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Your Environment. Your Health.

Person Details: Jonathan H. Freedman

Superfund Research Program

Jonathan H. Freedman

National Institute of Environmental Health Sciences (NIEHS)
MD E1-05
P.O. BOX 12233
Research Triangle Park, North Carolina 27709
Phone: 919-541-7899
Fax: 919-541-3647
Email: freedma1@niehs.nih.gov

Projects

Publications

2016

  • Petro A, Sexton HG, Miranda C, Rastogi A, Freedman JH, Levin ED. 2016. Persisting neurobehavioral effects of developmental copper exposure in wildtype and metallothionein 1 and 2 knockout mice. BMC Pharmacol Toxicol 17(1):55. doi:10.1186/s40360-016-0096-3 PMID:27802831 PMCID:PMC5090947
  • Portier CJ, Armstrong BK, Baguley B, Baur X, Belyaev I, Belle R, Belpoggi F, Biggeri A, Bosland MC, Bruzzi P, Budnik L, Bugge M, Burns K, Calaf GM, Carpenter DO, Carpenter H, Lopez-Carillo L, Clapp R, Cocco P, Consonni D, Comba P, Craft ES, Dalvie M, Davis D, Demers PA, De Roos AJ, DeWitt JC, Forastiere F, Freedman JH, Fritschi L, Gaus C, Gohlke J, Goldberg M, Greiser E, Hansen J, Hardell L, Hauptmann M, Huang W, Huff J, James MO, Jameson C, Kortenkamp A, Kopp-Schneider A, Kromhout H, Larramendy M, Landrigan PJ, Lash LH, Leszczynski D, Lynch CF, Magnani C, Mandrioli D, Martin FL, Merler E, Michelozzi P, Miligi L, Miller A, Mirabelli D, Mirer F, Naidoo S, Perry MJ, Petronio M, Pirastu R, Portier R, Ramos KS, Robertson LW, Rodriguez T, Roosli M, Ross M, Roy D, Rusyn I, Saldiva P, Sass J, Savolainen K, Scheepers P, Sergi C, Silbergeld EK, Smith MT, Stewart BW, Sutton P, Tateo F, Terracini B, Thielmann H, Thomas DB, Vainio H, Vena J, Vineis P, Weiderpass E, Weisenburger DD, Woodruff TJ, Yorifuji T, Yu I, Zambon P, Zeeb H, Zhou SF. 2016. Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA). J Epidemiol Community Health 70(8):741-745. doi:10.1136/jech-2015-207005 PMID:26941213 PMCID:PMC4975799

2010

  • Boyd W, Crocker T, Rodriguez A, Leung MC, Lehmann D, Freedman JH, Van Houten B, Meyer JN. 2010. Nucleotide excision repair genes are expressed at low levels and are not detectably inducible in Caenorhabditis elegans somatic tissues, but their function is required for normal adult life after UVC exposure. Mutat Res 683(1-2):57-67. doi:10.1016/j.mrfmmm.2009.10.008 PMID:19879883 PMCID:PMC2799044
  • Leung MC, Goldstone JV, Boyd W, Freedman JH, Meyer JN. 2010. Caenorhabditis elegans generates biologically relevant levels of genotoxic metabolites from aflatoxin B-1 but not benzo a pyrene in vivo. Toxicol Sci 118:444-453. doi:10.1093/toxsci/kfq295 PMID:20864627 PMCID:PMC2984530

2009

2008

2007

  • Beyer RP, Lasarev MR, Meira LB, Palmer VS, Ross PK, Bammler TK, Bradford BU, Cunningham ML, Higgins G, Hurban P, Kayton RJ, Kosyk O, Vliet PA, Wolfinger R, Woods CG, Freedman JH, Linney EA, Kaufmann WK, Kavanagh TJ, Rusyn I, Samson LD, Spencer PS, Suk WA, Zarbl HF. 2007. Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses. Toxicol Sci 99(1):326-337. PMID:17562736

2006

  • Denslow ND, Colbourne JK, Dix DJ, Freedman JH, Helbing CC, Kennedy SW, Williams PL. 2006. Selection of surrogate animal species for comparative toxicogenomics. Chapter 2 in: Genomic Approaches for Cross-Species Extrapolation in Toxicology. pp.33-75.
  • Levin ED, Perraut C, Pollard N, Freedman JH. 2006. Metallothionein expression and neurocognitive function in mice. Physiol Behav 87(3):513-518. PMID:16430929

