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Person Details: David E. Hinton

Superfund Research Program

David E. Hinton

Duke University
Division of Environmental Science & Policy
A333a LSRC
Box 90328
Durham, North Carolina 27708
Phone: 919-613-8038
Fax: 919-684-8741


Hazardous Waste Sites

Mare Island Naval Shipyard

  • University of California-Davis: Aquatic Biomarkers in Site Characterization and Remediation



  • Bozinovic G, Shea D, Feng Z, Hinton DE, Sit TL, Oleksiak MF. 2021. PAH-pollution effects on sensitive and resistant embryos: Integrating structure and function with gene expression. PLoS One 16(4):e0249432. doi:10.1371/journal.pone.0249432 PMID:33822796 PMCID:PMC8023486
  • Chernick M, Lieberman N, Brown DR, Di Giulio RT, Hinton DE, Burke T. 2021. Heart development in two populations of Atlantic killifish (Fundulus heteroclitus) following exposure to a polycyclic aromatic hydrocarbon mixture. Ecotoxicol Environ Saf 208:111580. doi:10.1016/j.ecoenv.2020.111580 PMID:33396103



  • Wang F, Fang M, Hinton DE, Chernick M, Jia S, Zhang Y, Xie L, Dong W, Dong W. 2018. Increased coiling frequency linked to apoptosis in the brain and altered thyroid signaling in zebrafish embryos (Danio rerio) exposed to the PBDE metabolite 6-OH-BDE-47. Chemosphere 198:342-350. doi:10.1016/j.chemosphere.2018.01.081 PMID:29421749


  • Brown DR, Thompson J, Chernick M, Hinton DE, Di Giulio RT. 2017. Later life swimming performance and persistent heart damage following subteratogenic PAH mixture exposure in the Atlantic killifish (Fundulus heteroclitus). Environ Toxicol Chem 36:3246-3253. doi:10.1002/etc.3877 PMID:28585726
  • Macaulay LJ, Chernick M, Chen A, Hinton DE, Bailey JM, Kullman SW, Levin ED, Stapleton HM. 2017. Exposure to a PBDE/OH-BDE mixture alters juvenile zebrafish (Danio rerio) development. Environ Toxicol Chem 36(1):36-48. doi:10.1002/etc.3535 PMID:27329031
  • Mu J, Chernick M, Dong W, Di Giulio RT, Hinton DE. 2017. Early life co-exposures to a real-world PAH mixture and hypoxia result in later life and next generation consequences in medaka (Oryzias latipes). Aquat Toxicol 190:162-173. doi:10.1016/j.aquatox.2017.06.026 PMID:28728047 PMCID:PMC5584607


  • Riley AK, Chernick M, Brown DR, Hinton DE, Di Giulio RT. 2016. Hepatic responses of juvenile Fundulus heteroclitus from pollution-adapted and nonadapted populations exposed to Elizabeth River sediment extract. Toxicol Pathol 44(5):738-748. doi:10.1177/0192623316636717 PMID:26992886 PMCID:PMC4912431



  • Colton MD, Kwok KW, Brandon JA, Warren IH, Ryde IT, Cooper EM, Hinton DE, Rittschof D, Meyer JN. 2014. Developmental toxicity and DNA damage from exposure to parking lot runoff retention pond samples in the Japanese medaka (Oryzias latipes). Mar Environ Res 99:117-124. doi:10.1016/j.marenvres.2014.04.007 PMID:24816191 PMCID:PMC4309550
  • Dong W, Macaulay LJ, Kwok KW, Hinton DE, Ferguson PL, Stapleton HM. 2014. The PBDE metabolite 6-OH-BDE 47 affects melanin pigmentation and THRβ MRNA expression in the eye of zebrafish embryos. Endocr Disruptors (Austin) 2(1):doi:10.4161/23273739.2014.969072 PMID:25767823 PMCID:PMC4354867


