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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Person Details: Aruni Bhatnagar

Superfund Research Program

Aruni Bhatnagar

University of Louisville
Cardiovascular Innovation Institute
320 E. Muhammad Ali Blvd.
Louisville, Kentucky 40202-1756
Phone: 502-852-5966
Email: aruni@louisville.edu

Projects

Publications

2024

  • Xie Z, Sutaria S, Chen JY, Gao H, Conklin DJ, Keith RJ, Srivastava S, Lorkiewicz P, Bhatnagar A. 2024. Evaluation of urinary limonene metabolites as biomarkers of exposure to greenness. Environ Res 245:doi:10.1016/j.envres.2023.117991

2023

  • Agbonlahor O, DeJarnett N, Hart J, Bhatnagar A, McLeish AC, Walker KL. 2023. Racial/ethnic discrimination and cardiometabolic diseases: A systematic review. J Racial Ethn Health Disparities 1-25. doi:10.1007/s40615-023-01561-1 PMID:36976513 PMCID:PMC1004413
  • Basner M, Smith MG, Jones CW, Ecker AJ, Howard K, Schneller V, Cordoza M, Kaizi-Lutu M, Park-Chavar S, Stahn AC, Dinges DF, Shou H, Mitchell JA, Bhatnagar A, Smith T, Smith AE, Stopforth CK, Yeager R, Keith RJ. 2023. Associations of bedroom PM2.5, CO2, temperature, humidity, and noise with sleep: an observational actigraphy study. Sleep Health 9(3):253-263. doi:10.1016/j.sleh.2023.02.010 PMID:37076419 PMCID:PMC10293115
  • McGraw KE, Konkle S, Riggs DW, Rai SN, DeJarnett N, Xie Z, Keith RJ, Oshunbade A, Hall ME, Shimbo D, Bhatnagar A. 2023. Exposure to volatile organic compounds is associated with hypertension in Black adults: The Jackson Heart Study. Environ Res 223:115384. doi:10.1016/j.envres.2023.115384 PMID:36796615 PMCID:PMC10134439
  • Riggs DW, Baumgartner K, Baumgartner R, Boone S, Judd S, Bhatnagar A. 2023. Associations between residential greenness and risk of stroke by ecoregions: The REGARDS Study. Environ Int
  • Wahlang B, Gao H, Rai SN, Keith RJ, McClain CJ, Srivastava S, Cave MC, Bhatnagar A. 2023. Associations between residential volatile organic compound exposures and liver injury markers: The role of biological sex and race. Environ Res 221:115228. doi:10.1016/j.envres.2023.115228 PMID:36610539 PMCID:PMC9957966
  • Xie Z, Chen JY, Gao H, Keith RJ, Bhatnagar A, Lorkiewicz P, Srivastava S. 2023. Global profiling of urinary mercapturic acids using integrated library-guided analysis. Environ Sci Technol 57(29):10563-10573. doi:10.1021/acs.est.2c09554 PMID:37432892
  • Yeager R, Browning MH, Breyer E, Ossola A, Larson LR, Riggs DW, Rigolon A, Chandler C, Fleischer D, Keith RJ, Walker KL, Hart J, Smith T, Bhatnagar A. 2023. Greenness and equity: Complex connections between intra-neighborhood contexts and residential tree planting implementation. Environ Int 176:107955. doi:10.1016/j.envint.2023.107955 PMID:37196566 PMCID:PMC10367429

2022

  • Bhatnagar A. 2022. Cardiovascular effects of particulate air pollution. Annu Rev Med 73:393-406. doi:10.1146/annurev-med-042220-011549 PMID:34644154
  • Coleman CJ, Yeager R, Pond ZA, Riggs DW, Bhatnagar A, Pope III C. 2022. Mortality risk associated with greenness, air pollution, and physical activity in a representative US cohort. Sci Total Environ 824:doi:10.1016/j.scitotenv.2022.153848 PMID:35176374
  • Hart J, Yeager R, Riggs DW, Fleischer D, Owolabi U, Walker KL, Bhatnagar A, Keith RJ. 2022. The relationship between perceptions and objective measures of greenness. Int J Environ Res Public Health 19(23):16317. doi:10.3390/ijerph192316317 PMID:36498387 PMCID:PMC9736070
  • Lorkiewicz P, Keith RJ, Lynch J, Jin L, Theis W, Krivokhizhina T, Riggs D, Bhatnagar A, Srivastava S, Conklin DJ. 2022. Electronic cigarette solvents, JUUL e-liquids, and biomarkers of exposure: In vivo evidence for acrolein and glycidol in e-cig-derived aerosols. Chem Res Toxicol doi:10.1021/acs.chemrestox.1c00328 PMID:35044764
  • McLeish AC, Smith T, Riggs DW, Hart J, Walker KL, Keith RJ, Anderson L, Sithu ID, Pinilla-Baquero J, Srivastava S, Bhatnagar A. 2022. Community-based evaluation of the associations between well-being and cardiovascular disease risk. J Am Heart Assoc 11(22):e027095. doi:10.1161/JAHA.122.027095 PMID:36370026
  • Riggs DW, Malovichko MV, Gao H, McGraw KE, Taylor BS, Krivokhizhina T, Rai SN, Keith RJ, Bhatnagar A, Srivastava S. 2022. Environmental exposure to volatile organic compounds is associated with endothelial injury. Toxicol Appl Pharmacol 437:115877. doi:10.1016/j.taap.2022.115877 PMID:35045333
  • Shuck B, Hart J, Walker KL, Rai J, Srivastava S, Srivastava S, Rai SN, Bhatnagar A, Keith RJ. 2022. Workplace culture and biomarkers of health risk. Int J Environ Res Public Health 19(19):11920. doi:10.3390/ijerph191911920 PMID:36231223 PMCID:PMC9565767
  • Wahlang B, Gripshover T, Gao H, Krivokhizhina T, Keith RJ, Sithu ID, Rai SN, Bhatnagar A, McClain CJ, Srivastava S, Cave MC. 2022. Associations between residential exposure to volatile organic compounds and liver injury markers. Toxicol Sci 185(1):doi:10.1093/toxsci/kfab119 PMID:34668566 PMCID:PMC8714366

