Superfund Research Program

Max Costa

New York University School of Medicine
Nelson Institute of Environmental Medicine
57 OLD FORGE ROAD
Tuxedo, New York 10987
Phone: 845-731-3515
Fax: 845-351-2118
Email: max.costa@nyumc.org

Projects

• New York University School of Medicine: Administrative Core (2000 - 2006)
• New York University School of Medicine: Administrative Core (ARRA Funded) (2009-2011)
• New York University School of Medicine: Detection of Cr-DNA Adducts in Human Cells (2000 - 2006)
• New York University School of Medicine: Epigenetic Mechanisms of Ni, As, Chromate and BaP Carcinogenesis (ARRA Funded) (2009-2011)
• New York University School of Medicine: Research Translation (ARRA Funded) (2009-2011)

Research Briefs

• 122 - Factors Affecting the Impact of Exposures to Metals

Publications

2020

• Chen Q, Shen S, Sun H, Wu F, Kluz T, Kibriya MG, Chen Y, Ahsan H, Costa M. 2020. PBMC gene expression profiles of female Bangladeshi adults chronically exposed to arsenic-contaminated drinking water. Environ Pollut 259:113672. doi:10.1016/j.envpol.2019.113672 PMID:31918125

2018

• Munoz A, Eldridge WJ, Jakobsen NM, Sorensen H, Wax A, Costa M. 2018. Cellular shear stiffness reflects progression of arsenic-induced transformation during G(1). Carcinogenesis 39(2):109-117. doi:10.1093/carcin/bgx116 PMID:29069374 PMCID:PMC5862275

2017

• Howe CG, Liu X, Hall MN, Ilievski V, Caudill MA, Malysheva O, Lomax-Luu A, Parvez F, Siddique A, Shahriar H, Uddin MN, Islam T, Graziano JH, Costa M, Gamble MV. 2017. Sex-specific associations between one-carbon metabolism indices and posttranslational histone modifications in arsenic-exposed Bangladeshi adults. Cancer Epidemiol Biomarkers Prev 26(2):261-269. doi:10.1158/1055-9965.EPI-16-0202 PMID:27765800 PMCID:PMC5296278

2016

• Howe CG, Liu X, Hall MN, Slavkovich VN, Ilievski V, Parvez F, Siddique A, Shahriar H, Uddin MN, Islam T, Graziano JH, Costa M, Gamble MV. 2016. Associations between blood and urine arsenic concentrations and global levels of post-translational histone modifications in Bangladeshi men and women. Environ Health Perspect 124(8):1234-1240. doi:10.1289/ehp.1510412 PMID:26967670 PMCID:PMC4977054

2015

• Brocato J, Chen D, Liu J, Fang L, Jin C, Costa M. 2015. A potential new mechanism of arsenic carcinogenesis: depletion of stem-loop binding protein and increase in polyadenylated canonical histone H31 mRNA. Biol Trace Elem Res 166(1):72-81. doi:10.1007/s12011-015-0296-5 PMID:25893362 PMCID:PMC4470754 (Completed with ARRA Funds)
• Brocato J, Costa M. 2015. SATB1 and 2 in colorectal cancer. Carcinogenesis 36(2):186-191. doi:10.1093/carcin/bgu322 PMID:25543122 PMCID:PMC4400443
• Brocato J, Hernandez M, Laulicht F, Sun H, Shamy MY, Alghamdi MA, Khoder MI, Kluz T, Chen L, Costa M. 2015. In vivo exposures to particulate matter collected from Saudi Arabia or nickel chloride display similar dysregulation of metabolic syndrome genes. J Toxicol Environ Health A 78(23-24):1421-1436. doi:10.1080/15287394.2015.1095689 PMID:26692068 PMCID:PMC4709028 (Completed with ARRA Funds)
• Brocato J, Wu F, Chen Y, Shamy MY, Alghamdi MA, Khoder MI, Alkhatim AA, Costa M, Abdou MH. 2015. Association between sleeping hours and cardiometabolic risk factors for metabolic syndrome in a Saudi Arabian population. BMJ Open 5(11):e008590. doi:10.1136/bmjopen-2015-008590 PMID:26621514 PMCID:PMC4679834
• Munoz A, Chervona Y, Hall MN, Kluz T, Gamble MV, Costa M. 2015. Sex-specific patterns and deregulation of endocrine pathways in the gene expression profiles of Bangladeshi adults exposed to arsenic contaminated drinking water. Toxicol Appl Pharmacol 284(3):330-338. doi:10.1016/j.taap.2015.02.025 PMID:25759245 PMCID:PMC4410068
• Niu Y, DesMarais TL, Tong Z, Yao Y, Costa M. 2015. Oxidative stress alters global histone modification and DNA methylation. Free Radic Biol Med 82:22-28. doi:10.1016/j.freeradbiomed.2015.01.028 PMID:25656994 PMCID:PMC4464695 (Completed with ARRA Funds)