  • Bess AS, Ryde IT, Hinton DE, Meyer JN. 2013. UVC-induced mitochondrial degradation via autophagy correlates with mtDNA damage removal in primary human fibroblasts. J Biochem Mol Toxicol 27(1):28-41. doi:10.1002/jbt.21440 PMID:23132756 PMCID:PMC3640456
  • Dong W, Macaulay LJ, Kwok KW, Hinton DE, Stapleton HM. 2013. Using whole mount in situ hybridization to examine thyroid hormone deiodinase expression in embryonic and larval zebrafish: a tool for examining OH-BDE toxicity to early life stages. Aquat Toxicol 132-133:190-199. doi:10.1016/j.aquatox.2013.02.008 PMID:23531416 PMCID:PMC3642849
  • Van Wettere AJ, Hinton DE, Kullman SW, Law JM. 2013. Anchoring hepatic gene expression with development of fibrosis and neoplasia in a toxicant-induced fish model of liver injury. Toxicol Pathol 41(5):744-760. doi:10.1177/0192623312464308 PMID:23197195 PMCID:PMC4096295




  • Wills LF, Jung D, Koehrn K, Zhu S, Hinton DE, Di Giulio RT. 2010. Comparative chronic liver toxicity of benzo a pyrene in two populations of the Atlantic Killifish (Fundulus heteroclitus) with different exposure histories. Environ Health Perspect 118:1376-1381. doi:10.1289/ehp.0901799 PMID:20501349 PMCID:PMC2957915



  • Hinton DE, Segner H, Au D, Kullman SW, Hardman R. 2007. Liver toxicity. In: The Toxicology of Fishes. Taylor & Francis, Boca Raton, FL.
  • Ostrander GK, Di Giulio RT, Hinton DE, Miller MR, Rotchell JR. 2007. Chemical Carcinogensis. In: The Toxicology of Fishes. Taylor & Francis, Boca Raton, FL.



  • Denton DL, Wheelock CE, Murray SA, Deanovic LA, Hammock BD, Hinton DE. 2003. Joint acute toxicity of esfenvalerate and diazinon to fathead minnow (Pimephales promelas) larvae. Environ Toxicol Chem 22(2):336-341. PMID:12558165
  • Kullman SW, Matsumura F, Hinton DE. 2003. Estrogen signaling in trout liver: estrogen receptor and mitogenic mediated cellular responses. Environ Sci (Ruse) 10(4):223-237.
  • Liu Z, Kullman SW, Bencic DC, Torten M, Hinton DE. 2003. ras oncogene mutations in diethylnitrosamine-induced hepatic tumors in medaka (Oryzias latipes), a teleost fish. Mutat Res 539(1-2):43-53. PMID:12948813


  • Davis CR, Okihiro MS, Hinton DE. 2002. Effects of husbandry practices, gender, and normal physiological variation on growth and reproduction of Japanese medaka, Oryzias latipes. Aquat Toxicol 60(3-4):185-201. PMID:12200085


  • Arukwe A, Kullman SW, Hinton DE. 2001. Differential biomarker gene and protein expressions in nonylphenol and estradiol-17b treated juvenile rainbow trout (Oncorhynchus mykiss). Comp Biochem Physiol C Toxicol Pharmacol 129(1):1-10.
  • Hamm JT, Wilson BW, Hinton DE. 2001. Increasing uptake and bioactivation with development positively modulate diazinon toxicity in early life stage medaka (Oryzias latipes). Toxicol Sci 61(2):304-313. PMID:11353139
  • Werner I, Koger CS, Hamm JT, Hinton DE. 2001. Ontogeny of the heat shock protein, hsp70 and hsp60, response and developmental effects of heat-shock in the teleost, Medaka (Oryzias latipes). Environ Sci (Ruse) 8:013-029.


  • Hamm JT, Hinton DE. 2000. The role of development and duration of exposure to the embryotoxicity of diazinon. Aquat Toxicol 48:403-418. PMID:10794827
  • Okihiro MS, Hinton DE. 2000. Partial hepatechtomy and bile duct ligation in rainbow trout (Oncorhynchus mykiss): histologic, immunohistochemical, and enzyme histochemical characterization of hepatic regeneration and biliary hyperplasis. Toxicol Pathol 28(2):342-356. PMID:10805153
  • Villalobos SA, Hamm JT, Teh SJ, Hinton DE. 2000. Thiobencarb-induced embryotoxicity in medaka (Oryzias latipes): stage specific toxicity and the protective role of chorion. Aquat Toxicol 48(2-3):309-326. PMID:10686335


