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Person Details: Kenneth S. Ramos

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Superfund Research Program

Kenneth S. Ramos

University of Louisville School of Medicine
2121 W. Holcombe Blvd.
Medical Research Tower
Houston, Texas 77030
Phone: 713-677-7440


Research Briefs



  • Hassanin AA, Tavera-Garcia MA, Moorthy B, Zhou GD, Ramos KS. 2019. Lung genotoxicity of benzo(a)pyrene in vivo involves reactivation of LINE-1 retrotransposon and early reprogramming of oncogenic regulatory networks. Am J Physiol Lung Cell Mol Physiol 317:L816-L822. doi:10.1152/ajplung.00304.2019 PMID:31596105 PMCID:PMC6962597 (accepted for publication)


  • Portier CJ, Armstrong BK, Baguley B, Baur X, Belyaev I, Belle R, Belpoggi F, Biggeri A, Bosland MC, Bruzzi P, Budnik L, Bugge M, Burns K, Calaf GM, Carpenter DO, Carpenter H, Lopez-Carillo L, Clapp R, Cocco P, Consonni D, Comba P, Craft ES, Dalvie M, Davis D, Demers PA, De Roos AJ, DeWitt JC, Forastiere F, Freedman JH, Fritschi L, Gaus C, Gohlke J, Goldberg M, Greiser E, Hansen J, Hardell L, Hauptmann M, Huang W, Huff J, James MO, Jameson C, Kortenkamp A, Kopp-Schneider A, Kromhout H, Larramendy M, Landrigan PJ, Lash LH, Leszczynski D, Lynch CF, Magnani C, Mandrioli D, Martin FL, Merler E, Michelozzi P, Miligi L, Miller A, Mirabelli D, Mirer F, Naidoo S, Perry MJ, Petronio M, Pirastu R, Portier R, Ramos KS, Robertson LW, Rodriguez T, Roosli M, Ross M, Roy D, Rusyn I, Saldiva P, Sass J, Savolainen K, Scheepers P, Sergi C, Silbergeld EK, Smith MT, Stewart BW, Sutton P, Tateo F, Terracini B, Thielmann H, Thomas DB, Vainio H, Vena J, Vineis P, Weiderpass E, Weisenburger DD, Woodruff TJ, Yorifuji T, Yu I, Zambon P, Zeeb H, Zhou SF. 2016. Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA). J Epidemiol Community Health 70(8):741-745. doi:10.1136/jech-2015-207005 PMID:26941213 PMCID:PMC4975799




  • Qian Y, Zheng Y, Abraham L, Ramos KS, Tiffany-Castiglioni E. 2005. Differential profiles of copper-induced ROS generation in human neuroblastoma and astrocytoma cells. Brain Res 134(2):323-332. doi:10.1016/j.molbrainres.2004.11.004 PMID:15836927
  • Qian Y, Zheng Y, Ramos KS, Tiffany-Castiglioni E. 2005. GRP78 compartmentalized redistribution in Pb-treated glia: role of GRP78 in lead-induced oxidative stress. Neurotoxicology 26(2):267-275. doi:10.1016/j.neuro.2004.09.002 PMID:15713347
  • Qian Y, Zheng Y, Ramos KS, Tiffany-Castiglioni E. 2005. The involvement of copper transporter in lead-induced oxidative stress in astroglia. Neurochem Res 30(4):429-438. PMID:16076012


  • Donnelly KC, Lingenfelter R, Cizmas LH, Falahatpisheh MH, Qian Y, Tang Y, Garcia SS, Ramos KS, Tiffany-Castiglioni E, Mumtaz MM. 2004. Toxicity assessment of complex mixtures remains a goal. Environ Toxicol Pharmacol 18(2):135-141. doi:10.1016/j.etap.2004.03.013 PMID:21782742
  • Falahatpisheh MH, Kerzee JK, Metz RP, Donnelly KC, Ramos KS. 2004. Inducible cytochrome P450 activities in renal glomerular mesangial cells: biochemical basis for antagonistic interactions among nephrocarcinogenic polycyclic aromatic hydrocarbons. J Carcinog 3(1):12. doi:10.1186/1477-3163-3-12 PMID:15315710 PMCID:PMC516019


