Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Person Details: David J. Waxman

Superfund Research Program

David J. Waxman

Boston University
5 Cummington Street
Boston, Massachusetts 02215
Phone: 617-353-7401
Fax: 617-353-7404
Email: djw@bu.edu

Projects

Research Briefs

Publications

2011

2010

2009

2008

  • Bagchi G, Waxman DJ. 2008. Toxicity of ethylene glycol monomethyl ether: impact on testicular gene expression. Int J Androl 31(2):269-274. doi:10.1111/j.1365-2605.2007.00846.x PMID:18179559 PMCID:PMC3286123
  • Holloway MG, Miles GD, Dombkowski AA, Waxman DJ. 2008. Liver-Specific Hepatocyte Nuclear Factor-4α Deficiency: Greater Impact on Gene Expression in Male than in Female Mouse Liver. Mol Endocrinol 22(5):1274-1286. doi:10.1210/me.2007-0564 PMID:18276827 PMCID:PMC2366185
  • Johnston TP, Waxman DJ. 2008. Circulating free fatty acids are increased independently of PPARgamma activity after administration of poloxamer 407 to mice. Can J Physiol Pharmacol 86(9):643-649. doi:10.1139/y08-070 PMID:18758514 PMCID:PMC2615679
  • Johnston TP, Waxman DJ. 2008. Peroxisome proiiferator-actlvated receptor (PPAR) agonists: using a mouse model of atherogenic dyslipidemia to better understand the PPAR-LXR-ABCA1 signaling pathway for accelerating cholesterol elimination. In: 22nd Ann Mtg Amer Assoc Pharm Sci.
  • Johnston TP, Waxman DJ. 2008. The induction of atherogenic dyslipidaemia in poloxamer 407-treated mice is not mediated through PPARalpha. J Pharm Pharmacol 60(6):753-759. doi:10.1211/jpp.60.6.0011 PMID:18498712 PMCID:PMC2496925
  • Waxman DJ, Chang TK. 2008. Nuclear receptor regulation of hepatic cytochrome P450 enzymes. In: Encyclopedia of Molecular Pharmacology (2nd ed.). Springer, pp.889-893.

2007

  • Clodfelter KH, Miles GD, Wauthier V, Holloway MG, Zhang X, Hodor P, Ray WJ, Waxman DJ. 2007. Role of STAT5a in regulation of sex-specific gene expression in female but not male mouse liver revealed by microarray analysis. Physiol Genomics 31:63-74. PMID:17536022
  • Ma X, Idle JR, Malfatti MA, Krausz KW, Nebert DW, Chen C, Felton JS, Waxman DJ, Gonzalez FJ. 2007. Mouse lung CYP1A1 catalyzes the metabolic activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Carcinogenesis 28(3):732-737. doi:10.1093/carcin/bgl184 PMID:17052995 PMCID:PMC1829392
  • Sun L, Chen C, Waxman DJ, Liu H, Halpert JR, Kumar S. 2007. Re-engineering cytochrome P450 2B11dH for enhanced metabolism of several substrates including the anti-cancer prodrugs cyclophosphamide and ifosfamide. Arch Biochem Biophys 458(2):167-174. doi:10.1016/j.abb.2006.12.021 PMID:17254539 PMCID:PMC1805465

