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Your Environment. Your Health.

Person Details: John P. Giesy

Superfund Research Program

John P. Giesy

Michigan State University
22 Natural Resources Bldg.
East Lansing, Michigan 48824
Phone: 517-353-2000
Fax: 517-432-1699


Hazardous Waste Sites

Federal Marine Terminal

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LCP Chemicals Georgia

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  • Ela WP, Sedlak DL, Barlaz MA, Henry HF, Muir DG, Swackhamer DL, Weber EJ, Arnold RG, Ferguson PL, Field JA, Furlong ET, Giesy JP, Halden RU, Henry T, Hites RA, Hornbuckle KC, Howard PH, Luthy RG, Meyer AK, Saez AE, vom Saal FS, Vulpe CD, Wiesner MR. 2011. Toward identifying the next generation of superfund and hazardous waste site contaminants. Environ Health Perspect 119(1):6-10. doi:10.1289/ehp.1002497 PMID:21205582 PMCID:PMC3018501


  • Blankenship AL, Hilscherova K, Nie M, Coady KK, Villalobos SA, Kannan K, Powell DC, Bursian SJ, Giesy JP. 2003. Mechanisms of TCDD-induced abnormalities and embryo lethality in white leghorn chickens. Comp Biochem Physiol C Toxicol Pharmacol 136(1):47-62. PMID:14522598
  • Carr JA, Gentles B, Smith EE, Goleman WL, Urquidi LJ, Thuett K, Kendall RJ, Giesy JP, Gross TS, Solomon KR, Van Der Kraak G. 2003. Response of larval Xenopus laevis to atrazine: assessment of growth, metamorphosis, and gonadal and laryngeal morphology. Environ Toxicol Chem 22(2):396-405. PMID:12558173
  • Giesy JP, Snyder EM, Nichols KM, Snyder SA, Villalobos SA, Jones PD, Fitzgerald SD. 2003. Examination of reproductive endpoints in goldfish (Carassius auratus) exposed in situ to municipal sewage treatment plant effluent discharges in Michigan, USA. Environ Toxicol Chem 22(10):2416-2431. PMID:14552007
  • Hilscherova K, Blankenship AL, Kannan K, Nie M, Williams LL, Coady KK, Upham BL, Trosko JE, Bursian SJ, Giesy JP. 2003. Oxidative stress in laboratory-incubated double-crested cormorant eggs collected from the Great Lakes. Arch Environ Contam Toxicol 45(4):533-546. PMID:14708670
  • Hilscherova K, Blankenship AL, Nie M, Coady KK, Upham BL, Trosko JE, Giesy JP. 2003. Oxidative stress in liver and brain of the hatchling chicken (Gallus domesticus) following in ovo injection with TCDD. Comp Biochem Physiol C Toxicol Pharmacol 136(1):29-45. PMID:14522597


