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Person Details: John J. Stegeman

Superfund Research Program

John J. Stegeman

Woods Hole Oceanographic Institution
Department of Biology
Redfield Building MS #32
Woods Hole, Massachusetts 02543-1049
Phone: 508-289-2320
Fax: 508-457-2134
Email: jstegeman@whoi.edu

Projects

Research Briefs

Hazardous Waste Sites

New Bedford Harbor

  • Boston University: Developmental Toxicity of non-Dioxin-like PCBs and Chemical Mixtures

Publications

2021

  • Brun NR, Panlilio JM, Zhang K, Zhao Y, Ivashkin E, Stegeman JJ, Goldstone JV. 2021. Developmental exposure to non-dioxin-like polychlorinated biphenyls promotes sensory deficits and disrupts dopaminergic and GABAergic signaling in zebrafish. Commun Biol 4:doi:10.1038/s42003-021-02626-9 PMID:34561524 PMCID:PMC8463681
  • Brun NR, Salanga MC, Mora-Zamorano FX, Lamb DC, Goldstone JV, Stegeman JJ. 2021. Orphan cytochrome P450 20a1 CRISPR/Cas9 mutants and neurobehavioral phenotypes in zebrafish. Sci Rep 11:doi:10.1038/s41598-021-03068-3 PMID:34903767 PMCID:PMC8669017
  • Celander MC, Goldstone JV, Brun NR, Clark BW, Jayaraman S, Nacci DE, Stegeman JJ. 2021. Resistance to Cyp3a induction by polychlorinated biphenyls, including non-dioxin-like PCB153, in gills of killifish (Fundulus heteroclitus) from New Bedford Harbor. Environ Toxicol Pharmacol 83:103580. doi:10.1016/j.etap.2020.103580 PMID:33429071
  • Eide M, Zhang X, Karlsen OA, Goldstone JV, Stegeman JJ, Jonassen I, Goksoyr A. 2021. The chemical defensome of five model teleost fish. Sci Rep doi:10.1038/s41598-021-89948-0 PMID:34006915 PMCID:PMC8131381

2020

  • Landrigan PJ, Stegeman JJ, Fleming LE, Allemand D, Anderson DM, Backer L, Brucker-Davis F, Chevalier N, Corra L, Czerucka D, Bottein MD, Demeneix B, Depledge MH, Deheyn DD, Dorman CJ, Fenichel P, Fisher S, Gaill F, Galgani F, Gaze WH, Giuliano L, Grandjean P, Hahn ME, Hamdoun A, Hess P, Judson B, Laborde A, McGlade J, Mu J, Mustapha A, Neira M, Noble RT, Pedrotti ML, Reddy C, Rocklov J, Scharler UM, Shanmugam H, Taghian G, van de Water JA, Vezzulli L, Weihe P, Zeka A, Raps H, Rampal P. 2020. Human health and ocean pollution. Ann Glob Health 86:64. doi:10.5334/aogh.2831 PMID:33354517 PMCID:PMC7731724

2019

2018

  • Eide M, Rydbeck H, Torresen OK, Lille-Langoy R, Puntervoll P, Goldstone JV, Jakobsen KS, Stegeman JJ, Goksoyr A, Karlsen OA. 2018. Independent losses of a xenobiotic receptor across teleost evolution. Sci Rep 8(1):10404. doi:10.1038/s41598-018-28498-4 PMID:29991818 PMCID:PMC6039460
  • Lemaire B, Karchner SI, Goldstone JV, Lamb DC, Drazen JC, Rees F, Hahn ME, Stegeman JJ. 2018. Molecular adaptation to high pressure in cytochrome P450 1A and aryl hydrocarbon receptor systems of the deep-sea fish Coryphaenoides armatus. Biochim Biophys Acta 1866:155-165. doi:10.1016/j.bbapap.2017.06.026 PMID:28694077 PMCID:PMC5693637
  • Lille-Langoy R, Karlsen OA, Myklebust LM, Goldstone JV, Mork-Jansson A, Male R, Blumberg B, Stegeman JJ, Goksoyr A. 2018. Sequence variations in pxr (nr1i2) from zebrafish (Danio rerio) strains affect nuclear receptor function. Toxicol Sci 168:28-39. doi:10.1093/toxsci/kfy269 PMID:30371853 PMCID:PMC6390661

2017

  • Holland EB, Goldstone JV, Pessah IN, Whitehead A, Reid NM, Karchner SI, Hahn ME, Nacci DE, Clark BW, Stegeman JJ. 2017. Ryanodine receptor and FK506 binding protein 1 in the Atlantic killifish (Fundulus heteroclitus): a phylogenetic and population-based comparison. Aquat Toxicol 192:105-115. doi:10.1016/j.aquatox.2017.09.002 PMID:28942070 PMCID:PMC5662517
  • Sant KE, Hansen JM, Williams LM, Tran NL, Goldstone JV, Stegeman JJ, Hahn ME, Timme-Laragy AR. 2017. The role of Nrf1 and Nrf2 in the regulation of glutathione and redox dynamics in the developing zebrafish embryo. Redox Biol 13:207-218. doi:10.1016/j.redox.2017.05.023 PMID:28582729 PMCID:PMC5458767

