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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Person Details: Miroslav Styblo

Superfund Research Program

Miroslav Styblo

University of North Carolina-Chapel Hill
2302 Michael Hooker Res. Center
Campus Box 7461
Chapel Hill, North Carolina 27599-7461
Phone: 919-966-5721
Email: styblo@med.unc.edu

Projects

Research Briefs

Publications

2023

  • Douillet C, Miller M, Cable PH, Shi Q, El-Masri HA, Matousek T, Koller BH, Thomas DJ, Styblo M. 2023. Fate of arsenicals in mice carrying the human AS3MT gene exposed to environmentally relevant levels of arsenite in drinking water. Sci Rep 13(1):3660. doi:10.1038/s41598-023-30723-8 PMID:36871058 PMCID:PMC9985638
  • Medina S, Zhang H, Santos-Medina LV, Yee ZA, Martin KJ, Wan G, Bolt AM, Zhou X, Styblo M, Liu K. 2023. Arsenite methyltransferase is an important mediator of hematoxicity induced by arsenic in drinking water. Water (Basel) 15(3):448. doi:10.3390/w15030448 PMID:36936034 PMCID:PMC1001945
  • Shang B, Venkatratnam A, Liu T, Douillet C, Shi Q, Miller M, Cable P, Zou F, Ideraabdullah FY, Fry RC, Styblo M. 2023. Sex-specific transgenerational effects of preconception exposure to arsenite: metabolic phenotypes of C57BL/6 offspring. Arch Toxicol doi:10.1007/s00204-023-03582-5 PMID:37615676
  • Soares MB, Duckworth O, Styblo M, Cable PH, Alleoni LR. 2023. Pyrolysis temperature and biochar redox activity on arsenic availability and speciation in a sediment. J Hazard Mater 460:132308. doi:10.1016/j.jhazmat.2023.132308 PMID:37639794
  • Todero JE, Douillet C, Shumway AJ, Koller BH, Kanke M, Phuong DJ, Styblo M, Sethupathy P. 2023. Molecular and metabolic analysis of arsenic-exposed humanized AS3MT mice. Environ Health Perspect 131(12):127021. doi:10.1289/EHP12785 PMID:38150313 PMCID:PMC10752418

2022

  • Clark J, Bommarito P, Styblo M, Rubio-Andrade M, Garcia-Vargas GG, Gamble MV, Fry RC. 2022. Maternal serum concentrations of one-carbon metabolism factors modify the association between biomarkers of arsenic methylation efficiency and birth weight. Environmental Health 21(1):68. doi:10.1186/s12940-022-00875-7 PMID:35836250 PMCID:PMC9281096
  • Mersaoui SY, Guilbert C, Chou H, Douillet C, Bohle DS, Styblo M, Richard S, Mann KK. 2022. Arsenic 3 methyltransferase (AS3MT) automethylates on cysteine residues in vitro. Arch Toxicol 96(5):1371-1386. doi:10.1007/s00204-022-03248-8 PMID:35244730 PMCID:PMC9013690
  • Shang B, Venkatratnam A, Hartwell HJ, Douillet C, Cable P, Liu T, Zou F, Ideraabdullah FY, Fry RC, Styblo M. 2022. Ex vivo exposures to arsenite and its methylated trivalent metabolites alter gene transcription in mouse sperm cells. Toxicol Appl Pharmacol 455:116266. doi:10.1016/j.taap.2022.116266 PMID:36209798
  • Todero JE, Koch-Laskowski K, Shi Q, Kanke M, Hung Y, Beck R, Styblo M, Sethupathy P. 2022. Candidate master microRNA regulator of arsenic-induced pancreatic beta cell impairment revealed by multi-omics analysis. Arch Toxicol 96(6):1685-1699. doi:10.1007/s00204-022-03263-9 PMID:35314868 PMCID:PMC9095563
  • Xenakis JG, Douillet C, Bell TA, Hock P, Farrington J, Liu T, Murphy C, Saraswatula A, Shaw GD, Nativio G, Shi Q, Venkatratnam A, Zou F, Fry RC, Styblo M, Pardo-Manuel de Villena F. 2022. An interaction of inorganic arsenic exposure with body weight and composition on type 2 diabetes indicators in Diversity Outbred mice. Mamm Genome doi:10.1007/s00335-022-09957-w PMID:35819478

