Superfund Research Program

David W. Hein

University of Louisville
505 S. Hancock Street
CTR Rm 303
Louisville, Kentucky 40292-0000
Phone: 502-852-6252
Email: d.hein@louisville.edu

Projects

• University of Louisville: Research Experience and Training Coordination Core (2022-2027)
• University of Louisville: Training Core (2017-2022)

Publications

2024

• Walls KM, Joh J, Hong KU, Hein DW. 2024. Heterocyclic amines disrupt lipid homeostasis in cryopreserved human hepatocytes. Cardiovasc Toxicol 24(8):747-756. doi:10.1007/s12012-024-09874-1 PMID:38851663

2023

• Habil MR, Hein DW. 2023. Effects of dose and human N-acetyltransferase 1 genetic polymorphism in benzidine metabolism and genotoxicity. Arch Toxicol doi:10.1007/s00204-023-03497-1 PMID:37097310 PMCID:PMC10192036
• Habil MR, Salazar-Gonzalez R, Doll MA, Hein DW. 2023. Effect of N-acetyltransferase 2 genetic polymorphism on 4,4'-methylenebis(2-chloroaniline)-induced genotoxicity and oxidative stress. Arch Toxicol 97(6):1773-1781. doi:10.1007/s00204-023-03508-1 PMID:37142755 PMCID:PMC10259506
• Hein DW, Salazar-Gonzalez R, Doll MA, Zang Y. 2023. The effect of the rs1799931 G857A (G286E) polymorphism on N-acetyltransferase 2-mediated carcinogen metabolism and genotoxicity differs with heterocyclic amine exposure. Arch Toxicol 97(10):2697-2705. doi:10.1007/s00204-023-03577-2 PMID:37592049
• Hong KU, Hein DW. 2023. N-acetyltransferase 2 haplotype modifies risks for both dyslipidemia and urinary bladder cancer. Pharmacogenet Genomics doi:10.1097/FPC.0000000000000500 PMID:37306342
• Walls KM, Hong KU, Hein DW. 2023. Heterocyclic amines reduce insulin-induced AKT phosphorylation and induce gluconeogenic gene expression in human hepatocytes. Arch Toxicol doi:10.1007/s00204-023-03488-2 PMID:37005939 PMCID:PMC10192068
• Walls KM, Hong KU, Hein DW. 2023. Induction of glucose production by heterocyclic amines is dependent on N-acetyltransferase 2 genetic polymorphism in cryopreserved human hepatocytes. Toxicol Lett 383:192-195. doi:10.1016/j.toxlet.2023.07.002 PMID:37423373
• Wise JT, Yin X, Ma X, Zhang X, Hein DW. 2023. Stable isotope tracing reveals an altered fate of glucose in n-acetyltransferase 1 knockout breast cancer cells. Genes (Basel) 14(4):843. doi:10.3390/genes14040843 PMID:37107601 PMCID:PMC1013786

2022

• Doll MA, Hein DW. 2022. 560G A (rs4986782) (R187Q) Single nucleotide polymorphism in arylamine N-acetyltransferase 1 increases affinity for the aromatic amine carcinogens 4-aminobiphenyl and N-hydroxy-4-aminobiphenyl: Implications for cancer risk assessment. Front Pharmacol doi:10.3389/fphar.2022.820082 PMID:35273499 PMCID:PMC8902414
• Habil MR, Doll MA, Hein DW. 2022. Acetyl coenzyme A kinetic studies on N-acetylation of environmental carcinogens by human N-acetyltransferase 1 and its NAT1*14B variant. Front Pharmacol 13:931323. doi:10.3389/fphar.2022.931323 PMID:36386142 PMCID:PMC9650386
• Habil MR, Salazar-Gonzalez R, Doll MA, Hein DW. 2022. Differences in beta-naphthylamine metabolism and toxicity in Chinese hamster ovary cell lines transfected with human CYP1A2 and NAT2*4, NAT2*5B or NAT2*7B N-acetyltransferase 2 haplotypes. Arch Toxicol doi:10.1007/s00204-022-03367-2 PMID:36040704
• Habil MR, Salazar-Gonzalez R, Doll MA, Hein DW. 2022. N-acetyltransferase 2 acetylator genotype-dependent N-acetylation and toxicity of the arylamine carcinogen beta-naphthylamine in cryopreserved human hepatocytes. Arch Toxicol doi:10.1007/s00204-022-03381-4 PMID:36112171
• Hein DW, Doll MA, Habil MR. 2022. Human N-acetyltransferase 1 and 2 differ in affinity towards acetyl-coenzyme A cofactor and N-hydroxy-arylamine carcinogens. Front Pharmacol doi:10.3389/fphar.2022.821133 PMID:35281898 PMCID:PMC8914035
• Wise JT, Salazar-Gonzalez R, Habil MR, Doll MA, Hein DW. 2022. Expression of arylamine N-acetyltransferase 2 activity in immortalized human bronchial epithelial cells. Toxicol Appl Pharmacol 442:115993. doi:10.1016/j.taap.2022.115993 PMID:35353990
• Wise JT, Salazar-Gonzalez R, Walls KM, Doll MA, Habil MR, Hein DW. 2022. Hexavalent chromium increases the metabolism and genotoxicity of aromatic amine carcinogens 4-aminobiphenyl and B-naphthylamine in immortalized human lung epithelial cells. Toxicol Appl Pharmacol 449:doi:10.1016/j.taap.2022.116095 PMID:35662664

2020

• Hong KU, Doll MA, Lykoudi A, Salazar-Gonzalez R, Habil MR, Walls KM, Bakr AF, Ghare S, Barve S, Arteel GE, Hein DW. 2020. Acetylator genotype-dependent dyslipidemia in rats congenic for N-acetyltransferase 2. Toxicol Rep 7:1319-1330. doi:10.1016/j.toxrep.2020.09.011 PMID:33083237 PMCID:PMC7553889
• Leggett CS, Doll MA, States JC, Hein DW. 2020. Acetylation of putative arylamine and alkylaniline carcinogens in immortalized human fibroblasts transfected with rapid and slow acetylator N-acetyltransferase 2 haplotypes. Arch Toxicol 95:doi:10.1007/s00204-020-02901-4 PMID:33136180

2019

• Hein DW, Habil MR, Doll MA. 2019. N-acetyltransferase 2 acetylator genotype-dependent N-acetylation of 4-aminobiphenyl in cryopreserved human hepatocytes. Pharmacogenet Genomics 30(3):doi:10.1097/fpc.0000000000000394 PMID:31895247 (ahead of print)
• Salazar-Gonzalez R, Zhang X, Doll MA, Lykoudi A, Hein DW. 2019. Role of the human N-acetyltransferase 2 genetic polymorphism in metabolism and genotoxicity of 4, 4'-methylenedianiline. Arch Toxicol 93(8):2237-2246. doi:10.1007/s00204-019-02516-4 PMID:31292670 PMCID:PMC6713601

2018

• Hein DW, Zhang X, Doll MA. 2018. Role of N-acetyltransferase 2 acetylation polymorphism in 4, 4'-methylene bis (2-chloroaniline) biotransformation. Toxicol Lett 283:100-105. doi:10.1016/j.toxlet.2017.11.028 PMID:29180287 PMCID:PMC5745265