokineticmodels to estimate PFAS serum levels based on life history and drinking water exposures. Environ Int 176:107974. doi:10.1016/j.envint.2023.107974 PMID:37245445
  • Oladeji O, Saitas M, Mustapha T, Johnson N, Chiu WA, Rusyn I, Robinson AL, Presto AA. 2023. Air pollutant patterns and human health risk following the East Palestine, Ohio, train derailment. Environ Sci Technol Lett 10(8):680-685. doi:10.1021/acs.estlett.3c00324 PMID:37577363 PMCID:PMC10413936
  • Tsai H, House JS, Wright FA, Chiu WA, Rusyn I. 2023. A tiered testing strategy based on in vitro phenotypic and transcriptomic data for selecting representative petroleum UVCBs for toxicity evaluation in vivo. Toxicol Sci doi:10.1093/toxsci/kfad041 PMID:37079747 PMCID:PMC10230285

2022

  • Abrahamsson DP, Siddharth A, Robinson JF, Soshilov AA, Elmore S, Cogliano VJ, Ng CA, Khan EM, Ashton R, Chiu WA, Fung J, Zeise L, Woodruff TJ. 2022. Modeling the transplacental transfer of small molecules using machine learning: a case study on perand polyfluorinated substances (PFAS). J Expo Sci Environ Epidemiol 32(6):doi:10.1038/s41370-022-00481-2 PMID:36207486 PMCID:PMC9742309
  • Bhandari S, Casillas GA, Aly NA, Zhu R, Newman G, Wright FA, Miller A, Adler G, Rusyn I, Chiu WA. 2022. Spatial and temporal analysis of impacts of Hurricane Florence on criteria air pollutants and air toxics in eastern North Carolina. Int J Environ Res Public Health 19(3):doi:10.3390/ijerph19031757 PMID:35162780 PMCID:PMC8835244
  • Blanchette A, Burnett SD, Rusyn I, Chiu WA. 2022. A tiered approach to population-based in vitro testing for cardiotoxicity: Balancing estimates of potency and variability. J Pharmacol Toxicol Methods 114:doi:10.1016/j.vascn.2022.107154 PMID:34999233 PMCID:PMC8930538
  • Boysen G, Rusyn I, Chiu WA, Wright FA. 2022. Characterization of population variability of 1,3-butadiene derived protein adducts in humans and mice. Regul Toxicol Pharmacol doi:10.1016/j.yrtph.2022.105171 PMID:35469930
  • Chiu WA, Lynch MT, Lay CR, Antezana A, Malek P, Sokolinski S, Rogers RD. 2022. Bayesian estimation of human population toxicokinetics of PFOA, PFOS, PFHxS, and PFNA from studies of contaminated drinking water. Environ Health Perspect 130(12):127001. doi:10.1289/EHP10103 PMID:36454223 PMCID:PMC9714558
  • Fawkes L, McDonald TJ, Roh T, Chiu WA, Taylor RJ, Sansom G. 2022. A participatory-based research approach for assessing exposure to lead-contaminated drinking water in the Houston neighborhood of the Greater Fifth Ward. Int J Environ Res Public Health 19(13):doi:10.3390/ijerph19138135
  • Ford L, Jang S, Chen Z, Zhou Y, Gallins P, Wright FA, Chiu WA, Rusyn I. 2022. A population-based human in vitro approach to quantify inter-individual variability in responses to chemical mixtures. Toxics 10(8):441. doi:10.3390/toxics10080441 PMID:36006120
  • Jang S, Ford L, Rusyn I, Chiu WA. 2022. Cumulative risk meets inter-individual variability: probabilistic concentration addition of complex mixture exposures in a population-based human in vitro model. Toxics 10(10):549. doi:10.3390/toxics10100549 PMID:36287830 PMCID:PMC9611413
  • Krewski D, Saunders-Hastings P, Baan R, Barton-Maclaren TS, Browne P, Chiu WA, Gwinn M, Hartung T, Kraft AD, Lam J, Lewis R, Sanaa M, Morgan RL, Paoli GM, Rhomberg L, Rooney AA, Sand S, Schunemann HJ, Straif K, Thayer KA, Tsaioun K. 2022. Development of an evidence-based risk assessment framework. ALTEX Vol.39No.4:667693. doi:10.14573/altex.2004041