2021

  • Douillet C, Ji J, Meenakshi IL, Lu K, Pardo-Manuel de Villena F, Fry RC, Styblo M. 2021. Diverse genetic backgrounds play a prominent role in the metabolic phenotype of CC021/Unc and CC027/GeniUNC mice exposed to inorganic arsenic. Toxicology 452:152696. doi:10.1016/j.tox.2021.152696 PMID:33524430 PMCID:PMC7914223
  • Ghiuzeli CM, Styblo M, Saunders RJ, Calabro A, Budman D, Allen S, Devoe C, Dhingra R. 2021. The pharmacokinetics of therapeutic arsenic trioxide in acute promyelocytic leukemia patients. Leuk Lymphoma 63:653-663. doi:10.1080/10428194.2021.1978084 PMID:34689693 PMCID:PMC8891048
  • Styblo M, Venkatratnam A, Fry RC, Thomas DJ. 2021. Origins, fate, and actions of methylated trivalent metabolites of inorganic arsenic: progress and prospects. Arch Toxicol 95(5):doi:10.1007/s00204-021-03028-w PMID:33768354 (ahead of print)

2020

  • Douillet C, Koller BH, Styblo M. 2020. Metabolism of inorganic arsenic in mice lacking genes encoding GST-P, GST-M, and GST-T. Chem Res Toxicol 33(8):2043-2046. doi:10.1021/acs.chemrestox.0c00273 PMID:32700902 PMCID:PMC7802361
  • Koller BH, Snouwaert JN, Douillet C, Jania LA, El-Masri HA, Thomas DJ, Styblo M. 2020. Arsenic metabolism in mice carrying a BORCS7/AS3MT locus humanized by syntenic replacement. Environ Health Perspect 128(8):87003. doi:10.1289/EHP6943 PMID:32779937 PMCID:PMC7418654
  • Li Y, Douillet C, Huang MC, Beck R, Sumner SJ, Styblo M. 2020. Exposure to inorganic arsenic and its methylated metabolites alters metabolomics profiles in INS-1 832/13 insulinoma cells and isolated pancreatic islets. Arch Toxicol 94(6):1955-1972. doi:10.1007/s00204-020-02729-y PMID:32277266
  • Styblo M, Schmidt S. 2020. Matching rodents to people: A humanized mouse model of iAs methylation. Environ Health Perspect 128(10):104003. doi:10.1289/EHP8093 PMID:33054428 PMCID:PMC7560904
  • Venkatratnam A, Douillet C, Topping BC, Shi Q, Addo KA, Ideraabdullah FY, Fry RC, Styblo M. 2020. Sex-dependent effects of preconception exposure to arsenite on gene transcription in parental germ cells and on transcriptomic profiles and diabetic phenotype of offspring. Arch Toxicol doi:10.1007/s00204-020-02941-w PMID:33145626

2019

  • Beck R, Chandi M, Kanke M, Styblo M, Sethupathy P. 2019. Arsenic is more potent than cadmium or manganese in disrupting the INS-1 beta cell microRNA landscape. Arch Toxicol doi:10.1007/s00204-019-02574-8 PMID:31555879

2018

  • Laine JE, Ilievski V, Richardson DB, Herring AH, Styblo M, Rubio-Andrade M, Garcia-Vargas G, Gamble MV, Fry RC. 2018. Maternal one carbon metabolism and arsenic methylation in a pregnancy cohort in Mexico. J Expo Sci Environ Epidemiol 28(5):505-514. doi:10.1038/s41370-018-0041-1 PMID:30068932

