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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Person Details: Karl T. Kelsey

Superfund Research Program

Karl T. Kelsey

Harvard School of Public Health
Department of Genetics and Complex Diseases
665 Huntington Avenue
Room 1-607
Boston, Massachusetts 02115
Phone: 617-432-3313
Fax: 617-432-0107
Email: kelsey@hsph.harvard.edu

Projects

Research Briefs

Publications

2014

  • Langevin SM, Houseman EA, Accomando WP, Koestler DC, Christensen BC, Nelson HH, Karagas MR, Marsit CJ, Wiencke JK, Kelsey KT. 2014. Leukocyte-adjusted epigenome-wide association studies of blood from solid tumor patients. Epigenetics 9(6):884-895. doi:10.4161/epi.28575 PMID:24671036 PMCID:PMC4065186

2012

  • Lesseur C, Gilbert-Diamond D, Andrew AS, Ekstrom RM, Li Z, Kelsey KT, Marsit CJ, Karagas MR. 2012. A case-control study of polymorphisms in zenobiotic and arsenic metabolism genes and arsenic-related bladder cancer in New Hampshire. Toxicol Lett 210:100-106. doi:10.1016/j.toxlet.2012.01.015 PMID:22306368 PMCID:PMC3374400

2009

2008

  • Rajan P, Kelsey KT, Schwartz J, Bellinger DC, Weuve J, Spiro, III A, Sparrow D, Smith TJ, Nie H, Weisskopf MG, Hu H, Wright RO. 2008. Interaction of the delta-aminolevulinic acid dehydratase polymorphism and lead burden on cognitive function: the VA normative aging study. J Occup Environ Med 50(9):1053-1061. doi:10.1097/JOM.0b013e3181792463 PMID:18784554 PMCID:PMC3664949
  • Schned AR, Andrew AS, Marsit CJ, Kelsey KT, Zens MS, Karagas MR. 2008. Histological classification and stage of newly diagnosed bladder cancer in a population-based study from the Northeastern United States. Scand J Urol Nephrol 42(3):237-42. PMID:18432530

2007

  • Hsiung DT, Marsit CJ, Houseman EA, Eddy K, Furniss CS, McClean MD, Kelsey KT. 2007. Global DNA methylation level in whole blood as a biomarker in head and neck squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev 16(1):108-14. PMID:17220338

2006

  • Andrew AS, Nelson HH, Kelsey KT, Moore JH, Meng AC, Casella DP, Tosteson TD, Schned AR, Karagas MR. 2006. Concordance of multiple analytical approaches demonstrates a complex relationship between DNA repair gene SNPs, smoking and bladder cancer susceptibility. Carcinogenesis 27(5):1030-1037. PMID:16311243
  • Marsit CJ, Eddy K, Kelsey KT. 2006. MicroRNA responses to cellular stress. Cancer Res 66(22):10843-10848. PMID:17108120
  • Marsit CJ, Houseman EA, Eddy K, Bueno R, Sugarbaker DJ, Nelson HH, Karagas MR, Kelsey KT, Christensen BC. 2006. Examination of a CpG island methylator phenotype and implications of methylation profiles in solid tumors. Cancer Res 66(21):10621-9. PMID:17079487
  • Marsit CJ, Karagas MR, Danaee H, Liu M, Andrew AS, Schned AR, Nelson HH, Kelsey KT. 2006. Carcinogen exposure and gene promoter hypermethylation in bladder cancer. Carcinogenesis 27(1):112-116. PMID:15987713
  • Marsit CJ, Karagas MR, Schned AR, Kelsey KT. 2006. Carcinogen exposure and epigenetic silencing in bladder cancer. Ann N Y Acad Sci 1076:810-821. doi:10.1196/annals.1371.031 PMID:17119258
  • Weuve J, Kelsey KT, Schwartz J, Bellinger DC, Wright RO, Rajan P, Spiro, III A, Sparrow D, Aro A, Hu H. 2006. Delta-aminolevulinic acid dehydratase polymorphism and the relation between low level lead exposure and the Mini-Mental Status Examination in older men: the Normative Aging Study. Occup Environ Med 63(11):746-753. PMID:16757504