2005

  • Bammler TK, Beyer RP, Bhattacharya S, Boorman GA, Boyles A, Bradford BU, Bumgarner RE, Bushel PR, Chaturvedi K, Choi D, Cunningham ML, Deng S, Dressman HK, Fannin RD, Farin FM, Freedman JH, Fry RC, Harper A, Humble MC, Hurban P, Kavanagh TJ, Kaufmann WK, Kerr KF, Jing L, Lapidus JA, Lasarev MR, Li J, Li Y, Lobenhofer EK, Lu X, Malek RL, Milton S, Nagalla SR, O'Malley JP, Palmer VS, Pattee P, Paules RS, Perou CM, Phillips K, Qin L, Qiu Y, Quigley SD, Rodland M, Rusyn I, Samson LD, Schwartz DA, Shi Y, Shin J, Sieber SO, Slifer S, Speer MC, Spencer PS, Sproles DI, Swenberg JA, Suk WA, Sullivan RC, Tian R, Tennant RW, Todd SA, Tucker CJ, Van Houten B, Weis BK, Xuan S, Zarbl HF. 2005. Standardizing global gene expression analysis between laboratories and across platforms. Nat Methods 2(5):351-6. PMID:15846362
  • Meyer JN, Volz DC, Freedman JH, Di Giulio RT. 2005. Differential display of hepatic mRNA from killifish (Fundulus heteroclitus) inhabiting a Superfund estuary. Aquat Toxicol 73(4):327-341. PMID:15916819
  • Song MO, Freedman JH. 2005. Activation of mitogen activated protein kinases by PCB126 (3,3',4,4',5-pentachlorobiphenyl) in HepG2 cells. Toxicol Sci 84(2):308-318. doi:10.1093/toxsci/kfi084 PMID:15647597
  • Song MO, Freedman JH. 2005. Expression of copper-responsive genes in HepG2 cells. Mol Cell Biochem 279(1-2):141-147. doi:10.1007/s11010-005-8286-0 PMID:16283523

2004

  • Craft ES, Embry MR, Di Giulio RT, Freedman JH. 2004. Evidence for the role of p53 in metal-induced activation of metallothionein gene expression. In: Metal Ions in Biology and Medicine: Proceedings of the Eighth International Symposium on Metal Ions in Biology and Medicine. John Libbey Eurotext Publishers, Montrouge, France.
  • Embry MR, Whitaker J, Freedman JH, Di Giulio RT. 2004. Differential susceptibility of fish and rat liver cells to oxidative stress and cytotoxicity upon exposure to prooxidants. Comp Biochem Physiol C Toxicol Pharmacol 137(4):335-342. PMID:15228951
  • Mattie MD, Freedman JH. 2004. Copper-inducible transcription: regulation by metal- and oxidative stress-responsive pathways. Am J Physiol Cell Physiol 286(2):C293-C301. doi:10.1152/ajpcell.00293.2003 PMID:14576086

2002

  • Adams TK, Saydam N, Steiner F, Schaffner W, Freedman JH. 2002. Activation of gene expression by metal-responsive signal transduction pathways. Environ Health Perspect 110(5):813-817. PMID:12426137
  • Kimura Y, Corcoran EE, Eto K, Gengyo-Ando K, Muramatsu M, Kobayashi R, Freedman JH, Mitani S, Hagiwara M, Means AR, Tokumitsu H. 2002. A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans. EMBO J 3:962-966. PMID:12231504
  • Liao VH, Dong J, Freedman JH. 2002. Molecular characterization of a novel, cadmium-inducible gene from the nematode Caenorhabditis elegans. A new gene that contributes to the resistance to cadmium toxicity. J Biol Chem 277(44):42049-42059. doi:10.1074/jbc.M206740200 PMID:12189149
  • Liao VH, Freedman JH. 2002. Differential display analysis of gene expression in invertebrates. Cellular and Molecular Life Sciences 59:1256-1263. PMID:12363029
  • Mattie MD, Freedman JH. 2002. Copper Inducible Gene Expression Regulated by Metals and Oxidative Stress Responsive Pathways. In: Metal Ions in Biology and Medicine: Proceedings of the Seventh International Symposium on Metal Ions in Biology and Medicine. John Libbey Eurotext Publishers, Reims, France. pp.108-112.
  • Mattie MD, Freedman JH. 2002. Copper inducible gene expression regulated by metals and oxidative stress responsive pathways. Trace Elem Med 3:46.
  • Saydam N, Adams TK, Steiner F, Schaffner W, Freedman JH. 2002. Regulation of metallothionein transcription by the metal responsive transcription factor MTF-1. Identification of signal transduction cascades that control metal-inducible transcription. J Biol Chem 277:20438-20445. PMID:11923282

2001

  • Mattie MD, Freedman JH. 2001. Protective effects of aspirin and Vitamin E (a-tocopherol) against copper- and cadmium-induced toxicity. Biochem Biophys Res Commun 285(4):921-925. PMID:11467839

2000

  • Cioci LK, Qui L, Freedman JH. 2000. Transgenic strains of the nematode caenorhabditis elegans as biomonitors metal contamination. Environ Toxicol Chem 19(8):2122-2129.
  • Tcherepanova I, Bhattacharyya L, Rubin CS, Freedman JH. 2000. Aspartic proteases from the nematode Caenorhabditis elegans. Structural organization and developmental and cell-specific expression of asp-1. J Biol Chem 275(34):26359-26369. doi:10.1074/jbc.M000956200 PMID:10854422
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