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Person Details: Toby G. Rossman

Superfund Research Program

Toby G. Rossman

New York University School of Medicine
Tuxedo, New York 10987
Phone: 845-731-3616
Fax: 845-351-3489


Research Briefs



  • Komissarova EV, Rossman TG. 2009. Arsenite induced poly(ADP-ribosyl)ation of tumor suppressor P53 in human skin keratinocytes as a possible mechanism for carcinogenesis associated with arsenic exposure. Toxicol Appl Pharmacol 243(3):399-404. doi:10.1016/j.taap.2009.12.014 PMID:20036271 PMCID:PMC2830301 (Completed with ARRA Funds)


  • Komissarova EV, Li P, Uddin AN, Chen X, Nadas A, Rossman TG. 2008. Gene expression levels in normal human lymphoblasts with variable sensitivities to arsenite: identification of GGT1 and NFKBIE expression levels as possible biomarkers of susceptibility. Toxicol Appl Pharmacol 226(2):199-205. PMID:17976673


  • Klein C, Leszczynska J, Hickey C, Rossman TG. 2007. Further evidence against a direct genotoxic mode of action for arsenic-induced cancer. Toxicol Appl Pharmacol 222(3):289-97. PMID:17316729
  • Uddin AN, Burns FJ, Rossman TG, Chen H, Kluz T, Costa M. 2007. Dietary chromium and nickel enhance UV-carcinogenesis in skin of hairless mice. Toxicol Appl Pharmacol 221(3):329-38. PMID:17499830


  • Komissarova EV, Saha SK, Rossman TG. 2005. Dead or dying: the importance of time in cytotoxicity assays using arsenite as an example. Toxicol Appl Pharmacol 202(1):99-107. PMID:15589980
  • Uddin AN, Burns FJ, Rossman TG. 2005. Vitamin E and organoselenium prevent the cocarcinogenic activity of arsenite with solar UVR in mouse skin. Carcinogenesis 26(12):2179-2186. doi:10.1093/carcin/bgi180 PMID:16014701
  • Yang C, Wu J, Zhang R, Zhang P, Eckard J, Yusuf R, Huang X, Rossman TG, Frenkel K. 2005. Caffeic acid phenethyl ester (CAPE) prevents transformation of human cells by arsenite (As) and suppresses growth of As-transformed cells. Toxicology 213(1-2):81-96. PMID:16085347


  • Burns FJ, Uddin AN, Wu F, Nadas A, Rossman TG. 2004. Arsenic-induced enhancement of ultraviolet radiation carcinogenesis in mouse skin: a dose-response study. Environ Health Perspect 112(5):599-603. PMID:15064167
  • Davidson T, Kluz T, Burns FJ, Rossman TG, Zhang Q, Uddin AN, Nadas A, Costa M. 2004. Exposure to chromium(VI) in the drinking water increases susceptibility to UV-induced skin tumors in hairless mice. Toxicol Appl Pharmacol 196(3):431-437. PMID:15094314
  • Li P, Uddin AN, Liu Z, Mukhopadhyay R, Komissarova EV, Rosen BP, Rossman TG. 2004. Variability in sensitivity to arsenite does not correlate with arsenic accumulation rate in normal human lymphoblasts. Mol Cell Biochem 255(1-2):79-85. PMID:14971648
  • Rossman TG, Uddin AN. 2004. Selenium prevents spontaneous and arsenite-induced mutagenesis. Int Congr Ser 1275:173-179.
  • Rossman TG, Uddin AN, Burns FJ. 2004. Evidence that arsenite acts as a cocarcinogen in skin cancer. Toxicol Appl Pharmacol 198(3):394-404. PMID:15276419


  • Mure K, Uddin AN, Lopez LC, Styblo M, Rossman TG. 2003. Arsenite induces delayed mutagenesis and transformation in human osteosarcoma cells at extremely low concentrations. Environ Mol Mutagen 41(5):322-331. PMID:12802802
  • Rossman TG. 2003. Mechanism of arsenic carcinogenesis: an integrated approach. Mutat Res 533(1-2):37-65. PMID:14643412
  • Rossman TG, Uddin AN, Burns FJ, Bosland MC. 2003. Does arsenic require a carcinogenic partner? (W.R. Chappell et al. eds. Elsevier, New York). In: Arsenic Exposure and Health Effects IV. Elsevier, New York, NY. pp.195-207.
  • Rossman TG, Visalli MA, Komissarova EV. 2003. fau and its ubiquitin-like domain (FUBI) transforms human osteogenic sarcoma (HOS) cells to anchorage-independence. Oncogene 22(12):1817-1821. PMID:12660817
  • Wu J, Eckard J, Rossman TG, Yang C, Frenkel K. 2003. p53 Signaling pathway involved in arsenite-induced HOS cell transformation and its prevention by caffeic acid phenethyl ester (CAPE). Toxicol Sci 72(1):1307Suppl.S.
  • Wu J, Yang C, Eckard J, Rossman TG, Frenkel K. 2003. Arsenite-induced human cell tranformation and down-regulation of stress and toxicity-related genes: Reversal by caffeic acid phenethyl ester (CAPE). In: Proceedings of the Ninety Fourth (AACR) American Association for Cancer Researcht, April 5-9, 2003, Toronto. Toronto, Canada.


  • Frenkel K, Rossman TG, Yang C. 2002. Caffeic acid phenethyl ester (CAPE) prevents arsenic-mediated transformation of human cells and down-regulation of inflammatory cytokines. Cancer Detect Prev 67.
  • Yang C, Zhang RH, Eckard J, Yusuf R, Rossman TG, Frenkel K. 2002. Critical role of inflammatory cytokines in the inhibition of arsenic-induced cell transformation by caffeic acid phenethyl ester (CAPE). In: Proceedings of Ninety Third Annual Meeting of the (AACR) American Association of Cancer Research, April 6-10, 2002, San Francisco. pp.1034.


  • Li P, Rossman TG. 2001. Genes upregulated in lead-resistant glioma cells reveal possible targets for lead-induced developmental neurotoxicity. Toxicol Sci 64:90-99. PMID:11606805
  • Mure K, Rossman TG. 2001. Reduction of spontaneous mutagenesis in mismatch repair-deficient and proficient cells by dietary antioxidants. Mutat Res 480-481:85-95. PMID:11506802
  • Rossman TG, Uddin AN, Burns FJ, Bosland MC. 2001. Arsenite is a cocarcinogen with solar ultraviolet radiation for mouse skin: an animal model for arsenic carcinogenesis. Toxicol Appl Pharmacol 176(1):64-71. PMID:11578149
  • Rossman TG, Visalli MA, Uddin AN, Hu Y. 2001. Human cell models for arsenic carcinogenicity and toxicity: Transformation and genetic susceptibility. In: Arsenic Exposure and Health Effects IV. Elsevier, New York, NY.
  • Rossman TG, Weisburger JH. 2001. Arsenic in water. Chemical & Engineering News 79:2.
  • Vogt BL, Rossman TG. 2001. Effects of arsenite on p53, p21 and cyclin D expression in normal human fibroblasts -- a possible mechanism for arsenite's comutagenicity. Mutat Res 478:159-168. PMID:11406180
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