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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Person Details: Kenneth W. Turteltaub

Superfund Research Program

Kenneth W. Turteltaub

Lawrence Livermore National Laboratory
Biology and Biotechnology Research Program
P.O. Box 808, L-231
Livermore, California 94531
Phone: 925-423-8152
Fax: 925-422-2282
Email: turteltaub2@llnl.gov

Projects

Publications

2023

  • Maier ML, Siddens LK, Pennington JM, Uesugi S, Tilton SC, Vertel EA, Anderson KA, Tidwell LG, Ognibene T, Turteltaub KW, Smith JN, Williams DE. 2023. Benzo[a]pyrene toxicokinetics in humans following dietary supplementation with 3,3'-diindolylmethane (DIM) or brussels sprouts. Toxicol Appl Pharmacol 460:116377. doi:10.1016/j.taap.2023.116377 PMID:36642108 PMCID:PMC9946811
  • Vermillion Maier ML, Siddens LK, Pennington J, Uesugi S, Labut EM, Vertel EA, Anderson KA, Tidwell LG, Tilton SC, Ognibene T, Turteltaub KW, Smith JN, Williams DE. 2023. Impact of phenanthrene co-administration on the toxicokinetics of benzo[a]pyrene in humans. UPLC-accelerator mass spectrometry following oral microdosing. Chem Biol Interact 382:110608. doi:10.1016/j.cbi.2023.110608

2022

  • Pande P, Madeen E, Williams DE, Crowell SR, Ognibene T, Turteltaub KW, Corley RA, Smith JN. 2022. Translating dosimetry of Dibenzo[def,p]chrysene (DBC) and metabolites across dose and species using physiologically based pharmacokinetic (PBPK) modeling. Toxicol Appl Pharmacol 438:doi:10.1016/j.taap.2021.115830 PMID:34933053 PMCID:PMC9264404
  • Vermillion Maier ML, Siddens LK, Pennington JM, Uesugi S, Anderson KA, Tidwell LG, Tilton SC, Ognibene T, Turteltaub KW, Smith JN, Williams DE. 2022. Benzo a pyrene (BaP) metabolites predominant in human plasma following escalating oral micro-dosing with C-14 -BaP. Environ Int 159:doi:10.1016/j.envint.2021.107045 PMID:34920278 PMCID:PMC8791557

2019

  • Madeen E, Siddens LK, Uesugi S, McQuistan TJ, Corley RA, Smith JN, Waters KM, Tilton SC, Anderson KA, Ognibene T, Turteltaub KW, Williams DE. 2019. Toxicokinetics of benzo[a]pyrene in humans: Extensive metabolism as determined by UPLC-accelerator mass spectrometry following oral micro-dosing. Toxicol Appl Pharmacol 364:97-105. doi:10.1016/j.taap.2018.12.010 PMID:30582946 PMCID:PMC6369707

2018

  • Hummel JM, Madeen E, Siddens LK, Uesugi S, McQuistan TJ, Anderson KA, Turteltaub KW, Ognibene T, Bench G, Krueger SK, Harris S, Smith JN, Tilton SC, Baird WM, Williams DE. 2018. Pharmacokinetics of [(14)C]-Benzo[a]pyrene (BaP) in humans: Impact of Co-Administration of smoked salmon and BaP dietary restriction. Food Chem Toxicol 115:136-147. doi:10.1016/j.fct.2018.03.003 PMID:29518434 PMCID:PMC5935529
  • Wang F, zhang H, Ma A, Yu W, Zimmermann M, Yang J, Hwang SH, Zhu D, Lin T, Malfatti MA, Turteltaub KW, Henderson PT, Airhart S, Hammock BD, Yuan J, de Vere White RW, Pan C. 2018. COX-2/sEH dual inhibitor PTUPB potentiates the antitumor efficacy of cisplatin. Mol Cancer Ther 17:474-483. doi:10.1158/1535-7163.MCT-16-0818 PMID:29284644 PMCID:PMC5824635

2016

  • Madeen E, Ognibene T, Corley RA, Henderson MC, Baird WM, Bench G, Turteltaub KW, Williams DE, McQuistan TJ. 2016. Human microdosing with carcinogenic polycyclic aromatic hydrocarbons: in vivo pharmacokinetics of dibenzo[def,p]chrysene and metabolites by UPLC accelerator mass spectrometry. Chem Res Toxicol 29(10):1641-1650. doi:10.1021/acs.chemrestox.6b00169 PMID:27494294 PMCID:PMC5380438