2005

  • Hirao S, Hirao T, Hirao Y, Marsit CJ, Schned AR, Devi-Ashok T, Nelson HH, Andrew AS, Karagas MR, Kelsey KT. 2005. Loss of heterozygosity on chromosome 9q and p53 alterations in human bladder cancer. Cancer 104(9):1918-1923. doi:10.1002/cncr.21423 PMID:16149093
  • Karagas MR, Park S, Nelson HH, Andrew AS, Mott LA, Schned AR, Kelsey KT. 2005. Methylenetetrahydrofolate reductase (MTHFR) variants and bladder cancer: a population-based case-control study. Int J Hyg Environ Health 208(5):321-327. PMID:16217917
  • Karagas MR, Park S, Warren AJ, Hamilton JW, Nelson HH, Mott LA, Kelsey KT. 2005. Gender, smoking, glutathione-S-transferase variants and bladder cancer incidence: a population-based study. Cancer Lett 219(1):63-69. doi:10.1016/j.canlet.2004.10.006 PMID:15694665
  • Kelsey KT, Hirao T, Hirao S, Devi-Ashok T, Nelson HH, Andrew AS, Colt JS, Baris D, Morris J, Schned AR, Karagas MR. 2005. TP53 alterations and patterns of carcinogen exposure in a US population-based study of bladder cancer. Int J Cancer 117(3):370-375. doi:10.1002/ijc.21195 PMID:15906354
  • Marsit CJ, Karagas MR, Andrew AS, Liu M, Danaee H, Schned AR, Nelson HH, Kelsey KT. 2005. Epigenetic inactivation of SFRP genes and TP53 alteration act jointly as markers of invasive bladder cancer. Cancer Res 65(16):7081-7085. PMID:16103055
  • Wiencke JK, Aldape K, McMillan A, Wiemels JL, Moghadassi M, Miike R, Kelsey KT, Patoka J, Long J, Wrensch MR. 2005. Molecular features of adult glioma associated with patient race/ethnicity, age, and a polymorphism in O6-methylguanine-DNA-methyltransferase. Cancer Epidemiol Biomarkers Prev 14(7):1774-1783. doi:10.1158/1055-9965.EPI-05-0089 PMID:16030116

2004

  • Danaee H, Nelson HH, Liber HL, Little JB, Kelsey KT. 2004. Low dose exposure to sodium arsenite synergistically interacts with UV radiation to induce mutations and alter DNA repair in human cells. Mutagenesis 19(2):143-148. PMID:14981161
  • Kelsey KT, Hirao T, Schned AR, Hirao S, Devi-Ashok T, Nelson HH, Andrew AS, Karagas MR. 2004. A population-based study of immunohistochemical detection of p53 alteration in bladder cancer. Br J Cancer 90(8):1572-1576. PMID:15083187
  • Kelsey KT, Park S, Nelson HH, Karagas MR. 2004. A population-based case-control study of the XRCC1 Arg399Gln polymorphism and susceptibility to bladder cancer. Cancer Epidemiol Biomarkers Prev 13(8):1337-1341. PMID:15298955
  • Ryan LM, Huang W, Thurston SW, Kelsey KT, Wiencke JK, Christiani DC. 2004. On the use of biomarkers for environmental health research. Stat Methods Med Res 13(3):207-225. PMID:15198487

2003

  • Wiencke JK, Zheng S, Smith MT, Zhang L, Ma X, Wiemels JL, Marsit CJ, Kelsey KT, Buffler PA. 2003. Methylation of transcribed PTEN pseudogene in pediatric leukemia is associated with subtypes of common ALL containing t(12;21) translocation. In: Proceedings of the Ninety Fourth Annual Meeting of the (AACR) American Association for Cancer Research, July 11-14, 2003, San Francisco. San Franciso, CA.