  • Roman-Hubers AT, Cordova AC, Rohde A, Chiu WA, McDonald TJ, Wright FA, Dodds J, Baker ES, Rusyn I. 2022. Characterization of compositional variability in petroleum substances. Fuel 317:doi:10.1016/j.fuel.2022.123547 PMID:35250041 PMCID:PMC8896784
  • Rusyn I, Chiu WA. 2022. Decision-Making with New Approach Methodologies: Time to Replace Default Uncertainty Factors with Data. Toxicol Sci doi:10.1093/toxsci/kfac033 PMID:35404442
  • Rusyn I, Chiu WA, Wright FA. 2022. Model systems and organisms for addressing inter- and intra-species variability in risk assessment. Regul Toxicol Pharmacol 132:105197. doi:10.1016/j.yrtph.2022.105197 PMID:35636685
  • Sansom G, Fawkes L, Thompson C, Losa LM, McDonald TJ, Chiu WA. 2022. Cancer risk associated with soil distribution of polycyclic aromatic hydrocarbons within three environmental justice neighborhoods in Houston, Texas. Environ Geochem Health doi:10.1007/s10653-022-01245-5 PMID:35246781
  • Shao K, Ji C, Chiu WA. 2022. Using prior toxicological data to support dose-response assessment-identifying plausible prior distributions for dichotomous dose-response models. Environ Sci Technol 56(22):16506-16516. doi:10.1021/acs.est.2c05872 PMID:36279400
  • Valdiviezo A, Brown GE, Michell AR, Trinconi CM, Bodke VV, Khetani SR, Luo Y, Chiu WA, Rusyn I. 2022. Reanalysis of trichloroethylene and tetrachloroethylene metabolism to glutathione conjugates using human, rat, and mouse liver in vitro models to improve precision in risk characterization. Environ Health Perspect 130(11):117009. doi:10.1289/EHP12006 PMID:36445294 PMCID:PMC9707501
  • Valdiviezo A, Kato Y, Baker ES, Chiu WA, Rusyn I. 2022. Evaluation of metabolism of a defined pesticide mixture through multiple in vitro liver models. Toxics 10(10):566. doi:10.3390/toxics10100566 PMID:36287846 PMCID:PMC9609317

2021

  • Burnett SD, Blanchette A, Chiu WA, Rusyn I. 2021. Cardiotoxicity hazard and risk characterization of ToxCast chemicals using human induced pluripotent stem cell-derived cardiomyocytes from multiple donors. Chem Res Toxicol 34(9):2110-2124. doi:10.1021/acs.chemrestox.1c00203 PMID:34448577
  • Burnett SD, Blanchette A, Chiu WA, Rusyn I. 2021. Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes as an in vitro model in toxicology: Strengths and weaknesses for hazard identification and risk characterization. Expert Opin Drug Metab Toxicol 17(8):1-16. doi:10.1080/17425255.2021.1894122 PMID:33612039 (ahead of print)
  • Burnett SD, Karmakar M, Murphy WJ, Chiu WA, Rusyn I. 2021. A new approach method for characterizing inter-species toxicodynamic variability. J Toxicol Environ Health A 84(24):doi:10.1080/15287394.2021.1966861 PMID:34427174 (ahead of print)
  • Camargo K, Foster M, Buckingham B, McDonald TJ, Chiu WA. 2021. Characterizing baseline legacy chemical contamination in urban estuaries for disaster-research through systematic evidence mapping: A case study. Chemosphere 281:doi:10.1016/j.chemosphere.2021.130925 (ahead of print)
  • Camargo K, Vogelbein MA, Horney JA, Dellapenna TM, Knap A, Sericano JL, Wade TL, McDonald TJ, Chiu WA, Unger M. 2021. Biosensor applications in contaminated estuaries: Implications for disaster research response. Environ Res 204:111893. doi:10.1016/j.envres.2021.111893 PMID:34419473 PMCID:PMC8639622
  • Casillas GA, Johnson N, Chiu WA, Ramirez J, McDonald TJ, Horney JA. 2021. Polycyclic aromatic hydrocarbons in Houston parks after Hurricane Harvey. Environ Justice 14(4):277-287. doi:10.1089/env.2020.0073 PMID:34484557 PMCID:PMC8404169
