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Person Details: Dr. John Godleski

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Superfund Research Program

Dr. John Godleski

665 Huntington Avenue

Boston, Massachusetts 02115
Phone: 617-432-1252
Fax: 617-432-0219
Email: jgodlesk@hsph.harvard.edu

Projects

Research Briefs

Publications

2015

  • Bobb JF, Valeri L, Henn BC, Wright RO, Mazumdar M, Godleski J, Coull BA, Christiani DC. 2015. Bayesian kernel machine regression for estimating the health effects of multi-pollutant mixtures. Biostatistics 16(3):493-508. doi:10.1093/biostatistics/kxu058 PMID:25532525

2000

  • Al-Mutairi E, Godleski J, Koziel H, Bullock BP, Paulauskis JD. 2000. Genetic response of human alveolar macrophages to residual oil fly ash particles. FASEB J 14(4):A171.
  • Rice T, Clarke RW, Hauser R, Antonini JM, Godleski J, Paulauskis JD. 2000. Differential ability of transition metals to induce pulmonary inflammation. Toxicol Sci 54(1):36. PMID:11708899
  • Stearns R, Clarke RW, Rice T, Al-Mutairi E, Oakberg K, Paulauskis JD, Godleski J. 2000. Compositional heterogeneity influences induction of lung inflammation by residual oil fly-ash. FASEB J 14(4):173.

1999

  • Clarke RW, Al-Mutairi E, Love JA, Rice T, Antonini JM, Paulauskis JD, Godleski J. 1999. Residual oil ashes with differing composition elicit pro-inflammatory chemokines in the lung and heart. Toxicol Sci 48(15):259.
  • Clarke RW, Catalano PJ, Koutrakis P, Krishna-Murthy GG, Sioutas C, Paulauskis JD, Coull BA, Ferguson S, Godleski J. 1999. Urban air particulate inhalation alters pulmonary function and induces pulmonary inflammation in a rodent model of chronic bronchitis. Inhal Toxicol 11(8):637-656. doi:10.1080/089583799196781 PMID:10477440
  • Godleski J, Clarke RE. 1999. Systemic responses to inhaled ambient particles: Pathophysiologic Mechanisms of Cardiopulmonary Effects. In: Inhaled Particles (Lung Biology in Health and Disease Series). Marcel Dekker, Inc., pp.577-601.
  • Grabowski GM, Paulauskis JD, Godleski J. 1999. Mediating phosphorylation events in the vanadium-induced respiratory burst of alveolar macrophages. Toxicol Appl Pharmacol 156:170-178. PMID:10222309
  • Paulauskis JD, Danaee H, Antonini JM, Al-Mutairi E, Rice T, Godleski J, Clarke RW. 1999. Instilled soluble vanadium evokes pulmonary inflammation but does not elicit pro-inflammatory chemokine mRNA in the heart. Toxicol Sci 48(15):52.
  • Shi MM, Chong I, Godleski J, Paulauskis JD. 1999. Regulation of macrophage inflammatory protein-2 gene expression by oxidative stress in rat alveolar macrophages. Immunology 97(2):309-315. PMID:10447747
  • Shi MM, Godleski J, Paulauskis JD. 1999. Transcriptional and posttranscriptional regulation of macrophage inflammatory protein-1. In: Proceedings of the Oxygen Society Meeting.

1998

  • Shi MM, Chong I, Long NC, Love JA, Godleski J, Paulauskis JD. 1998. Functional characterization of recombinant rat macrophage inflammatory protein-1α and mRNA expression in pulmonary inflammation. Inflammation 22:29-43. PMID:9484648