2021

  • Coleman CJ, Yeager R, Riggs DW, Coleman NC, Garcia GR, Bhatnagar A, Pope CA. 2021. Greenness, air pollution, and mortality risk: A US cohort study of cancer patients and survivors. Environ Int 157:106797. doi:10.1016/j.envint.2021.106797 PMID:34332301
  • Jin L, Lorkiewicz P, Xie Z, Bhatnagar A, Srivastava S, Conklin DJ. 2021. Acrolein but not its metabolite, 3-Hydroxypropylmercapturic acid (3HPMA), activates vascular transient receptor potential Ankyrin-1 (TRPA1): Physiological to toxicological implications. Toxicol Appl Pharmacol 426:115647. doi:10.1016/j.taap.2021.115647 PMID:34271065 PMCID:PMC8343963
  • Jin L, Lynch J, Richardson A, Lorkiewicz P, Srivastava S, Theis W, Shirk G, Hand A, Bhatnagar A, Srivastava S, Conklin DJ. 2021. Electronic cigarette solvents, pulmonary irritation and endothelial dysfunction: role of acetaldehyde and formaldehyde. Am J Physiol Heart Circ Physiol doi:10.1152/ajpheart.00878.2020 PMID:33543686
  • Malovichko MV, Abplanalp WT, McFall SA, Taylor BS, Wickramasinghe NS, Sithu ID, Zelko I, Uchida S, Hill BG, Sutaria S, Nantz MH, Bhatnagar A, Conklin DJ, O'Toole TE, Srivastava S. 2021. Subclinical markers of cardiovascular toxicity of benzene inhalation in mice. Toxicol Appl Pharmacol 431(9):115742. doi:10.1016/j.taap.2021.115742 PMID:34624356 PMCID:PMC8647905
  • McGraw KE, Riggs DW, Rai SN, Navas-Acien A, Xie Z, Lorkiewicz P, Lynch J, Zafar N, Krishnasamy SS, Taylor KC, Conklin DJ, DeFilippis A, Srivastava S, Bhatnagar A. 2021. Exposure to volatile organic compounds - acrolein, 1,3-butadiene, and crotonaldehyde - is associated with vascular dysfunction. Environ Res 196:110903. doi:10.1016/j.envres.2021.110903 PMID:33636185 PMCID:PMC8119348
  • Pfeiffer JA, Hart J, Wood LA, Bhatnagar A, Keith RJ, Yeager R, Smith T, Tomlinson M, Gilkey D, Kerstiens S, Gao H, Srivastava S, Walker KL. 2021. The importance of urban planning: Views of greenness and open space is reversely associated with self-reported views and depressive symptoms. Popul Med 3:20. doi:10.18332/popmed/139173 PMID:34368779 PMCID:PMC8341459
  • Riggs DW, Yeager R, Conklin DJ, DeJarnett N, Keith RJ, DeFilippis A, Rai SN, Bhatnagar A. 2021. Residential proximity to greenness mitigates the hemodynamic effects of ambient air pollution. Am J Physiol Heart Circ Physiol 320(3):doi:10.1152/ajpheart.00689.2020 PMID:33416460 (ahead of print)
  • Wood LA, Tomlinson M, Pfeiffer JA, Walker KL, Keith RJ, Smith T, Yeager R, Bhatnagar A, Kerstiens S, Gilkey D, Gao H, Srivastava S, Hart J. 2021. Time spent outdoors and sleep normality: A preliminary investigation. Popul Med 3:7. doi:10.18332/popmed/132119 PMID:34485920 PMCID:PMC8411876