  • Chen Z, Jang S, Kaihatu JM, Zhou Y, Wright FA, Chiu WA, Rusyn I. 2021. Potential human health hazard of post-Hurricane Harvey sediments in Galveston Bay and Houston Ship Channel: A case study of using in vitro bioactivity data to inform risk management decisions. Int J Environ Res Public Health 18:doi:10.3390/ijerph182413378 PMID:34948986 PMCID:PMC8702027
  • Chen Z, Lloyd D, Zhou Y, Chiu WA, Wright FA, Rusyn I. 2021. Risk characterization of environmental samples using in vitro bioactivity and polycyclic aromatic hydrocarbon (PAH) concentrations data. Toxicol Sci 179(1):108-120. doi:10.1093/toxsci/kfaa166 PMID:33165562 PMCID:PMC7797768
  • Dalaijamts C, Cichocki JA, Luo Y, Rusyn I, Chiu WA. 2021. Quantitative characterization of population-wide tissue- and metabolite-specific variability in perchloroethylene toxicokinetics in male mice. Toxicol Sci 182(2):doi:10.1093/toxsci/kfab057 PMID:33988684 (ahead of print)
  • Erber L, Goodman S, Wright FA, Chiu WA, Tretyakova N, Rusyn I. 2021. Intra- and inter-species variability in urinary N7-(1-hydroxy-3-buten-2-yl)guanine adducts following inhalation exposure to 1,3-butadiene. Chem Res Toxicol 34(11):2375-2383. doi:10.1021/acs.chemrestox.1c00291 PMID:34726909 PMCID:PMC8715497
  • Fantke P, Chiu WA, Aylward L, Judson RR, Huang L, Jang S, Gouin T, Rhomberg L, Aurisano N, McKone TE, Jolliet O. 2021. Exposure and toxicity characterization of chemical emissions and chemicals in products: Global recommendations and implementation in USEtox. Int J Life Cycle Assess 17:doi:10.1007/s11367-021-01889-y
  • Hsieh N, Bois FY, Tsakalozou E, Ni Z, Yoon M, Sun W, Klein M, Reisfeld B, Chiu WA. 2021. A Bayesian population physiologically based pharmacokinetic absorption modeling approach to support generic drug development: application to bupropion hydrochloride oral dosage forms. J Pharmacokinet Pharmacodyn 48(6):doi:10.1007/s10928-021-09778-5 PMID:34553275 (ahead of print)
  • Hsieh N, Chen Z, Rusyn I, Chiu WA. 2021. Risk Characterization and Probabilistic Concentration Response Modeling of Complex Environmental Mixtures Using New Approach Methodologies (NAMs) Data from Organotypic in Vitro Human Stem Cell Assays. Environ Health Perspect 129:doi:10.1289/EHP7600 PMID:33395322 PMCID:PMC7781439
  • Jang S, McDonald TJ, Bhandari S, Rusyn I, Chiu WA. 2021. Spatial and temporal distribution of surface water contaminants in the Houston Ship Channel after the Intercontinental Terminal Company Fire. J Expo Sci Environ Epidemiol 31(5):doi:10.1038/s41370-021-00343-3 PMID:34079063 (ahead of print)
  • Lind L, Araujo JA, Barchowsky A, Belcher SM, Berridge BR, Chiamvimonvat N, Chiu WA, Cogliano VJ, Elmore S, Farraj AK, Gomes AV, McHale CM, Meyer-Tamaki KB, Posnack NG, Vargas HM, Yang X, Zeise L, Zhou C, Smith MT. 2021. Key characteristics of cardiovascular toxicants. Environ Health Perspect 129(9):95001. doi:10.1289/EHP9321 PMID:34558968 PMCID:PMC8462506
  • Luo Y, Chen Z, Blanchette A, Zhou Y, Wright FA, Baker ES, Chiu WA, Rusyn I. 2021. Relationships between constituents of energy drinks and beating parameters in human induced pluripotent stem cell (iPSC)-derived cardiomyocytes. Food Chem Toxicol doi:10.1016/j.fct.2021.111979 PMID:33450301
  • Marvel S, House JS, Wheeler M, Song K, Zhou Y, Wright FA, Chiu WA, Rusyn I, Motsinger-Reif A, Reif DM. 2021. The COVID-19 Pandemic Vulnerability Index (PVI) dashboard: Monitoring county-level vulnerability using visualization, statistical modeling, and machine learning. Environ Health Perspect 129:17701. doi:10.1289/EHP8690 PMID:33400596 PMCID:PMC7785295