2016

  • Goldstone JV, Sundaramoorthy M, Zhao B, Waterman MR, Stegeman JJ, Lamb DC. 2016. Genetic and structural analyses of cytochrome P450 hydroxylases in sex hormone biosynthesis: Sequential origin and subsequent coevolution. Mol Phylogenet Evol 94(PtB):676-687. doi:10.1016/j.ympev.2015.09.012 PMID:26432395 PMCID:PMC4801120
  • Hunt G, Stegeman JJ, Robertson LW. 2016. PCBs: exposures, effects, remediation, and regulation with special emphasis on PCBs in schools. Environ Sci Pollut Res Int 23(3):1971-1974. doi:10.1007/s11356-015-5774-y PMID:26620856 PMCID:PMC4718839
  • Lemaire B, Kubota A, O'Meara CM, Lamb DC, Tanguay RL, Goldstone JV, Stegeman JJ. 2016. Cytochrome P450 20A1 in zebrafish: Cloning, regulation and potential involvement in hyperactivity disorders. Toxicol Appl Pharmacol 296:73-84. doi:10.1016/j.taap.2016.02.001 PMID:26853319 PMCID:PMC4807407
  • Parente T, Moreira DA, Magalhaes M, Andrade PC, Furtado C, Haas B, Stegeman JJ, Hahn ME. 2016. The liver transcriptome of suckermouth armoured catfish (Pterygoplichthys anisitsi, Loricariidae): Identification of expansions in defensome gene families. Mar Pollut Bull 115:352-361. PMID:28062095 PMCID:PMC5310677
  • Tokunaga S, Woodin BR, Stegeman JJ. 2016. Plant lignan secoisolariciresinol suppresses pericardial edema caused by dioxin-like compounds in developing zebrafish: Implications for suppression of morphological abnormalities. Food Chem Toxicol 96:160-166. doi:10.1016/j.fct.2016.07.012 PMID:27427306
  • Wincent E, Kubota A, Timme-Laragy A, Jonsson ME, Hahn ME, Stegeman JJ. 2016. Biological effects of 6-formylindolo[3,2-b]carbazole (FICZ) in vivo are enhanced by loss of CYP1A function in an Ahr2-dependent manner. Biochem Pharmacol 110-111:117-129. doi:10.1016/j.bcp.2016.04.012 PMID:27112072 PMCID:PMC4887394

2015

  • Fritsch EB, Stegeman JJ, Goldstone JV, Nacci DE, Champlin D, Jayaraman S, Connon RE, Pessah IN. 2015. Expression and function of ryanodine receptor related pathways in PCB tolerant Atlantic killifish (Fundulus heteroclitus) from New Bedford Harbor, MA, USA. Aquat Toxicol 159:156-166. doi:10.1016/j.aquatox.2014.12.017 PMID:25546006 PMCID:PMC4300256
  • Grans J, Wassmur B, Fernandez-Santoscoy M, Zanette J, Woodin BR, Karchner SI, Nacci DE, Champlin D, Jayaraman S, Hahn ME, Stegeman JJ, Celander MC. 2015. Regulation of pregnane-X-receptor, CYP3A and P-glycoprotein genes in the PCB-resistant killifish (Fundulus heteroclitus) population from New Bedford Harbor. Aquat Toxicol 159:198-207. doi:10.1016/j.aquatox.2014.12.010 PMID:25553538 PMCID:PMC4311260
  • Hahn ME, Timme-Laragy AR, Karchner SI, Stegeman JJ. 2015. Nrf2 and Nrf2-related proteins in development and developmental toxicity: Insights from studies in zebrafish (Danio rerio). Free Radic Biol Med 88(PtB):275-289. doi:10.1016/j.freeradbiomed.2015.06.022 PMID:26130508 PMCID:PMC4698826
  • Kubota A, Goldstone JV, Lemaire B, Takata M, Woodin BR, Stegeman JJ. 2015. Role of pregnane X receptor and aryl hydrocarbon receptor in transcriptional regulation of pxr, CYP2, and CYP3 genes in developing zebrafish. Toxicol Sci 143(2):398-407. doi:10.1093/toxsci/kfu240 PMID:25424564 PMCID:PMC4306721
  • Lille-Langoy R, Goldstone JV, Rusten M, Milnes MR, Male R, Stegeman JJ, Blumberg B, Goksoyr A. 2015. Environmental contaminants activate human and polar bear (Ursus maritimus) pregnane X receptors (PXR, NR1I2) differently. Toxicol Appl Pharmacol 284(1):54-64. doi:10.1016/j.taap.2015.02.001 PMID:25680588 PMCID:PMC4387200
  • Stegeman JJ, Behrendt L, Woodin BR, Kubota A, Lemaire B, Pompon D, Goldstone JV, Urban P. 2015. Functional characterization of zebrafish cytochrome P450 1 family proteins expressed in yeast. Biochim Biophys Acta 1850(11):2340-2352. doi:10.1016/j.bbagen.2015.07.010 PMID:26231923 PMCID:PMC4587093
  • Wincent E, Stegeman JJ, Jonsson ME. 2015. Combination effects of AHR agonists and Wnt/β-catenin modulators in zebrafish embryos: implications for physiological and toxicological AHR functions. Toxicol Appl Pharmacol 284(2):163-179. doi:10.1016/j.taap.2015.02.014 PMID:25711857 PMCID:PMC4747639

