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Your Environment. Your Health.

Person Details: Max Costa

Superfund Research Program

Max Costa

New York University School of Medicine
Nelson Institute of Environmental Medicine
57 OLD FORGE ROAD
Tuxedo, New York 10987
Phone: 845-731-3515
Fax: 845-351-2118
Email: max.costa@nyumc.org

Projects

Research Briefs

Publications

2019

  • Chen Q, Shen S, Sun H, Wu F, Kluz T, Kibriya MG, Chen Y, Ahsan H, Costa M. 2019. PBMC gene expression profiles of female Bangladeshi adults chronically exposed to arsenic-contaminated drinking water. Environ Pollut 259:113672. doi:10.1016/j.envpol.2019.113672 PMID:31918125

2018

2017

  • Howe CG, Liu X, Hall MN, Ilievski V, Caudill MA, Malysheva O, Lomax-Luu A, Parvez F, Siddique A, Shahriar H, Uddin MN, Islam T, Graziano JH, Costa M, Gamble MV. 2017. Sex-specific associations between one-carbon metabolism indices and posttranslational histone modifications in arsenic-exposed Bangladeshi adults. Cancer Epidemiol Biomarkers Prev 26(2):261-269. doi:10.1158/1055-9965.EPI-16-0202 PMID:27765800 PMCID:PMC5296278

2016

  • Howe CG, Liu X, Hall MN, Slavkovich VN, Ilievski V, Parvez F, Siddique A, Shahriar H, Uddin MN, Islam T, Graziano JH, Costa M, Gamble MV. 2016. Associations between blood and urine arsenic concentrations and global levels of post-translational histone modifications in Bangladeshi men and women. Environ Health Perspect 124(8):1234-1240. doi:10.1289/ehp.1510412 PMID:26967670 PMCID:PMC4977054

2015

2014

2013

2012

2011

2010

2009

2008

2007

  • Uddin AN, Burns FJ, Rossman TG, Chen H, Kluz T, Costa M. 2007. Dietary chromium and nickel enhance UV-carcinogenesis in skin of hairless mice. Toxicol Appl Pharmacol 221(3):329-38. PMID:17499830

2006

  • Arakawa H, Wu F, Costa M. 2006. Sequence specificity of Cr(III)-DNA adduct formation in the p53 gene: NGG sequences are preferential adduct-forming sites. Carcinogenesis 27(3):639-645. PMID:16251206
  • Chen H, Ke Q, Kluz T, Yan Y, Costa M. 2006. Nickel ions increase histone H3 lysine 9 dimethylation and induce transgene silencing. Mol Cell Biol 26(10):3728-3737. PMID:16648469
  • Costa M, Klein C. 2006. Toxicity and carcinogenicity of chromium compounds in humans. Crit Rev Toxicol 36(2):155-163. PMID:16736941
  • Davidson T, Chen H, Di Toro DM, D'Angelo G, Costa M. 2006. Soluble nickel inhibits HIF-prolyl-hydroxylases creating persistent hypoxic signaling in A549 cells. Mol Carcinog 45(7):479-489. PMID:16649251
  • Garrick MD, Singleton S, Vargas F, Kuo H, Zhao L, Knopfel M, Davidson T, Costa M, Paradkar P, Roth JA, Garrick LM. 2006. DMT1: which metals does it transport?. Biol Res 39(1):79-85. PMID:16629167
  • Kang GS, Li Q, Chen H, Costa M. 2006. Effect of metal ions on HIF-1alpha and Fe homeostasis in human A549 cells. Mutat Res 610(1-2):48-55. doi:10.1016/j.mrgentox.2006.06.012 PMID:16877034
  • Ke Q, Davidson T, Chen H, Kluz T, Costa M. 2006. Alterations of histone modifications and transgene silencing by nickel chloride. Carcinogenesis 27(7):1481-1488. PMID:16522665
  • Li Q, Chen H, Huang X, Costa M. 2006. Effects of 12 metal ions on iron regulatory protein 1 (IRP-1) and hypoxia-inducible factor-1 alpha (HIF-1alpha) and HIF-regulated genes. Toxicol Appl Pharmacol 213(3):245-255. doi:10.1016/j.taap.2005.11.006 PMID:16386771 PMCID:PMC2965073
  • Wu J, Eckard J, Chen H, Costa M, Frenkel K, Huang X. 2006. Altered iron homeostasis involvement in arsenite-mediated cell transformation. Free Radic Biol Med 40(3):444-452. PMID:16443159

2005

  • Chen H, Davidson T, Singleton S, Garrick MD, Costa M. 2005. Nickel decreases cellular iron level and converts cytosolic aconitase to iron-regulatory protein 1 in A549 cells. Toxicol Appl Pharmacol 206(3):275-287. PMID:16039939
  • Davidson T, Chen H, Garrick MD, D'Angelo G, Costa M. 2005. Soluble nickel interferes with cellular iron homeostasis. Mol Cell Biochem 279(1-2):157-162. PMID:16283525

