Superfund Research Program

Dr. Mark H. Ellisman

University of California-San Diego
Neurosciences and National Center for Microscopy and Imaging Research
Basic Science Building, Room 1000
9500 Gilman Drive, MC 0608
La Jolla, California 92093-0608
Phone: 858-534-2251
Fax: 858-534-7497
Email: mellisman@ucsd.edu

Projects

• University of California-San Diego: Macromolecular Characterization (2000 - 2005)
• University of California-San Diego: Multiscale Imaging and Proteomics Core (2005-2017)

Publications

2016

• Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins GA, Ali S, McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M. 2016. NF-κB restricts inflammasome activation via elimination of damaged mitochondria. Cell 164(5):896-910. doi:10.1016/j.cell.2015.12.057 PMID:26919428 PMCID:PMC4769378

2015

• Antonucci L, Fagman JB, Kim J, Todoric J, Gukovsky I, Mackey MR, Ellisman MH, Karin M. 2015. Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress. Proc Natl Acad Sci U S A 112(45):E6166-E6174. doi:10.1073/pnas.1519384112 PMID:26512112 PMCID:PMC4653219

2014

• Dowding JM, Song W, Bossy K, Karakoti A, Kumar A, Kim AH, Bossy B, Seal S, Ellisman MH, Perkins GA, Self WT, Bossy-Wetzel E. 2014. Cerium oxide nanoparticles protect against A beta -induced mitochondrial fragmentation and neuronal cell death. Cell Death Differ 21(10):1622-1632. doi:10.1038/cdd.2014.72 PMID:24902900 PMCID:PMC4158687
• Inokuchi-Shimizu S, Park E, Roh Y, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W, Mackey MR, Akira S, Ellisman MH, Sears DD, Olefsky J, Karin M, Brenner DA, Seki E. 2014. TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. J Clin Invest 124(8):3566-3578. doi:10.1172/JCI74068 PMID:24983318 PMCID:PMC4109552

2012

• Falivelli G, De Jaco A, Favaloro FL, Kim H, Wilson J, Dubi N, Ellisman MH, Abrahams BS, Taylor PW, Comoletti D. 2012. Inherited genetic variants in autism-related CNTNAP2 show perturbed trafficking and ATF6 activation. Hum Mol Genet 21:4761-4773. doi:10.1093/hmg/dds320 PMID:22872700 PMCID:PMC3471401
• Lee J, Budanov AV, Talukdar S, Park E, Park H, Park H, Bandyopadhyay G, Li N, Aghajan M, Jang I, Wolfe AM, Perkins GA, Ellisman MH, Bier E, Scadeng M, Foretz M, Viollet B, Olefsky J, Karin M. 2012. Maintenance of metabolic homeostasis by Sestrin 2 and Sestrin 3. Cell Metab 16(3):311-321. doi:10.1016/j.cmet.2012.08.004 PMID:22958918 PMCID:PMC3687365
• Perkins GA, Scott RT, Perez A, Ellisman MH, Johnson JE, Fox DA. 2012. Bcl-xL-mediated remodeling of rod and cone synaptic mitochondria after postnatal lead exposure: Electron microscopy, tomography and oxygen consumption. Mol Vis 18:3029-3048. PMID:23288995 PMCID:PMC3534145

2010

• De Jaco A, Lin MZ, Dubi N, Comoletti D, Miller MT, Camp S, Ellisman MH, Butko MT, Tsien RY, Taylor PW. 2010. Neuroligin trafficking deficiencies arising from mutations in the alpha/beta-hydrolase fold protein family. J Biol Chem 285:28674-28682. doi:10.1074/jbc.M110.139519 PMID:20615874 PMCID:PMC2937894
• Lee J, Budanov AV, Park E, Birse R, Kim TE, Perkins GA, Ocorr K, Ellisman MH, Bodmer R, Bier E, Karin M. 2010. Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science 327(5970):1223-1228. doi:10.1126/science.1182228 PMID:20203043 PMCID:PMC2866632
• Suhr ST, Chang E, Tjong J, Alcasid N, Perkins GA, Goissis M, Ellisman MH, Perez GI, Cibelli J. 2010. Mitochondrial rejuvenation after induced pluripotency. PLoS One 5:e14095:doi:10.1371/journal.pone.0014095 PMID:21124794 PMCID:PMC2991355

2009

• Perkins GA, Bossy-Wetzel E, Ellisman MH. 2009. New insights into mitochondrial structure during cell death. Experimental Neurology 218(2):183-92. doi:10.1016/j.expneurol.2009.05.021 PMID:19464290 PMCID:PMC2712651

2008

• Yamaguchi R, Lartigue L, Perkins GA, Scott RT, Dixit A, Kushnareva Y, Kuwana T, Ellisman MH, Newmeyer DD. 2008. Opa1-mediated cristae opening is Bax/Bak and BH3 dependent, required for apoptosis, and independent of Bak oligomerization. Mol Cell 31(4):557-569. doi:10.1016/j.molcel.2008.07.010 PMID:18691924 PMCID:PMC2636708