2014

  • Hahn ME, McArthur AG, Karchner SI, Franks DG, Jenny MJ, Timme-Laragy AR, Stegeman JJ, Woodin BR, Cipriano MJ, Linney EA. 2014. The transcriptional response to oxidative stress during vertebrate development: effects of tert-butylhydroquinone and 2,3,7,8-tetrachlorodibenzo-p-dioxin. PLoS One 9(11):e113158. doi:10.1371/journal.pone.0113158 PMID:25402455 PMCID:PMC4234671
  • Morrison AM, Goldstone JV, Lamb DC, Kubota A, Lemaire B, Stegeman JJ. 2014. Identification, modeling and ligand affinity of early deuterostome CYP51s, and functional characterization of recombinant zebrafish sterol 14α-demethylase. Biochim Biophys Acta 1840(6):1825-1836. doi:10.1016/j.bbagen.2013.12.009 PMID:24361620 PMCID:PMC4118742
  • Teraoka H, Okuno Y, Nijoukubo D, Yamakoshi A, Peterson RE, Stegeman JJ, Kitazawa T, Hiraga T, Kubota A. 2014. Involvement of COX2-thromboxane pathway in TCDD-induced precardiac edema in developing zebrafish. Aquat Toxicol 154:19-26. doi:10.1016/j.aquatox.2014.04.025 PMID:24858302 PMCID:PMC4326229
  • Tokunaga S, Stegeman JJ. 2014. Elimination of nonspecific bands in non-radioactive electrophoretic mobility shift assays using the digoxigenin system. Anal Biochem 465:70-72. doi:10.1016/j.ab.2014.06.020 PMID:25004462 PMCID:PMC4318779

2013

  • Bainy AC, Kubota A, Goldstone JV, Lille-Langoy R, Karchner SI, Celander MC, Hahn ME, Goksoyr A, Stegeman JJ. 2013. Functional characterization of a full length pregnane X receptor, expression in vivo, and identification of PXR alleles, in Zebrafish (Danio rerio). Aquat Toxicol 142-143:447-457. doi:10.1016/j.aquatox.2013.09.014 PMID:24121122 PMCID:PMC3873750
  • Kubota A, Bainy AC, Woodin BR, Goldstone JV, Stegeman JJ. 2013. The cytochrome P450 2AA gene cluster in zebrafish (Danio rerio): expression of CYP2AA1 and CYP2AA2 and response to phenobarbital-type inducers. Toxicol Appl Pharmacol 272(1):172–179. doi:10.1016/j.taap.2013.05.017 PMID:23726801 PMCID:PMC3846545
  • Nelson DR, Goldstone JV, Stegeman JJ. 2013. The cytochrome P450 genesis locus: the origin and evolution of animal cytochrome P450s. Philos Trans R Soc Lond B Biol Sci 368:20120474. doi:10.1098/rstb.2012.0474 PMID:23297357 PMCID:PMC3538424
  • Timme-Laragy AR, Goldstone JV, Imhoff BR, Stegeman JJ, Hahn ME, Hansen JM. 2013. Glutathione redox dynamics and expression of glutathione-related genes in the developing embryo. Free Radic Biol Med 65:89-101. doi:10.1016/j.freeradbiomed.2013.06.011 PMID:23770340 PMCID:PMC3823629
  • Williams LM, Timme-Laragy AR, Goldstone JV, McArthur AG, Stegeman JJ, Smolowitz RM, Hahn ME. 2013. Developmental expression of the Nfe2-related factor (Nrf) transcription factor family in the zebrafish, Danio rerio. PLoS One doi:10.1371/journal.pone.0079574 PMID:24298298 PMCID:PMC3840143
  • Zanette J, Jenny MJ, Goldstone JV, Parente T, Woodin BR, Bainy AC, Stegeman JJ. 2013. Identification and expression of multiple CYP1-like and CYP3-like genes in the bivalve mollusk Mytilus edulis. Aquat Toxicol 128-129:101-112. doi:10.1016/j.aquatox.2012.11.017 PMID:23277104 PMCID:PMC3846546
  • Zanette J, Stegeman JJ. 2013. The members of cytochrome P450 family 1 and new perspectives in aquatic pollution. In: Exploring Themes on Aquatic Toxicology. pp.89-101.