2002

  • Danaee H, Nelson HH, Karagas MR, Schned AR, Devi-Ashok T, Hirao T, Perry AE, Kelsey KT. 2002. Microsatellite instability at tetranucleotide repeats in skin and bladder cancer. Oncogene 21(32):4894-4899. PMID:12118368
  • Danaee H, Nelson HH, Karagas MR, Schned AR, Devi-Ashok T, Hirao T, Perry AE, Kelsey KT. 2002. Microsatellite instability at tetranucleotide repeats in skin and bladder cancer. In: Proceedings of the 93rd Annual Meeting of the American Association for Cancer Research, April 6-10, 2002. San Francisco, CA.
  • Hernan MA, Checkoway H, O'Brien R, Costa-Mallen P, De Vivo I, Colditz GA, Hunter DJ, Kelsey KT, Ascherio A. 2002. MAOB intron 13 and COMT codon 158 polymorphisms, cigarette smoking, and the risk of PD. Neurology 58(9):1381-1387. PMID:12011284
  • Karagas MR, Nelson HA, Kelsey KT, Morris S, Blum JD, Tosteson TD, Carey M, Le X. 2002. Urinary arsenic species in relation to drinking water and toenail arsenic concentrations and genetic polymorphisms in GSTM1 in New Hampshire. Proceedings in Nucleic Research 17:251-261.
  • Karagas MR, Nelson HA, Kelsey KT, Morris S, Blum JD, Tosteson TD, Carey M, Le X. 2002. Urinary Arsenic species in relation to drinking water and toenail arsenic concentrations and genetic polymorphisms in GSTM1 in New Hampshire. Chapter 17 in: Biomarkers of Environmentally Associated Disease: Technologies, Concepts, and Perspectives. CRC Press Company, Boca Raton, FL.
  • Nelson HH, Kelsey KT. 2002. The molecular epidemiology of asbestos and tobacco in lung cancer. Oncogene 21(48):7284-7288. PMID:12379872
  • Schned AR, Karagas MR, Kelsey KT. 2002. Prevalence of bladder tumour types in a non-selected patient Population, classified according tothe World Health Organization/International Society of Urologic Pathologists(WHO/ISUP) System. Histopathology 41(S1):52-53.

2001

  • Caggana M, Kilgallen J, Conroy JM, Wiencke JK, Kelsey KT, Miike R, Chen P, Wrensch MR. 2001. Associations between ERCC2 polymorphisms and gliomas. Cancer Epidemiol Biomarkers Prev 10:355-360. PMID:11319176
  • Chen P, Aldape K, Wiencke JK, Kelsey KT, Miike R, Davis RL, Liu J, Kesler-Diaz A, Takahashi M, Wrensch MR. 2001. Ethnicity delineates different genetic pathways in malignant glioma. Cancer Res 61:3949-3954. PMID:11358811
  • Danaee H, Liber HL, Nelson HH, Ebie KN, Kelsey KT. 2001. Sodium arsenate and UV induced mutation at the TK locus. Environ Mol Mutagen 37(suppl32):27.
  • Hirao T, Nelson HH, Devi-Ashok T, Wain JC, Mark EJ, Christiani DC, Wiencke JK, Kelsey KT. 2001. Tobacco smoke-induced DNA damage and an early age of smoking initiation induce chromosome loss at 3p21 in lung cancer. Cancer Res 61(2):612-615. PMID:11212258
  • Park S, Karagas MR, Nelson HH, Mott LA, Bronson KM, Kelsey KT. 2001. X-ray repair cross-complementing gene 1 (XRCC1) polymorphisms and the risk of bladder cancer. In: Proceedings of the American Association for Cancer Research Annual Meeting, 2001.
  • Peters ES, Kelsey KT, Wiencke JK, Park S, Chen P, Miike R, Wrensch MR. 2001. NAT2 and NQO1 polymorphisms are not associated with adult glioma. Cancer Epidemiol Biomarkers Prev 10(2):151-152.
  • Wiencke JK, Kelsey KT, Zuo Z, Weinberg A, Wrensch MR. 2001. Genetic resistance factor for HIV-1 and immune response to varicella tester virus. Lancet 357(9253):360-361. PMID:11211001

2000

  • Chen P, Wiencke JK, Aldape K, Kesler-Diaz A, Miike R, Kelsey KT, Lee M, Liu J, Wrensch MR. 2000. Association of an ERCC1 polymorphism with adult-onset glioma. Cancer Epidemiol Biomarkers Prev 9(8):843-847. PMID:10952103
  • Duell EJ, Wiencke JK, Cheng T, Varkonyi A, Zuo Z, Devi-Ashok T, Mark EJ, Wain JC, Christiani DC, Kelsey KT. 2000. Polymorphisms in the DNA repair genes XRCC1 and ERCC2 and biomarkers of DNA damage in human blood mononuclear cells. Carcinogenesis 21(5):965-971. PMID:10783319
  • Platz EA, Wiencke JK, Kelsey KT, Janower ML, Schottenfeld D, Travis LB, Goldman MB. 2000. Chromosomal aberrations and hprt mutant frequencies in long-term US Thorotrast survivors. Int J Radiat Biol 76(7):955-961. PMID:10923619
  • Schwartz BS, Stewart WF, Kelsey KT, Simon D, Park S, Links JM, Todd AC. 2000. Associations of tibial lead levels with Bsm1 polymorphisms in the vitamin D receptor in former organolead manufacturing workers. Environ Health Perspect 108(3):199-203.