2014

• Brocato J, Chervona Y, Costa M. 2014. Molecular responses to hypoxia-inducible factor 1α and beyond. Mol Pharmacol 85(5):651-657. doi:10.1124/mol.113.089623 PMID:24569087 PMCID:PMC3990019 (Completed with ARRA Funds)
• Brocato J, Fang L, Chervona Y, Chen D, Kiok K, Sun H, Tseng H, Xu D, Shamy MY, Jin C, Costa M. 2014. Arsenic induces polyadenylation of canonical histone mRNA by down-regulating stem-loop-binding protein gene expression. J Biol Chem 289(46):31751-31764. doi:10.1074/jbc.M114.591883 PMID:25266719 PMCID:PMC4231654

2013

• Arita A, Munoz A, Chervona Y, Niu J, Qu Q, Zhao N, Ruan Y, Kiok K, Kluz T, Sun H, Clancy HA, Shamy MY, Costa M. 2013. Gene expression profiles in peripheral blood mononuclear cells of Chinese nickel refinery workers with high exposures to nickel and control subjects. Cancer Epidemiol Biomarkers Prev 22(2):261-269. doi:10.1158/1055-9965.epi-12-1011 PMID:23195993 PMCID:PMC3565097
• Brocato J, Costa M. 2013. Basic mechanics of DNA methylation and the unique landscape of the DNA methylome in metal-induced carcinogenesis. Crit Rev Toxicol 43(6):493-514. doi:10.3109/10408444.2013.794769 PMID:23844698 PMCID:PMC3871623
• Passantino L, Munoz A, Costa M. 2013. Sodium metavanadate exhibits carcinogenic tendencies in vitro in immortalized human bronchial epithelial cells. Metallomics 5:1357-1367. doi:10.1039/c3mt00149k PMID:23963610 PMCID:PMC3982314

2012

• Arita A, Shamy MY, Chervona Y, Clancy HA, Sun H, Hall MN, Qu Q, Gamble MV, Costa M. 2012. The effect of exposure to carcinogenic metals on histone tail modifications and gene expression in human subjects. Journal of Trace Elements in Medicine and Biology 26(2-3):174-178. doi:10.1016/j.jtemb.2012.03.012 PMID:22633395 PMCID:PMC3620044
• Chervona Y, Costa M. 2012. The control of histone methylation and gene expression by oxidative stress, hypoxia, and metals. Free Radic Biol Med 53:1041-1047. doi:10.1016/j.freeradbiomed.2012.07.020 PMID:22841757 PMCID:PMC3432141
• Chervona Y, Hall MN, Arita A, Wu F, Sun H, Tseng H, Ali E, Uddin MN, Liu X, Zoroddu MA, Gamble MV, Costa M. 2012. Association between arsenic exposure and global posttranslational histone modifications among adults in Bangladesh. Cancer Epidemiol Biomarkers Prev 21:2252-2260. doi:10.1158/1055-9965.epi-12-0833 PMID:23064002 PMCID:PMC3518638
• Clancy HA, Sun H, Passantino L, Kluz T, Munoz A, Zavadil J, Costa M. 2012. Gene expression changes in human lung cells exposed to arsenic, chromium, nickel or vanadium indicate the first steps in cancer. Metallomics 4(8):784-793. doi:10.1039/c2mt20074k PMID:22714537 PMCID:PMC3563094
• Munoz A, Costa M. 2012. Elucidating the mechanisms of nickel compound uptake: A review of particulate and nano-nickel endocytosis and toxicity. Toxicol Appl Pharmacol 260(1):1-16. doi:10.1016/j.taap.2011.12.014 PMID:22206756 PMCID:PMC3306469
• Wu F, Sun H, Kluz T, Clancy HA, Kiok K, Costa M. 2012. Epigallocatechin-3-gallate (EGCG) protects against chromate-induced toxicity in vitro. Toxicol Appl Pharmacol 258:166-175. doi:10.1016/j.taap.2011.10.018 PMID:22079256 PMCID:PMC3259276 (Completed with ARRA Funds)
• Zuo Z, Ouyang W, Li J, Costa M, Huang C. 2012. Cyclooxygenase-2 (COX-2) mediates arsenite inhibition of UVB-induced cellular apoptosis in mouse epidermal C141 cells. Curr Cancer Drug Targets 12(6):607-616. PMID:22463588 PMCID:PMC3782088

