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Your Environment. Your Health.

Person Details: Weihsueh A. Chiu

Superfund Research Program

Weihsueh A. Chiu

Texas A&M University
4458 TAMU
College Station, Texas 77846-4458
Phone: 979-845-4106
Email: wchiu@cvm.tamu.edu

Projects

Publications

2020

  • Bhandari S, Lewis PT, Craft ES, Marvel S, Reif DM, Chiu WA. 2020. HGBEnviroScreen: Enabling community action through data integration in the Houston-Galveston-Brazoria region. Int J Environ Res Public Health 17:doi:10.3390/ijerph17041130 PMID:32053902
  • Chen Z, Liu Y, Wright FA, Chiu WA, Rusyn I. 2020. Rapid hazard characterization of environmental chemicals using a compendium of human cell lines from different organs. ALTEX doi:10.14573/altex.2002291 PMID:32521033 (ahead of print)
  • Dalaijamts C, Cichocki JA, Luo Y, Rusyn I, Chiu WA. 2020. PBPK modeling of impact of nonalcoholic fatty liver disease on toxicokinetics of perchloroethylene in mice. Toxicol Appl Pharmacol 400:115069. doi:10.1016/j.taap.2020.115069 PMID:32445755
  • Danforth C, Chiu WA, Rusyn I, Schultz K, Bolden A, Kwiatkowski C, Craft ES. 2020. An integrative method for identification and prioritization of constituents of concern in produced water from onshore oil and gas extraction. Environ Int 134:105280. doi:10.1016/j.envint.2019.105280 PMID:31704566
  • Luo Y, Ferguson K, Rusyn I, Chiu WA. 2020. In Vitro Bioavailability of the Hydrocarbon Fractions of Dimethyl Sulfoxide Extracts of Petroleum Substances. Toxicol Sci doi:10.1093/toxsci/kfaa007 PMID:32040194
  • Sakolish C, Chen Z, Dalaijamts C, Mitra K, Liu Y, Fulton T, Wade TL, Kelly EJ, Rusyn I, Chiu WA. 2020. Predicting tubular reabsorption with a human kidney proximal tubule tissue-on-a-chip and physiologically-based modeling. Toxicol In Vitro 63:doi:10.1016/j.tiv.2019.104752 PMID:31857146
  • Smith MT, Guyton KZ, Kleinstreuer N, Borrell A, Cardenas A, Chiu WA, Felsher DW, Gibbons CF, Goodson III WH, Houck K, Kane AB, La Merrill MA, Lebrec H, Lowe L, McHale CM, Minocherhomji S, Rieswijk L, Sandy MS, Sone H, Wang A, Zhang L, Zeise L, Fielden MR. 2020. The Key Characteristics of Carcinogens: Relationship to the Hallmarks of Cancer, Relevant Biomarkers, and Assays to Measure Them. Cancer Epidemiol Biomarkers Prev doi:10.1158/1055-9965.EPI-19-1346

