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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Person Details: Matthew C. Cave

Superfund Research Program

Matthew C. Cave

University of Louisville
505 S. Hancock Street
CTR509
Louisville, Kentucky 40202-1617
Phone: 502-852-6189
Email: m0cave01@louisville.edu

Projects

Publications

2024

2023

  • Bolatimi OE, Head KZ, Luo J, Gripshover T, Lin Q, Adiele NV, Watson WH, Wilkerson C, Cai L, Cave MC, Young JL. 2023. Can zinc supplementation attenuate high fat diet-induced non-alcoholic fatty liver disease?. Int J Mol Sci 24(2):1763. doi:10.3390/ijms24021763 PMID:36675277 PMCID:PMC9864360
  • Ge Y, Bruno M, Nash MS, Coates NH, Chorley BN, Cave MC, Beier JI. 2023. Vinyl chloride enhances high-fat diet-induced proteome alterations in the mouse pancreas related to metabolic dysfunction. Toxicol Sci 193(1):103-114. doi:10.1093/toxsci/kfad024 PMID:36892438 PMCID:PMC10176240
  • Groswald AM, Gripshover T, Watson WH, Wahlang B, Luo J, Jophlin LL, Cave MC. 2023. Investigating the acute metabolic effects of the N-methyl carbamate insecticide, methomyl, on mouse liver. Metabolites 13(8):901. doi:10.3390/metabo13080901 PMID:37623845 PMCID:PMC10456691
  • Head KZ, Bolatimi OE, Gripshover T, Tan M, Li Y, Audam TN, Jones SP, Klinge CM, Cave MC, Wahlang B. 2023. Investigating the effects of long-term Aroclor 1260 exposure on fatty liver disease in a diet-induced obesity mouse model. Front Gastroenterol 2:1180712. doi:10.3389/fgstr.2023.1180712 PMID:37426695 PMCID:PMC10327714
  • Hopkins CD, Wessel C, Chen O, El-Kersh K, Cave MC, Cai L, Huang J. 2023. Potential roles of metals in the pathogenesis of pulmonary and systemic hypertension. Int J Biol Sci 19(16):5036-5054. doi:10.7150/ijbs.85590 PMID:37928257 PMCID:PMC10620830
  • Liu S, He L, Bannister OB, Li J, Schnegelberger RD, Vanderpuye C, Althouse AD, Schopfer FJ, Wahlang B, Cave MC, Monga SP, Zhang X, Arteel GE, Beier JI. 2023. Western diet unmasks transient low-level vinyl chloride-induced tumorigenesis; potential role of the (epi-)transcriptome. Toxicol Appl Pharmacol 468:116514. doi:10.1016/j.taap.2023.116514 PMID:37061008 PMCID:PMC1016411
  • Nault R, Cave MC, Ludewig G, Moseley HN, Pennell KG, Zacharewski TR. 2023. A case for accelerating standards to achieve the FAIR principles of environmental health research experimental data. Environ Health Perspect 131(6):65001. doi:10.1289/EHP11484 PMID:37352010 PMCID:PMC10289218
  • Pavuk M, Rosenbaum PF, Lewin M, Serio TC, Rago P, Cave MC, Birnbaum LS. 2023. Polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, pesticides, and diabetes in the Anniston Community Health Survey follow-up (ACHS II): single exposure and mixture analysis approaches. Sci Total Environ 877:162920. doi:10.1016/j.scitotenv.2023.162920 PMID:36934946
  • Petri BJ, Cave MC, Klinge CM. 2023. Changes in m6A in steatotic liver disease. Genes (Basel) 14(8):1653. doi:10.3390/genes14081653 PMID:37628704 PMCID:PMC10454815
  • Petri BJ, Piell KM, Wahlang B, Head KZ, Andreeva K, Rouchka EC, Cave MC, Klinge CM. 2023. Polychlorinated biphenyls alter hepatic m6A mRNA methylation in a mouse model of environmental liver disease. Environ Res 216:114686. doi:10.1016/j.envres.2022.114686 PMID:36341798 PMCID:PMC10120843
  • Petri BJ, Piell KM, Wahlang B, Head KZ, Rouchka EC, Park JW, Hwang JY, Banerjee M, Cave MC, Klinge CM. 2023. Altered splicing factor and alternative splicing events in a mouse model of diet- and polychlorinated biphenyl-induced liver disease. Environ Toxicol Pharmacol 103:104260. doi:10.1016/j.etap.2023.104260 PMID:37683712 PMCID:PMC10591945
  • Piell KM, Petri BJ, Head KZ, Wahlang B, Xu R, Zhang X, Pan J, Rai SN, Silva Kd, Chariker JH, Rouchka EC, Tan M, Li Y, Cave MC, Klinge CM. 2023. Disruption of the mouse liver epitranscriptome by long-term aroclor 1260 exposure. Environ Toxicol Pharmacol 100:104138. doi:10.1016/j.etap.2023.104138 PMID:37137421 PMCID:PMC10330322
  • Wahlang B, Gao H, Rai SN, Keith RJ, McClain CJ, Srivastava S, Cave MC, Bhatnagar A. 2023. Associations between residential volatile organic compound exposures and liver injury markers: The role of biological sex and race. Environ Res 221:115228. doi:10.1016/j.envres.2023.115228 PMID:36610539 PMCID:PMC9957966