1997

  • Alessandrini F, Shi MM, Godleski J, Paulauskis JD. 1997. Comparative antioxidant capabilities of lazaroid U-83836E and N-acetylcysteine in lung macrophages. Am J Respir Crit Care Med 155:A188.
  • Grabowski GM, Paulauskis JD, Godleski J. 1997. Role of phosphotyrosine phosphatase, PTP.1C in the initiation of the vanadium-induced respiratory burst in lung macrophages. In: Proceedings of EMBO-FMI Workshop "Europhosphatase 1996".
  • Killingsworth CR, Alessandrini F, Krishna-Murthy GG, Catalano PJ, Paulauskis JD, Godleski J. 1997. Inflammation, chemokine expression, and death in monocrotaline-treated rats following fuel oil ash inhalation. Inhal Toxicol 9(6):541-565.
  • Shi MM, Chong I, Chen AX, Godleski J, Paulauskis JD. 1997. Budesonide inhibits macrophage inflammatory protein -2 mRNA increase in response to bacterial lipopolysaccharide. Pharm Res 14:S-387.
  • Shi MM, Chong I, Paulauskis JD, Godleski J. 1997. Regulation of chemokine gene expression by oxidative stress in alveolar macrophages. FASEB J 11:1330.
  • Tsai CS, Shi MM, Chong I, Godleski J, Paulauskis JD. 1997. Vanadium-induced expression of macrophage inflammatory protein (MIP)-1α and MIP-2 mRNA in lung macrophages is dependent on macrophage:epithelial interaction. Am J Respir Crit Care Med 155:A960.

1996

  • Alessandrini F, Shi MM, Godleski J, Paulauskis JD. 1996. The lazaroid U-83836E protects alveolar macrophages from oxidative stress. Am J Respir Crit Care Med 153:A811.
  • Grabowski GM, Tsai CS, Paulauskis JD, Godleski J. 1996. Signal transduction in the metal-induced respiratory burst of lung macrophages. Am J Respir Crit Care Med 153:A544.
  • Hauser R, Godleski J, Hatch V, Christiani DC. 1996. Ultrafine particles in human lung macrophages and their relationship with lung function. Am J Respir Crit Care Med 153:A544.
  • Killingsworth CR, Alessandrini F, Krishna-Murthy GG, Catalano PJ, Paulauskis JD, Godleski J. 1996. Death from inhalation of fuel oil fly ash particles in rats with pre-existing pulmonary inflammation. In: Proceedings of the Second Colloquium on Particulate Air Pollution and Health. pp.238-244.
  • Nearing BD, Verrier RL, Skornick WA, Gazula G, Killingsworth CR, Oakberg K, Godleski J. 1996. Inhaled fly ash results in alteration in cardiac electrophysiologic function. Am J Respir Crit Care Med 153:A543.
  • Pierce LM, Alessandrini F, Godleski J, Paulauskis JD. 1996. Vanadium-induced chemokine mRNA expression and pulmonary inflammation. Toxicol Appl Pharmacol 138(1):1-11. doi:10.1006/taap.1996.9999 PMID:8658498
  • Shi MM, Godleski J, Paulauskis JD. 1996. An oxidative stress increases macrophage inflammatory protein-1α mRNA levels by increasing transcription of the gene and by transcript stabilization. FASEB J 10:156.
  • Shi MM, Godleski J, Paulauskis JD. 1996. Elevation of KC (cytokine-induced neutrophil chemoattractant) mRNA in alveolar macrophages by quinone-induced oxidative stress. Am J Respir Crit Care Med 153:A30.
  • Shi MM, Godleski J, Paulauskis JD. 1996. Regulation of macrophage inflammatory protein-1α mRNA by oxidative stress. J Biol Chem 271:5878-5883. PMID:8621460
  • Tsai CS, Shi MM, Godleski J, Paulauskis JD. 1996. Manganese-induced pulmonary inflammation and increased expression of pro-inflammatory cytokine mRNA in rat lung cells. Am J Respir Crit Care Med 153:A614.

1995

  • Grabowski GM, Paulauskis JD, Godleski J. 1995. Tyrosine phosphorylation events in the respiratory burst of rat lung macrophages induced by vanadium. FASEB J 9(4):947.
  • Shi MM, Godleski J, Paulauskis JD. 1995. Effect of oxidative stress on inflammatory cytokine mRNA expression in rat alveolar macrophages. FASEB J 9(4):346.
  • Shi MM, Godleski J, Paulauskis JD. 1995. Molecular cloning and posttranscriptional regulation of macrophage inflammatory protein-1 alpha in alveolar macrophages. Biochem Biophys Res Commun 211(1):289-295. doi:10.1006/bbrc.1995.1809 PMID:7779098
  • Sweeney TD, Skornick WA, Brain JD, Hatch V, Godleski J. 1995. Chronic bronchitis alters the pattern of aerosol deposition in the lung. Am J Respir Crit Care Med 151:482-488. PMID:7842210
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