  • Okihiro MS, Hinton DE. 1999. Progression of hepatic neoplasia in medaka (Oryzias latipes) exposed to diethylnitrosamine. Carcinogenesis 20(6):933-940. PMID:10357770
  • Teh SJ, Clark SL, Brown CL, Luoma SN, Hinton DE. 1999. Enzymatic and histopathologic biomarkers as indicators of contaminant exposure and effect in Asian clam (Potamocorbula amurensis). Biomarkers 4(6):497-509. PMID:23902395
  • Werner I, Hinton DE. 1999. Field validation of hsp 70 stress proteins as biomarker in Asian clam (Potamocorbula amurensis). Biomarkers 4(6):473-484. PMID:23902392


  • Hamm JT, Wilson BW, Hinton DE. 1998. Organophosphate-induced acetylcholinesterase inhibition and embryonic retinal cell necrosis in vivo in the teleost (Oryzias latipes). Neurotoxicology 19(6):853-870. PMID:9863774
  • Hinton DE. 1998. Multiple stressors in the Sacramento River watershed. Chapter 86 in: EXS (Basel); Fish Ecotoxicology. Birkhauser Publishers, Basel, Switzerland. pp.303-317.
  • Hinton DE, Crouch JA. 1998. Architectural pattern, tissue and cellular morphology in livers of fishes: Relationship to experimentally-induced neoplastic responses. Chapter 86 in: EXS (Basel); Fish Ecotoxicology. Birkhauser Publishers, Basel, Switzerland. pp.141-164.
  • Teh SJ, Hinton DE. 1998. Gender-specific growth and hepatic neoplasia in medaka (Oryzias latipes). Aquat Toxicol 41(1-2):141-159.


  • Boorman GA, Botts S, Bunton TE, Fournie JW, Harshbarger JC, Hawkins WE, Hinton DE, Jokinen MP, Okihiro MS, Wolfe MJ. 1997. Diagnostic criteria for degenerative, inflammatory, proliferative nonneoplastic and neoplastic liver lesions in medaka (Oryzias latipes): Consensus of a national toxicology program pathology working group. Toxicol Pathol 25(2):202-210. PMID:9125779
  • Hinton DE. 1997. Histologic responses signifying exposure or effect and their application to aquatic ecotoxicology. In: Ecotoxicology: Responses, Biomarkers, & Risk Assessment, an OECD Workshop. SOS Publications, Fair Haven, NJ. pp.293-309.
  • Teh SJ, Adams SM, Hinton DE. 1997. Histopathologic biomarkers in feral freshwater fish populations exposed to different types of contaminant stress. Aquat Toxicol 37(1):51-70.
  • Washburn BS, Rein KS, Baden DG, Walsh PJ, Hinton DE, Tullis K, Denison MS. 1997. Brevetoxin-6 (PbTx-6), a nonaromatic marine neurotoxin, is a ligand of the aryl hydrocarbon receptor. Arch Biochem Biophys 343(2):149-156. PMID:9224724


  • Anderson MJ, Miller MR, Hinton DE. 1996. In vitro modulation of 17-²-estradiol-induced vitellogenin synthesis: Effects of cytochrome P4501A1 inducing compounds on rainbow trout (Oncorhynchus mykiss) liver cells. Aquat Toxicol 34(4):327-350. doi:10.1016/0166-445X(95)00047-8
  • Anderson MJ, Olsen H, Matsumura F, Hinton DE. 1996. In vivo modulation of 17²-estradiol-induced vitellogenin synthesis and estrogen receptor in rainbow trout (Oncorhynchus mykiss) liver cells by ²-naphthoflavone. Toxicol Appl Pharmacol 137(2):210-218. doi:10.1006/taap.1996.0074 PMID:8661346
  • Hinton DE. 1996. Eighth international symposium "Pollutant responses in marine organisms" (PRIMO 8). Mar Environ Res 42(1-4):
  • Villalobos SA, Anderson MJ, Denison MS, Hinton DE, Tullis K, Kennedy IM, Jones AD, Chang DP, Yang G, Kelly PB. 1996. Dioxin-like properties of a trichloroethylene combustion-generated aerosol. Environ Health Perspect 104(7):734-743. PMID:8841759


  • Wolfe MJ, Hinton DE, Seiber JN. 1995. Aqueous sample preparation for bioassay using supercritical fluid extraction. Environ Toxicol Chem 14(6):1001-1009.
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