2006

  • Chang TK, Crespi CL, Waxman DJ. 2006. Spectrophotometric analysis of human CYP2E1-catalyzed p-nitrophenol hydroxylation. Methods Mol Biol 320:127-131. doi:10.1385/1-59259-998-2:127 PMID:14577224
  • Chang TK, Crespi CL, Waxman DJ. 2006. Spectrophotometric analysis of human CYP2E1-catalyzed p-nitrophenol hydroxylation. In: Methods in Molecular Biology, Vol 320. Humana Press, Inc, Louisville, KY. pp.127-131.
  • Chang TK, Waxman DJ. 2006. Catalytic assays for human cytochrome P450. In: Methods in Molecular Biology, Vol 320. Humana Press, Inc, Louisville, KY. pp.73-83.
  • Chang TK, Waxman DJ. 2006. Enzymatic analysis of cDNA-expressed human CYP1A1, CYP1A2 and CYP1B1 with 7-ethoxyresorufin as substrate. In: Methods in Molecular Biology, Vol 320. Humana Press, Inc, Louisville, KY. pp.85-90.
  • Chang TK, Waxman DJ. 2006. Synthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and pregnane X receptor (PXR). J Mol Biol 38(1-2):51-73. PMID:16684648
  • Clodfelter KH, Holloway MG, Hodor P, Park S, Ray WJ, Waxman DJ. 2006. Sex-dependent liver gene expression is extensive and largely dependent upon signal transducer and activator of transcription 5b (STAT5b): STAT5b-dependent activation of male genes and repression of female genes revealed by microarray analysis. Mol Endocrinol 20(6):1333-1351. doi:10.1210/me.2005-0489 PMID:16469768
  • Clodfelter KH, Waxman DJ, Vajda S. 2006. Computational solvent mapping reveals the importance of local conformational changes for broad substrate specificity in mammalian cytochromes P450. Biochemistry 45(31):9393-407. PMID:16878974
  • Crespi CL, Chang TK, Waxman DJ. 2006. CYP2D6-dependent bufuralol 1'-hydroxylation assayed by reversed-phase ion-pair high performance liquid chromatography with fluorescence detection. In: Methods in Molecular Biology, Vol 320. Humana Press, Inc, Louisville, KY. pp.121-125.
  • Kaya T, Mohr SC, Waxman DJ, Vajda S. 2006. Computational screening of phthalate monoesters for binding to PPARgamma. Chem Res Toxicol 19(8):999-1009. doi:10.1021/tx050301s PMID:16918238
  • Shipley JM, Waxman DJ. 2006. Aryl hydrocarbon receptor-independent activation of estrogen receptor-dependent transcription by 3-methycholanthrene. Toxicol Appl Pharmacol 213(2):87-97. PMID:16257430
  • Waxman DJ, Chang TK. 2006. Use of 7-ethoxycoumarin to monitor multiple enzymes in the human CYP1, CYP2 and CYP3 families. In: Methods in Molecular Biology, Vol 320. Humana Press, Inc, Louisville, KY. pp.153-156.
  • Waxman DJ, Chang TK. 2006. Use of 7-ethoxycoumarin to monitor multiple enzymes in the human CYP1, CYP2, and CYP3 families. Methods Mol Biol 320:153-156. doi:10.1385/1-59259-998-2:153 PMID:14577228

2005

  • Chang TK, Waxman DJ. 2005. Pregnane X receptor-mediated transcription. Methods Enzymol 400:588-598. doi:10.1016/S0076-6879(05)00033-9 PMID:16399372
  • Hurst CH, Waxman DJ. 2005. Interactions of endocrine-active environmental chemicals with the nuclear receptor PXR. Toxicol Sci 87:299-311.
  • Kumar S, Chen C, Waxman DJ, Halpert JR. 2005. Directed evolution of mammalian cytochrome P450 2B1: mutations outside of the active site enhance the metabolism of several substrates, including the anticancer prodrugs cyclophosphamide and ifosfamide. J Biol Chem 280(20):19569-19575. doi:10.1074/jbc.M500158200 PMID:15774478
  • Sheu S, Kaya T, Waxman DJ, Vajda S. 2005. Exploring the binding site structure of the PPAR gamma ligand-binding domain by computational solvent mapping. Biochemistry 44(4):1193-1209. doi:10.1021/bi048032c PMID:15667213