2019

  • Bera G, Camargo K, Sericano JL, Liu Y, Sweet S, Horney JA, Jun M, Chiu WA, Rusyn I, Wade TL, Knap A. 2019. Baseline data for distribution of contaminants by natural disasters: Results from a residential Houston neighborhood during Hurricane Harvey flooding. Heliyon 5:e02860. doi:10.1016/j.heliyon.2019.e02860 PMID:31763489 PMCID:PMC6861583
  • Blanchette A, Grimm FA, Dalaijamts C, Hsieh N, Ferguson K, Luo Y, Rusyn I, Chiu WA. 2019. Thorough QT/QTc in a dish: An In Vitro human model that accurately predicts clinical concentration-QTc relationships. Clin Pharmacol Ther 105:1175-1186. doi:10.1002/cpt.1259 PMID:30346629 PMCID:PMC6465173
  • Burnett SD, Blanchette A, Grimm FA, House JS, Reif DM, Wright FA, Chiu WA, Rusyn I. 2019. Population-based toxicity screening in human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol 381:114711. doi:10.1016/j.taap.2019.114711 PMID:31425687 PMCID:PMC6745256
  • Englehardt JD, Chiu WA. 2019. A general dose-response relationship for chronic chemical and other health stressors and mixtures based on an emergent illness severity model. PLoS One 14(2):e0211780. doi:10.1371/journal.pone.0211780 PMID:30768598 PMCID:PMC6377108
  • Ferguson K, Luo Y, Rusyn I, Chiu WA. 2019. Comparative analysis of Rapid Equilibrium Dialysis (RED) and solid phase micro-extraction (SPME) methods for In Vitro-In Vivo extrapolation of environmental chemicals. Toxicol In Vitro 60:245-251. doi:10.1016/j.tiv.2019.06.006 PMID:31195086 PMCID:PMC6717004
  • Horney JA, Casillas GA, Miller A, Craft ES, Burdette K, Ferguson PL, Knap A, Baker ES, McDonald TJ, Bhandari S, Chiu WA, Rusyn I. 2019. Conducting environmental health research after disaster: Disaster research response to Hurricane Florence. Environmental Health
  • Kvasnicka J, Stylianou KS, Nguyen VK, Huang L, Chiu WA, Burton AG, Semrau J, Jolliet O. 2019. Human Health Benefits from Fish Consumption vs. Risks from Inhalation Exposures Associated with Contaminated Sediment Remediation: Dredging of the Hudson River. Environ Health Perspect 127:doi:10.1289/EHP5034 PMID:31834828
  • Lewis L, Borowa-Mazgaj B, de Conti A, Chappell G, Luo Y, Bodnar WM, Konganti K, Wright FA, Threadgill DW, Chiu WA, Pogribny IP, Rusyn I. 2019. Population-based analysis of DNA damage and epigenetic effects of 1,3-butadiene in the mouse. Chem Res Toxicol doi:10.1021/acs.chemrestox.9b00035 PMID:30990016 (ahead of print)
  • Luo Y, Cichocki JA, Hsieh N, Lewis L, Wright FA, Threadgill DW, Chiu WA, Rusyn I. 2019. Using Collaborative Cross mouse population to fill data gaps in risk assessment: A case study of population-based analysis of toxicokinetics and kidney toxicodynamics of tetrachloroethylene. Environ Health Perspect 127(6):67011. doi:10.1289/EHP5105 PMID:31246107 PMCID:PMC6792382
  • Onel M, Beykal B, Ferguson K, Chiu WA, McDonald TJ, Zhou L, House JS, Wright FA, Sheen D, Rusyn I, Pistikopoulos EN. 2019. Grouping of complex substances using analytical chemistry data: A framework for quantitative evaluation and visualization. PLoS One 14(10):e0223517. doi:10.1371/journal.pone.0223517 PMID:31600275 PMCID:PMC6786635
  • Stermer A, Klein D, Wilson S, Dalaijamts C, Bai CY, Hall SJ, Madnick SJ, Bianchi E, Chiu WA, Boekelheide K. 2019. Differential toxicity of water versus gavage exposure to trichloroethylene in rats. Environ Toxicol Pharmacol 68:1-3. doi:10.1016/j.etap.2019.02.003 PMID:30836291 PMCID:PMC6594756
  • Wang M, Orr AA, He S, Dalaijamts C, Chiu WA, Tamamis P, Phillips TD. 2019. Montmorillonite clays can tightly sorb glyphosate and paraquat onto interlamellar surfaces and protect against exposure and toxicity. ACS Omega 4:
  • Wang M, Orr AA, He S, Dalaijamts C, Chiu WA, Tamamis P, Phillips TD. 2019. Montmorillonites can tightly bind glyphosate and paraquat reducing toxin exposures and toxicity. ACS Omega 4:17702-17713. doi:10.1021/acsomega.9b02051 PMID:31681876 PMCID:PMC6822125

