Superfund Research Program

Jacqueline F. Sinclair

Dartmouth Medical School
VA Medical Center 151
White River Jct., New Hampshire 05009
Phone: 802-295-9363 x5662
Fax: 802-296-6308
Email: jacqueline.sinclair@dartmouth.edu

Projects

• Dartmouth College: Effects of Arsenic on Cytochrome P450 (1995 - 2005)

Research Briefs

• 3 - Low Levels of Arsenite Found to Decrease Hepatic Cytochrome P450 Activity

Publications

2012

• Noreault-Conti TL, Fellows A, Jacobs JM, Trask HW, Strom S, Evans RM, Wrighton SA, Sinclair PR, Sinclair JF, Nichols RC. 2012. Arsenic decreases RXRα-dependent transcription of CYP3A and suppresses immune regulators in hepatocytes. Int Immunopharmacol 12(4):651-60. doi:10.1016/j.intimp.2012.01.008 PMID:22310326 PMCID:PMC3345897

2000

• Jacobs JM, Nichols C, Marek D, Gorman N, Walton HS, Sinclair PR, Sinclair JF. 2000. Effect of arsenite on induction of CYP1A4 and CYP1A5 in cultured chick embryo hepatocytes. Toxicol Appl Pharmacol 168(3):177-182. PMID:11042089

1999

• Jacobs JM, Marek D, Walton HS, Sinclair PR, Sinclair JF. 1999. Effect of sodium arsenite on heme metabolism in cultured chick embryo hepatocytes. Arch Biochem Biophys 371(1):8-14. PMID:10525283
• Jacobs JM, Nichols C, Andrew AS, Marek D, Wood SG, Sinclair PR, Wrighton SA, Kostrubsky VE, Sinclair JF. 1999. Effect of arsenite on induction of CYP1A, CYP2B and CYP3A in primary cultures of rat hepatocytes. Toxicol Appl Pharmacol 157(1):51-59. PMID:10329507

1998

• Jacobs JM, Roussel RR, Roberts M, Marek D, Wood SG, Walton HS, Dwyer B, Sinclair PR, Sinclair JF. 1998. Effect of arsenite on induction of CYP1A and CYP2H in primary cultures of chick hepatocytes. Toxicol Appl Pharmacol 150(2):376-382. PMID:9653069
• Jacobs JM, Sinclair PR, Sinclair JF, Gorman N, Walton HS, Wood SG, Nichols C. 1998. Formation of zinc protoporphyrin in cultured hepatocytes: Effects of ferrochelatase inhibition, iron chelation or lead. Toxicology 125(2-3):95-105. PMID:9570325
• Louis CA, Wood SG, Walton HS, Sinclair PR, Sinclair JF. 1998. Mechanism of the synergistic induction of CYP2H by isopentanol plus ethanol: comparison to glutethimide and relation to induction of 5-aminolevulinate synthase. Arch Biochem Biophys 360(2):239-247. PMID:9851836

1997

• Sinclair PR, Walton HS, Gorman N, Jacobs JM, Sinclair JF. 1997. Multiple roles of polyhalogenated biphenyls in causing increases in cytochrome P450 and uroporphyrin accumulation in cultured hepatocytes. Toxicol Appl Pharmacol 147(2):171-179. PMID:9439713