Superfund Research Program

Dr. Robert H. Tukey

University of California-San Diego
Department of Pharmacology
9500 Gilman Drive, MC 0722
La Jolla, California 92093-0722
Phone: 858-822-0288
Fax: 858-822-0363
Email: rtukey@health.ucsd.edu

Projects

• University of California-San Diego: Administrative Core (2000-2023)
• University of California-San Diego: Antioxidant Protection by Hyperbilirubinemia in Toxicity and Disease (2000-2017)
• University of California-San Diego: Molecular and Microbial Mechanisms Leading to Triclosan Induced Liver Fibrosis (2017-2023)
• University of California-San Diego: Training Core (2000-2023)

Research Briefs

• 314 - Triclosan and a High-fat Diet Worsen Liver Disease in Mice
• 241 - SRP Researchers Determine that Triclosan Promotes Liver Tumor Growth in Mice

Publications

2024

• Rabin B, Cain KL, Ayers LO, Lomeli A, Escoto AA, Burola M, Aguilar M, Tinoco-Calvillo S, Reyes B, Salgin L, Tukey RH, Laurent LC, Stadnick NA. 2024. Adaptation of the brainwriting premortem technique to inform the co-creation of COVID-19 testing strategies in underserved communities in South San Diego. BM Health Serv Res 24(1):12. doi:10.1186/s12913-023-10341-w PMID:38172787 PMCID:PMC10765849
• Weber AA, Yang X, Mennillo E, Wong S, Le S, Tukey RH, Ashley Teo J, Chang M, Benner CW, Ding J, Jain M, Chen S, Karin M. 2024. Triclosan administration to humanized UDP-glucuronosyltransferase 1 neonatal mice induces UGT1A1 through a dependence on PPARα and ATF4. J Biol Chem 300(6):doi:10.1016/j.jbc.2024.107340 PMID:38705390

2023

• Rabin B, Cain KL, Salgin L, Watson P, Oswald W, Kaiser BN, Ayers LO, Yi C, Alegre A, Ni J, Reyes A, Yu KE, Broyles SL, Tukey RH, Laurent LC, Stadnick NA. 2023. Using ethnographic approaches to document, evaluate, and facilitate virtual community-engaged implementation research. BMC Public Health 23(1):409. doi:10.1186/s12889-023-15299-2 PMID:36855118 PMCID:PMC9974043
• Salgin L, Ayers LO, Burola M, Engler A, Osuna A, Gay L, Cain KL, Stadnick NA, Rabin AB, Zaslavsky I, Laurent LC, Tukey RH, Seifert M. 2023. Perceived COVID-19 risk and testing experiences in the San Ysidro U.S./Mexico border region. Transl Behav Med doi:10.1093/tbm/ibac120 PMID:36999822 PMCID:PMC10314726
• Yang X, Weber AA, Mennillo E, Paszek M, Wong S, Le S, Teo JY, Chang M, Benner CW, Tukey RH, Chen S. 2023. Oral arsenic administration to humanizedUDP-glucuronosyltransferase1 neonatal mice induces UGT1A1 through a dependence on Nrf2 and PXR. J Biol Chem 299(3):102955. doi:10.1016/j.jbc.2023.102955 PMID:36720308 PMCID:PMC9996368
• Yang X, Weber AA, Mennillo E, Secrest P, Chang M, Wong S, Le S, Liu J, Benner CW, Karin M, Gordts P, Tukey RH, Chen S. 2023. Effects of early life oral arsenic exposure on intestinal tract development and lipid homeostasis in neonatal mice: Implications for NAFLD development. Environ Health Perspect 131(9):doi:10.1289/ehp12381 PMID:37668303 PMCID:10478510

2022

• Mennillo E, Yang X, Weber AA, Maruo Y, Verreault M, Barbier O, Chen S, Tukey RH. 2022. Intestinal UDP-glucuronosyltransferase 1A1 and protection against irinotecan-induced toxicity in a novel UDP-glucuronosyltransferase 1A1 tissue-specific humanized mouse model. Drug Metab Dispos 50:33-42. doi:10.1124/dmd.121.000644 PMID:34697081
• Stadnick NA, Cain KL, Watson P, Oswald W, Ibarra M, Lagoc R, Pezzoli K, Laurent LC, Tukey RH, Rabin AB. 2022. Engaging underserved communities in COVID-19 health equity implementation research: an analysis of community engagement resource needs and costs. Front Health Serv 2:850427. doi:10.3389/frhs.2022.850427 PMID:36258685 PMCID:PMC9574473
• Weber AA, Yang X, Mennillo E, Ding J, Watrous JD, Jain M, Chen S, Karin M, Tukey RH. 2022. Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice. Nat Commun 13(1):4346. doi:10.1038/s41467-022-31947-4 PMID:35896521 PMCID:PMC9329322