2004

  • Caruso RP, Levinson B, Melamed J, Wieczorek R, Taneja S, Polsky D, Chang C, Zeleniuch-Jacquotte A, Salnikow K, Yee H, Costa M, Osman I. 2004. Altered N-myc downstream-regulated gene 1 protein expression in African-American compared with caucasian prostate cancer patients. Clin Cancer Res 10(1):222-227. PMID:14734473
  • Davidson T, Kluz T, Burns FJ, Rossman TG, Zhang Q, Uddin AN, Nadas A, Costa M. 2004. Exposure to chromium(VI) in the drinking water increases susceptibility to UV-induced skin tumors in hairless mice. Toxicol Appl Pharmacol 196(3):431-437. PMID:15094314
  • Li J, Chen H, Ke Q, Feng Z, Tang M, Liu B, Amin S, Costa M, Huang C. 2004. Differential effects of polycyclic aromatic hydrocarbons on transactivation of AP-1 and NF-kappa B in mouse epidermal Cl41 cells. Mol Carcinog 40(2):104-115. PMID:15170815
  • Li J, Chen H, Tang M, Shi X, Amin S, Desai D, Costa M, Huang C. 2004. PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cells. J Cell Biol 165(1):77-86. PMID:15067018
  • Li J, Davidson G, Huang Y, Jiang B, Shi X, Costa M, Huang C. 2004. Nickel compounds act through phosphatidylinositol-3-kinase/Akt-dependent, p70(S6k)-independent pathway to induce hypoxia inducible factor transactivation and Cap43 expression in mouse epidermal Cl41 cells. Cancer Res 64(1):94-101. PMID:14729612
  • Li J, Dokka S, Wang L, Shi X, Castranova V, Yan Y, Costa M, Huang C. 2004. Activation of aPKC is required for vanadate-induced phosphorylation of protein kinase B (Akt), but not p70S6k in mouse epidermal JB6 cells. Mol Cell Biochem 255(1-2):217-225. PMID:14971662
  • Zhao J, Chen H, Davidson T, Kluz T, Zhang Q, Costa M. 2004. Nickel-induced 1,4-alpha-glucan branching enzyme 1 up-regulation via the hypoxic signaling pathway. Toxicol Appl Pharmacol 196(3):404-409. PMID:15094311
  • Zhao J, Yan Y, Salnikow K, Kluz T, Costa M. 2004. Nickel-induced down-regulation of serpin by hypoxic signaling. Toxicol Appl Pharmacol 194(1):60-68. PMID:14728980

2003

  • Costa M. 2003. Potential hazards of hexavalent Cr in our drinking water. Toxicol Appl Pharmacol 188(1):1-5. PMID:12668116
  • Costa M, Yan Y, Zhou D, Salnikow K. 2003. Molecular mechanisms of nickel carcinogenesis: gene silencing by nickel delivery to the nucleus and gene activation/inactivation by nickel-induced cell signaling. J Environ Monit 5(2):222-223. PMID:12729258
  • Davidson T, Salnikow K, Costa M. 2003. Hypoxia inducible factor-1 alpha-independent suppression of aryl hydrocarbon receptor-regulated genes by nickel. Mol Pharmacol 64(6):1485-1493. PMID:14645679
  • Feng Z, Hu W, Rom WN, Costa M, Tang M. 2003. Chromium(VI) exposure enhances polycyclic aromatic hydrocarbon-DNA binding at the p53 gene in human lung cells. Carcinogenesis 24(4):771-778. PMID:12727806
  • Salnikow K, Davidson T, Kluz T, Chen H, Zhou D, Costa M. 2003. GeneChip analysis of signaling pathways effected by nickel. J Environ Monit 5(2):206-209. PMID:12729255
  • Salnikow K, Davidson T, Zhang Q, Chen L, Su W, Costa M. 2003. The involvement of hypoxia-inducible transcription factor-1-dependent pathway in nickel carcinogenesis. Cancer Res 63(13):3524-3530. PMID:12839937
  • Yan Y, Kluz T, Zhang P, Chen H, Costa M. 2003. Analysis of specific lysine histone H3 and H4 acetylation and methylation status in clones of cells with a gene silenced by nickel exposure. Toxicol Appl Pharmacol 190(3):272-277. PMID:12902198
  • Zhang Q, Salnikow K, Kluz T, Chen L, Su W, Costa M. 2003. Inhibition and reversal of nickel-induced transformation by the histone deacetylase inhibitor trichostatin A. Toxicol Appl Pharmacol 192(3):201-211. PMID:14575637