2012

2011

  • Godard-Codding CJ, Clark R, Fossi MC, Marsili L, Maltese S, West AG, Valenzuela L, Rowntree V, Polyak I, Cannon JC, Pinkerton K, Rubio-Cisneros N, Mesnick SL, Cox SB, Kerr I, Payne R, Stegeman JJ. 2011. Pacific ocean-wide profile of CYP1A1 expression, stable carbon and nitrogen isotope ratios, and organic contaminant burden in Sperm Whale skin biopsies. Environ Health Perspect 119:337-343. doi:10.1289/ehp.0901809 PMID:21134820 PMCID:PMC3059996
  • Jonsson ME, Berg C, Goldstone JV, Stegeman JJ. 2011. New CYP1 genes in the frog Xenopus (Silurana) tropicalis: induction patterns and effects of AHR agonists during development. Toxicol Appl Pharmacol 250:170-183. doi:10.1016/j.taap.2010.10.010 PMID:20965207 PMCID:PMC3014448
  • Jonsson ME, Woodin BR, Stegeman JJ, Brunstrom B. 2011. Cytochrome P450 1 genes in birds: evolutionary relationships and transcription profiles in chicken and Japanese quail embryos. PLoS One 6(12):e28257. doi:10.1371/journal.pone.0028257 PMID:22164255 PMCID:PMC3229566
  • Kubota A, Stegeman JJ, Goldstone JV, Nelson DR, Kim EY, Tanabe S, Iwata H. 2011. Cytochrome P450 CYP2 genes in the common cormorant: Evolutionary relationships with 130 diapsid CYP2 clan sequences and chemical effects on their expression. Comp Biochem Physiol C Toxicol Pharmacol 153:280-289. doi:10.1016/j.cbpc.2010.11.006 PMID:21130899 PMCID:PMC3560406
  • Parente T, Rebelo MF, da-Silva ML, Woodin BR, Goldstone JV, Bisch PM, Paumgartten FJ, Stegeman JJ. 2011. Structural features of cytochrome P450 1A associated with the absence of EROD activity in liver of the loricariid catfish Pterygoplichthys sp. Gene 489:111-118. doi:10.1016/j.gene.2011.07.023 PMID:21840383 PMCID:PMC3200446

2010

2007

  • Burnett KG, Bain LJ, Baldwin WS, Callard GV, Cohen S, Di Giulio RT, Evans DH, Gomez-Chiarri M, Hahn ME, Hoover CA, Karchner SI, Katoh F, MacLatchy DL, Marshall WS, Meyer JN, Nacci DE, Rees BB, Singer TD, Stegeman JJ, Towle DW, van Veld PA, Vogelbein WK, Whitehead A, Winn RN, Crawford DL, Oleksiak MF. 2007. Fundulus as the premier teleost model in environmental biology: opportunities for new insights using genomics. Comp Biochem Physiol Part D Genomics Proteomics 2(4):257-286. doi:10.1016/j.cbd.2007.09.001 PMID:18071578 PMCID:PMC2128618
  • Goldstone JV, Handley-Goldstone HM, Morrison AM, Tarrant AM, Kern SE, Woodin BR, Stegeman JJ. 2007. Cytochrome P450 1 genes in early deuterostomes (tunicates and sea urchins) and vertebrates (chicken and frog): origin and diversification of the CYP1 gene family. Mol Biol Evol 24(12):2619-31. doi:10.1093/molbev/msm200 PMID:17916789
  • Goldstone JV, Stegeman JJ. 2007. Gene structure of the novel cytochrome P4501D1 genes in stickleback (Gasterosteus aculeatus) and medaka (Oryzias latipes). Mar Environ Res 66(1):19--20. PMID:18400289
  • Jonsson ME, Jenny MJ, Woodin BR, Hahn ME, Stegeman JJ. 2007. Role of AHR2 in the expression of novel cytochrome P450 1 family genes, cell cycle genes, and morphological defects in developing zebra fish exposed to 3,3',4,4',5-pentachlorobiphenyl or 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci 100(1):180-93. PMID:17686920
  • Jonsson ME, Orrego R, Woodin BR, Goldstone JV, Stegeman JJ. 2007. Basal and 3,3',4,4',5-pentachlorobiphenyl-induced expression of cytochrome P450 1A, 1B and 1C genes in zebrafish. Toxicol Appl Pharmacol 221(1):29-41. PMID:17445853
  • Prasad JC, Goldstone JV, Camacho CJ, Vajda S, Stegeman JJ. 2007. Ensemble modeling of substrate binding to cytochromes P450: Analysis of catalytic differences between CYP1A orthologues. Biochemistry 46(10):2640-2654. PMID:17300179
  • Reddy CM, Stegeman JJ, Hahn ME. 2007. Organic Pollutants: Presence and Effects in Humans and Marine Animals. Chapter 7 in: Oceans and Human Health: Risks and Remedies from the Seas. pp.121-144.
  • Wilson JY, Wells R, Aguilar AA, Borrell A, Tornero V, Reijnders P, Moore M, Stegeman JJ. 2007. Correlates of cytochrome P450 1A1 expression in bottlenose dolphin (Tursiops truncatus) integument biopsies. Toxicol Sci 97(1):111-9. PMID:17324949