  • Carr JA, Gentles B, Smith EE, Goleman WL, Kendall RJ, Giesy JP, Gross TS, Solomon KR, Van Der Kraak G. 2002. Response of developing frogs (Xenopus laevis) to atrazine: Assessment of gonadal and laryngeal morphology. In: Proceedings of the Society of Environmental Toxicology and Chemistry (SETC), 23rd Annual Meeting, Salt Lake City, Utah. November 16 - 20.
  • Du Preez L, Solomon KR, Jooste AM, Jasen van Rensburg PJ, Smith EE, Carr JA, Kendall RJ, Giesy JP, Gross TS, Van Der Kraak G. 2002. Exposure characterization and responses to field exposures of Xenopus laevis to atrazine and related triazines in South African corn growing regions. In: Proceedings of the Society of Environmental Toxicology and Chemistry (SETC), 23rd Annual Meeting, Salt Lake City, Utah. November 16 - 20.
  • Gross TS, Wieser CM, Ruessler DS, Carr JA, Giesy JP, Hosmer AJ, Kendall RJ, Smith EE, Solomon KR, Van Der Kraak G. 2002. Determination of potential effects of 20 day exposure of atrazine on endocrine function in adult largemouth bass(Micropterus salmoides). In: Proceedings of the Society of Environmental Toxicology and Chemistry (SETC), 23rd Annual Meeting, Salt Lake City, Utah. November 16 - 20.
  • Hu W, Jones PD, Upham BL, Trosko JE, Lau C, Giesy JP. 2002. Inhibition of gap junctional intercellular communication by perfluorinated compounds in rat liver and dolphin kidney epithelial cell lines in vitro and Sprague-Dawley rats in vivo. Toxicol Sci 68(2):429-436. PMID:12151638
  • Villeneuve DL, Khim JS, Kannan K, Giesy JP. 2002. Relative potencies of individual polycyclic aromatic hydrocarbons to induce dioxinlike and estrogenic responses in three cell lines. Environ Toxicol Chem 17:128-137. PMID:11979591
  • Villeneuve DL, Villalobos SA, Keith TL, Snyder EM, Fitzgerald SD, Giesy JP. 2002. Effects of waterborne exposure to 4-nonylphenol on plasma sex steroid and vitellogenin concentrations in sexually mature male carp (Cyprinus carpio). Chemosphere 47(1):15-28. PMID:11996132


  • Verbrugge LA, Giesy JP, Verbrugge DA, Woodin BR, Stegeman JJ. 2001. Catalytic and immunochemical properties of hepatic cytochrome P450 1A in three avian species treated with beta-naphthoflavone or isosafrole. Comp Biochem Physiol C Toxicol Pharmacol 130(1):67-83. doi:10.1016/S1532-0456(01)00221-6 PMID:11544144


  • Miles-Richardson S, Kramer VJ, Fitzgerald SD, Render J, Barbee S, Giesy JP. 1999. Effects of waterborne exposure of 17 beta-estradiol on secondary sex characteristics and gonads of fathead minnows (Pimephales promelas). Aquat Toxicol 47(2):129-145. doi:10.1016/S0166-445X(99)00009-0
  • Miles-Richardson S, Pierens SL, Nichols KM, Kramer VJ, Giesy JP. 1999. Effects of waterborne exposure to 4-nonylphenol and nonylphenol ethoxylate on secondary sex characteristics and gonads of fathead minnows (Pimephales promelas). Environ Res 80(2):S122-S137. doi:10.1006/enrs.1998.3945 PMID:10092426