2011

• Kiok K, Sun H, Clancy HA, Bose S, Kluz T, Wu F, Costa M. 2011. Liprin-alpha4 is required for nickel induced receptor protein tyrosine phosphatase-leukocyte antigen related receptor F (RPTP-LAR) activity. PLoS One 6(8):doi:10.1371/journal.pone.0022764 PMID:21829649 PMCID:PMC3150438 (Completed with ARRA Funds)
• Sun H, Clancy HA, Kluz T, Zavadil J, Costa M. 2011. Comparison of gene expression profiles in chromate transformed BEAS-2B cells. PLoS One 6(3):1-13. doi:10.1371/journal.pone.0017982 PMID:21437242 PMCID:PMC3060877 (Completed with ARRA Funds)
• Tchou-Wong KM, Kiok K, Tang Z, Kluz T, Smith PR, Brown S, Costa M, Arita A. 2011. Effects of nickel treatment on H3K4 trimethylation and gene expression. PLoS One 6(3):doi:10.1371/journal.pone.0017728 PMID:21455298 PMCID:PMC3063782 (Completed with ARRA Funds)

2010

• Chen H, Kluz T, Zhang R, Costa M. 2010. Hypoxia and nickel inhibit histone demethylase JMJD1A and repress Spry2 expression in human bronchial epithelial BEAS-2B cells. Carcinogenesis 31:2136-2144. doi:10.1093/carcin/bgq197 PMID:20881000 PMCID:PMC2994281 (Completed with ARRA Funds)
• Zhang D, Li J, Costa M, Gao J, Huang C. 2010. JNK1 mediates degradation HIF-1alpha by a VHL-independent mechanism that involves the chaperones Hsp90/Hsp70. Cancer Res 70(2):813-823. doi:10.1158/0008-5472.CAN-09-0448 PMID:20068160 PMCID:PMC2939838 (Completed with ARRA Funds)

2009

• Ellen TP, Kluz T, Harder ME, Xiong J, Costa M. 2009. Heterochromatinization as a potential mechanism of nickel-induced carcinogenesis. Biochemistry 48(21):4626-4632. doi:10.1021/bi900246h PMID:19338343 PMCID:PMC2713359 (Completed with ARRA Funds)
• Li Q, Suen T, Sun H, Arita A, Costa M. 2009. Nickel compounds induce apoptosis in human bronchial epithelial Beas-2B cells by activation of c-Myc through ERK pathway. Toxicol Appl Pharmacol 235(2):191-198. doi:10.1016/j.taap.2008.12.005 PMID:19135467 PMCID:PMC2657554 (Completed with ARRA Funds)
• Sun H, Zhou X, Chen H, Li Q, Costa M. 2009. Modulation of histone methylation and MLH1 gene silencing by hexavalent chromium. Toxicol Appl Pharmacol 237(3):258-266. doi:10.1016/j.taap.2009.04.008 PMID:19376149 PMCID:PMC2701251 (Completed with ARRA Funds)
• Zhou X, Li Q, Arita A, Sun H, Costa M. 2009. Effects of nickel, chromate, and arsenite on histone 3 lysine methylation. Toxicol Appl Pharmacol 236(1):78-84. doi:10.1016/j.taap.2009.01.009 PMID:19371620 PMCID:PMC2684878 (Completed with ARRA Funds)

2008

• Ke Q, Ellen TP, Costa M. 2008. Nickel compounds induce histone ubiquitination by inhibiting histone deubiquitinating enzyme activity. Toxicol Appl Pharmacol 228(2):190-199. doi:10.1016/j.taap.2007.12.015 PMID:18279901 PMCID:PMC2424130
• Ke Q, Li Q, Ellen TP, Sun H, Costa M. 2008. Nickel compounds induce phosphorylation of histone H3 at serine 10 by activating JNK-MAPK pathway. Carcinogenesis 29(6):1276-1281. doi:10.1093/carcin/bgn084 PMID:18375956 PMCID:PMC2829883
• Zhou X, Sun H, Ellen TP, Chen H, Costa M. 2008. Arsenite alters global histone H3 methylation. Carcinogenesis 29(9):1831-1836. doi:10.1093/carcin/bgn063 PMID:18321869 PMCID:PMC2722848