2006

  • Dong W, Muramoto W, Nagai Y, Takehana K, Stegeman JJ, Teraoka H, Hiraga T. 2006. Retinal neuronal cell is a toxicological target of tributyltin in developing zebrafish. J Vet Med Sci 68(6):573-9. PMID:16820714
  • Dong W, Muramoto W, Takehana K, Stegeman JJ, Teraoka H, Hiraga T. 2006. Oxidative stress and apoptosis induced by tributyltin in retinal neuronal cells of developing zebrafish. Nihon Juigaku Zasshi
  • Garrick RA, Woodin BR, Wilson JY, Middlebrooks BL, Stegeman JJ. 2006. Cytochrome P4501A is induced in endothelial cell lines from the kidney and lung of the bottlenose dolphin, Tursiops truncatus. Aquat Toxicol 76(3-4):295-305. PMID:16290286
  • Goldstone JV, Hamdoun A, Cole BJ, Howard-Ashby M, Nebert DW, Scally M, Dean M, Epel D, Hahn ME, Stegeman JJ. 2006. The chemical defensome: environmental sensing and response genes in the Strongylocentrotus purpuratus genome. Dev Biol 300(1):366-384. doi:10.1016/j.ydbio.2006.08.066 PMID:17097629 PMCID:PMC3166225
  • Handley-Goldstone HM, Stegeman JJ. 2006. A revised evolutionary history of the CYP1A subfamily: gene duplication, gene conversion, and positive selection. J Mol Evol 62(6):708-717. PMID:16752211
  • Handley-Goldstone HM, Stegeman JJ. 2006. Molecular mechanisms of 2,3,7,8-tetrachlorodibenzo-p-dioxin cardiovascular embryotoxicity. J Mol Biol 38(1-2):261-289. PMID:16684661
  • Kubota A, Iwata H, Handley-Goldstone HM, Kim EY, Stegeman JJ, Tanabe S. 2006. Cytochrome P450 1A4 and 1A5 in common cormorant (Phalacrocorax carbo): evolutionary relationships and functional implications associated with dioxin and related compounds. Toxicol Sci 92(2):394-408. doi:10.1093/toxsci/kfl001 PMID:16679348
  • Malins DC, Anderson KM, Stegeman JJ, Jaruga P, Green VM, Gilman NK, Dizdaroglu M. 2006. Biomarkers signal contaminant effects on the organs of English sole (Parophrys vetulus) from Puget Sound. Environ Health Perspect 114(6):823-829. PMID:16759979
  • Matsuo AY, Woodin BR, Reddy CM, Val AL, Stegeman JJ. 2006. Humic substances and crude oil induce cytochrome P450 1A expression in the Amazonian fish species Colossoma macropomum (Tambaqui). Environ Sci Technol 40(8):2851-8. PMID:16683634
  • Schlezinger JJ, Struntz WD, Goldstone JV, Stegeman JJ. 2006. Uncoupling of cytochrome P450 1A and stimulation of reactive oxygen species production by co-planar polychlorinated biphenyl congeners. Aquat Toxicol 77(4):422-432. PMID:16500718
  • Stuchal L, Kleinow KM, Stegeman JJ, James MO. 2006. Demethylation of the pesticide methoxychlor in liver and intestine from untreated, methoxychlor-treated, and 3-methylcholanthrene-treated channel catfish (Ictalurus punctatus): evidence for roles of CYP1 and CYP3A family isozymes. Drug Metab Dispos 34(6):932-8. PMID:16510540
  • Teraoka H, Urakawa S, Nanba S, Nagai Y, Dong W, Imagawa T, Tanguay RL, Svoboda K, Handley-Goldstone HM, Stegeman JJ, Hiraga T. 2006. Muscular contractions in the zebrafish embryo are necessary to reveal thiuram-induced notochord distortions. Toxicol Appl Pharmacol 212(1):24-34. PMID:16051294
  • Verslycke T, Goldstone JV, Stegeman JJ. 2006. Isolation and phylogeny of novel cytochrome P450 genes from tunicates (Ciona spp): a CYP3 line in early deuterostomes?. Mol Phylogenet Evol 40(3):760-771. doi:10.1016/j.ympev.2006.04.017 PMID:16777437

