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Your Environment. Your Health.

Person Details: Peter S. Spencer

Superfund Research Program

Peter S. Spencer

Oregon Health and Science University
Center for Research on Occupational and Environmental Toxicology
3181 S.W. Sam Jackson Park Road, L606
Portland, Oregon 97239-3098
Phone: 503-494-4273
Fax: 503-494-4278


Hazardous Waste Sites

Portland Harbor

  • Invalid project




  • Beyer RP, Lasarev MR, Meira LB, Palmer VS, Ross PK, Bammler TK, Bradford BU, Cunningham ML, Higgins G, Hurban P, Kayton RJ, Kosyk O, Vliet PA, Wolfinger R, Woods CG, Freedman JH, Linney EA, Kaufmann WK, Kavanagh TJ, Rusyn I, Samson LD, Spencer PS, Suk WA, Zarbl HF. 2007. Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses. Toxicol Sci 99(1):326-337. PMID:17562736


  • Bammler TK, Beyer RP, Bhattacharya S, Boorman GA, Boyles A, Bradford BU, Bumgarner RE, Bushel PR, Chaturvedi K, Choi D, Cunningham ML, Deng S, Dressman HK, Fannin RD, Farin FM, Freedman JH, Fry RC, Harper A, Humble MC, Hurban P, Kavanagh TJ, Kaufmann WK, Kerr KF, Jing L, Lapidus JA, Lasarev MR, Li J, Li Y, Lobenhofer EK, Lu X, Malek RL, Milton S, Nagalla SR, O'Malley JP, Palmer VS, Pattee P, Paules RS, Perou CM, Phillips K, Qin L, Qiu Y, Quigley SD, Rodland M, Rusyn I, Samson LD, Schwartz DA, Shi Y, Shin J, Sieber SO, Slifer S, Speer MC, Spencer PS, Sproles DI, Swenberg JA, Suk WA, Sullivan RC, Tian R, Tennant RW, Todd SA, Tucker CJ, Van Houten B, Weis BK, Xuan S, Zarbl HF. 2005. Standardizing global gene expression analysis between laboratories and across platforms. Nat Methods 2(5):351-6. PMID:15846362
  • Tshala-Katumbay DD, Palmer VS, Kayton RJ, Sabri MI, Spencer PS. 2005. A new murine model of giant proximal axonopathy. Acta Neuropathol 109(4):405-410. PMID:15759132


  • Palmer VS, Tshala-Katumbay DD, Hashemi SB, Sabri MI, Spencer PS. 2004. Tetralin and metabolites: protein reactivity, chromogenicity and neurotoxicity. In: Proceedings of the 43rd Annual Meeting of the Society of Toxicology (SOT), March 21-25, 2004. Baltimore, MD.
  • Trimpin S, Mixon AE, Stapels MD, Kim M, Spencer PS, Deinzer ML. 2004. Identification of endogenous phosphorylation sites of bovine medium and low molecular weight neurofilament proteins by tandem mass spectrometry. Biochemistry 43(7):2091-2105. PMID:14967049
  • Tshala-Katumbay DD, Palmer VS, Dixon DA, Deinzer ML, Sabri MI, Spencer PS. 2004. Structural requirements for hydrocarbon axonopathy. J Neurochem 90:19-19Suppl.1.
  • Zhan C, Spencer PS, Dixon DA. 2004. Chromogenic and neurotoxic effects of an aliphatic gamma-diketone: Computational insights into the molecular structures and mechanism. Journal of Physical Chemistry B 108(19):6098-6104.


  • Dixon DA, Zhan C, Spencer PS, Sabri MI, Kim M. 2003. Theoretical determination of chromophores to determine the chromogenic effects of neurotoxicants. In: Proceedings of the 226th ACS (American Chemical Society) National Meeting - Fall 2003. New York, NY.
  • Kim M, Lasarev MR, Hashemi SB, Nagalla SR, Sabri MI, Spencer PS. 2003. Gene modulation patterns associated with aromatic y-diketones neurotoxicity. Environ Health Perspect 67:740.
  • Sabri MI, Hashemi SB, Spencer PS. 2003. Neurotoxicity and reactivity of 1,2-diacetylbenzene (1,2-DAB) with motor and cytoskeletal proteins in rat spinal cord and sciatic nerves. Toxicol Lett 144(Suppl.1):s130.
  • Tshala-Katumbay DD, Palmer VS, Kayton RJ, Sabri MI, Spencer PS. 2003. Demonstration of murine neurotoxic responses to 1,2-diacetylbenzene preparatory to toxicogenomic characterization. Environ Health Perspect 67:357.
  • Zhan C, Spencer PS, Dixon DA. 2003. Computational insights into the chemical structures and mechanisms of the chromogenic and neurotoxic effects of aromatic gamma-diketones. Journal of Physical Chemistry B 107(12):2853-2861.


  • Kim M, Spencer PS, Sabri MI. 2002. Amino acid and protein targets of 1,2-diacetylbenzene, a potent aromatic gamma-diketone that induces proximal neurofilamentous axonopathy. Toxicol Appl Pharmacol 183(1):55-65. PMID:12217642
  • Kim M, Taylor MJ, Sabri MI, Spencer PS. 2002. In vivo reactivity of the axonal toxin 1,2-diacetylbenzene with neurofilament and microtubule proteins. Environ Health Perspect 66:15.
  • Sabri MI, Hashemi SB, Kim M, Spencer PS. 2002. Aromatic hydrocarbon 1,2-diacetylbenzene cross-links neurofilaments and other proteins. J Neurochem 81:103.
  • Sabri MI, Spencer PS. 2002. How does acrylamide perturb axon transport and induce nerve fiber degeneration? Commentary on forum position paper. Neurotoxicology 23(2):259-63;discussion265-70. PMID:12224766
  • Spencer PS, Kim M, Sabri MI. 2002. Aromatic as well as aliphatic hydrocarbon solvent axonopathy. Int J Hyg Environ Health 205(1-2):131-136. PMID:12018006
  • Zhan C, Dixon DA, Spencer PS, Kim M, Sabri MI. 2002. Theoretical determination of chromophores in the chromogenic effects of aromatic neurotoxicants. J Am Chem Soc 124(11):2744-2752. PMID:11890826


  • Kim M, Sabri MI, Miller VH, Kayton RJ, Dixon DA, Spencer PS. 2001. 1,2-diacetylbenzene, the neurotoxic metabolite of a chromogenic aromatic solvent, induces proximal axonopathy. Toxicol Appl Pharmacol 177(2):121-131. PMID:11740911
  • Kim M, Spencer PS. 2001. Protein reactivity of the neurotoxic metabolite (1,2-DAB) of the aromatic hydrocarbon solvent 1,2-diethylbenzene. Environ Health Perspect 60(1):366.


  • Sabri MI, Kim M, Spencer PS. 2000. The aromatic hydrocarbon 1,2-diacetylbenzene induces pathological changes in the rodent nervous system. Toxicol Lett 116(1):72.
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