2021

• van der Schoor LW, Verkade HJ, Bertolini A, de Wit S, Mennillo E, Rettenmeier E, Weber AA, Havinga R, Valaskova P, Jasprova J, Struik D, Bloks VW, Chen S, Schreuder AB, Vitek L, Tukey RH, Jonker JW. 2021. Potential of therapeutic bile acids in the treatment of neonatal Hyperbilirubinemia. Sci Rep 11:11107. doi:10.1038/s41598-021-90687-5 PMID:34045606 PMCID:PMC8160219
• Weber AA, Mennillo E, Yang X, van der Schoor LW, Jonker JW, Chen S, Tukey RH. 2021. Regulation of Intestinal UDP-Glucuronosyltransferase 1A1 by the Farnesoid X Receptor Agonist Obeticholic Acid Is Controlled by Constitutive Androstane Receptor through Intestinal Maturation. Drug Metab Dispos 49:12-19. doi:10.1124/dmd.120.000240 PMID:33154041 PMCID:PMC7745083

2020

• Hansmann E, Mennillo E, Yoda E, Verreault M, Barbier O, Chen S, Tukey RH. 2020. Differential role of LXRa and LXRy in the regulation of UDP-glucuronosyltransferase 1A1 in humanized UGT1 mice. Drug Metab Dispos 48:255-263. doi:10.1124/dmd.119.090068 PMID:31980500 PMCID:PMC7065491
• Paszek M, Tukey RH. 2020. NRF2-Independent regulation of intestinal constitutive androstane receptor by the pro-oxidants cadmium and isothiocyanate in hUGT1 mice. Drug Metab Dispos 48:25-30. doi:10.1124/dmd.119.089508 PMID:31704714 PMCID:PMC6904881
• Yueh MF, He F, Chen C, Vu C, Tripathi A, Knight R, Karin M, Chen S, Tukey RH. 2020. Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease. Proc Natl Acad Sci U S A 117:31259-31266. doi:10.1073/pnas.2017129117 PMID:33229553 PMCID:PMC7733785

2018

• Chen S, Tukey RH. 2018. Humanized UGT1 mice, regulation of UGT1A1, and the role of the intestinal tract in neonatal hyperbilirubinemia and breast milk-induced jaundice. Drug Metab Dispos 46(11):1745-1755. doi:10.1124/dmd.118.083212 PMID:30093417 PMCID:PMC6199628
• Gonzalez FJ, Coughtrie MW, Tukey RH. 2018. Drug Metabolism. Chapter 6 in: The Pharmacological Basis of Therapeutics. McGraw Hill Education,