2005

  • Garrick RA, Woodin BR, Stegeman JJ. 2005. Cytochrome p4501a induced differentially in endothelial cells cultured from different organs of Anguilla rostrata. In Vitro Cell Dev Biol Anim 41(1-2):57-63. doi:10.1290/0409063.1 PMID:15926861
  • Godard-Codding CJ, Goldstone JV, Said MR, Dickerson RL, Woodin BR, Stegeman JJ. 2005. The new vertebrate CYP1C family: cloning of new subfamily members and phylogenetic analysis. Biochem Biophys Res Commun 331(4):1016-1024. PMID:15882979
  • Handley-Goldstone HM, Grow MW, Stegeman JJ. 2005. Cardiovascular gene expression profiles of dioxin exposure in zebrafish embryos. Toxicol Sci 85(1):683-693. PMID:15716485
  • Malins DC, Stegeman JJ, Green VM, Gilman NK, Anderson KM. 2005. Spectral Models for Assessing Exposure of Fish to Contaminants. In: Techniques in Aquatic Toxicology. CRC Press, Inc., Boca Raton, FL. pp.537-545.

2004

  • Dong W, Teraoka H, Tsujimoto Y, Stegeman JJ, Hiraga T. 2004. Role of aryl hydrocarbon receptor in mesencephalic circulation failure and apoptosis in zebrafish embryos exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci 77(1):109-116. PMID:14657521
  • Malins DC, Stegeman JJ, Anderson JW, Johnson PM, Gold J, Anderson KM. 2004. Structural changes in gill DNA reveal the effects of contaminants on Puget Sound fish. Environ Health Perspect 112(5):511-515. PMID:15064153
  • Powell WH, Morrison HG, Weil EJ, Karchner SI, Sogin ML, Stegeman JJ, Hahn ME. 2004. Cloning and analysis of the CYP1A promoter from the atlantic killifish (Fundulus heteroclitus). Mar Environ Res 58(2-5):119-124. PMID:15178023
  • Zodrow JM, Stegeman JJ, Tanguay RL. 2004. Histological analysis of acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in zebrafish. Aquat Toxicol 66(1):25-38. PMID:14687977

2003

  • Goldstone JV, Stegeman JJ. 2003. Quantification of ROS Production and Enzyme Inactivation of CYP 1A by Polychlorinated Biphenyls and by 2,3,7,8-Tetrachlorodibenzo-P-Dioxin. In: Presented at the International Society for the study of Xenobiotics, October. Providence, RI.
  • McArthur AG, Hegelund T, Cox RL, Stegeman JJ, Liljenberg M, Olsson U, Sundberg P, Celander MC. 2003. Phylogenetic analysis of the cytochrome P450 3 (CYP3) gene family. J Mol Evol 57(2):200-211. doi:10.1007/s00239-003-2466-x PMID:14562963
  • Morrison A, Stegeman JJ. 2003. In Vitro Assessment of CYP51 Azole Sensitivity in Fish: Dos Upregulation of CYP1A Protect the CYP51?. In: Presented at the International Society for the study of Xenobiotics, October. Providence, RI.
  • Oleksiak MF, Wu S, Parker C, Qu W, Cox RL, Zeldin DC, Stegeman JJ. 2003. Identification and regulation of a new vertebrate cytochrome P450 subfamily, the CYP2Ps, and functional characterization of CYP2P3, a conserved arachidonic acid epoxygenase/19-hydroxylase. Arch Biochem Biophys 411(2):223-234. PMID:12623071
  • Prasad JC, Vajda S, Goldstone JV, Camacho CJ, Stegeman JJ. 2003. Differences in Substrate Binding Between Mammalian and Fish Cytochrome P450 1As Predicted by Comparative Modeling and Flexible Docking. In: Presented at the International Society for the study of Xenobiotics, October. Providence, RI.
  • Prasch AL, Teraoka H, Carney SA, Dong W, Hiraga T, Stegeman JJ, Heideman W, Peterson RE. 2003. Aryl hydrocarbon receptor 2 mediates 2,3,7,8-tetrachlorodibenzo-p-dioxin developmental toxicity in zebrafish. Toxicol Sci 76(1):138-150. PMID:12883077
  • Teraoka H, Dong W, Tsujimoto Y, Iwasa H, Endoh D, Ueno N, Stegeman JJ, Peterson RE, Hiraga T. 2003. Induction of cytochrome P450 1A is required for circulation failure and edema by 2,3,7,8-tetrachlorodibenzo-p-dioxin in zebrafish. Biochem Biophys Res Commun 304(2):223-228. PMID:12711302