2007

• Uddin AN, Burns FJ, Rossman TG, Chen H, Kluz T, Costa M. 2007. Dietary chromium and nickel enhance UV-carcinogenesis in skin of hairless mice. Toxicol Appl Pharmacol 221(3):329-38. PMID:17499830

2006

• Arakawa H, Wu F, Costa M. 2006. Sequence specificity of Cr(III)-DNA adduct formation in the p53 gene: NGG sequences are preferential adduct-forming sites. Carcinogenesis 27(3):639-645. PMID:16251206
• Chen H, Ke Q, Kluz T, Yan Y, Costa M. 2006. Nickel ions increase histone H3 lysine 9 dimethylation and induce transgene silencing. Mol Cell Biol 26(10):3728-3737. PMID:16648469
• Costa M, Klein C. 2006. Toxicity and carcinogenicity of chromium compounds in humans. Crit Rev Toxicol 36(2):155-163. PMID:16736941
• Davidson T, Chen H, Di Toro DM, D'Angelo G, Costa M. 2006. Soluble nickel inhibits HIF-prolyl-hydroxylases creating persistent hypoxic signaling in A549 cells. Mol Carcinog 45(7):479-489. PMID:16649251
• Garrick MD, Singleton S, Vargas F, Kuo H, Zhao L, Knopfel M, Davidson T, Costa M, Paradkar P, Roth JA, Garrick LM. 2006. DMT1: which metals does it transport?. Biol Res 39(1):79-85. PMID:16629167
• Kang GS, Li Q, Chen H, Costa M. 2006. Effect of metal ions on HIF-1alpha and Fe homeostasis in human A549 cells. Mutat Res 610(1-2):48-55. doi:10.1016/j.mrgentox.2006.06.012 PMID:16877034
• Ke Q, Davidson T, Chen H, Kluz T, Costa M. 2006. Alterations of histone modifications and transgene silencing by nickel chloride. Carcinogenesis 27(7):1481-1488. PMID:16522665
• Li Q, Chen H, Huang X, Costa M. 2006. Effects of 12 metal ions on iron regulatory protein 1 (IRP-1) and hypoxia-inducible factor-1 alpha (HIF-1alpha) and HIF-regulated genes. Toxicol Appl Pharmacol 213(3):245-255. doi:10.1016/j.taap.2005.11.006 PMID:16386771 PMCID:PMC2965073
• Wu J, Eckard J, Chen H, Costa M, Frenkel K, Huang X. 2006. Altered iron homeostasis involvement in arsenite-mediated cell transformation. Free Radic Biol Med 40(3):444-452. PMID:16443159

2005

• Chen H, Davidson T, Singleton S, Garrick MD, Costa M. 2005. Nickel decreases cellular iron level and converts cytosolic aconitase to iron-regulatory protein 1 in A549 cells. Toxicol Appl Pharmacol 206(3):275-287. PMID:16039939
• Davidson T, Chen H, Garrick MD, D'Angelo G, Costa M. 2005. Soluble nickel interferes with cellular iron homeostasis. Mol Cell Biochem 279(1-2):157-162. PMID:16283525

