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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Person Details: Shesh N. Rai

Superfund Research Program

Shesh N. Rai

University of Louisville
505 S. Hancock Street
CTR Building Room 211
Louisville, Kentucky 402021617
Phone: 502-852-4030
Email: shesh.rai@louisville.edu

Projects

Publications

2023

  • McGraw KE, Konkle S, Riggs DW, Rai SN, DeJarnett N, Xie Z, Keith RJ, Oshunbade A, Hall ME, Shimbo D, Bhatnagar A. 2023. Exposure to volatile organic compounds is associated with hypertension in Black adults: The Jackson Heart Study. Environ Res 223:115384. doi:10.1016/j.envres.2023.115384 PMID:36796615 PMCID:PMC10134439
  • Piell KM, Petri BJ, Head KZ, Wahlang B, Xu R, Zhang X, Pan J, Rai SN, Silva Kd, Chariker JH, Rouchka EC, Tan M, Li Y, Cave MC, Klinge CM. 2023. Disruption of the mouse liver epitranscriptome by long-term aroclor 1260 exposure. Environ Toxicol Pharmacol 100:104138. doi:10.1016/j.etap.2023.104138 PMID:37137421 PMCID:PMC10330322
  • Wahlang B, Gao H, Rai SN, Keith RJ, McClain CJ, Srivastava S, Cave MC, Bhatnagar A. 2023. Associations between residential volatile organic compound exposures and liver injury markers: The role of biological sex and race. Environ Res 221:115228. doi:10.1016/j.envres.2023.115228 PMID:36610539 PMCID:PMC9957966

2022

  • Bhattacharyya A, Pal S, Mitra R, Rai SN. 2022. Applications of Bayesian shrinkage prior models in clinical research with categorical responses. BMC Med Res Methodol doi:10.1186/s12874-022-01560-6 PMID:35484507 PMCID:PMC9046716
  • Cave MC, Pinkston CM, Rai SN, Wahlang B, Pavuk M, Head KZ, Carswell GK, Nelson GM, Klinge CM, Bell DA, Birnbaum LS, Chorley BN. 2022. Circulating microRNAs, polychlorinated biphenyls, and environmental liver disease in the Anniston Community Health Survey. Environ Health Perspect 130:doi:10.1289/EHP9467 PMID:34989596 PMCID:PMC8734566
  • Petri BJ, Piell KM, Wahlang B, Head KZ, Andreeva K, Rouchka EC, Pan J, Rai SN, Cave MC, Klinge CM. 2022. Multiomics analysis of the impact of polychlorinated biphenyls on environmental liver disease in a mouse model. Environ Toxicol Pharmacol 94:doi:10.1016/j.etap.2022.103928 PMID:35803474
  • Rai SN, Das S, Pan J, Mishra DC, Fu X. 2022. Multigroup prediction in lung cancer patients and comparative controls using signature of volatile organic compounds in breath samples. PLoS One 17(11):e0277431. doi:10.1371/journal.pone.0277431 PMID:36449484 PMCID:PMC9710764
  • Riggs DW, Malovichko MV, Gao H, McGraw KE, Taylor BS, Krivokhizhina T, Rai SN, Keith RJ, Bhatnagar A, Srivastava S. 2022. Environmental exposure to volatile organic compounds is associated with endothelial injury. Toxicol Appl Pharmacol 437:115877. doi:10.1016/j.taap.2022.115877 PMID:35045333
  • Shuck B, Hart J, Walker KL, Rai J, Srivastava S, Srivastava S, Rai SN, Bhatnagar A, Keith RJ. 2022. Workplace culture and biomarkers of health risk. Int J Environ Res Public Health 19(19):11920. doi:10.3390/ijerph191911920 PMID:36231223 PMCID:PMC9565767
  • Wahlang B, Gripshover T, Gao H, Krivokhizhina T, Keith RJ, Sithu ID, Rai SN, Bhatnagar A, McClain CJ, Srivastava S, Cave MC. 2022. Associations between residential exposure to volatile organic compounds and liver injury markers. Toxicol Sci 185(1):doi:10.1093/toxsci/kfab119 PMID:34668566 PMCID:PMC8714366