2004

  • Ahluwalia A, Clodfelter KH, Waxman DJ. 2004. Sexual dimorphism of rat liver gene expression: Regulatory role of growth hormone revealed by deoxyribonucleic acid microarray analysis. Mol Endocrinol 18(3):747-760. PMID:14684848
  • Clodfelter KH, Waxman DJ. 2004. Computational solvent mapping reveals major differences in substrate binding between bacterial and mammalian cytochrome. In: Proceedings of the New England Member Enzyme Conference.
  • Hurst CH, Waxman DJ. 2004. Environmental phthalate monoesters activate pregnane X receptor-mediated transcription. Toxicol Appl Pharmacol 199(3):266-274. PMID:15364542
  • Schlezinger JJ, Howard G, Hurst CH, Emberley JK, Waxman DJ, Webster TF, Sherr DH. 2004. Environmental and endogenous peroxisome proliferator-activated receptor gamma agonists induce bone marrow B cell growth arrest and apoptosis: Interactions between mono(2-ethylhexyl)phthalate, 9-cis-retinoic acid, and 15-Deoxy-Delta(12,14)-prostaglandin J(2). J Immunol 173(5):3165-3177. PMID:15322177
  • Shipley JM, Waxman DJ. 2004. Simultaneous, bidirectional inhibitory crosstalk between PPAR and STAT5b. Toxicol Appl Pharmacol 199(3):275-284. PMID:15364543
  • Su T, Waxman DJ. 2004. Impact of dimethyl sulfoxide on expression of nuclear receptors and drug-inducible cytochromes P450 in primary rat hepatocytes. Arch Biochem Biophys 424(2):226-234. doi:10.1016/j.abb.2004.02.008 PMID:15047195

2003

  • Hurst CH, Waxman DJ. 2003. Activation of PPARalpha and PPARgamma by environmental phthalate monoesters. Toxicol Sci 74(2):297-308. doi:10.1093/toxsci/kfg145 PMID:12805656
  • Shipley JM, Waxman DJ. 2003. Down-regulation of STAT5b transcriptional activity by ligand-activated peroxisome proliferator-activated receptor (PPAR) alpha and PPAR gamma. Mol Pharmacol 64(2):355-364. PMID:12869640
  • Su T, Waxman DJ. 2003. Impact of dimethyl sulphoxide on expression of nuclear receptors and drug-inducible cytochromes P450 (CYPs) in primary rat hepatocytes. FASEB J 17(4):A240-A240Part1Suppl..
  • Waxman DJ. 2003. Nuclear receptor regulation of drug-metzbolizing P450 enzymes. In: Encyclopedia Reference of Molecular Pharmacology. Springer-Verlag Press,

2002

  • Ahluwalia A, Waxman DJ. 2002. Global gene expression profiling in rat liver using oligonucleotide microarrays: evaluation of the regulatory role of hormones and xenobiotics. In: New England Drug Metabolism Discussion Group Summer Symposium. Worcester, MA.
  • Goss KA, Clodfelter KH, Waxman DJ. 2002. Understanding P450 structure-function relationships using DNA shuffling mutagenesis. In: Boston University-Humboldt University Bioinformatics Workshop, Boston, MA.
  • Zhou Y, Davey HW, McLachlan MJ, Xie T, Waxman DJ. 2002. Elevated basal expression of liver peroxisomal beta-oxidation enzymes and CYP4A microsomal fatty acid omega-hydroxylase in STAT5b(-/-) mice: cross-talk in vivo between peroxisome proliferator-activated receptor and signal transducer and activator of transcription signaling pathways. Toxicol Appl Pharmacol 182(1):1-10. PMID:12127257

2001

  • Xie W, Radominska-Pandya A, Shi Y, Simon CM, Nelson MC, Ong ES, Waxman DJ, Evans RM. 2001. An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. Proc Natl Acad Sci U S A 98(6):3375-3380. PMID:11248086

2000

  • Waxman DJ. 2000. Receptor-mediated signaling events in cytochrome P450 gene regulation. In: Proceedings of the Early Toxicity Screening in Drug Discovery Conference.