  • Newman G, Cai Z, Zhu R, Horney JA, Jang S, Chiu WA. 2021. Gauging the effects of potential chemical transferal on high flood-risk fenceline communities. JEIL 6(2):doi:10.3808/jeil.202100073
  • Roman-Hubers AT, Cordova AC, Aly NA, McDonald TJ, Lloyd D, Wright FA, Baker ES, Chiu WA, Rusyn I. 2021. Data processing workflow to identify structurally related compounds in petroleum substances using ion mobility spectrometry-mass spectrometry. Energy Fuels 35:10529-10539. doi:10.1021/acs.energyfuels.1c00892 PMID:34366560 PMCID:PMC8341389
  • Roman-Hubers AT, McDonald TJ, Baker ES, Chiu WA, Rusyn I. 2021. A comparative analysis of analytical techniques for rapid oil spill identification. Environ Toxicol Chem 40(4):1034-1049. doi:10.1002/etc.4961 PMID:33315271 PMCID:PMC8104454
  • Sakolish C, Luo Y, Chiu WA, Rusyn I, Reese CE, Valdiviezo A, Schurdak ME, Gough A, Taylor DL, Vernetti LA. 2021. Analysis of reproducibility and robustness of a human microfluidic four-cell liver acinus microphysiology system (LAMPS). Toxicology 448:doi:10.1016/j.tox.2020.152651 PMID:33307106 PMCID:PMC7785655
  • Sakolish C, Luo Y, Valdiviezo A, Vernetti LA, Rusyn I, Chiu WA. 2021. Prediction of hepatic drug clearance with a human microfluidic four-cell liver acinus microphysiology system. Toxicology 463:152954. doi:10.1016/j.tox.2021.152954 PMID:34543702 PMCID:PMC8585690
  • Valdiviezo A, Luo Y, Chen Z, Chiu WA, Rusyn I. 2021. Quantitative in vitro-to-in vivo extrapolation for mixtures: A case study of Superfund priority list pesticides. Toxicol Sci 183(1):doi:10.1093/toxsci/kfab076 PMID:34142158 (ahead of print)

2020

  • Aly NA, Luo Y, Liu Y, Casillas GA, McDonald TJ, Kaihatu JM, Jun M, Ellis N, Gossett S, Dodds J, Baker ES, Bhandari S, Chiu WA, Rusyn I. 2020. Temporal and spatial analysis of per and polyfluoroalkyl substances in surface waters of Houston ship channel following a large-scale industrial fire incident. Environ Pollut 265:115009. doi:10.1016/j.envpol.2020.115009 PMID:32574947 PMCID:PMC7857671
  • Bhandari S, Lewis PT, Craft ES, Marvel S, Reif DM, Chiu WA. 2020. HGBEnviroScreen: Enabling community action through data integration in the Houston-Galveston-Brazoria region. Int J Environ Res Public Health 17:doi:10.3390/ijerph17041130 PMID:32053902
  • Blanchette A, Burnett SD, Grimm FA, Rusyn I, Chiu WA. 2020. A Bayesian method for population-wide cardiotoxicity hazard and risk characterization using an in vitro human model. Toxicol Sci 178(2):391-403. doi:10.1093/toxsci/kfaa151 PMID:33078833 PMCID:PMC7751158
  • Blessinger T, Davis JA, Chiu WA, Stanek J, Woodall G, Gift J, Thayer KA, Bussard D. 2020. Application of a unified probabilistic framework to the dose-response assessment of acrolein. Environ Int 143:105953. doi:10.1016/j.envint.2020.105953 PMID:32768806 (ahead of print)
  • Bois FY, Hsieh N, Gao W, Chiu WA, Reisfeld B. 2020. Well-tempered MCMC simulations for population pharmacokinetic models. J Pharmacokinet Pharmacodyn doi:10.1007/s10928-020-09705-0 PMID:32737765
  • Camargo K, Sericano JL, Bhandari S, Hoelscher C, McDonald TJ, Chiu WA, Wade TL, Dellapenna TM, Liu Y, Knap A. 2020. Polycyclic aromatic hydrocarbon status in post-hurricane Harvey sediments: considerations for environmental sampling in the Galveston Bay/Houston Ship Channel region. Mar Pollut Bull 162:111872. doi:10.1016/j.marpolbul.2020.111872 PMID:33256967 PMCID:PMC7867649
  • Chen Z, Liu Y, Wright FA, Chiu WA, Rusyn I. 2020. Rapid hazard characterization of environmental chemicals using a compendium of human cell lines from different organs. ALTEX 37:623-638. doi:10.14573/altex.2002291 PMID:32521033