2021

  • Das S, Rai A, Merchant ML, Cave MC, Rai SN. 2021. A comprehensive survey of statistical approaches for differential expression analysis in single-cell RNA sequencing studies. Genes (Basel) 12(12):1947. doi:10.3390/genes12121947 PMID:34946896 PMCID:PMC8701051
  • Das S, Rai SN. 2021. SwarnSeq: An improved statistical approach for differential expression analysis of single-cell RNA-seq data. Genomics 113:1308-1324. doi:10.1016/j.ygeno.2021.02.014 PMID:33662531
  • Jin J, Wahlang B, Thapa M, Head KZ, Hardesty JE, Srivastava S, Merchant ML, Rai SN, Prough RA, Cave MC. 2021. Proteomics and metabolic phenotyping define principal roles for the aryl hydrocarbon receptor in mouse liver. Acta Pharm Sin B 11:3806-3819. doi:10.1016/j.apsb.2021.10.014 PMID:35024308 PMCID:PMC8727924
  • Klinge CM, Piell KM, Petri BJ, He L, Zhang X, Pan J, Rai SN, Andreeva K, Rouchka EC, Wahlang B, Beier JI, Cave MC. 2021. Combined exposure to polychlorinated biphenyls and high-fat diet modifies the global epitranscriptomic landscape in mouse liver. Environ Epigenet 7:doi:10.1093/eep/dvab008 PMID:34548932 PMCID:PMC8448424
  • Linder MW, Egger ME, Van Meter T, Rai SN, Valdes R, Hall MB, Wu X, Alghamdi N, Chesney JA. 2021. Longitudinal relationship between Idylla plasma ctBRAF V600 mutation detection and tumor burden in patients with metastatic melanoma. Mol Diagn Ther 25:361-371. doi:10.1007/s40291-021-00528-4 PMID:33970440
  • McGraw KE, Riggs DW, Rai SN, Navas-Acien A, Xie Z, Lorkiewicz P, Lynch J, Zafar N, Krishnasamy SS, Taylor KC, Conklin DJ, DeFilippis A, Srivastava S, Bhatnagar A. 2021. Exposure to volatile organic compounds - acrolein, 1,3-butadiene, and crotonaldehyde - is associated with vascular dysfunction. Environ Res 196:110903. doi:10.1016/j.envres.2021.110903 PMID:33636185 PMCID:PMC8119348
  • Riggs DW, Yeager R, Conklin DJ, DeJarnett N, Keith RJ, DeFilippis A, Rai SN, Bhatnagar A. 2021. Residential proximity to greenness mitigates the hemodynamic effects of ambient air pollution. Am J Physiol Heart Circ Physiol 320(3):doi:10.1152/ajpheart.00689.2020 PMID:33416460 (ahead of print)
  • Srivastava DK, George E, Lu Z, Rai SN. 2021. Impact of unequal censoring and insufficient follow-up on comparing survival outcomes: Applications to clinical studies. Stat Methods Med Res 30:PMID:34232837

2020

  • Jin J, Wahlang B, Shi H, Hardesty JE, Falkner KC, Head KZ, Srivastava S, Merchant ML, Rai SN, Cave MC, Prough RA. 2020. Dioxin-like and non-dioxin-like PCBs differentially regulate the hepatic proteome and modify diet-induced nonalcoholic fatty liver disease severity. Med Chem Res 29:1247-1263. doi:10.1007/s00044-020-02581-w
  • Rai SN, Qian C, Pan J, McClain CJ, McClain M, Eichenberger MR, Galandiuk S. 2020. Statistical issues and group classification in plasma microRNA studies with data application. Evol Bioinform 16:9. doi:10.1177/1176934320913338 PMID:32313420 PMCID:PMC7157974
  • Riggs DW, Zafar N, Krishnasamy SS, Yeager R, Rai SN, Bhatnagar A, O'Toole TE. 2020. Exposure to airborne fine particulate matter is associated with impaired endothelial function and biomarkers of oxidative stress and inflammation. Environ Res 180:doi:10.1016/j.envres.2019.108890 PMID:31718786 PMCID:PMC6899204
  • Yeager R, Riggs DW, DeJarnett N, Srivastava S, Lorkiewicz P, Xie Z, Krivokhizhina T, Keith RJ, Srivastava S, Browning MH, Zafar N, Krishnasamy SS, DeFilippis A, Turner JR, Rai SN, Bhatnagar A. 2020. Association between residential greenness and exposure to volatile organic compounds. Sci Total Environ 707:doi:10.1016/j.scitotenv.2019.135435 PMID:31865083

2019

2018

  • Clair HB, Pinkston CM, Rai SN, Pavuk M, Dutton ND, Brock GN, Prough RA, Falkner KC, McClain CJ, Cave MC. 2018. Liver disease in a residential cohort with elevated polychlorinated biphenyl exposures. Toxicol Sci 164:39-49. doi:10.1093/toxsci/kfy076 PMID:29684222 PMCID:PMC6016643
  • Yeager R, Riggs DW, DeJarnett N, Tollerud DJ, Wilson J, Conklin DJ, O'Toole TE, McCracken J, Lorkiewicz P, Xie Z, Zafar N, Krishnasamy SS, Srivastava S, Finch J, Keith RJ, DeFilippis A, Rai SN, Liu G, Bhatnagar A. 2018. Association between residential greenness and cardiovascular disease risk. J Am Heart Assoc 7(24):e009117. doi:10.1161/JAHA.118.009117 PMID:30561265 PMCID:PMC6405613
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