2017

  • Beck R, Styblo M, Sethupathy P. 2017. Arsenic exposure and type 2 diabetes: microRNAs as mechanistic links?. Curr Diab Rep 17:18. doi:10.1007/s11892-017-0845-8 PMID:28275977 PMCID:PMC5343073
  • Grau-Perez M, Kuo C, Spratlen MJ, Thayer KA, Mendez MA, Hamman RF, Dabelea D, Adgate JL, Knowler WC, Bell RA, Miller FW, Liese AD, Zhang C, Douillet C, Drobna Z, Mayer-Davis E, Styblo M, Navas-Acien A. 2017. The association of arsenic exposure and metabolism with type 1 and type 2 diabetes in youth: the SEARCH case-control study. Diabetes Care 40(1):46-53. doi:10.2337/dc16-0810 PMID:27810988 PMCID:PMC5180459
  • Huang MC, Douillet C, Su M, Zhou K, Wu T, Chen W, Galanko JA, Drobna Z, Saunders RJ, Martin EM, Fry RC, Jia W, Styblo M. 2017. Metabolomic profiles of arsenic (+3 oxidation state) methyltransferase knockout mice: effect of sex and arsenic exposure. Arch Toxicol 91(1):189-202. doi:10.1007/s00204-016-1676-0 PMID:26883664 PMCID:PMC4987274
  • Laine JE, Bailey KA, Olshan A, Smeester L, Drobna Z, Styblo M, Douillet C, Garcia-Vargas G, Rubio-Andrade M, Pathmasiri W, McRitchie S, Sumner SJ, Fry RC. 2017. Neonatal metabolomic profiles related to prenatal arsenic exposure. Environ Sci Technol 51(1):625-633. doi:10.1021/acs.est.6b04374 PMID:27997141
  • Martin EM, Styblo M, Fry RC. 2017. Genetic and epigenetic mechanisms underlying arsenic-associated diabetes mellitus: a perspective of the current evidence. Epigenomics 9(5):doi:10.2217/epi-2016-0097 PMID:28470093 PMCID:PMC5480787

2016

  • Drobna Z, Martin EM, Kim K, Smeester L, Bommarito P, Rubio-Andrade M, Garcia-Vargas GG, Styblo M, Zou F, Fry RC. 2016. Analysis of maternal polymorphisms in arsenic (+3 oxidation state)-methyltransferase AS3MT and fetal sex in relation to arsenic metabolism and infant birth outcomes: Implications for risk analysis. Reprod Toxicol 61:28-38. doi:10.1016/j.reprotox.2016.02.017 PMID:26928318 PMCID:PMC4970429
  • Mendez MA, Gonzalez-Horta C, Sanchez-Ramirez B, Ballinas-Casarrubias L, Ceron RH, Morales DV, Baeza Terrazas FA, Ishida MC, Gutierrez-Torres DS, Saunders RJ, Drobna Z, Fry RC, Buse JB, Loomis D, Garcia-Vargas GG, Styblo M. 2016. Chronic exposure to arsenic and markers of cardiometabolic risk: a cross-sectional study in Chihuahua, Mexico. Environ Health Perspect 124(1):104-111. doi:10.1289/ehp.1408742 PMID:26068977 PMCID:PMC4710594
  • Xu X, Drobna Z, Voruganti VS, Barron K, Gonzalez-Horta C, Sanchez-Ramirez B, Ballinas-Casarrubias L, Ceron RH, Morales DV, Baeza Terrazas FA, Ishida MC, Gutierrez-Torres DS, Saunders RJ, Crandell J, Fry RC, Loomis D, Garcia-Vargas G, Del Razo LM, Styblo M, Mendez MA. 2016. Association between variants in arsenic (+3 oxidation state) methyltranserase (AS3MT) and urinary metabolites of inorganic arsenic: role of exposure level. Toxicol Sci 153(1):112-123. doi:10.1093/toxsci/kfw112 PMID:27370415 PMCID:PMC5808745