2018

  • Chiu WA, Axelrad DA, Dalaijamts C, Dockins C, Shao K, Shapiro AJ, Paoli GM. 2018. Beyond the RfD: Broad application of a probabilistic approach to improve chemical dose response assessments for noncancer effects. Environ Health Perspect 126(6):067009. doi:10.1289/EHP3368 PMID:29968566 PMCID:PMC6084844
  • Chiu WA, Guyton KZ, Martin MT, Reif DM, Rusyn I. 2018. Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups. ALTEX 35(1):51-64. doi:10.14573/altex.1703231 PMID:28738424 PMCID:PMC5783793
  • Chiu WA, Rusyn I. 2018. Advancing chemical risk assessment decision-making with population variability data: challenges and opportunities. Mamm Genome 29(1-2):182-189. doi:10.1007/s00335-017-9731-6 PMID:29299621 PMCID:PMC5849521
  • Cichocki JA, Luo Y, Furuya S, Venkatratnam A, Konganti K, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I. 2018. Modulation of Tetrachloroethylene-Associated Kidney Effects by Nonalcoholic Fatty Liver or Steatohepatitis in Male C57BL/6J Mice. Toxicol Sci 167(1):126-137. doi:10.1093/toxsci/kfy223 PMID:30202895 PMCID:PMC6317418
  • Dalaijamts C, Cichocki JA, Luo Y, Rusyn I, Chiu WA. 2018. Incorporation of the glutathione conjugation pathway in an updated physiologically-based pharmacokinetic model for perchloroethylene in mice. Toxicol Appl Pharmacol 352:142-152. doi:10.1016/j.taap.2018.05.033 PMID:29857080 PMCID:PMC6051410
  • Fantke P, Aylward L, Bare J, Chiu WA, Dodson R, Dwyer R, Ernstoff A, Howard B, Jantunen M, Jolliet O, Judson RR, Kirchhubel N, Li D, Miller A, Paoli GM, Price P, Rhomberg L, Shen B, Shin H, Teeguarden J, Vallero D, Wambaugh J, Wetmore BA, Zaleski R, McKone TE. 2018. Advancements in life cycle human exposure and toxicity characterization. Environ Health Perspect 126:10. doi:10.1289/ehp3871 PMID:30540492
  • Grimm FA, Blanchette A, House JS, Ferguson K, Hsieh N, Dalaijamts C, Wright AA, Anson B, Wright FA, Chiu WA, Rusyn I. 2018. A human population-based organotypic in vitro model for cardiotoxicity screening. ALTEX 35:441-452. doi:10.14573/altex.1805301 PMID:29999168 PMCID:PMC6231908
  • Guyton KZ, Rieswijk L, Wang A, Chiu WA, Smith MT. 2018. Key characteristics approach to carcinogenic hazard identification. Chem Res Toxicol 31(12):1290-1292. doi:10.1021/acs.chemrestox.8b00321 PMID:30521319 PMCID:PMC6424613
  • Guyton KZ, Rusyn I, Chiu WA, Corpet DE, van den Berg M, Ross MK, Christiani DC, Beland FA, Smith MT. 2018. Application of the key characteristics of carcinogens in cancer hazard identification. Carcinogenesis 39(4):614-622. doi:10.1093/carcin/bgy031 PMID:29562322 PMCID:PMC5888955
  • Guyton KZ, Rusyn I, Chiu WA, Corpet DE, van den Berg M, Ross MK, Christiani DC, Beland FA, Smith MT. 2018. Re: Application of the key characteristics of carcinogens in cancer hazard evaluation : response to Goodman, Lynch and Rhomberg. Carcinogenesis 39(8):1091-1093. doi:10.1093/carcin/bgy082 PMID:29982359 PMCID:PMC6067125
  • Luo Y, Furuya S, Chiu WA, Rusyn I. 2018. Characterization of inter-tissue and inter-strain variability of TCE glutathione conjugation metabolites DCVG, DCVC, and NAcDCVC in the mouse. J Toxicol Environ Health A 81:37-52. doi:10.1080/15287394.2017.1408512 PMID:29190187
  • Luo Y, Hsieh N, Soldatow VY, Chiu WA, Rusyn I. 2018. Comparative analysis of metabolism of trichloroethylene and tetrachloroethylene among mouse tissues and strains. Toxicology 409:33-43. doi:10.1016/j.tox.2018.07.012 PMID:30053492 PMCID:PMC6186498
  • Venkatratnam A, House JS, Konganti K, McKenney C, Threadgill DW, Chiu WA, Aylor DL, Wright FA, Rusyn I. 2018. Population-based dose-response analysis of liver transcriptional response to trichloroethylene in mouse. Mamm Genome 29:168-181. doi:10.1007/s00335-018-9734-y PMID:29353386 PMCID:PMC6094947
  • Wignall JA, Muratov EN, Sedykh A, Guyton KZ, Tropsha A, Rusyn I, Chiu WA. 2018. Conditional toxicity value (CTV) predictor: an in silico approach for generating quantitative risk estimates for chemicals. Environ Health Perspect 126(5):057008. doi:10.1289/EHP2998 PMID:29847084 PMCID:PMC6071978