  • Ankley GT, Giesy JP, Kendall RJ. 1998. Weight of evidence. Chapter 16. In: Principles and Processes for Evaluating Endocrine Disruptors in Wildlife. SETAC Press, Pensacola, FL.
  • Ankley GT, Mahaich E, Stahl R, Tillitt DE, Colborn T, McMaster S, Miller R, Bantle J, Campbell P, Denslow ND, Dickerson RL, Folmar LC, Fry M, Giesy JP, Gray LE, Guiney PD, Hutchinson T, Kennedy SP, Kramer VJ, LeBlank G, Mayes M, Nimrod A, Patino R, Peterson R, Purdy R, Ringer R, Thomas P, Touart L, Van Der Kraak G, Zacharewski TR. 1998. Overview of a workshop on screening methods for detecting potential (anti-) estrogenic/androgenic chemicals in wildlife. Environ Toxicol Chem 17(1):68-87.
  • Feyk LL, Giesy JP. 1998. Wildlife sentinels-xenoestrogen modulation of endocrine function in birds. Chapter 6. In: Principles and Processes for Evaluating Endocrine Disruptors in Wildlife. SETAC Press, Pensacola, FL.
  • Giesy JP, Snyder EM. 1998. Environmental endocrine disruption in fish: Weight of the evidence. Chapter 7. In: Principles and Processes for Evaluating Endocrine Disruptors in Wildlife. SETAC Press, Pensacola, FL.
  • Kannan K, Guruge KS, Thomas NJ, Tanabe S, Giesy JP. 1998. Butyltin residues in southern sea otters found dead along California coastal waters. Environ Sci Technol 32(9):1169-1175.
  • Kannan K, Nakata H, Stafford R, Masson GR, Tanabe S, Giesy JP. 1998. Bioaccumulation and toxic potential of polychlorinated biphenyl congeners in biota collected at a superfund site contaminated with Aroclor 1268. Environ Sci Technol 32(9):1214-1221.
  • Kannan K, Villenueve DA, Blankenship AL, Giesy JP. 1998. Interaction of tributyltin with 3,3',4,4',5-pentachlorobiphenyl-induced ethoxyresorufin O-deethylase activity in rat hepatoma cells. J Toxicol Environ Health A 55(5):373-384. PMID:9829560
  • Kendall JJ, Brouwer A, Giesy JP. 1998. Wildlife conservation concerns and endocrine disruption in wildlife: A risk-based field and laboratory approach to assess effects. Chapter 1. In: Principles and Processes for Evaluating Endocrine Disruptors in Wildlife. SETAC Press, Pensacola, FL.
  • Klasson-Wehler E, Bergman A, Auman H, Summer C, Murk T, van den Berg M, Kannan K, Giesy JP. 1998. Hydroxylated and methylsolfonyl PCBs in albatross from Midway Atoll, North Pacific Ocean. Environ Toxicol Chem 17(8):1620-1625.
  • Koistinen J, Soimasuo R, Tukia K, Blankenship AL, Giesy JP. 1998. Induction of EROD activity in hepa-1 mouse hepatoma cells and estrogenicity in MCF-7 human breast cancer cells by extracts of pulp mill effluents, biosludge, and sediment exposed effluents. Toxicol Sci 17(8):1499-1507.
  • Kramer VJ, Miles-Richardson S, Pierens SL, Giesy JP. 1998. Reproductive impairment and induction of alkaline-labile phosphate, a biomarker of estrogen exposure, in fathead minnows (Pimephales promelas) exposed to waterborne 17 beta-estradiol. Aquat Toxicol 40(4):335-360.
  • Mousa MA, Ganey PE, Quensen JF, Madhukar BV, Chou K, Giesy JP, Fischer L, Boyd SA. 1998. Altered biological activity of commercial PCB mixtures due to microbial reductive dechlorination. In: Proceedings of the 17th International Symposium on Chlorinated Dioxins and Related Compounds. pp.1-5.
  • Quensen JF, Mousa MA, Boyd SA, Sanderson J, Fruese KL, Giesy JP. 1998. Reduction in aryl hydrocarbon receptor-mediated activity of polychlorinated biphenyl mixtures due to anaerobic microbial dechlorination. Environ Toxicol Chem 17(5):806-813.
  • Sanderson J, Giesy JP. 1998. Functional response assays in wildlife toxicology. In: Encyclopedia of environmental analysis and remediation. Wiley-Interscience,
  • Sanderson J, Kennedy SW, Giesy JP. 1998. In vitro induction of ethoxyres orufin-O-deethylase and porphyrins by halogenated aromatic hydrocarbons in avian primary hepatocytes. Environ Toxicol Chem 17(10):2006-2018.
  • Snyder SS, Villenueve DA, Pierens SL, Nichols KM, Snyder EM, Miles-Richardson S, Blankenship AL, Giesy JP. 1998. Monitoring for Complex Mixtures of Estrogen Agonists in the Aquatic Environment. In: Proceedings of the Superfund Basic Research Program: A Decade of Improving Health through Multi-Disciplinary Research. Chapel Hill, NC.
  • Villenueve DA, Blankenship AL, Giesy JP. 1998. Estrogen receptors-environmental xenobiotics. Chapter 5. In: Toxicant-Receptor Interactions and Modulation of Gene Expression. Lippincott-Raven Publishers, Philadelphia, PA.


