Superfund Research Program

Geoffrey D. Bothun

University of Rhode Island
203 Crawford Hall
16 Greenhouse Road
Kingston, Rhode Island 02881-2018
Phone: 401-874-9518
Email: bothun@egr.uri.edu

Projects

• University of Rhode Island: Mechanisms of Exposure (2022-2027)
• University of Rhode Island: PFAS Compound Effects on Metabolic Abnormalities in Rodents (2017-2022)

Publications

2024

• Alesio J, Bothun GD. 2024. Differential scanning fluorimetry to assess PFAS binding to bovine serum albumin protein. Sci Rep 14(1):6501. doi:10.1038/s41598-024-57140-9 PMID:38499613

2022

• Marques E, Pfohl M, Wei W, Tarantola G, Ford L, Amaeze O, Alesio J, Ryu S, Jia X, Zhu H, Bothun GD, Slitt AL. 2022. Replacement per- and polyfluoroalkyl substances (PFAS) are potent modulators of lipogenic and drug metabolizing gene expression signatures in primary human hepatocytes. Toxicol Appl Pharmacol 442:115991. doi:10.1016/j.taap.2022.115991 PMID:35337807 PMCID:PMC9036616
• Naumann A, Alesio J, Poonia M, Bothun GD. 2022. PFAS fluidize synthetic and bacterial lipid monolayers based on hydrophobicity and lipid charge. J Environ Chem Eng 10:107351. doi:10.1016/j.jece.2022.107351 PMID:35463622 PMCID:PMC9029377

2021

• Alesio J, Slitt AL, Bothun GD. 2021. Critical new insights into the binding of poly- and perfluoroalkyl substances (PFAS) to albumin protein. Chemosphere 287(Pt1):131979. doi:10.1016/j.chemosphere.2021.131979 PMID:34450368 (ahead of print)
• Fedorenko M, Alesio J, Fedorenko A, Slitt AL, Bothun GD. 2021. Dominant entropic binding of perfluoroalkyl substances (PFASs) to albumin protein revealed by 19 F NMR. Chemosphere 263(9):doi:10.1016/j.chemosphere.2020.128083 PMID:33297081