2015

  • Laine JE, Bailey KA, Rubio-Andrade M, Olshan A, Smeester L, Drobna Z, Herring AH, Styblo M, Garcia-Vargas GG, Fry RC. 2015. Maternal arsenic exposure, arsenic methylation efficiency, and birth outcomes in the Biomarkers of Exposure to ARsenic (BEAR) pregnancy cohort in Mexico. Environ Health Perspect 123(2):186-192. doi:10.1289/ehp.1307476 PMID:25325819 PMCID:PMC4314242
  • Martin EA, Gonzalez-Horta C, Rager JE, Bailey KA, Sanchez-Ramirez B, Ballinas-Casarrubias L, Ishida MC, Gutierrez-Torres DS, Ceron RH, Morales DV, Baeza Terrazas FA, Saunders RJ, Drobna Z, Mendez MA, Buse JB, Loomis D, Jia W, Garcia-Vargas GG, Del Razo LM, Styblo M, Fry RC. 2015. Metabolomic characteristics of arsenic-associated diabetes in a prospective cohort in Chihuahua, Mexico. Toxicol Sci 144(2):338-346. doi:10.1093/toxsci/kfu318 PMID:25577196 PMCID:PMC4372663
  • Rager JE, Tilley SK, Tulenko SE, Smeester L, Ray PD, Yosim A, Currier JM, Ishida MC, del Carmen Gonzalez-Horta M, Sanchez-Ramirez B, Ballinas-Casarrubias L, Gutierrez-Torres DS, Drobna Z, Del Razo LM, Garcia-Vargas GG, Kim WY, Zhou Y, Wright FA, Styblo M, Fry RC. 2015. Identification of novel gene targets and putative regulators of arsenic-associated DNA methylation in human urothelial cells and bladder cancer. Chem Res Toxicol 28(6):1144-1155. doi:10.1021/tx500393y PMID:26039340 PMCID:PMC4748849
  • Rojas D, Rager JE, Smeester L, Bailey KA, Drobna Z, Rubio-Andrade M, Styblo M, Garcia-Vargas GG, Fry RC. 2015. Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci 143(1):97-106. doi:10.1093/toxsci/kfu210 PMID:25304211 PMCID:PMC4274382

2014

  • Bailey KA, Laine JE, Rager JE, Sebastian E, Olshan A, Smeester L, Drobna Z, Styblo M, Rubio-Andrade M, Garcia-Vargas GG, Fry RC. 2014. Prenatal arsenic exposure and shifts in the newborn proteome: interindividual differences in tumor necrosis factor (TNF)-responsive signaling. Toxicol Sci 139(2):328-337. doi:10.1093/toxsci/kfu053 PMID:24675094 PMCID:PMC4031624
  • Currier JM, Ishida MC, Gonzalez-Horta C, Sanchez-Ramirez B, Ballinas-Casarrubias L, Gutierrez-Torres DS, Ceron RH, Morales DV, Baeza Terrazas FA, Del Razo LM, Garcia-Vargas GG, Saunders RJ, Drobna Z, Fry RC, Matousek T, Buse JB, Mendez MA, Loomis D, Styblo M. 2014. Associations between arsenic species in exfoliated urothelial cells and prevalence of diabetes among residents of Chihuahua, Mexico. Environ Health Perspect 122(10):1088-1094. doi:10.1289/ehp.1307756 PMID:25000461 PMCID:PMC4181927

2003

  • Mure K, Uddin AN, Lopez LC, Styblo M, Rossman TG. 2003. Arsenite induces delayed mutagenesis and transformation in human osteosarcoma cells at extremely low concentrations. Environ Mol Mutagen 41(5):322-331. PMID:12802802
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