2017

• Chen S, Lu W, Yueh MF, Rettenmeier E, Liu M, Auwerx J, Yu RT, Evans RM, Wang K, Karin M, Tukey RH. 2017. Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. Proc Natl Acad Sci U S A 114(8):E1432-E1440. doi:10.1073/pnas.1700232114 PMID:28167773 PMCID:PMC5338369
• Fujiwara R, Mitsugi R, Uemura A, Itoh T, Tukey RH. 2017. Severe neonatal hyperbilirubinemia in Crigler-Najjar Syndrome model mice can be reversed with zinc protoporphyrin. Hepatol Commun 1(8):792-802. doi:10.1002/hep4.1082 PMID:29399656 PMCID:PMC567892
• Fujiwara R, Yoda E, Tukey RH. 2017. Species differences in drug glucuronidation: humanized UDP-glucuronosyltransferase 1 mice and their application for predicting drug glucuronidation and drug-induced toxicity in humans. Drug Metab Pharmacokinet 33(1):9-16. doi:10.1016/j.dmpk.2017.10.002 PMID:29079228 PMCID:PMC5809266
• Hirashima R, Itoh T, Tukey RH, Fujiwara R. 2017. Prediction of drug-induced liver injury using keratinocytes. J Appl Toxicol 37:863-872. doi:10.1002/jat.3435 PMID:28138970 PMCID:PMC5500258
• Lu W, Rettenmeier E, Paszek M, Yueh MF, Tukey RH, Trottier J, Barbier O, Chen S. 2017. Crypt organoid culture as an in vitro model in drug metabolism and cytotoxicity studies. Drug Metab Dispos 45:748-754. doi:10.1124/dmd.117.075945 PMID:28468837 PMCID:PMC5478905
• Tukey RH. 2017. Mice with hyperbilirubinemia due to Gilbert's syndrome polymorphism are resistant to hepatic steatosis by decreased serine 73 phosphorylation of PPAR alpha. Am J Physiol Endocrinol Metab 312:E244-E252. doi:10.1152/ajpendo.00396.2016 PMID:28096081 PMCID:PMC5406988
• Yoda E, Paszek M, Konopnicki CM, Fujiwara R, Chen S, Tukey RH. 2017. Isothiocyanates induce UGT1A1 in humanized UGT1 mice in a CAR dependent fashion that is highly dependent upon oxidative stress. Sci Rep 7:46489. doi:10.1038/srep46489 PMID:28422158 PMCID:PMC5395973
• Yueh MF, Chen S, Nguyen N, Tukey RH. 2017. Developmental, genetic, dietary, and xenobiotic influences on neonatal hyperbilirubinemia. Mol Pharmacol 91(5):545-553. doi:10.1124/mol.116.107524 PMID:28283555 PMCID:PMC5416747

2016

• Barateiro A, Chen S, Yueh MF, Fernandes A, Domingues HS, Relvas J, Barbier O, Nguyen N, Tukey RH, Brites D. 2016. Reduced myelination and increased glia reactivity resulting from severe neonatal hyperbilirubinemia. Mol Pharmacol 89(1):84-93. doi:10.1124/mol.115.098228 PMID:26480925 PMCID:PMC4702100
• Hirashima R, Michimae H, Takemoto H, Sasaki A, Kobayashi Y, Itoh T, Tukey RH, Fujiwara R. 2016. Induction of the UDP-glucuronosyltransferase 1A1 during the perinatal period can cause neurodevelopmental toxicity. Mol Pharmacol 90(3):265-274. doi:10.1124/mol.116.104174 PMID:27413119 PMCID:PMC4998668
• Liu M, Chen S, Yueh MF, Fujiwara R, Konopnicki CM, Hao H, Tukey RH. 2016. Cadmium and arsenic override NF-κB developmental regulation of the intestinal UGT1A1 gene and control of hyperbilirubinemia. Biochem Pharmacol 110-111:37-46. doi:10.1016/j.bcp.2016.04.003 PMID:27060662 PMCID:PMC5010383
• Liu M, Chen S, Yueh MF, Wang G, Hao H, Tukey RH. 2016. Reduction of p53 by knockdown of the UGT1 locus in colon epithelial cells causes an increase in tumorigenesis. Cell Mol Gastroenterol Hepatol 2(1):63-76.e5. doi:10.1016/j.jcmgh.2015.08.008 PMID:26807433 PMCID:PMC4721636
• Mitsugi R, Sumida K, Fujie Y, Tukey RH, Itoh T, Fujiwara R. 2016. Acyl-glucuronide as a possible cause of trovafloxacin-induced liver toxicity: Induction of chemokine (C-X-C Motif) ligand 2 by trovafloxacin acyl-glucuronide. Biol Pharm Bull 39(10):1604-1610. doi:10.1248/bpb.b16-00195 PMID:27725437
• Touboul T, Chen S, To CC, Mora-Castilla S, Sabatini K, Tukey RH, Laurent LC. 2016. Stage-specific regulation of the WNT/β-catenin pathway enhances differentiation of hESCs into hepatocytes. J Hepatol 64(6):1315-1326. doi:10.1016/j.jhep.2016.02.028 PMID:26921690 PMCID:PMC5010388
• Yueh MF, Tukey RH. 2016. Triclosan: a widespread environmental toxicant with many biological effects. Annu Rev Pharmacol Toxicol 56:251-272. doi:10.1146/annurev-pharmtox-010715-103417 PMID:26738475 PMCID:PMC4774862