  • Chiu WA, Paoli GM. 2020. Recent Advances in Probabilistic Dose-Response Assessment to Inform Risk Based Decision Making. Risk Anal doi:10.1111/risa.13595 PMID:32966629
  • Dalaijamts C, Cichocki JA, Luo Y, Rusyn I, Chiu WA. 2020. PBPK modeling of impact of nonalcoholic fatty liver disease on toxicokinetics of perchloroethylene in mice. Toxicol Appl Pharmacol 400:115069. doi:10.1016/j.taap.2020.115069 PMID:32445755 PMCID:PMC7339121
  • Danforth C, Chiu WA, Rusyn I, Schultz K, Bolden A, Kwiatkowski C, Craft ES. 2020. An integrative method for identification and prioritization of constituents of concern in produced water from onshore oil and gas extraction. Environ Int 134:14. doi:10.1016/j.envint.2019.105280 PMID:31704566
  • Grimm FA, Klaren WD, Li X, Lehmler H, Karmakar M, Robertson LW, Chiu WA, Rusyn I. 2020. Cardiovascular effects of polychlorinated biphenyls and their major metabolites. Environ Health Perspect 128:77008. doi:10.1289/EHP7030 PMID:32701041 PMCID:PMC7377239
  • Hsieh N, Reisfeld B, Chiu WA. 2020. pksensi: An R package to apply global sensitivity analysis in physiologically based kinetic modeling. SoftwareX 12:doi:10.1016/j.softx.2020.100609 PMID:33426260 PMCID:PMC7790364
  • Luo Y, Aly NA, McCord JP, Strynar M, Chiu WA, Dodds J, Baker ES, Rusyn I. 2020. Rapid characterization of emerging per- and polyfluoroalkyl substances in aqueous film-forming foams using ion mobility spectrometry-mass spectrometry. Environ Sci Technol 54(23):15024-15034. doi:10.1021/acs.est.0c04798 PMID:33176098 PMCID:PMC7719402
  • Luo Y, Ferguson K, Rusyn I, Chiu WA. 2020. In Vitro Bioavailability of the Hydrocarbon Fractions of Dimethyl Sulfoxide Extracts of Petroleum Substances. Toxicol Sci doi:10.1093/toxsci/kfaa007 PMID:32040194
  • Marvel S, House JS, Wheeler M, Song K, Zhou Y, Wright FA, Chiu WA, Rusyn I, Motsinger-Reif A, Reif DM. 2020. The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: Monitoring county-level vulnerability using visualization, statistical modeling, and machine learning. (non-peer reviewed)
  • Rusyn I, Chiu WA, Wright FA. 2020. Questioning existing cancer hazard evaluation standards in the name of statistics. Toxicol Sci 177:521-522. doi:10.1093/toxsci/kfaa077 PMID:32462183
  • Sakolish C, Chen Z, Dalaijamts C, Mitra K, Liu Y, Fulton T, Wade TL, Kelly EJ, Rusyn I, Chiu WA. 2020. Predicting tubular reabsorption with a human kidney proximal tubule tissue-on-a-chip and physiologically-based modeling. Toxicol In Vitro 63:doi:10.1016/j.tiv.2019.104752 PMID:31857146
  • Smith MT, Guyton KZ, Kleinstreuer N, Borrell A, Cardenas A, Chiu WA, Felsher DW, Gibbons CF, Goodson III WH, Houck K, Kane AB, La Merrill MA, Lebrec H, Lowe L, McHale CM, Minocherhomji S, Rieswijk L, Sandy MS, Sone H, Wang A, Zhang L, Zeise L, Fielden MR. 2020. The Key Characteristics of Carcinogens: Relationship to the Hallmarks of Cancer, Relevant Biomarkers, and Assays to Measure Them. Cancer Epidemiol Biomarkers Prev 29(10):doi:10.1158/1055-9965.EPI-19-1346 PMID:32152214 PMCID:PMC7483401

2019

  • Bera G, Camargo K, Sericano JL, Liu Y, Sweet S, Horney JA, Jun M, Chiu WA, Rusyn I, Wade TL, Knap A. 2019. Baseline data for distribution of contaminants by natural disasters: Results from a residential Houston neighborhood during Hurricane Harvey flooding. Heliyon 5:e02860. doi:10.1016/j.heliyon.2019.e02860 PMID:31763489 PMCID:PMC6861583