2004

• Caruso RP, Levinson B, Melamed J, Wieczorek R, Taneja S, Polsky D, Chang C, Zeleniuch-Jacquotte A, Salnikow K, Yee H, Costa M, Osman I. 2004. Altered N-myc downstream-regulated gene 1 protein expression in African-American compared with caucasian prostate cancer patients. Clin Cancer Res 10(1):222-227. PMID:14734473
• Davidson T, Kluz T, Burns FJ, Rossman TG, Zhang Q, Uddin AN, Nadas A, Costa M. 2004. Exposure to chromium(VI) in the drinking water increases susceptibility to UV-induced skin tumors in hairless mice. Toxicol Appl Pharmacol 196(3):431-437. PMID:15094314
• Li J, Chen H, Ke Q, Feng Z, Tang M, Liu B, Amin S, Costa M, Huang C. 2004. Differential effects of polycyclic aromatic hydrocarbons on transactivation of AP-1 and NF-kappa B in mouse epidermal Cl41 cells. Mol Carcinog 40(2):104-115. PMID:15170815
• Li J, Chen H, Tang M, Shi X, Amin S, Desai D, Costa M, Huang C. 2004. PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cells. J Cell Biol 165(1):77-86. PMID:15067018
• Li J, Davidson G, Huang Y, Jiang B, Shi X, Costa M, Huang C. 2004. Nickel compounds act through phosphatidylinositol-3-kinase/Akt-dependent, p70(S6k)-independent pathway to induce hypoxia inducible factor transactivation and Cap43 expression in mouse epidermal Cl41 cells. Cancer Res 64(1):94-101. PMID:14729612
• Li J, Dokka S, Wang L, Shi X, Castranova V, Yan Y, Costa M, Huang C. 2004. Activation of aPKC is required for vanadate-induced phosphorylation of protein kinase B (Akt), but not p70S6k in mouse epidermal JB6 cells. Mol Cell Biochem 255(1-2):217-225. PMID:14971662
• Zhao J, Chen H, Davidson T, Kluz T, Zhang Q, Costa M. 2004. Nickel-induced 1,4-alpha-glucan branching enzyme 1 up-regulation via the hypoxic signaling pathway. Toxicol Appl Pharmacol 196(3):404-409. PMID:15094311
• Zhao J, Yan Y, Salnikow K, Kluz T, Costa M. 2004. Nickel-induced down-regulation of serpin by hypoxic signaling. Toxicol Appl Pharmacol 194(1):60-68. PMID:14728980

2003

• Costa M. 2003. Potential hazards of hexavalent Cr in our drinking water. Toxicol Appl Pharmacol 188(1):1-5. PMID:12668116
• Costa M, Yan Y, Zhou D, Salnikow K. 2003. Molecular mechanisms of nickel carcinogenesis: gene silencing by nickel delivery to the nucleus and gene activation/inactivation by nickel-induced cell signaling. J Environ Monit 5(2):222-223. PMID:12729258
• Davidson T, Salnikow K, Costa M. 2003. Hypoxia inducible factor-1 alpha-independent suppression of aryl hydrocarbon receptor-regulated genes by nickel. Mol Pharmacol 64(6):1485-1493. PMID:14645679
• Feng Z, Hu W, Rom WN, Costa M, Tang M. 2003. Chromium(VI) exposure enhances polycyclic aromatic hydrocarbon-DNA binding at the p53 gene in human lung cells. Carcinogenesis 24(4):771-778. PMID:12727806
• Salnikow K, Davidson T, Kluz T, Chen H, Zhou D, Costa M. 2003. GeneChip analysis of signaling pathways effected by nickel. J Environ Monit 5(2):206-209. PMID:12729255
• Salnikow K, Davidson T, Zhang Q, Chen L, Su W, Costa M. 2003. The involvement of hypoxia-inducible transcription factor-1-dependent pathway in nickel carcinogenesis. Cancer Res 63(13):3524-3530. PMID:12839937
• Yan Y, Kluz T, Zhang P, Chen H, Costa M. 2003. Analysis of specific lysine histone H3 and H4 acetylation and methylation status in clones of cells with a gene silenced by nickel exposure. Toxicol Appl Pharmacol 190(3):272-277. PMID:12902198
• Zhang Q, Salnikow K, Kluz T, Chen L, Su W, Costa M. 2003. Inhibition and reversal of nickel-induced transformation by the histone deacetylase inhibitor trichostatin A. Toxicol Appl Pharmacol 192(3):201-211. PMID:14575637