1999

  • Maloney EK, Waxman DJ. 1999. trans-Activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals. Toxicol Appl Pharmacol 161(2):209-218. PMID:10581215
  • Waxman DJ. 1999. P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR and PPAR. Arch Biochem Biophys 369(1):11-23. PMID:10462436
  • Zhou Y, Waxman DJ. 1999. Inhibitory cross-talk between JAK2/STAT5b and PPARa. In: Proceedings of the 81st Annual Endocrine Society Meeting. pp.108.
  • Zhou Y, Waxman DJ. 1999. STAT5b down-regulates peroxisome proliferator-activated receptor alpha transcription by inhibition of ligand-independent activation function region-1 trans-activation domain. J Biol Chem 274(42):29874-29882. PMID:10514468

1998

  • Chang TK, Waxman DJ. 1998. Catalytic assays for human cytochrome P450. Methods Mol Biol 107:95-102. PMID:14577216
  • Chang TK, Waxman DJ. 1998. Enzymatic analysis of cDNA-expressed human CYP1A1, CYP1A2, and CYP1B1 with 7-ethoxyresorufin as substrate. Methods Mol Biol 107:103-109. PMID:14577217
  • Crespi CL, Chang TK, Waxman DJ. 1998. CYP2D6-dependent bufuralol 1'-hydroxylation assayed by reversed-phase ion-pair high-performance liquid chromatography with fluorescence detection. Methods Mol Biol 107:141-145. PMID:14577223
  • Zhou Y, Waxman DJ. 1998. Activation of peroxisome proliferator-activated receptors by chlorinated hydrocarbons and endogenous steroids. Environ Health Perspect 106Suppl.4:983-988. PMID:9703482
  • Zhou Y, Waxman DJ. 1998. Cross-talk between JAK-STAT and PPARα signaling pathways: Growth hormone (GH) inhibition of PPARα activity mediated by STAT5b. In: Proceedings of the 12th International Symposium on Microsomes and Drug Oxidations. pp.123.

1997

  • Chang TK, Crespi CL, Waxman DJ. 1997. Spectrophotometric Analysis of Human CY P2El -Catalyzed pNitrophenol Hydroxylation. Chapter 17 in: Methods in Molecular Biology series: Cytochrome P450 Protocols. Humana Press, Inc., pp.147-152.
  • Crespi CL, Chang TK, Waxman DJ. 1997. CYP2D6-dependent bufuralol 1'-hydroxylation assayed by reversed-phase ion-pair high performance liquid chromatography with fluorescence detection. Chapter 16 in: Methods in Molecular Biology series: Cytochrome P450 Protocols. Humana Press, Inc., pp.141-146.
  • Waxman DJ, Chang TK. 1997. Use of 7-Ethoxycoumarin to Monitor Multiple Enzymes in the Human CYPI, CYP2, and CYP3 Families. Chapter 21 in: Methods in Molecular Biology series: Cytochrome P450 Protocols. Humana Press, Inc., pp.175-180.
  • Zhou Y, Waxman DJ. 1997. Cross-talk between PPAR and JAK-STAT signaling pathways regulating liver P450 expression. In: Proceedings of the 15th New England Membrane Enzyme Conference.

1996

  • Peters JM, Zhou Y, Ram PA, Lee SS, Gonzalez FJ, Waxman DJ. 1996. Peroxisome proliferator-activated receptor a required for gene induction by dehydroepiandrosterone 3b-sulfate. Mol Pharmacol 50(1):67-74.
  • Waxman DJ. 1996. Role of metabolism in the activation of dehydroepiandrosterone as a peroxisome proliferator. Journal of Endocrinology 150:S129-S147. PMID:8943797
  • Zhou Y, Peters JM, Ram PA, Lee SS, Gonzalez FJ, Waxman DJ. 1996. Peroxisome proliferator-activated receptor a (PPARa) mediates gene induction by dehydroepiandrosterone 3b-sulfate (DHEA-S). In: Proceedings of the 11th International Symposium on Microsomes and Drug Oxidations. pp.209.

1995

  • Waxman DJ. 1995. Metabolism of DHEA and related steroids: interaction with liver cytochromes P450 (CYPs). In: Proceedings of the International Symposium on DHEA (Dehydroepiandrosterone) Transformation. pp.29.
Back
to Top