Superfund Research Program

Robert A. Roth

Michigan State University
Department of Pharmacology & Toxicology
221 Food Safety Toxicology Building
East Lansing, Michigan 48824
Phone: 517-353-9841
Fax: 517-432-2310
Email: rothr@msu.edu

Projects

• Michigan State University: Mechanisms and Consequences of Neutrophil Activation by Hazardous Chemicals (1995 - 2000)

Publications

2021

• Olivero-Verbal J, Harkema JR, Roth RA, Ganey PE. 2021. Fenofibrate, a peroxisome proliferator-activated receptor-alpha agonist, blocks steatosis and alters the inflammatory response in a mouse model of inflammation-dioxin interaction. Chem Biol Interact 345:PMID:34052195
• Rusyn I, Arzuaga X, Cattley RC, Corton JC, Ferguson SS, Godoy P, Guyton KZ, Kaplowitz N, Khetani SR, Roberts RA, Roth RA, Smith MT. 2021. Key characteristics of human hepatotoxicants as a basis for identification and characterization of the causes of liver toxicity. Hepatology 74(6):doi:10.1002/hep.31999 PMID:34105804 (ahead of print)

2012

• Fullerton AM, Roth RA, Ganey PE. 2012. 2,3,7,8-TCDD enhances the sensitivity of mice to concanavalin A immune-mediated liver injury. Toxicol Appl Pharmacol 266(2):317-327. doi:10.1016/j.taap.2012.11.009 PMID:23164664 PMCID:PMC3535831

2011

• Olivero-Verbal J, Roth RA, Ganey PE. 2011. Dioxin alters inflammatory responses to lipopolysaccharide. Toxicol Sci 93:1180-1194. doi:10.1080/02772248.2011.577554

2007

• Bezdecny SA, Karmaus P, Roth RA, Ganey PE. 2007. 2,2',4,4'-Tetrachlorobiphenyl upregulates cyclooxygenase-2 in HL-60 cells via p38 mitogen-activated protein kinase and NF-kappaB. Toxicol Appl Pharmacol 221(3):285-294. doi:10.1016/j.taap.2007.03.019 PMID:17482227 PMCID:PMC1950673
• Lee K, Roth RA, LaPres JJ. 2007. Hypoxia, therapeutics, and toxicity. J Pharmacol Exp Ther 113(2):229-46. PMID:17046066

2005

• Bezdecny SA, Roth RA, Ganey PE. 2005. Effects of 2,2',4,4'-tetrachlorobiphenyl on granulocytic HL-60 cell function and expression of cyclooxygenase-2. Toxicol Sci 84(2):328-334. doi:10.1093/toxsci/kfi093 PMID:15673847

2003

• Bezdecny SA, Roth RA, Ganey PE. 2003. Expression of cyclooxygenase-2 in HL-60 cells exposed to polychlorinated biphenyls. Toxicol Sci 72(1):1571Suppl.S..

1998

• Narayanan PK, Carter WO, Ganey PE, Roth RA, Voytik-Harbin SL, Robinson JP. 1998. Impairment of human neutrophil oxidative burst by polychlorinated biphenyls: inhibition of superoxide dismutase activity. J Leukoc Biol 63:216-224. PMID:9468280

1996

• Brown AP, Schultze AE, Holdan W, Buchweitz JP, Roth RA, Ganey PE. 1996. Lipopolysaccharide-induced hepatic injury is enhanced by polychlorinated biphenyls. Environ Health Perspect 104(6):634-640. PMID:8793352
• Ho JS, Buchweitz JP, Roth RA, Ganey PE. 1996. Identification of factors from rat neutrophils responsible for cytotoxicity to isolated hepatocytes. J Leukoc Biol 59:716-724. PMID:8656057
• Jaeschke H, Smith CW, Clemens MG, Ganey PE, Roth RA. 1996. Mechanisms of inflammatory liver injury: adhesion molecules and cytotoxicity of neutrophils. Toxicol Appl Pharmacol 139:213-226. PMID:8806837
• Wagner JG, Ganey PE, Roth RA. 1996. Nitric oxide is not involved in hepatocyte killing by neutrophils activated by N-formyl-methionyl-leucyl-phenylalanine or phorbol myristate acetate in vitro. Hepatology 23(4):803-810. PMID:8666335