  • Giesy JP. 1997. Trends and implications of chlorinated hydrocarbons in the Great Lakes. In: Great Lakes Fisheries Policy and Management: A Binational Perspective. Michigan State University Press, East Lansing, MI.
  • Giesy JP, Jude DJ, Tillitt DE, Gale RW, Meadows JC, Zajieck JL, Peterman PH, Verbrugge DA, Sanderson J, Schwartz TR, Tuchman ML. 1997. Polychlorinated dibenzo-p-dioxins, dibenzofurans, biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents in fishes from Saginaw Bay, Michigan. Environ Toxicol Chem 16(4):713-724. doi:10.1002/etc.5620160416
  • Giesy JP, Kramer VJ, Bergman A, Klasson-Wehler E. 1997. Hydroxylated polychlorinated biphenyl metabolites are anti-estrogenic in a stably transfected human breast adenocarcinoma (MCF-7) cell line. In: Biotransformation in Environmental Risk Assessment. SETAC-Europe Press, Brussels, Belgium. pp.115-121.
  • Gray LE, Klece WR, Wiese T, Tyl R, Gaido KW, Cook J, Klinefelter G, Desaulniers D, Wilson E, Zacharewski TR, Waller C, Foster P, Laskey J, Reel J, Giesy JP, Laws S, McLachlan JA, Breslin W, Cooper R, Di Giulio RT, Johnson R, Purdy R, Mihaich E, Safe SH, Sonnenschein C, Welshons W, Miller R, McMaster S, Colborn T. 1997. Endocrine screening methods workshop report: detection of estrogenic and androgenic hormonal and antihormonal activity for chemicals that act via receptor or steroidogenic enzyme mechanisms. Reprod Toxicol 11(5):719-750. PMID:9311581
  • Kannan K, Tanabe S, Giesy JP. 1997. Organochlorine pesticides and polychlorinated biphenyls in foodstuffs from Asian and oceanic countries: contamination levels and dietary exposures. Rev Environ Contam Toxicol 152:1-55. PMID:9297984
  • Koistinen J, Koivusaari J, Nuuja I, Paasivarta J, Giesy JP. 1997. 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents in extracts of Baltic White-Tailed Sea Eagles. Environ Toxicol Chem 16:1533-1544.
  • Kramer VJ, Helferich WG, Bergman A, Klasson-Wehler E, Giesy JP. 1997. Hydroxylated polychlorinated biphenyl metabolites are anti-estrogenic in a stably transfected human breast adenocarcinoma (MCF7) cell line. Toxicol Appl Pharmacol 144(2):363-376. doi:10.1006/taap.1997.8163 PMID:9194421
  • Richter CA, Giesy JP, Tieber VL, Denison MS. 1997. An in vitro rainbow trout cell bioassay for AhR-mediated toxins. Environ Toxicol Chem 16:543-550.
  • Sanderson J, Janz DM, Bellward GD, Giesy JP. 1997. Effects of embryonic and adult exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on hepatic microsomal testosterone hydroxylase activities in Great Blue Herons (Ardea herodias). Environ Toxicol Chem 16:1304-1310.
  • Vethaak D, Jobling S, Waldock M, Bjerregaard P, Dickerson R, Giesy JP, Grothe D, Karbe L, Munkittrick KR, Schlumpf M, Sumpter J. 1997. Approaches for the conduct of field surveys and toxicity identification and evaluation in identifying the hazards of endocrine modulating chemicals in wildlife. In: Proceedings of the SETAC (Society of Environmental Toxicology and Chemistry)-Europe/OECD (Organisation for Economic Co-Operation and Development) Expert Workshop on (Endocrine Modulators and Wildlife: Assessment and Testing) EMWAT. SETAC-Europe, Brussels, Belgium. pp.13-23.