2002

  • Cangul H, Broday L, Salnikow K, Sutherland JE, Peng W, Zhang Q, Poltaratsky V, Yee H, Zoroddu MA, Costa M. 2002. Molecular mechanisms of nickel carcinogenesis. Toxicol Lett 127(1-3):69-75. PMID:12052643
  • Cangul H, Salnikow K, Yee H, Zagzag D, Commes T, Costa M. 2002. Enhanced expression of a novel protein in human cancer cells: a potential aid to cancer diagnosis. Cell Biol Toxicol 18(2):87-96. PMID:12046693
  • Cangul H, Salnikow K, Yee H, Zagzag D, Commes T, Costa M. 2002. Enhanced overexpression of an HIF-1/hypoxia-related protein in cancer cells. Environ Health Perspect 110(Suppl.5):783-788. PMID:12429530
  • Costa M. 2002. Molecular mechanisms of nickel carcinogenesis. Biol Chem 383(6):961-967. doi:10.1515/BC.2002.102 PMID:12222685
  • Costa M, Salnikow K, Sutherland JE, Broday L, Peng W, Zhang Q, Kluz T. 2002. The role of oxidative stress in nickel and chromate genotoxicity. Mol Cell Biochem 234-235(1-2):265-275. PMID:12162442
  • Costa M, Zoroddu MA, Suk WA, Thompson CL, Rossman T. 2002. Preface - Third International Meeting on the Molecular Mechanisms of Metal Toxicity and Carcinogenicity. Environ Health Perspect 110(Suppl.5):687-687.
  • Salnikow K, Davidson T, Costa M. 2002. The role of hypoxia-inducible signaling pathway in nickel carcinogenesis. Environ Health Perspect 110(Suppl.5):831-834. PMID:12426141
  • Salnikow K, Kluz T, Costa M, Piquemal D, Demidenko ZN, Xie K, Blagosklonny MV. 2002. The regulation of hypoxic genes by calcium involves c-Jun/AP-1, which cooperates with hypoxia-inducible factor 1 in response to hypoxia. Mol Cell Biol 22(6):1734-1741. PMID:11865053 PMCID:PMC135615
  • Zhang Q, Kluz T, Salnikow K, Costa M. 2002. Comparison of the cytotoxicity, cellular uptake, and DNA-protein crosslinks induced by potassium chromate in lymphoblast cell lines derived from three different individuals. Biol Trace Elem Res 86(1):11-22. PMID:12002656
  • Zoroddu MA, Peana M, Kowalik-Jankowska T, Kozlowski H, Costa M. 2002. The binding of Ni(II) and Cu(II) with the N-terminal tail of the histone H4. Journal of the Chemical Society - Dalton Transactions 3:458-465.

2001

  • Costa M, Sutherland JE, Peng W, Salnikow K, Broday L, Kluz T. 2001. Molecular biology of nickel carcinogenesis. Mol Cell Biochem 222(1-2):205-211. PMID:11678603
  • Huang C, Li J, Costa M, Zhang Z, Leonard SS, Castranova V, Vallyathan V, Ju G, Shi X. 2001. Hydrogen peroxide mediates activation of nuclear factor of activated T cells (NFAT) by nickel subsulfide. Cancer Res 61:8051-8057. PMID:11719426
  • Huang C, Li J, Ding M, Costa M, Castranova V, Vallyathan V, Ju G, Shi X. 2001. Transactivation of RARE and GRE in the cellular response to arsenic. Mol Cell Biochem 222:119-125. PMID:11678593
  • Huang C, Li J, Ding M, Wang L, Shi X, Castranova V, Vallyathan V, Ju G, Costa M. 2001. Arsenic-induced NF kappa beta transactivation through Erks- and JNKs-dependent pathways in mouse epidermal JB6 cells. Mol Cell Biochem 222:29-34. PMID:11678607
  • Huang C, Zhang Q, Li J, Shi X, Castranova V, Ju G, Costa M, Dong Z. 2001. Involvement of Erks activation in cadmium-induced AP-1 transactivation in vitro and in vivo. Mol Cell Biochem 222(1-2):141-147. doi:10.1023/A:1017953927347 PMID:11678596
  • Sutherland JE, Peng W, Zhang Q, Costa M. 2001. The histone deacetylase inhibitor trichostatin A reduces nickel-induced gene silencing in yeast and mammalian cells. Mutat Res 479(1-2):225-233. PMID:11470494
  • Zoroddu MA, Kowalik-Jankowska T, Kozlowski H, Salnikow K, Costa M. 2001. Ni(II) and Cu(II) binding with a 14-aminoacid sequence of Cap43 protein, TRSRSHTSEGTRSR. J Inorg Biochem 84:47-54. PMID:11330481

2000

  • Cohen M, Costa M. 2000. Chromium. In: Environmental Toxicants, Human Exposures and their Health Effects (2nd Edition). John Wiley & Sons, Inc, New York, NY. pp.173-192.
  • Costa M. 2000. Chromium. In: Molecular Biology and Toxicology of Metals. Taylor & Francis, Inc., New York, NY. pp.113-128.
  • Sutherland JE, Zhitkovich A, Kluz T, Costa M. 2000. Rats retain chromium in tissues following chronic ingestion of drinking water containing hexavalent chromium. Biol Trace Elem Res 74(1):41-53. PMID:11049199
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