2015

• Fujiwara R, Maruo Y, Chen S, Tukey RH. 2015. Role of extrahepatic UDP-glucuronosyltransferase 1A1: advances in understanding breast milk-induced neonatal hyperbilirubinemia. Toxicol Appl Pharmacol 289(1):124-132. doi:10.1016/j.taap.2015.08.018 PMID:26342858 PMCID:PMC4708261
• Kutsuno Y, Hirashima R, Sakamoto M, Ushikubo H, Michimae H, Itoh T, Tukey RH, Fujiwara R. 2015. Expression of UDP-Glucuronosyltransferase 1 (UGT1) and Glucuronidation Activity toward Endogenous Substances in Humanized UGT1 Mouse Brain. Drug Metab Dispos 43(7):1071-1076. doi:10.1124/dmd.115.063719 PMID:25953521 PMCID:PMC4468441
• Landrigan PJ, Wright RO, Cordero JF, Eaton DL, Goldstein BD, Hennig B, Maier RM, Ozonoff DM, Smith MT, Tukey RH. 2015. The NIEHS Superfund Research Program: 25 Years of Translational Research for Public Health. Environ Health Perspect 123(10):909-918. doi:10.1289/ehp.1409247 PMID:25978799 PMCID:PMC4590764
• Sakamoto M, Itoh T, Tukey RH, Fujiwara R. 2015. Nicotine regulates the expression of UDP-glucuronosyltransferase (UGT) in humanized UGT1 mouse brain. Drug Metab Pharmacokinet 30(4):269-275. doi:10.1016/j.dmpk.2015.04.004 PMID:26210671 PMCID:PMC4752199

2014

• Aoshima N, Fujie Y, Itoh T, Tukey RH, Fujiwara R. 2014. Glucose induces intestinal human UDP-glucuronosyltransferase (UGT) 1A1 to prevent neonatal hyperbilirubinemia. Sci Rep 4:6343. doi:10.1038/srep06343 PMID:25209391 PMCID:PMC4160704
• Kutsuno Y, Itoh T, Tukey RH, Fujiwara R. 2014. Glucuronidation of drugs and drug-induced toxicity in humanized UDP-glucuronosyltransferase 1 mice. Drug Metab Dispos 42(7):1146-1152. doi:10.1124/dmd.114.057083 PMID:24764149 PMCID:PMC4053997
• Maruo Y, Morioka Y, Fujito H, Nakahara S, Yanagi T, Matsui K, Mori A, Sato H, Tukey RH, Takeuchi Y. 2014. Bilirubin uridine diphosphate-glucuronosyltransferase variation is a genetic basis of breast milk jaundice. J Pediatr 165(1):36-41.e1. doi:10.1016/j.jpeds.2014.01.060 PMID:24650397 PMCID:PMC4123958
• Yueh MF, Chen S, Nguyen N, Tukey RH. 2014. Developmental onset of bilirubin-induced neurotoxicity involves Toll-like receptor 2-dependent signaling in humanized UDP-glucuronosyltransferase1 mice. J Biol Chem 289(8):4699-4709. doi:10.1074/jbc.M113.518613 PMID:24403077 PMCID:PMC3931032
• Yueh MF, Taniguchi K, Chen S, Evans RM, Hammock BD, Karin M, Tukey RH. 2014. The commonly used antimicrobial additive triclosan is a liver tumor promoter. Proc Natl Acad Sci U S A 111(48):17200-17205. doi:10.1073/pnas.1419119111 PMID:25404284 PMCID:PMC4260592

2013

• Chen S, Yueh MF, Bigo C, Barbier O, Wang K, Karin M, Nguyen N, Tukey RH. 2013. Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11). Proc Natl Acad Sci U S A 110(47):19143-19148. doi:10.1073/pnas.1319123110 PMID:24191041 PMCID:PMC3839688
• Konopnicki CM, Dickmann LJ, Tracy JM, Tukey RH, Wienkers LC, Foti RS. 2013. Evaluation of UGT protein interactions in human hepatocytes: Effect of siRNA down regulation of UGT1A9 and UGT2B7 on propofol glucuronidation in human hepatocytes. Arch Biochem Biophys 535(2):143-149. doi:10.1016/j.abb.2013.03.012 PMID:23562620 PMCID:PMC4059507
• Sumida K, Kawana M, Kouno E, Itoh T, Takano S, Narawa T, Tukey RH, Fujiwara R. 2013. Importance of UDP-Glucuronosyltransferase 1A1 expression in skin and its induction by UVB in neonatal hyperbilirubinemias. Mol Pharmacol 84(5):679-686. doi:10.1124/mol.113.088112 PMID:23950218 PMCID:PMC3807078