2002

• Cangul H, Broday L, Salnikow K, Sutherland JE, Peng W, Zhang Q, Poltaratsky V, Yee H, Zoroddu MA, Costa M. 2002. Molecular mechanisms of nickel carcinogenesis. Toxicol Lett 127(1-3):69-75. PMID:12052643
• Cangul H, Salnikow K, Yee H, Zagzag D, Commes T, Costa M. 2002. Enhanced expression of a novel protein in human cancer cells: a potential aid to cancer diagnosis. Cell Biol Toxicol 18(2):87-96. PMID:12046693
• Cangul H, Salnikow K, Yee H, Zagzag D, Commes T, Costa M. 2002. Enhanced overexpression of an HIF-1/hypoxia-related protein in cancer cells. Environ Health Perspect 110(Suppl.5):783-788. PMID:12429530
• Costa M. 2002. Molecular mechanisms of nickel carcinogenesis. Biol Chem 383(6):961-967. doi:10.1515/BC.2002.102 PMID:12222685
• Costa M, Salnikow K, Sutherland JE, Broday L, Peng W, Zhang Q, Kluz T. 2002. The role of oxidative stress in nickel and chromate genotoxicity. Mol Cell Biochem 234-235(1-2):265-275. PMID:12162442
• Costa M, Zoroddu MA, Suk WA, Thompson CL, Rossman T. 2002. Preface - Third International Meeting on the Molecular Mechanisms of Metal Toxicity and Carcinogenicity. Environ Health Perspect 110(Suppl.5):687-687.
• Salnikow K, Davidson T, Costa M. 2002. The role of hypoxia-inducible signaling pathway in nickel carcinogenesis. Environ Health Perspect 110(Suppl.5):831-834. PMID:12426141
• Salnikow K, Kluz T, Costa M, Piquemal D, Demidenko ZN, Xie K, Blagosklonny MV. 2002. The regulation of hypoxic genes by calcium involves c-Jun/AP-1, which cooperates with hypoxia-inducible factor 1 in response to hypoxia. Mol Cell Biol 22(6):1734-1741. PMID:11865053 PMCID:PMC135615
• Zhang Q, Kluz T, Salnikow K, Costa M. 2002. Comparison of the cytotoxicity, cellular uptake, and DNA-protein crosslinks induced by potassium chromate in lymphoblast cell lines derived from three different individuals. Biol Trace Elem Res 86(1):11-22. PMID:12002656
• Zoroddu MA, Peana M, Kowalik-Jankowska T, Kozlowski H, Costa M. 2002. The binding of Ni(II) and Cu(II) with the N-terminal tail of the histone H4. Journal of the Chemical Society - Dalton Transactions 3:458-465.

2001

• Costa M, Sutherland JE, Peng W, Salnikow K, Broday L, Kluz T. 2001. Molecular biology of nickel carcinogenesis. Mol Cell Biochem 222(1-2):205-211. PMID:11678603
• Huang C, Li J, Costa M, Zhang Z, Leonard SS, Castranova V, Vallyathan V, Ju G, Shi X. 2001. Hydrogen peroxide mediates activation of nuclear factor of activated T cells (NFAT) by nickel subsulfide. Cancer Res 61:8051-8057. PMID:11719426
• Huang C, Li J, Ding M, Costa M, Castranova V, Vallyathan V, Ju G, Shi X. 2001. Transactivation of RARE and GRE in the cellular response to arsenic. Mol Cell Biochem 222:119-125. PMID:11678593
• Huang C, Li J, Ding M, Wang L, Shi X, Castranova V, Vallyathan V, Ju G, Costa M. 2001. Arsenic-induced NF kappa beta transactivation through Erks- and JNKs-dependent pathways in mouse epidermal JB6 cells. Mol Cell Biochem 222:29-34. PMID:11678607
• Huang C, Zhang Q, Li J, Shi X, Castranova V, Ju G, Costa M, Dong Z. 2001. Involvement of Erks activation in cadmium-induced AP-1 transactivation in vitro and in vivo. Mol Cell Biochem 222(1-2):141-147. doi:10.1023/A:1017953927347 PMID:11678596
• Sutherland JE, Peng W, Zhang Q, Costa M. 2001. The histone deacetylase inhibitor trichostatin A reduces nickel-induced gene silencing in yeast and mammalian cells. Mutat Res 479(1-2):225-233. PMID:11470494
• Zoroddu MA, Kowalik-Jankowska T, Kozlowski H, Salnikow K, Costa M. 2001. Ni(II) and Cu(II) binding with a 14-aminoacid sequence of Cap43 protein, TRSRSHTSEGTRSR. J Inorg Biochem 84:47-54. PMID:11330481

2000

• Cohen M, Costa M. 2000. Chromium. In: Environmental Toxicants, Human Exposures and their Health Effects (2nd Edition). John Wiley & Sons, Inc, New York, NY. pp.173-192.
• Costa M. 2000. Chromium. In: Molecular Biology and Toxicology of Metals. Taylor & Francis, Inc., New York, NY. pp.113-128.
• Sutherland JE, Zhitkovich A, Kluz T, Costa M. 2000. Rats retain chromium in tissues following chronic ingestion of drinking water containing hexavalent chromium. Biol Trace Elem Res 74(1):41-53. PMID:11049199