2002

  • Andreasen EA, Spitsbergen JM, Tanguay RL, Stegeman JJ, Heideman W, Peterson RE. 2002. Tissue-specific expression of AHR2, ARNT2, and CYP1A in zebrafish embryos and larvae: effects of developmental stage and 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure. Toxicol Sci 68(2):403-419. PMID:12151636
  • Baader M, Gnerre C, Stegeman JJ, Meyer UA. 2002. Transcriptional activation of cytochrome P-450 CYP2C45 by drugs is mediated by the chicken xenobiotic receptor CXR interacting with a phenobarbital-response enhancer unit. J Biol Chem 277(18):15647-15653. PMID:11867618
  • Bard SM, Bello SM, Hahn ME, Stegeman JJ. 2002. Expression of P-glycoprotein in killifish (Fundulus heteroclitus) exposed to environmental xenobiotics. Aquat Toxicol 59(3-4):237-251. PMID:12127740
  • Bard SM, Woodin BR, Stegeman JJ. 2002. Expression of P-glycoprotein and cytochrome p450 1A in intertidal fish (Anoplarchus purpurescens) exposed to environmental contaminants. Aquat Toxicol 60(1-2):17-32. PMID:12204584
  • Iwata H, Yoshinari K, Negishi M, Stegeman JJ. 2002. Species-specific responses of constitutively active receptor (CAR)-CYP2B coupling: lack of CYP2B inducer-responsive nuclear translocation of CAR in marine teleost, scup (Stenotomus chrysops). Comp Biochem Physiol C Toxicol Pharmacol 131(4):501-510. PMID:11976065
  • Yamazaki K, Teraoka H, Dong W, Stegeman JJ, Hiraga T. 2002. cDNA cloning and expressions of cytochrome P450 1A in zebrafish embryos. J Vet Med Sci 64(9):829-833. PMID:12399609

2001

  • Bello SM, Franks DG, Stegeman JJ, Hahn ME. 2001. Acquired resistance to Ah receptor agonists in a population of Atlantic killifish (Fundulus heteroclitus) inhabiting a marine superfund site: in vivo and in vitro studies on the inducibility of xenobiotic metabolizing enzymes. Toxicol Sci 60(1):77-91. PMID:11222875
  • Handley H, Grow MW, Fishman MC, Stegeman JJ. 2001. Broad-scale characterization of gene expression patterns associated with embryonic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci 60(1):1604S.
  • Huang Y, Stegeman JJ, Woodin BR, Karasov WH. 2001. Immunohistochemical localization of cytochrome P450 1A induced by 3,3',4,4',5-pentachlorobiphenyl (PCB126) in multiple organs of the northern leopard frog Rana pipiens. Environ Toxicol Chem 20(1):191-197.
  • Verbrugge LA, Giesy JP, Verbrugge DA, Woodin BR, Stegeman JJ. 2001. Catalytic and immunochemical properties of hepatic cytochrome P450 1A in three avian species treated with beta-naphthoflavone or isosafrole. Comp Biochem Physiol C Toxicol Pharmacol 130(1):67-83. doi:10.1016/S1532-0456(01)00221-6 PMID:11544144

2000

  • Godard-Codding CJ, Leaver MJ, Said MR, Dickerson RL, George S, Stegeman JJ. 2000. Identification of cytochrome P450 1B-like sequences in two teleost fish species (scup, Stenotomus chrysops and plaice, Pleuronectes platessa) and in a cetacean (striped dolphin, Stenella coeruleoalba). Mar Environ Res 50(1-5):7-10. PMID:11460754
  • Iwata H, Stegeman JJ. 2000. In situ RT-PCR detection of CYP1A mRNA in pharyngeal epithelium and chondroid cells from chemically untreated fish: involvement in vertebrate craniofacial skeletal development?. Biochem Biophys Res Commun 271(1):130-137. doi:10.1006/bbrc.2000.2543 PMID:10777692
  • Rie MT, Lendas KA, Woodin BR, Stegeman JJ, Callard IP. 2000. Hepatic biotransformation enzymes in a sentinel species, the painted turtle (Chrysemys picta), from Cape Cod, Massachusetts: seasonal-, sex- and location related differences. Biomarkers 5(5):382-394. doi:10.1080/135475000424384 PMID:23886024
  • Rie MT, Lendas KA, Woodin BR, Stegeman JJ, Callard IP. 2000. Multiple bioindicators of environmental pollution in a sentinel species, Chrysemys picta, on Cape Cod,MA. Mar Environ Res 50(1):436-437.
  • Schlezinger JJ, Blickarz CE, Mann KK, Doerre S, Stegeman JJ. 2000. Identification of NF-kB in the marine fish Stenotomus chrysops and examination of its activation by aryl hydrocarbon receptor agonists. Chem Biol Interact 126(2):137-157. PMID:10862814
  • Schlezinger JJ, Keller J, Verbrugge LA, Stegeman JJ. 2000. 3,3',4,4'-Tetrachlorobiphenyl oxidation in fish, bird and reptile species: relationship to cytochrome P450 1A inactivation and reactive oxygen production. Comp Biochem Physiol C Toxicol Pharmacol 125(3):273-286. PMID:11790349
  • Schlezinger JJ, Stegeman JJ. 2000. Dose and inducer-dependent induction of cytochrome P450 1A in endothelia of the eel, including in the swimbladder rete mirabile, a model microvascular structure. Drug Metab Dispos 28(6):701-708. PMID:10820144
  • Schlezinger JJ, Stegeman JJ. 2000. Induction of cytochrome P450 1A in the American Eel by model halogenated and non-halogenated aryl hydrocarbon receptor agonists. Aquat Toxicol 50(4):375-386. PMID:10967399