2012

• Chen S, Yueh MF, Evans RM, Tukey RH. 2012. Pregnane-x-receptor controls hepatic glucuronidation during pregnancy and neonatal development in humanized UGT 1 mice. Hepatology 56(2):658-667. doi:10.1002/hep.25671 PMID:22371261 PMCID:PMC3383890
• Fujiwara R, Chen S, Karin M, Tukey RH. 2012. Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-kappa B leads to hyperbilirubinemia. Gastroenterology 142:109-U259. doi:10.1053/j.gastro.2011.09.045 PMID:21983082 PMCID:PMC3428231
• Li T, Yu RT, Atkins AR, Downes M, Tukey RH, Evans RM. 2012. Targeting the pregnane X receptor in liver injury. Expert Opin Ther Targets 16(11):1075-1083. doi:10.1517/14728222.2012.715634 PMID:22913318 PMCID:PMC4319648
• Yueh MF, Li T, Evans RM, Hammock BD, Tukey RH. 2012. Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alpha. PLoS One 7(6):e37705. doi:10.1371/journal.pone.0037705 PMID:22761658 PMCID:PMC3376094 (Completed with ARRA Funds)

2011

• Yueh MF, Mellon PL, Tukey RH. 2011. Inhibition of human UGT2B7 gene expression in transgenic mice by the constitutive androstane receptor. Mol Pharmacol 79:1053-1060. doi:10.1124/mol.110.070649 PMID:21415305 PMCID:PMC3102552

2010

• Cai H, Nguyen N, Peterkin V, Yang Y, Hotz K, La Placa D, Chen S, Tukey RH, Stevens J. 2010. A humanized UGT1 mouse model expressing the UGT1A1*28 allele for assessing drug clearance by UGT1A1-dependent glucuronidation. Drug Metab Dispos 38(5):879-886. doi:10.1124/dmd.109.030130 PMID:20124398 PMCID:PMC2872941
• Fujiwara R, Nguyen N, Chen S, Tukey RH. 2010. Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP glucuronosyltransferase 1 (UGT1) locus. Proc Natl Acad Sci U S A 107(11):5024-5029. doi:10.1073/pnas.0913290107 PMID:20194756 PMCID:PMC2841904

2009

• Savas U, Machemer DE, Hsu M, Gaynor P, Lasker JM, Tukey RH, Johnson EF. 2009. Opposing roles of peroxisome proliferator-activated receptor alpha and growth hormone in the regulation of CYP4A11 expression in a transgenic mouse model. J Biol Chem 284(24):16541-16552. doi:10.1074/jbc.M902074200 PMID:19366684 PMCID:PMC2713544
• Senekeo-Effenberger K, Tukey RH, Remmel RP, Larson EE, Argikar U. 2009. Studies on induction of lamotrigine metabolism in transgenic UGT1 mice. Xenobiotica 39(11):826-835. doi:10.3109/00498250903188985 PMID:19845433 PMCID:PMC2891280

2008

• Nguyen N, Bonzo JA, Chen S, Chouinard S, Kelner MJ, Hardiman G, Belanger A, Tukey RH. 2008. Disruption of the ugt1 locus in mice resembles human Crigler-Najjar type I disease. J Biol Chem 283(12):7901-7911. doi:10.1074/jbc.M709244200 PMID:18180294
• Yueh MF, Tukey RH, Chouinard S, Giton F, Fiet J, Pelletier G, Barbier O, Belanger A. 2008. Inactivation by UDP-glucuronosyltransferase enzymes: the end of androgen signaling. Psychiatr Pol 109(3-5):247-253. doi:10.1016/j.jsbmb.2008.03.016 PMID:18467088