2022

  • Cave MC, Pinkston CM, Rai SN, Wahlang B, Pavuk M, Head KZ, Carswell GK, Nelson GM, Klinge CM, Bell DA, Birnbaum LS, Chorley BN. 2022. Circulating microRNAs, polychlorinated biphenyls, and environmental liver disease in the Anniston Community Health Survey. Environ Health Perspect 130:doi:10.1289/EHP9467 PMID:34989596 PMCID:PMC8734566
  • Gripshover T, Wahlang B, Head KZ, Young JL, Luo J, Mustafa mT, Kirpich IA, Cave MC. 2022. The environmental pollutant, polychlorinated biphenyl 126, alters liver function in a rodent model of alcohol-associated liver disease. Alcohol Clin Exp Res doi:10.1111/acer.14976 PMID:36377258
  • Heindel JJ, Howard S, Agay-Shay K, Arrebola J, Audouze K, Babin P, Barouki R, Bansal A, Blanc E, Cave MC, Chatterjee S, Chevalier N, Choudhury M, Collier D, Connolly L, Coumoul X, Garruti G, Gilbertson M, Hoepner L, Holloway A, Howell G, Kassotis CD, Kay M, Kim MJ, Lagadic-Gossmann D, Langouet S, Legrand A, Li Z, Mentec H, Lind L, Lind PM, Lustig R, Martin-Chouly C, Kos VM, Podechard N, Roepke T, Sargis R, Starling AP, Tomlinson CR, Touma C, Vondracek J, vom Saal FS, Blumberg B. 2022. Obesity II: Establishing causal links between chemical exposures and obesity. Biochem Pharmacol doi:10.1016/j.bcp.2022.115015 PMID:35395240 PMCID:PMC9124454
  • Lustig R, Collier D, Kassotis CD, Roepke T, Kim MJ, Blanc E, Barouki R, Bansal A, Cave MC, Chatterjee S, Choudhury M, Gilbertson M, Lagadic-Gossmann D, Howard S, Lind L, Tomlinson CR, Vondracek J, Heindel JJ. 2022. Obesity I: Overview and molecular and biochemical mechanisms. Biochem Pharmacol 199:doi:10.1016/j.bcp.2022.115012 PMID:35393120 PMCID:PMC9050949
  • Petri BJ, Piell KM, Wahlang B, Head KZ, Andreeva K, Rouchka EC, Pan J, Rai SN, Cave MC, Klinge CM. 2022. Multiomics analysis of the impact of polychlorinated biphenyls on environmental liver disease in a mouse model. Environ Toxicol Pharmacol 94:doi:10.1016/j.etap.2022.103928 PMID:35803474
  • Petriello MC, Mottaleb MA, Serio TC, Balyan B, Cave MC, Birnbaum LS, Morris AJ. 2022. Serum concentrations of legacy and emerging per- and polyfluoroalkyl substances in the Anniston Community Health Surveys (ACHS I and ACHS II). Environ Int 158:106907. doi:10.1016/j.envint.2021.106907 PMID:34763231
  • Wahlang B, Gripshover T, Gao H, Krivokhizhina T, Keith RJ, Sithu ID, Rai SN, Bhatnagar A, McClain CJ, Srivastava S, Cave MC. 2022. Associations between residential exposure to volatile organic compounds and liver injury markers. Toxicol Sci 185(1):doi:10.1093/toxsci/kfab119 PMID:34668566 PMCID:PMC8714366
  • Young JL, Cave MC, Xu Q, Kong M, Xu J, Lin Q, Tan Y, Cai L. 2022. Whole life exposure to low dose cadmium alters diet-induced NAFLD. Toxicol Appl Pharmacol 436:doi:10.1016/j.taap.2021.115855 PMID:34990729 PMCID:PMC8796138