  • Falahatpisheh MH, Ramos KS. 2003. Ligand-activated Ahr signaling leads to disruption of nephrogenesis and altered Wilms' tumor suppressor mRNA splicing. Oncogene 22(14):2160-2171. PMID:12687018


  • Parrish AR, Alejandro NF, Bral CM, Kerzee JK, Bowes RC, Ramos KS. 2002. Characterization of glomerular cell phenotypes following repeated cycles of benzo[a]pyrene injury in vitro. Biochem Pharmacol 64(1):31-39. PMID:12106603


  • Falahatpisheh MH, Donnelly KC, Ramos KS. 2001. Antagonistic interactions among nephrotoxic polycyclic aromatic hydrocarbons. J Toxicol Environ Health A 62(7):543-560. PMID:11289703


  • Alejandro NF, Parrish AR, Bowes RC, Burghardt RC, Ramos KS. 2000. Phenotypic profiles of cultured glomerular cells following repeated cycles of hydrocarbon injury. Kidney International 57:1571-1580. PMID:10760092
  • Barhoumi R, Mouneimne Y, Ramos KS, Safe SH, Phillips TD, Centonze VE, Ainley C, Gupta MS, Burghardt RC. 2000. Analysis of Benzo[a]pyrene partitioning and cellular homeostasis in a rat liver cell line. Toxicol Sci 53:264-270. PMID:10696774


  • Gupta MS, Miggins J, Parrish AR, Womack J, Ramos KS, Rodriguez LV, Goldstein L, Holtzapple C, Stanker LH, Safe SH. 1998. Ah receptor-independent induction of CYP1A2 gene expression in genetically inbred mice. Environ Toxicol Pharmacol 5:205-213. PMID:21781866
  • Parrish AR, Fisher RL, Bral CM, Burghardt RC, Gandolfi A, Brendel K, Ramos KS. 1998. Benzo(a)pyrene-induced alterations in growth-related gene expression and signaling in precision-cut adult rat liver slices. Toxicol Appl Pharmacol 152:302-308. PMID:9852999


  • Bowes RC, Parrish AR, Steinberg MA, Willett KL, Zhao W, Savas U, Jefcoate CR, Safe SH, Ramos KS. 1996. Atypical cytochrome P450 profiles in glomerular mesangial cells at the mRNA and enzyme level. Evidence for CYP1A1 and CYP1B1 expression and their involvement in benzo(a)pyrene metabolism. Biochem Pharmacol 52(4):587-595. doi:10.1016/0006-2952(96)00310-3 PMID:8759031
  • Weber TJ, Chapkin RS, Davidson LA, Ramos KS. 1996. Modulation of protein kinase C (PKC)-related signal transduction by 2,3,7,8-tetrachlorodibenzo-p-dioxin exhibits cell cycle dependence. Arch Biochem Biophys 328(2):227-232. PMID:8644998


  • Bowes RC, Ramos KS. 1995. Renal mesangial cell proliferation is enhanced by sequential challenge with benzo(a)pyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin. Organohalogen Compounds 25:253-258.
  • Bowes RC, Weber TJ, Ramos KS. 1995. Induction of highly proliferative phenotypes in cultured glomerular mesangial cells by benzo(a)pyrene alone or in combination with methoxamine. Arch Biochem Biophys 323:243-250. PMID:7487084
  • Ou X, Ramos KS. 1995. Regulation of cytochrome P451A1 gene expression in vascular smooth muscle cells through aryl hydrocarbon receptor-mediated signal transduction requires a protein synthesis inhibitor. Arch Biochem Biophys 318:122-130. PMID:7840604
  • Ramos KS, Zhao W. 1995. Inhibition of DNA synthesis in primary cultures of adult rat hepatocytes by benzo(a)pyrene: Role of Ah receptor-dependent events. Toxicology 99(3):179-189. doi:10.1016/0300-483X(94)03028-Z PMID:7610464
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