2007

• Bonzo JA, Belanger A, Tukey RH. 2007. The role of chrysin and the Ah receptor in induction of the human UGT1A1 gene in vitro and in transgenic UGT1 mice. Hepatology 45(2):349-360. PMID:17256720
• Operana T, Nguyen N, Chen S, Beaton D, Tukey RH. 2007. Human CYP1A1GFP expression in transgenic mice serves as a biomarker for environmental toxicant exposure. Toxicol Sci 95(1):98-107. doi:10.1093/toxsci/kfl144 PMID:17065433
• Pezzoli K, Tukey RH, Sarabia H, Zaslavsky I, Miranda ML, Suk WA, Lin A, Ellisman MH. 2007. The NIEHS Environmental Health Sciences Data Resource Portal: placing advanced technologies in service to vulnerable communities. Environ Health Perspect 115(4):564-571. doi:10.1289/ehp.9817 PMID:17450225 PMCID:PMC1852670
• Senekeo-Effenberger K, Chen S, Brace-Sinnokrak E, Bonzo JA, Yueh MF, Argikar U, Kaeding J, Trottier J, Remmel RP, Ritter JK, Barbier O, Tukey RH. 2007. Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation. Drug Metab Dispos 35(3):419-427. doi:10.1124/dmd.106.013243 PMID:17151188
• Yueh MF, Tukey RH. 2007. Nrf2-Keap1 signaling pathway regulates human UGT1A1 expression in vitro and in transgenic UGT1 mice. J Biol Chem 282(12):8749-8758. doi:10.1074/jbc.M610790200 PMID:17259171

2006

• Zaslavsky I, Pezzoli K, Valentine D, Lin A, Sarabia H, Ellisman MH, Tukey RH, Hull A, Miranda ML, Avakian MD. 2006. Intgrating GIS and portal Technologies for assessing environmental health impacts of Hurricane Katrina. In: Proceedings of the Second International Conference on Environmental Science and Technology Vol II, August 19-22. American Science Press, Houston, TX. pp.385-390.

2005

• Bonzo JA, Chen S, Galijatovic A, Tukey RH. 2005. Arsenite inhibition of CYP1A1 induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin is independent of cell cycle arrest. Mol Pharmacol 67(4):1247-1256. PMID:15630080
• Chen S, Beaton D, Nguyen N, Senekeo-Effenberger K, Brace-Sinnokrak E, Argikar U, Remmel RP, Trottier J, Barbier O, Ritter JK, Tukey RH. 2005. Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus. J Biol Chem 280(45):37547-37557. doi:10.1074/jbc.M506683200 PMID:16155002
• Chen S, Operana T, Bonzo JA, Nguyen N, Tukey RH. 2005. ERK kinase inhibition stabilizes the aryl hydrocarbon receptor: implications for transcriptional activation and protein degradation. J Biol Chem 280(6):4350-4359. doi:10.1074/jbc.M411554200 PMID:15572374
• Machemer DE, Tukey RH. 2005. The role of protein kinase C in regulation of TCDD-mediated CYP1A1 gene expression. Toxicol Sci 87(1):27-37. PMID:15947024

2004

• Galijatovic A, Beaton D, Nguyen N, Chen S, Bonzo JA, Johnson RS, Maeda S, Karin M, Guengerich FP, Tukey RH. 2004. The human CYP1A1 gene is regulated in a developmental and tissue-specific fashion in transgenic mice. J Biol Chem 279(23):23969-23976. PMID:15037607

2003

• Chen S, Nguyen N, Tamura K, Karin M, Tukey RH. 2003. The role of the Ah receptor and p38 in benzo[a]pyrene-7,8-dihydrodiol and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced apoptosis. J Biol Chem 278(21):19526-19533. PMID:12637498
• Yueh MF, Huang Y, Hiller A, Chen S, Nguyen N, Tukey RH. 2003. Involvement of the xenobiotic response element (XRE) in ah receptor-mediated induction of human UDP-glucuronosyltransferase 1A1. J Biol Chem 278(17):15001-15006. PMID:12566446

2002

• Huang Y, Galijatovic A, Nguyen N, Geske D, Beaton D, Green J, Green M, Peters WH, Tukey RH. 2002. Identification and functional characterization of UDP-glucuronosyltransferases UGT1A8*1, UGT1A8*2 and UGT1A8*3. Pharmacogenet Genomics 12(4):287-297. PMID:12042666

2001

• Yueh MF, Nguyen N, Famourzadeh M, Strassburg CP, Oda Y, Guengerich FP, Tukey RH. 2001. The contribution of UDP-glucuronosyltransferase 1A9 on CYP1A2-mediated genotoxicity by aromatic and heterocyclic amines. Carcinogenesis 22(6):943-950. PMID:11375903