  • Blanchette A, Grimm FA, Dalaijamts C, Hsieh N, Ferguson K, Luo Y, Rusyn I, Chiu WA. 2019. Thorough QT/QTc in a dish: An In Vitro human model that accurately predicts clinical concentration-QTc relationships. Clin Pharmacol Ther 105:1175-1186. doi:10.1002/cpt.1259 PMID:30346629 PMCID:PMC6465173
  • Burnett SD, Blanchette A, Grimm FA, House JS, Reif DM, Wright FA, Chiu WA, Rusyn I. 2019. Population-based toxicity screening in human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol 381:114711. doi:10.1016/j.taap.2019.114711 PMID:31425687 PMCID:PMC6745256
  • Englehardt JD, Chiu WA. 2019. A general dose-response relationship for chronic chemical and other health stressors and mixtures based on an emergent illness severity model. PLoS One 14(2):e0211780. doi:10.1371/journal.pone.0211780 PMID:30768598 PMCID:PMC6377108
  • Ferguson K, Luo Y, Rusyn I, Chiu WA. 2019. Comparative analysis of Rapid Equilibrium Dialysis (RED) and solid phase micro-extraction (SPME) methods for In Vitro-In Vivo extrapolation of environmental chemicals. Toxicol In Vitro 60:245-251. doi:10.1016/j.tiv.2019.06.006 PMID:31195086 PMCID:PMC6717004
  • Kvasnicka J, Stylianou KS, Nguyen VK, Huang L, Chiu WA, Burton AG, Semrau J, Jolliet O. 2019. Human Health Benefits from Fish Consumption vs. Risks from Inhalation Exposures Associated with Contaminated Sediment Remediation: Dredging of the Hudson River. Environ Health Perspect 127:doi:10.1289/EHP5034 PMID:31834828
  • Lewis L, Borowa-Mazgaj B, de Conti A, Chappell G, Luo Y, Bodnar WM, Konganti K, Wright FA, Threadgill DW, Chiu WA, Pogribny IP, Rusyn I. 2019. Population-based analysis of DNA damage and epigenetic effects of 1,3-butadiene in the mouse. Chem Res Toxicol 32(5):doi:10.1021/acs.chemrestox.9b00035 PMID:30990016 (ahead of print)
  • Luo Y, Cichocki JA, Hsieh N, Lewis L, Wright FA, Threadgill DW, Chiu WA, Rusyn I. 2019. Using Collaborative Cross mouse population to fill data gaps in risk assessment: A case study of population-based analysis of toxicokinetics and kidney toxicodynamics of tetrachloroethylene. Environ Health Perspect 127(6):67011. doi:10.1289/EHP5105 PMID:31246107 PMCID:PMC6792382
  • Onel M, Beykal B, Ferguson K, Chiu WA, McDonald TJ, Zhou L, House JS, Wright FA, Sheen D, Rusyn I, Pistikopoulos EN. 2019. Grouping of complex substances using analytical chemistry data: A framework for quantitative evaluation and visualization. PLoS One 14(10):e0223517. doi:10.1371/journal.pone.0223517 PMID:31600275 PMCID:PMC6786635
  • Stermer A, Klein D, Wilson S, Dalaijamts C, Bai CY, Hall SJ, Madnick SJ, Bianchi E, Chiu WA, Boekelheide K. 2019. Differential toxicity of water versus gavage exposure to trichloroethylene in rats. Environ Toxicol Pharmacol 68:1-3. doi:10.1016/j.etap.2019.02.003 PMID:30836291 PMCID:PMC6594756
  • Wang M, Orr AA, He S, Dalaijamts C, Chiu WA, Tamamis P, Phillips TD. 2019. Montmorillonites can tightly bind glyphosate and paraquat reducing toxin exposures and toxicity. ACS Omega 4(18):17702-17713. doi:10.1021/acsomega.9b02051 PMID:31681876 PMCID:PMC6822125

2018

  • Chiu WA, Axelrad DA, Dalaijamts C, Dockins C, Shao K, Shapiro AJ, Paoli GM. 2018. Beyond the RfD: Broad application of a probabilistic approach to improve chemical dose response assessments for noncancer effects. Environ Health Perspect 126(6):067009. doi:10.1289/EHP3368 PMID:29968566 PMCID:PMC6084844
  • Chiu WA, Guyton KZ, Martin MT, Reif DM, Rusyn I. 2018. Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups. ALTEX 35(1):51-64. doi:10.14573/altex.1703231 PMID:28738424 PMCID:PMC5783793