2021

  • Das S, Rai A, Merchant ML, Cave MC, Rai SN. 2021. A comprehensive survey of statistical approaches for differential expression analysis in single-cell RNA sequencing studies. Genes (Basel) 12(12):1947. doi:10.3390/genes12121947 PMID:34946896 PMCID:PMC8701051
  • Guardiola JJ, Hardesty JE, Beier JI, Prough RA, McClain CJ, Cave MC. 2021. Plasma metabolomics analysis of polyvinyl chloride workers identifies altered processes and candidate biomarkers for hepatic hemangiosarcoma and its development. Int J Mol Sci 22:doi:10.3390/ijms22105093 PMID:34065028 PMCID:PMC8150673
  • Hardesty JE, Wahlang B, Prough RA, Head KZ, Wilkey D, Merchant ML, Shi H, Jin J, Cave MC. 2021. Effect of epidermal growth factor treatment and polychlorinated biphenyl exposure in a dietary-exposure mouse model of steatohepatitis. Environ Health Perspect 129:37010. doi:10.1289/EHP8222 PMID:33788613 PMCID:PMC8011667
  • Jin J, Wahlang B, Thapa M, Head KZ, Hardesty JE, Srivastava S, Merchant ML, Rai SN, Prough RA, Cave MC. 2021. Proteomics and metabolic phenotyping define principal roles for the aryl hydrocarbon receptor in mouse liver. Acta Pharm Sin B 11:3806-3819. doi:10.1016/j.apsb.2021.10.014 PMID:35024308 PMCID:PMC8727924
  • Klinge CM, Piell KM, Petri BJ, He L, Zhang X, Pan J, Rai SN, Andreeva K, Rouchka EC, Wahlang B, Beier JI, Cave MC. 2021. Combined exposure to polychlorinated biphenyls and high-fat diet modifies the global epitranscriptomic landscape in mouse liver. Environ Epigenet 7:doi:10.1093/eep/dvab008 PMID:34548932 PMCID:PMC8448424
  • Wahlang B, Alexander II NC, Li X, Rouchka EC, Kirpich IA, Cave MC. 2021. Polychlorinated biphenyls altered gut microbiome in CAR and PXR knockout mice exhibiting toxicant-associated steatohepatitis. Toxicol Rep 8:doi:10.1016/j.toxrep.2021.03.010 PMID:33777700 PMCID:PMC7985695
  • Zelko I, Taylor BS, Das TP, Watson WH, Sithu ID, Wahlang B, Malovichko MV, Cave MC, Srivastava S. 2021. Effect of vinyl chloride exposure on cardiometabolic toxicity. Environ Toxicol 37(2):245-255. doi:10.1002/tox.23394 PMID:34717031 PMCID:PMC8724461

2020

  • Cave MC. 2020. Environmental Pollution and the Developmental Origins of Childhood Liver Disease. Hepatology 72:1518-1521. doi:10.1002/hep.31549 PMID:32910501
  • Jin J, Wahlang B, Shi H, Hardesty JE, Falkner KC, Head KZ, Srivastava S, Merchant ML, Rai SN, Cave MC, Prough RA. 2020. Dioxin-like and non-dioxin-like PCBs differentially regulate the hepatic proteome and modify diet-induced nonalcoholic fatty liver disease severity. Med Chem Res 29:1247-1263. doi:10.1007/s00044-020-02581-w
  • Werder EJ, Beier JI, Sandler DP, Falkner K, Gripshover T, Wahlang B, Engel LS, Cave MC. 2020. Blood BTEXS and heavy metal levels are associated with liver injury and systemic inflammation in Gulf states residents. Food Chem Toxicol 139:doi:10.1016/j.fct.2020.111242 PMID:32205228