2020

  • Keith RJ, Fetterman JL, Orimoloye OA, Dardari Z, Lorkiewicz P, Hamburg NM, DeFilippis A, Blaha MJ, Bhatnagar A. 2020. Characterization of volatile organic compound metabolites in cigarette smokers, electronic nicotine device users, dual users, and nonusers of tobacco. Nicotine Tob Res 22:264-272. doi:10.1093/ntr/ntz021 PMID:30759242 PMCID:PMC7297089
  • Konkle S, Zierold K, Taylor KC, Riggs DW, Bhatnagar A. 2020. National secular trends in ambient air volatile organic compound levels and biomarkers of exposure in the United States. Environ Res 182:10. doi:10.1016/j.envres.2019.108991 PMID:31835113
  • Riggs DW, Zafar N, Krishnasamy SS, Yeager R, Rai SN, Bhatnagar A, O'Toole TE. 2020. Exposure to airborne fine particulate matter is associated with impaired endothelial function and biomarkers of oxidative stress and inflammation. Environ Res 180:doi:10.1016/j.envres.2019.108890 PMID:31718786 PMCID:PMC6899204
  • Yeager R, Riggs DW, DeJarnett N, Srivastava S, Lorkiewicz P, Xie Z, Krivokhizhina T, Keith RJ, Srivastava S, Browning MH, Zafar N, Krishnasamy SS, DeFilippis A, Turner JR, Rai SN, Bhatnagar A. 2020. Association between residential greenness and exposure to volatile organic compounds. Sci Total Environ 707:doi:10.1016/j.scitotenv.2019.135435 PMID:31865083

2019

  • Abplanalp WT, Wickramasinghe NS, Sithu S, Conklin DJ, Xie Z, Bhatnagar A, Srivastava S, O'Toole TE. 2019. Benzene exposure induces insulin resistance in mice. Toxicol Sci 167(2):426-437. doi:10.1093/toxsci/kfy252 PMID:30346588 PMCID:PMC6358255
  • Conklin DJ, Guo Y, Nystoriak M, Jagatheesan G, Obal D, Kilfoil PJ, Hoetker JD, Guo L, Bolli R, Bhatnagar A. 2019. TRPA1 channel contributes to myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol 316:H889-H899. doi:10.1152/ajpheart.00106.2018 PMID:30735434 PMCID:PMC6483018
  • Conklin DJ, Schick SF, Blaha MJ, Carll AP, DeFilippis A, Ganz P, Hall MN, Hamburg NM, O'Toole TE, Reynolds LM, Srivastava S, Bhatnagar A. 2019. Cardiovascular injury induced by tobacco products: Assessment of risk factors and biomarkers of harm A Tobacco Center of Regulatory Science (TCORS) Compilation. Am J Physiol Heart Circ Physiol 316(4):H801-H827. doi:10.1152/ajpheart.00591.2018 PMID:30707616
  • Finch J, Riggs DW, O'Toole TE, Pope III C, Bhatnagar A, Conklin DJ. 2019. Acute exposure to air pollution is associated with novel changes in blood levels of endothelin-1 and circulating angiogenic cells in young, healthy adults. AIMS Environ Sci 6(4):265-276. doi:10.3934/environsci.2019.4.265

2018

  • Conklin DJ, Ogunwale M, Chen Y, Theis W, Nantz MH, Fu X, Chen L, Riggs DW, Lorkiewicz P, Bhatnagar A, Srivastava S. 2018. Electronic cigarette-generated aldehydes: the contribution of e-liquid components to their formation and the use of urinary aldehyde metabolites as biomarkers of exposure. Aerosol Science and Technology 52:1219-1232. doi:10.1080/02786826.2018.1500013
  • Lorkiewicz P, Riggs DW, Keith RJ, Conklin DJ, Xie Z, Sutaria S, Lynch BJ, Srivastava S, Bhatnagar A. 2018. Comparison of urinary biomarkers of exposure in humans using electronic cigarettes, combustible cigarettes, and smokeless tobacco. Nicotine Tob Res doi:10.1093/ntr/nty089 PMID:29868926
  • Riggs DW, Yeager R, Bhatnagar A. 2018. Defining the human envirome: an omics approach for assessing the environmental risk of cardiovascular disease. Circ Res 122:1259-1275. doi:10.1161/circresaha.117.311230 PMID:29700071 PMCID:PMC6398443
  • Xie Z, Lorkiewicz P, Riggs DW, Bhatnagar A, Srivastava S. 2018. Comprehensive, robust, and sensitive UPLC-MS/MS analysis of free biogenic monoamines and their metabolites in urine. J Chromatogr B Analyt Technol Biomed Life Sci 1099:83-91. doi:10.1016/j.jchromb.2018.09.012 PMID:30248561 PMCID:PMC6398444
  • Yeager R, Riggs DW, DeJarnett N, Tollerud DJ, Wilson J, Conklin DJ, O'Toole TE, McCracken J, Lorkiewicz P, Xie Z, Zafar N, Krishnasamy SS, Srivastava S, Finch J, Keith RJ, DeFilippis A, Rai SN, Liu G, Bhatnagar A. 2018. Association between residential greenness and cardiovascular disease risk. J Am Heart Assoc 7(24):e009117. doi:10.1161/JAHA.118.009117 PMID:30561265 PMCID:PMC6405613
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