1999

  • Ishibe N, Wiencke JK, Zuo Z, McMillan A, Spitz MR, Kelsey KT. 1999. Cytochrome P450 1A1 polymorphisms and lung cancer susceptibility in Mexican-Hispanic and African-American minority populations. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999.
  • Nelson HH, Christiani DC, Mark EJ, Wiencke JK, Wain JC, Kelsey KT. 1999. Implications and prognostic value of K-ras mutation for early-stage lung cancer in women. J Natl Cancer Inst 91(23):2032-2038. PMID:10580029
  • Nelson HH, Christiani DC, Wiencke JK, Mark EJ, Wain JC, Kelsey KT. 1999. K-ras mutation and occupational asbestos exposure in lung adenocarcinoma: asbestos-related cancer without asbestosis. Cancer Res 59:4570-4573. PMID:10493509
  • Spitz MR, Wu X, Jiang HH, Kelsey KT, Wiencke JK, Hsu TC. 1999. Glutathione S-transferase (GSTM1 & GSTT1) genotypes, mutagen sensitivity, cigarette smoking and lung cancer risk. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999.
  • Wang X, Christiani DC, Mark EJ, Nelson HH, Wiencke JK, Gunn L, Wain JC, Kelsey KT. 1999. Carcinogen exposure, p53 alteration and K-ras mutation in synchronous multiple primary lung carcinoma. Cancer 85(8):1734-1739. PMID:10223567
  • Wiencke JK, Thurston SW, Kelsey KT, Varkonyi A, Wain JC, Mark EJ, Christiani DC. 1999. Early age at smoking initiation and tobacco carcinogen DNA damage in the lung. J Natl Cancer Inst 91(7):614-619. PMID:10451453
  • Wiencke JK, Varkonyi A, Kelsey KT, Wain JC, Mark EJ, Christiani DC. 1999. Polyphenol-related DNA adducts in blood mononuclear cells are increased in newly diagnosed patients with lung cancer. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999.
  • Wiencke JK, Varkonyi A, Semey K, Levay G, Wain JC, Mark EJ, Kelsey KT, Christiani DC. 1999. Detection of benzene-related DNA adducts in human tissues and evidence of co-activation with polyaromatic hydrocarbons (PAHs). In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.135.
  • Wiencke JK, Varkonyi A, Semey K, Levay G, Wain JC, Mark EJ, Kelsey KT, Christiani DC. 1999. Validation of blood mononuclear cell DNA-adducts as a marker of DNA damage in human lung. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.283.

1998

  • Alexander BH, Checkoway H, Costa-Mallen P, Faustman EM, Woods JS, Kelsey KT, Van Netten C, Costa LG. 1998. Interaction of blood lead and delta-aminolevulinic acid dehydratase genotype on markers of heme synthesis and sperm production in lead smelter workers. Environ Health Perspect 106(4):213-216. PMID:9495797 PMCID:PMC1532970
  • Kelsey KT, Wiencke JK. 1998. Growing pains for the environmental genetics of breast cancer: observations on a study of the glutathione s-transferases. J Natl Cancer Inst 90:484-485. PMID:9539238
  • Lee BW, Wain JC, Kelsey KT, Wiencke JK, Christiani DC. 1998. Association of cigarette smoking and asbestos exposure with location and histology of lung cancer. Am J Respir Crit Care Med 157:748-755. PMID:9517586
  • Nelson HH, Wiencke JK, Gunn L, Wain JC, Christiani DC, Kelsey KT. 1998. Chromosome 3p14 alterations in lung cancer: evidence that FHIT exon deletion is a target of tobacco carcinogens and asbestos. Cancer Res 58(9):1804-1807. PMID:9581816
  • Xu X, Wiencke JK, Niu T, Wang M, Watanabe H, Kelsey KT, Christiani DC. 1998. Benzene exposure, glutathione S-transferase theta homozygous deletion and sister chromatid exchanges. Am J Ind Med 33(2):157-163. PMID:9438048