2017

  • Bokkers BG, Mengelers MJ, Bakker MI, Chiu WA, Slob W. 2017. APROBA-Plus: A probabilistic tool to evaluate and express uncertainty in hazard characterization and exposure assessment of substances. Food Chem Toxicol 110:408-417. doi:10.1016/j.fct.2017.10.038 PMID:29074418 PMCID:PMC5793872
  • Cichocki JA, Furuya S, Konganti K, Luo Y, McDonald TJ, Iwata Y, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I. 2017. Impact of nonalcoholic fatty liver disease on toxicokinetics of tetrachloroethylene in mice. J Pharmacol Exp Ther 361(1):17-28. doi:10.1124/jpet.116.238790 PMID:28148637 PMCID:PMC5363767
  • Cichocki JA, Furuya S, Venkatratnam A, McDonald TJ, Knap A, Wade TL, Sweet S, Chiu WA, Threadgill DW, Rusyn I. 2017. Characterization of variability in toxicokinetics and toxicodynamics of tetrachloroethylene using the collaborative cross mouse population. Environ Health Perspect 125(5):057006. doi:10.1289/ehp788 PMID:28572074 PMCID:PMC5726344
  • Grimm FA, Russell WK, Luo Y, Iwata Y, Chiu WA, Roy T, Boogaard PJ, Ketelslegers HB, Rusyn I. 2017. Grouping of petroleum substances as example UVCBs by ion mobility-mass spectrometry to enable chemical composition-based read-across. Environ Sci Technol 51:7197-7207. doi:10.1021/acs.est.6b06413 PMID:28502166 PMCID:PMC5627358
  • Sirenko O, Grimm FA, Ryan KR, Iwata Y, Chiu WA, Parham F, Wignall JA, Anson B, Cromwell EF, Behl M, Rusyn I, Tice RR. 2017. In vitro cardiotoxicity assessment of environmental chemicals using an organotypic human induced pluripotent stem cell-derived model. Toxicol Appl Pharmacol 322:60-74. doi:10.1016/j.taap.2017.02.020 PMID:28259702 PMCID:PMC5734940
  • Venkatratnam A, Furuya S, Kosyk O, Gold A, Bodnar WM, Konganti K, Threadgill DW, Gillespie DA, Aylor DL, Wright FA, Chiu WA, Rusyn I. 2017. Editor's Highlight: Collaborative Cross mouse population enables refinements to characterization of the variability in toxicokinetics of trichloroethylene and provides genetic evidence for the role of PPAR pathway in its oxidative metabolism. Toxicol Sci 158(1):48-62. doi:10.1093/toxsci/kfx065 PMID:28369613
  • Zhou Y, Cichocki JA, Soldatow VY, Scholl EH, Gallins P, Jima DD, Yoo HS, Chiu WA, Wright FA, Rusyn I. 2017. Editor's highlight: comparative dose-response analysis of liver and kidney transcriptomic effects of trichloroethylene and tetrachloroethylene in B6C3F1 mouse. Toxicol Sci 160(1):95-110. doi:10.1093/toxsci/kfx165 PMID:28973375 PMCID:PMC5837274

2016

  • Cichocki JA, Guyton KZ, Guha N, Chiu WA, Rusyn I, Lash LH. 2016. Target organ metabolism, toxicity, and mechanisms of trichloroethylene and perchloroethylene: key similarities, differences, and data gaps. J Pharmacol Exp Ther 359(1):110-123. doi:10.1124/jpet.116.232629 PMID:27511820 PMCID:PMC5034707
  • Cote I, Andersen ME, Ankley GT, Barone S, Birnbaum LS, Boekelheide K, Bois FY, Burgoon LD, Chiu WA, Crawford-Brown D, Crofton K, DeVito MJ, Devlin RB, Edwards SW, Guyton KZ, Hattis D, Judson RS, Knight D, Krewski D, Lambert J, Maull EA, Mendrick D, Paoli GM, Patel CJ, Perkins EJ, Poje G, Portier CJ, Rusyn I, Schulte PA, Simeonov A, Smith MT, Thayer KA, Thomas RS, Thomas R, Tice RR, Vandenberg JJ, Villeneuve DL, Wesselkamper SC, Whelan M, Whittaker C, White R, Xia M, Yauk C, Zeise L, Zhao J, DeWoskin RS. 2016. The next generation of risk assessment multi-year study-highlights of findings, applications to risk assessment, and future directions. Environ Health Perspect 124(11):1671-1682. doi:10.1289/ehp233 PMID:27091369 PMCID:PMC5089888
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