1999

  • Elskus AA, Monosson E, McElroy AE, Stegeman JJ, Woltering DS. 1999. Altered CYP1A expression in Fundulus heteroclitus adults and larvae: a sign of pollutant resistance?. Aquat Toxicol 45(2-3):99-113.
  • Rie MT, Lendas KA, Woodin BR, Stegeman JJ, Callard IP. 1999. Multiple bioindicators of environmental pollution, Chrysemys picta, on Cape Cod, MA. In: Proceedings of the PRIMO Meeting. pp.58.
  • Schlezinger JJ, White RD, Stegeman JJ. 1999. Oxidative inactivation of cytochrome P450 1A stimulated by 3,3',4,4'-tetrachlorobiphenyl: production of reactive oxygen by vertebrate CYP1As. Mol Pharmacol 56(3):588-597. PMID:10462547

1998

  • Bello SM, Franks DG, Stegeman JJ, Hahn ME. 1998. Dioxin Resistance in Killifish (Fundulus heteroclitus) from the New Bedford Harbor Superfund Site: In Vivo and In Vitro studies of CYP1A1 Inducibility. In: Proceedings of the Society of Environmental Toxicology and Chemistry (SETC) 19th Annual Meeting. Charlotte, NC. pp.168.
  • Morrison HG, Weil EJ, Karchner SI, Sogin ML, Stegeman JJ. 1998. Molecular cloning of CYP1A from the estuarine fish Fundulus heteroclitus and phylogenetic analysis of CYP1A genes: Update with new sequences. Comp Biochem Physiol 121C:231-240. PMID:9972465
  • Rie MT, Lendas KA, Woodin BR, Stegeman JJ, Callard IP. 1998. Seasonal, sex-related and habitat differences in hepatic CYP1A and glutathione-s-transferase in field-trapped turtles (Chrysemys picta). In: Proceedings of the Superfund Basic Research Program (SBRP) Conference, 1998. Boston, MA. pp.45.
  • Rie MT, Lendas KA, Woodin BR, Stegeman JJ, Callard IP. 1998. Seasonal, sex-related and habitat differences in hepatic CYP1A and glutathione-s-transferase in field-trapped turtles (Chrysemys picta). Biol Reprod 58(1):351.
  • Schlezinger JJ, Parker C, Zeldin DC, Stegeman JJ. 1998. Arachidonic acid metabolism in the marine fish Stenotomus chrysops (scup) and the effects of cytochrome P4501A inducers. Arch Biochem Biophys 353(2):265-275. PMID:9606961
  • Schlezinger JJ, Struntz WD, Stegeman JJ. 1998. Cytochrome P4501A (CYP1A) and planar halogenated hydrocarbons (pHAH): Oxidative inactivation and reactive oxygen production. In: Proceedings of the 37th Society of Toxicology Annual Meeting, March 1-5. Seattle, WA.
  • Yawetz A, Woodin BR, Stegeman JJ. 1998. Cytochromes P450 (CYP) in liver of the turtle, Chrysemes picta picta and the induction and partial purification of CYP1A-like proteins. Biochim Biophys Acta 1381(1):12-26. PMID:9659368

1997

  • Bello SM, Stegeman JJ, Hahn ME. 1997. Lack of cytochrome P450-1A inducibility in Fundulus heteroclitus from New Bedford Harbor: A case of dioxin resistance?. In: Proceedings of the Society for Environmental Toxicology and Chemistry Annual Meeting. San Francisco, CA.
  • Guiney PD, Smolowitz RM, Peterson RE, Stegeman JJ. 1997. Correlation of 2,3,7,8-tetrachlorodibenzo-p-dioxin induction of cytochrome P450 1A in vascular endothelium with toxicity in early life stages of lake trout. Toxicol Appl Pharmacol 143(2):256-273. PMID:9144443
  • Schlezinger JJ, White RD, Stegeman JJ. 1997. Inactivation of cytochrome P4501A1 by 3,3',4,4'-tetrachlorobiphenyl and the formation of reactive oxygen species. In: Proceedings of the Society for Environmental Toxicology and Chemistry Annual Meeting. San Francisco, CA.
  • White RD, Shea D, Stegeman JJ. 1997. Metabolism of the aromatic hydrocarbon receptor agonist 3,3',4,4'-tetrachlorobiphenyl by the marine fish scup (Stenotomus chrysops) in vivo and in vitro. Drug Metab Dispos 25(5):564-572. PMID:9152595

1996

  • Schlezinger JJ, White RD, Stegeman JJ. 1996. 3,3',4,4'-tetrachlorobiphenyl stimulates release of active oxygen from hepatic microsomes and the oxidative inactivation of cytochrome P4501A1. In: Proceedings of the 11th International Symposium on Microsomes and Drug Oxidations. pp.192.
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Last Reviewed: October 17, 2024