  • Chiu WA, Rusyn I. 2018. Advancing chemical risk assessment decision-making with population variability data: challenges and opportunities. Mamm Genome 29(1-2):182-189. doi:10.1007/s00335-017-9731-6 PMID:29299621 PMCID:PMC5849521
  • Cichocki JA, Luo Y, Furuya S, Venkatratnam A, Konganti K, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I. 2018. Modulation of Tetrachloroethylene-Associated Kidney Effects by Nonalcoholic Fatty Liver or Steatohepatitis in Male C57BL/6J Mice. Toxicol Sci 167(1):126-137. doi:10.1093/toxsci/kfy223 PMID:30202895 PMCID:PMC6317418
  • Dalaijamts C, Cichocki JA, Luo Y, Rusyn I, Chiu WA. 2018. Incorporation of the glutathione conjugation pathway in an updated physiologically-based pharmacokinetic model for perchloroethylene in mice. Toxicol Appl Pharmacol 352:142-152. doi:10.1016/j.taap.2018.05.033 PMID:29857080 PMCID:PMC6051410
  • Fantke P, Aylward L, Bare J, Chiu WA, Dodson RE, Dwyer R, Ernstoff A, Howard B, Jantunen M, Jolliet O, Judson RR, Kirchhubel N, Li D, Miller A, Paoli GM, Price P, Rhomberg L, Shen B, Shin H, Teeguarden J, Vallero D, Wambaugh J, Wetmore BA, Zaleski R, McKone TE. 2018. Advancements in life cycle human exposure and toxicity characterization. Environ Health Perspect 126:10. doi:10.1289/ehp3871 PMID:30540492
  • Grimm FA, Blanchette A, House JS, Ferguson K, Hsieh N, Dalaijamts C, Wright AA, Anson B, Wright FA, Chiu WA, Rusyn I. 2018. A human population-based organotypic in vitro model for cardiotoxicity screening. ALTEX 35:441-452. doi:10.14573/altex.1805301 PMID:29999168 PMCID:PMC6231908
  • Guyton KZ, Rieswijk L, Wang A, Chiu WA, Smith MT. 2018. Key characteristics approach to carcinogenic hazard identification. Chem Res Toxicol 31(12):1290-1292. doi:10.1021/acs.chemrestox.8b00321 PMID:30521319 PMCID:PMC6424613
  • Guyton KZ, Rusyn I, Chiu WA, Corpet DE, van den Berg M, Ross MK, Christiani DC, Beland FA, Smith MT. 2018. Application of the key characteristics of carcinogens in cancer hazard identification. Carcinogenesis 39(4):614-622. doi:10.1093/carcin/bgy031 PMID:29562322 PMCID:PMC5888955
  • Guyton KZ, Rusyn I, Chiu WA, Corpet DE, van den Berg M, Ross MK, Christiani DC, Beland FA, Smith MT. 2018. Re: Application of the key characteristics of carcinogens in cancer hazard evaluation : response to Goodman, Lynch and Rhomberg. Carcinogenesis 39(8):1091-1093. doi:10.1093/carcin/bgy082 PMID:29982359 PMCID:PMC6067125
  • Luo Y, Furuya S, Chiu WA, Rusyn I. 2018. Characterization of inter-tissue and inter-strain variability of TCE glutathione conjugation metabolites DCVG, DCVC, and NAcDCVC in the mouse. J Toxicol Environ Health A 81:37-52. doi:10.1080/15287394.2017.1408512 PMID:29190187
  • Luo Y, Hsieh N, Soldatow VY, Chiu WA, Rusyn I. 2018. Comparative analysis of metabolism of trichloroethylene and tetrachloroethylene among mouse tissues and strains. Toxicology 409:33-43. doi:10.1016/j.tox.2018.07.012 PMID:30053492 PMCID:PMC6186498
  • Venkatratnam A, House JS, Konganti K, McKenney C, Threadgill DW, Chiu WA, Aylor DL, Wright FA, Rusyn I. 2018. Population-based dose-response analysis of liver transcriptional response to trichloroethylene in mouse. Mamm Genome 29:168-181. doi:10.1007/s00335-018-9734-y PMID:29353386 PMCID:PMC6094947
  • Wignall JA, Muratov EN, Sedykh A, Guyton KZ, Tropsha A, Rusyn I, Chiu WA. 2018. Conditional toxicity value (CTV) predictor: an in silico approach for generating quantitative risk estimates for chemicals. Environ Health Perspect 126(5):057008. doi:10.1289/EHP2998 PMID:29847084 PMCID:PMC6071978

2017