2019

  • Bassler J, Ducatman A, Elliott M, Wen S, Wahlang B, Barnett J, Cave MC. 2019. Environmental perfluoroalkyl acid exposures are associated with liver disease characterized by apoptosis and altered serum adipocytokines. Environ Pollut 247:1055-1063. doi:10.1016/j.envpol.2019.01.064 PMID:30823334 PMCID:PMC6404528
  • Hardesty JE, Wahlang B, Falkner KC, Shi H, Jin J, Wilkey D, Merchant ML, Watson C, Prough RA, Cave MC. 2019. Hepatic signalling disruption by pollutant polychlorinated biphenyls in steatohepatitis. Cell Signal 53:132-139. doi:10.1016/j.cellsig.2018.10.004 PMID:30300668 PMCID:PMC6289731
  • Hardesty JE, Wahlang B, Falkner KC, Shi H, Jin J, Zhou Y, Wilkey D, Merchant ML, Watson C, Feng W, Morris AJ, Hennig B, Prough RA, Cave MC. 2019. Proteomic analysis reveals novel mechanisms by which polychlorinated biphenyls compromise the liver promoting diet-induced steatohepatitis. J Proteome Res 18(4):1582-1594. doi:10.1021/acs.jproteome.8b00886 PMID:30807179 PMCID:PMC7059562
  • Shi H, Hardesty JE, Jin J, Head KZ, Cave MC, Prough RA. 2019. Concentration dependence of human and mouse aryl hydrocarbon receptor responsiveness to polychlorinated biphenyl exposures: Implications for aroclor mixtures. Xenobiotica 1-9. doi:10.1080/00498254.2019.1566582 PMID:30991879
  • Shi H, Jan J, Hardesty JE, Falkner KC, Prough RA, Balamurugan AN, Mokshagundam S, Chari ST, Cave MC. 2019. Polychlorinated biphenyl exposures differentially regulate hepatic metabolism and pancreatic function: Implications for nonalcoholic steatohepatitis and diabetes. Toxicol Appl Pharmacol 363:22-33. doi:10.1016/j.taap.2018.10.011 PMID:30312631
  • Wahlang B, Appana S, Falkner KC, McClain CJ, Brock GN, Cave MC. 2019. Insecticide and metal exposures are associated with a surrogate biomarker for non-alcoholic fatty liver disease in the National Health and Nutritional Examination Survey 2003-2004. Environ Sci Pollut Res Int 6(4):265-276. doi:10.1007/s11356-019-07066-x PMID:31873887
  • Wahlang B, Hardesty JE, Head KZ, Jin J, Falkner K, Prough RA, Cave MC, Beier JI. 2019. Hepatic injury caused by the environmental toxicant vinyl chloride is sex-dependent in mice. Toxicol Sci 174(1):79-91. doi:10.1093/toxsci/kfz236 PMID:31774537 PMCID:PMC7043220
  • Wahlang B, Hardesty JE, Jin J, Falkner K, Cave MC. 2019. Polychlorinated biphenyls and nonalcoholic fatty liver disease. Curr Opin Toxicol 14:21-28. doi:10.1016/j.cotox.2019.06.001
  • Wahlang B, Jin J, Beier JI, Hardesty JE, Daly EF, Schnegelberger RD, Falkner KC, Prough RA, Kirpich IA, Cave MC. 2019. Mechanisms of environmental contributions to fatty liver disease. Curr Environ Health Rep 6:80-94. doi:10.1007/s40572-019-00232-w PMID:31134516 PMCID:PMC6698418
  • Wahlang B, Jin J, Hardesty JE, Head KZ, Shi H, Falkner KC, Prough RA, Klinge CM, Cave MC. 2019. Identifying sex differences arising from polychlorinated biphenyl exposures in toxicant-associated liver disease. Food Chem Toxicol 129:64-76. doi:10.1016/j.fct.2019.04.007 PMID:31026535 PMCID:PMC6555661

2018

  • Clair HB, Pinkston CM, Rai SN, Pavuk M, Dutton ND, Brock GN, Prough RA, Falkner KC, McClain CJ, Cave MC. 2018. Liver disease in a residential cohort with elevated polychlorinated biphenyl exposures. Toxicol Sci 164:39-49. doi:10.1093/toxsci/kfy076 PMID:29684222 PMCID:PMC6016643
  • Hardesty JE, Al-Eryani L, Wahlang B, Falkner KC, Shi H, Jin J, Vivace BJ, Ceresa BP, Prough RA, Cave MC. 2018. Epidermal growth factor receptor signaling disruption by endocrine and metabolic disrupting chemicals. Toxicol Sci 162:622-634. doi:10.1093/toxsci/kfy004 PMID:29329451 PMCID:PMC5888991
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