1997

  • Ishibe N, Wiencke JK, Zuo Z, McMillan A, Spitz MR, Kelsey KT. 1997. Susceptibility to lung cancer in light smokers associated with Cyp1A1 polymorphisms and lung cancer in Mexican- and African-Americans. Cancer Epidemiol Biomarkers Prev 6(12):1075-1080. PMID:9419406
  • Kelsey KT, Ross D, Traver RD, Christiani DC, Zuo Z, Spitz MR, Wang M, Xu X, Lee BK, Schwartz BS, Wiencke JK. 1997. Ethnic variation in the prevalence of a common NAD(P)H quinone oxidoreductase polymorphism and its implications for anti-cancer chemotherapy. Br J Cancer 76(7):852-854. doi:10.1038/bjc.1997.474 PMID:9328142
  • Kelsey KT, Spitz MR, Zuo Z, Wiencke JK. 1997. Polymorphisms in the glutathione S-transferase class mu and theta genes interact and increase susceptibility to lung cancer in minority populations (Texas, United States). Cancer Causes Control 8(4):554-559. PMID:9242470
  • Schwartz BS, Lee B, Stewart WF, Ahn KD, Kelsey KT, Bressler JP. 1997. Associations of subtypes of hemoglobin with delta-aminolevulinic acid dehydratase genotype and dimercaptosuccinic acid-chelatable lead levels. Arch Environ Health 52(2):97-103. PMID:9124882
  • Schwartz BS, Lee B, Stewart WF, Sithisarankul P, Strickland PT, Ahn KD, Kelsey KT. 1997. delta-Aminolevulenic acid dehydratase genotype modifies four hour urinary lead excretion after oral administration of dimercaptosuccinic acid. Occup Environ Med 54(4):241-246. doi:10.1136/oem.54.4.241 PMID:9166129
  • Sithisarankul P, Schwartz BS, Lee B, Kelsey KT, Strickland PT. 1997. Aminolevulenic acid dehydratase genotype mediates plasma levels of the neurotoxin, 5-aminolevulenic acid, in lead-exposed workers. Am J Ind Med 32(1):15-20. PMID:9131207
  • Wiencke JK, Spitz MR, McMillan A, Kelsey KT. 1997. Lung cancer in Mexican-Americans and African-Americans is associated with the wildtype genotype of the NAD(P)H:quinone oxidoreductase polymorphism. Cancer Epidemiol Biomarkers Prev 6(2):87-92. PMID:9037558
  • Wiencke JK, Wrensch MR, Miike R, Zuo Z, Kelsey KT. 1997. Population-based study of glutathione S-transferase mu gene deletion in adult glioma cases and controls. Carcinogenesis 18(7):1431-1433. PMID:9230293
  • Wu MT, Kelsey KT, Mao IF, Wypij D, Liu H, Christiani DC. 1997. Elevated serum liver enzymes in coke-oven and by-product workers. J Occup Environ Med 39:527-534. PMID:9211210

1996

  • Wiencke JK, Spitz MR, McMillan A, Kelsey KT. 1996. Lung cancer in Mexican-American and African-Americans is associated with the wildtype genotype of the NAD(P)H:quinone oxidoreductase polymorphism. Am J Hum Genet 59:A294.

1995

  • Kelsey KT, Wiencke JK, Ward J, Bechtold WE, Fajen J. 1995. Sister-chromatid exchanges, glutathione S-transferase theta deletion and cytogenetic sensitivity to diepoxybutane in lymphocytes from butadiene monomer production workers. Mutat Res 335(3):267-273. PMID:8524342
  • Nelson HH, Wiencke JK, Christiani DC, Cheng T, Zuo Z, Schwartz BS, Lee B, Spitz MR, Wang M, Xu X, Kelsey KT. 1995. Ethnic differences in the prevalence of the homozygous deleted genotype of glutathione S-transferase theta. Carcinogenesis 16(5):1243-1246. PMID:7767992
  • Smith CM, Hu H, Wang X, Kelsey KT. 1995. ALA-D genotype is not associated with HT or HB levels among workers exposed to low levels of lead. Med Lav 86(3):229-235. PMID:7565283
  • Smith CM, Wang X, Hu H, Kelsey KT. 1995. A polymorphism in the δ-aminolevulinic acid dehydratase gene may modify the pharmacokinetics and toxicity of lead. Environ Health Perspect 103:248-253. PMID:7768225
  • Wiencke JK, Kelsey KT, Varkonyi A, Semey K, Wain JC, Mark EJ, Christiani DC. 1995. Correlation of DNA adducts in blood mononuclear cells with tobacco carcinogen-induced damage in human lung. Cancer Res 55(21):4910-4914. PMID:7585529
  • Wiencke JK, Pemble S, Ketterer B, Kelsey KT. 1995. Gene deletion in glutathione S-transferase theta: correlation with induced genetic damage and potential role in endogenous mutagenesis. Cancer Epidemiol Biomarkers Prev 4(3):253-259. PMID:7606200
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