  • Garrison PA, Tullis K, Aarts JM, Brouwer A, Giesy JP, Denison MS. 1996. Species-specific recombinant cell lines as bioassay systems for the detection of 2,3,7,8-tetrachlorodibenzo-p-dioxin-like chemicals. Fundam Appl Toxicol 30(2):194-203. PMID:8812265
  • Giesy JP. 1996. Are Endocrine Disruptors Impacting Wildlife? A Review of the Evidence. In: Proceedings of the ILSI (International Life Sciences Institute ), Risk Science Institute, Brookings Institution and Society for Risk Analysis. Washington, DC.
  • Giesy JP. 1996. Endocrine Modulation: Perspectives on Aquatic Exposure and Effects Testing. In: Proceedings of the Endocrine Modulators Forum at the 83rd Annual meeting of the Chemical Specialties Manufacturers Association. Fort Lauderdale, FL.
  • Giesy JP. 1996. Hydroxylated Polychlorinated Biphenyl Metabolites are Anti-estrogenic in a stably Transfected Human Breast Adenocarcinoma (MCF-7) Cell Line. In: Proceedings of the (Society of Environmental Toxicology and Chemistry) SETAC-Europe workshop: Biotransformation in Ecological Risk Assessment. Noordwijerhout, Netherlands.
  • Giesy JP. 1996. Monitoring for Complex Mixtures of Estrogen Agonists and Antagonists in Aquatic Environments. In: Proceedings of the University of Guelph Toxicology Students' Association 11th Annual Toxicology Symposium-- Endocrine Modulators: Are They Stealing Our Future?. Guelph, Canada.
  • Giesy JP. 1996. Monitoring for Complex Mixtures of Estrogen Agonists in the Aquatic Environment: Development of Biomarkers and in vitro Assays and Determination of Effects in Fishes.
  • Giesy JP. 1996. Principles for Assessing Effects on the Endocrine System: Field and Laboratory Research. In: Proceedings of a Scientific Panel Discussion on Endocrine Disruptors in the Environment. Kiawah Island, SC.
  • Koistinen J, Sanderson J, Nevalainen T, Paasivarta J, Giesy JP. 1996. Ethoxyresorufin-o-deethylase (EROD) induction potency of polychlorinated diphenyl ethers (PCDE) in H4IIE rat hepatoma cells. Environ Toxicol Chem 15:2028-2034.
  • Kramer VJ, Helferisch WT, Bergman C, Giesy JP. 1996. In vitro Estrogenicity and Anti-estrogenicity of Hydroxylated, Chlorinated Biphenyls in Human Brest Cancer Tumor (MCF-7) Cells. In: Proceedings of the Environmental Remediation and Toxicology Forum. Lansing, MI.
  • Murk AJ, Legler J, Denison MS, Giesy JP, van der Guchte CJ, Brouwer A. 1996. Chemical-activated luciferase gene expression (CALUX): a novel in vitro bioassay for Ah receptor active compounds in sediments and pore water. Fundam Appl Toxicol 33(1):149-160. PMID:8812260
  • Sanderson J, Aarts JM, Brouwer A, Froese KL, Denison MS, Giesy JP. 1996. Comparison of Ah receptor-mediated luciferase and ethoxyresorufin-O-deethylase induction in H4IIE cells: implications for their use as bioanalytical tools for the detection of polyhalogenated aromatic hydrocarbons. Toxicol Appl Pharmacol 137(2):316-325. PMID:8661358
  • Starodub ME, Miller PA, Ferguson GM, Giesy JP, Willes RF. 1996. The use of risk assessment techniques to develop a protocol for determining acceptable concentrations of bioaccumulative chlorinated organic chemicals in sediments for the protection of piscivorous wildlife. Toxicol Sci 54:243-259. doi:10.1080/02772249609358316


  • Kramer VJ, Giesy JP. 1995. Environmental estrogens: a significant risk?. Human and Ecological Risk Assessment: An International Journal 1:37-42.
  • Newsted JL, Giesy JP, Ankley GT, Tillitt DE, Crawford RA, Gooch JL, Jones PD, Denison MS. 1995. Development of toxic equivalency factors for PCB congeners and the assessment of TCDD and PCB mixtures in rainbow trout. Environ Toxicol Chem 14(5):861-871.
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