Superfund Research Program

Nishad Jayasundara

Duke University
Nicholas School of the Environment
Box 90328
Durham, North Carolina 27708
Email: nj58@duke.edu

Projects

• Duke University: Neurobehavioral and Bioenergetic Consequences of Evolving Resistance to Polycyclic Aromatic Hydrocarbons in a Multi-Stressor Environment (2022-2027)
• University of Pittsburgh: Metal mixture effects on mitochondrial dysfunction in kidney development and maturation: Towards a whole mixture risk assessment (2023-2026)

Research Briefs

• 363 - Using a New Model to Identify Health-Impacting Metal Mixtures

Hazardous Waste Sites

Atlantic Wood Site, Elizabeth River

• Duke University: Mechanisms and Consequences of Evolved Adaptation to Environmental Pollution
• Duke University: Mechanisms and Consequences of Evolved Adaptation to Environmental Pollution

Money Point, Elizabeth River

• Duke University: Mechanisms and Consequences of Evolved Adaptation to Environmental Pollution

Republic Creosoting, Elizabeth River

• Duke University: Mechanisms and Consequences of Evolved Adaptation to Environmental Pollution

Publications

2024

• Babich R, Merutka IR, Craig E, Harichandara A, De Silva P, Gunasekara T, Jayasundara N. 2024. Transcriptomic and behavioral analyses reveal unique target tissues and molecular pathways associated with embryonic exposure to low level glyphosate and metal mixtures in zebrafish. Sci Total Environ 912:doi:10.1016/j.scitotenv.2023.169271 PMID:38114029
• Dilrukshi KR, Merutka IR, Chernick M, Rohrbach S, Babich R, Withanage N, Fernando PW, Jayasundara N. 2024. Determining bad actors: A linear mixed effects model approach to elucidate behavioral toxicity of metal mixtures in drinking water. Ecotoxicol Environ Saf 15:287:117296. doi:10.1016/j.ecoenv.2024.117296 PMID:39536556 PMCID:PMC11629772
• Guelfo J, Ferguson L, Beck J, Chernick M, Doria-Manzur A, Faught P, Flug T, Gray EP, Jayasundara N, Knappe D, Joyce A, Meng P, Shojaei M. 2024. Lithium-ion battery components are at the nexus of sustainable energy and environmental release of per- and polyfluoroalkyl substances. Nat Commun 15(1):doi:10.1038/s41467-024-49753-5 PMID:38977667 PMCID:11231300

2023

• Jasperse L, Di Giulio RT, Jayasundara N. 2023. Bioenergetic effects of polycyclic aromatic hydrocarbon resistance manifest later in life in offspring of fundulus heteroclitus from the Elizabeth River. Environ Sci Technol 57(42):15806-15815. doi:10.1021/acs.est.3c03610 PMID:37818763
• Kozal JS, Jayasundara N, Massarsky A, Lindberg C, Oliveri A, Cooper EM, Levin ED, Meyer JN, Di Giulio RT. 2023. Mitochondrial dysfunction and oxidative stress contribute to cross-generational toxicity of benzo(a)pyrene in Danio rerio. Aquat Toxicol 263:106658. doi:10.1016/j.aquatox.2023.106658 PMID:37722151 PMCID:PMC10591944

2022

• Trevisan R, Ranasinghe P, Jayasundara N, Di Giulio RT. 2022. Nanoplastics in aquatic environments: Impacts on aquatic species and interactions with environmental factors and pollutants. Toxics 10(6):doi:10.3390/toxics10060326 PMID:35736934 PMCID:PMC9230143

2021

• Redfern L, Jayasundara N, Singleton D, Di Giulio RT, Carlson J, Sumner SJ, Gunsch C. 2021. The role of gut microbial community and metabolomic shifts in adaptive resistance of Atlantic killifish (Fundulus heteroclitus) to polycyclic aromatic hydrocarbons. Sci Total Environ 776:145955. doi:10.1016/j.scitotenv.2021.145955 PMID:33647645 PMCID:PMC8294123

2020

• Babich R, Ulrich JC, Dilini V. Ekanyake E, Massarsky A, De Silva PC, Manage PM, Jackson BP, Ferguson PL, Di Giulio RT, Drummond IA, Jayasundara N. 2020. Kidney developmental effects of metal-herbicide mixtures: Implications for chronic kidney disease of unknown etiology. Environ Int 144:doi:10.1016/j.envint.2020.106019

2019

• Volkoff SJ, Osterberg JS, Jayasundara N, Cooper EM, Hsu-Kim H, Rogers LA, Gehrke GE, Jayaraman S, Di Giulio RT. 2019. Embryonic fundulus heteroclitus responses to sediment extracts from differentially contaminated sites in the Elizabeth River, VA. Ecotoxicology 28:9:1126-1135. doi:10.1007/s10646-019-02116-z PMID:31620948 PMCID:PMC7768734

2018

• Gearhart-Serna LM, Jayasundara N, Tacam M, Di Giulio RT, Devi GR. 2018. Assessing cancer risk associated with aquatic polycyclic aromatic hydrocarbon pollution reveals dietary routes of exposure and vulnerable populations. J Environ Public Health 2018:5610462. doi:10.1155/2018/5610462 PMID:30327676 PMCID:PMC6169233
• Pitt JA, Kozal JS, Jayasundara N, Massarsky A, Trevisan R, Geiter N, Wiesner MR, Levin ED, Di Giulio RT. 2018. Uptake, tissue distribution, and toxicity of polystyrene nanoparticles in developing zebrafish (Danio rerio). Aquat Toxicol 194:185-194. doi:10.1016/j.aquatox.2017.11.017 PMID:29197232

2017

• Jayasundara N, Fernando PW, Osterberg JS, Cammen KM, Schultz TF, Di Giulio RT. 2017. Cost of tolerance: Physiological consequences of evolved resistance to inhabit a polluted environmental in Teleost fish Fundulus heteroclitus. Environ Sci Technol 51:8763-8772. doi:10.1021/acs.est.7b01913 PMID:28682633
• Lindberg C, Jayasundara N, Kozal JS, Leuthner T, Di Giulio RT. 2017. Resistance to polycyclic aromatic hydrocarbon toxicity and associated bioenergetic consequences in a population of Fundulus heteroclitus. Ecotoxicology 26(3):435-448. doi:10.1007/s10646-017-1775-6 PMID:28213827
• Raftery TD, Jayasundara N, Di Giulio RT. 2017. A bioenergetics assay for studying the effects of environmental stressors on mitochondrial function in vivo in zebrafish larvae. Comp Biochem Physiol C Toxicol Pharmacol 192:23-32. doi:10.1016/j.cbpc.2016.12.001 PMID:27939721 PMCID:PMC5218841