2007

• Bencheikh-Latmani R, Obraztsova AY, Mackey MR, Ellisman MH, Tebo BM. 2007. Toxicity of Cr(III) to Shewanella sp. strain MR-4 during Cr(VI) reduction. Environ Sci Technol 41(1):214-220. PMID:17265950
• Pezzoli K, Tukey RH, Sarabia H, Zaslavsky I, Miranda ML, Suk WA, Lin A, Ellisman MH. 2007. The NIEHS Environmental Health Sciences Data Resource Portal: placing advanced technologies in service to vulnerable communities. Environ Health Perspect 115(4):564-571. doi:10.1289/ehp.9817 PMID:17450225 PMCID:PMC1852670

2006

• De Jaco A, Comoletti D, Kovarik Z, Gaietta G, Radic Z, Lockridge O, Ellisman MH, Taylor PW. 2006. A mutation linked with autism reveals a common mechanism of endoplasmic retic a, B-beta-hydrolase fold protein family. J Biol Chem 281(14):9667-9676. PMID:16434405
• Zaslavsky I, Pezzoli K, Valentine D, Lin A, Sarabia H, Ellisman MH, Tukey RH, Hull A, Miranda ML, Avakian MD. 2006. Intgrating GIS and portal Technologies for assessing environmental health impacts of Hurricane Katrina. In: Proceedings of the Second International Conference on Environmental Science and Technology Vol II, August 19-22. American Science Press, Houston, TX. pp.385-390.

2005

• Bencheikh-Latmani R, Obraztsova AY, Mackey MR, Ellisman MH, Tebo BM. 2005. Toxicity of uncomplexed trivalent chromium to Shewanella oneidensis MR-4 during Cr(VI) reduction. Environ Sci Technol
• Coggan JS, Bartol TM, Esquenazi E, Stiles JR, Lamont S, Martone ME, Berg DK, Ellisman MH, Sejnowski TJ. 2005. Evidence for ectopic neurotransmission at a neuronal synapse. Science 309:446-451. PMID:16020730
• Giepmans BN, Deerinck TJ, Smarr BL, Jones YZ, Ellisman MH. 2005. Correlated light and electron microscopic imaging of multiple endogenous proteins using Quantum dots. Nat Methods 2(10):743-749. PMID:16179920
• Sosinsky GE, Deerinck TJ, Greco R, Buitenhuys CH, Bartol TM, Ellisman MH. 2005. Development of a model for microphysiological simulations: small nodes of ranvier from peripheral nerves of mice reconstructed by electron tomography. Neuroinformatics 3(2):133-162. doi:10.1385/NI:3:2:133 PMID:15988042
• Weis BK, Balshaw DM, Barr JR, Brown D, Ellisman MH, Lioy PJ, Omenn G, Potter JD, Smith MT, Sohn L, Suk WA, Sumner S, Swenberg JA, Walt DR, Watkins S, Thompson CL, Wilson SH. 2005. Personalized exposure assessment: promising approaches for human environmental health research. Environ Health Perspect 113(7):840-848. PMID:16002370 PMCID:PMC1257643

2004

• Comoletti D, De Jaco A, Jennings LL, Flynn RE, Gaietta G, Tsigelny I, Ellisman MH, Taylor PW. 2004. The Arg451Cys-neuroligin-3 mutation associated with autism reveals a defect in protein processing. J Neurosci 24(20):4889-4893. PMID:15152050
• Martone ME, Gupta A, Ellisman MH. 2004. e-Neuroscience: challenges and triumphs in integrating distributed data from molecules to brains. Nat Neurosci 7:467-472. PMID:15114360

2003

• He L, Perkins GA, Poblenz AT, Harris JB, Hung M, Ellisman MH, Fox DA. 2003. Bcl-xL overexpression blocks bax-mediated mitochondrial contact site formation and apoptosis in rod photoreceptors of lead-exposed mice. Proc Natl Acad Sci U S A 100(3):1022-1027. doi:10.1073/pnas.0333594100 PMID:12540825 PMCID:PMC298719
• Martone ME, Zhang S, Gupta A, Qian X, He H, Price DL, Wong M, Santini S, Ellisman MH. 2003. The cell-centered database: a database for multiscale structural and protein localization data from light and electron microscopy. Neuroinformatics 1(4):379-396. PMID:15043222
• Middleton SS, Bencheikh-Latmani R, Mackey MR, Ellisman MH, Tebo BM, Criddle CS. 2003. Cometabolism of Cr(VI) by Shewanella oneidensis MR-1 produces cell-associated reduced chromium and inhibits growth. Biotechnol Bioeng 83(6):627-637. PMID:12889027