  • Bokkers BG, Mengelers MJ, Bakker MI, Chiu WA, Slob W. 2017. APROBA-Plus: A probabilistic tool to evaluate and express uncertainty in hazard characterization and exposure assessment of substances. Food Chem Toxicol 110:408-417. doi:10.1016/j.fct.2017.10.038 PMID:29074418 PMCID:PMC5793872
  • Cichocki JA, Furuya S, Konganti K, Luo Y, McDonald TJ, Iwata Y, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I. 2017. Impact of nonalcoholic fatty liver disease on toxicokinetics of tetrachloroethylene in mice. J Pharmacol Exp Ther 361(1):17-28. doi:10.1124/jpet.116.238790 PMID:28148637 PMCID:PMC5363767
  • Cichocki JA, Furuya S, Venkatratnam A, McDonald TJ, Knap A, Wade TL, Sweet S, Chiu WA, Threadgill DW, Rusyn I. 2017. Characterization of variability in toxicokinetics and toxicodynamics of tetrachloroethylene using the collaborative cross mouse population. Environ Health Perspect 125(5):057006. doi:10.1289/ehp788 PMID:28572074 PMCID:PMC5726344
  • Grimm FA, Russell WK, Luo Y, Iwata Y, Chiu WA, Roy T, Boogaard PJ, Ketelslegers HB, Rusyn I. 2017. Grouping of petroleum substances as example UVCBs by ion mobility-mass spectrometry to enable chemical composition-based read-across. Environ Sci Technol 51:7197-7207. doi:10.1021/acs.est.6b06413 PMID:28502166 PMCID:PMC5627358
  • Sirenko O, Grimm FA, Ryan KR, Iwata Y, Chiu WA, Parham F, Wignall JA, Anson B, Cromwell EF, Behl M, Rusyn I, Tice RR. 2017. In vitro cardiotoxicity assessment of environmental chemicals using an organotypic human induced pluripotent stem cell-derived model. Toxicol Appl Pharmacol 322:60-74. doi:10.1016/j.taap.2017.02.020 PMID:28259702 PMCID:PMC5734940
  • Venkatratnam A, Furuya S, Kosyk O, Gold A, Bodnar WM, Konganti K, Threadgill DW, Gillespie DA, Aylor DL, Wright FA, Chiu WA, Rusyn I. 2017. Editor's Highlight: Collaborative Cross mouse population enables refinements to characterization of the variability in toxicokinetics of trichloroethylene and provides genetic evidence for the role of PPAR pathway in its oxidative metabolism. Toxicol Sci 158(1):48-62. doi:10.1093/toxsci/kfx065 PMID:28369613
  • Zhou Y, Cichocki JA, Soldatow VY, Scholl EH, Gallins P, Jima DD, Yoo HS, Chiu WA, Wright FA, Rusyn I. 2017. Editor's highlight: comparative dose-response analysis of liver and kidney transcriptomic effects of trichloroethylene and tetrachloroethylene in B6C3F1 mouse. Toxicol Sci 160(1):95-110. doi:10.1093/toxsci/kfx165 PMID:28973375 PMCID:PMC5837274

2016

  • Cichocki JA, Guyton KZ, Guha N, Chiu WA, Rusyn I, Lash LH. 2016. Target organ metabolism, toxicity, and mechanisms of trichloroethylene and perchloroethylene: key similarities, differences, and data gaps. J Pharmacol Exp Ther 359(1):110-123. doi:10.1124/jpet.116.232629 PMID:27511820 PMCID:PMC5034707
  • Cote I, Andersen ME, Ankley GT, Barone S, Birnbaum LS, Boekelheide K, Bois FY, Burgoon LD, Chiu WA, Crawford-Brown D, Crofton K, DeVito MJ, Devlin RB, Edwards SW, Guyton KZ, Hattis D, Judson RS, Knight D, Krewski D, Lambert J, Maull EA, Mendrick D, Paoli GM, Patel CJ, Perkins EJ, Poje G, Portier CJ, Rusyn I, Schulte PA, Simeonov A, Smith MT, Thayer KA, Thomas RS, Thomas R, Tice RR, Vandenberg JJ, Villeneuve DL, Wesselkamper SC, Whelan M, Whittaker C, White R, Xia M, Yauk C, Zeise L, Zhao J, DeWoskin RS. 2016. The next generation of risk assessment multi-year study-highlights of findings, applications to risk assessment, and future directions. Environ Health Perspect 124(11):1671-1682. doi:10.1289/ehp233 PMID:27091369 PMCID:PMC5089888
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