2015

  • Madeen E, Corley RA, Crowell SR, Turteltaub KW, Ognibene T, Malfatti MA, McQuistan TJ, Garrard M, Sudakin D, Williams DE. 2015. Human in vivo pharmacokinetics of [(14)C]dibenzo[def,p]chrysene by accelerator mass spectrometry following oral microdosing. Chem Res Toxicol 28(1):126-134. doi:10.1021/tx5003996 PMID:25418912 PMCID:PMC4303324

2005

2004

  • Chepanoske CL, Brown K, Turteltaub KW, Dingley KH. 2004. Characterization of a peptide adduct formed by N-acetoxy-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a reactive intermediate of the food carcinogen PhIP. Food Chem Toxicol 42(8):1367-1372. doi:10.1016/j.fct.2003.11.012 PMID:15207388
  • Chiarappa-Zucca ML, Finkel RC, Martinelli RE, McAninch JE, Nelson DO, Turteltaub KW. 2004. Measurement of beryllium in biological samples by accelerator mass spectrometry: applications for studying chronic beryllium disease. Chem Res Toxicol 17(12):1614-20. PMID:15606137
  • Cupid BC, Lightfoot TJ, Russell D, Gant SJ, Turner PC, Dingley KH, Curtis KD, Leveson SH, Turteltaub KW, Garner RC. 2004. The formation of AFB(1)-macromolecular adducts in rats and humans at dietary levels of exposure. Food Chem Toxicol 42(4):559-569. PMID:15019179

2003

  • Brown K, Harvey CA, Turteltaub KW, Shields SJ. 2003. Structural characterization of carcinogen-modified oligodeoxynucleotide adducts using matrix-assisted laser desorption/ionization mass spectrometry. J Mass Spectrom 38(1):68-79. PMID:12526008
  • Martin EA, Brown K, Gaskell M, Al-Azzawi F, Garner RC, Boocock DJ, Mattock E, Pring DW, Dingley KH, Turteltaub KW, Smith LL, White IN. 2003. Tamoxifen DNA damage detected in human endometrium using accelerator mass spectrometry. Cancer Res 63(23):8461-8465. PMID:14679010
  • Turesky RJ, Richoz J, Constable A, Curtis KD, Dingley KH, Turteltaub KW. 2003. The effects of coffee on enzymes involved in metabolism of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine in rats. Chem Biol Interact 145(3):251-265. PMID:12732453
  • Turteltaub KW, Mani C. 2003. Benzene metabolism in rodents at doses relevant to human exposure from urban air. Res Rep Health Eff Inst (113):1-26;discussion27-35. PMID:12675491

2002

  • Brown K, Dingley KH, Vogel JS, Turteltaub KW. 2002. Accelerator Mass Spectrometry for Biomedical Research. In: Encyclopedia of Mass Spectrometry, Volume 1.

2001

  • Brown K, Guenther EA, Dingley KH, Cosman M, Harvey CA, Shields SJ, Turteltaub KW. 2001. Synthesis and spectroscopic characterization of site-specific 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine oligodeoxyribonucleotide adducts. Nucleic Acids Res 29:1951-1959. PMID:11328879
  • Vogel JS, Grant PG, Buchholz BA, Dingley KH, Turteltaub KW. 2001. Attomole quantitation of protein separations with accelerator mass spectrometry. Electrophoresis 22(10):2037-2045. PMID:11465504

2000

  • Phillips DH, Farmer PB, Beland FA, Nath RG, Poirier MC, Reddy MV, Turteltaub KW. 2000. Methods of DNA adduct determination and their application to testing compounds for genotoxicity. Environ Mol Mutagen 35(3):222-233. PMID:10737957

1999

  • Holland NT, Ahlborn T, Turteltaub KW, Markee C, Moore DH, Wyrobek AJ, Smith MT. 1999. Acrylamide causes preimplantation abnormalities in embryos and induces chromatin-adducts in male germ cells of mice. Reprod Toxicol 13(3):167-178. PMID:10378466
  • Mauthe RJ, Dingley KH, Leveson SH, Freeman SP, Turesky RJ, Garner RC, Turteltaub KW. 1999. MeIQx-DNA adduct formation in rodent and human colon at low dose. Int J Cancer 4:539-545.
  • Turteltaub KW, Dingley KH, Curtis KD, Malfatti MA, Turesky RJ, Garner RC, Felton JS, Lang NP. 1999. Macromolecular adduct formation and metabolism of heterocyclic amines in humans and rodents at low doses. Cancer Lett 143(2):149-155. PMID:10503895

1998

  • Dingley KH, Roberts ML, Velsko CA, Turteltaub KW. 1998. Attomole detection of 3H in biological samples using accelerator mass spectrometry: application in low-dose, dual-isotope tracer studies in conjunction with 14C accelerator mass spectrometry. Chem Res Toxicol 11(10):1217-1222. PMID:9778319
  • Mauthe RJ, Sideras-Haddad E, Turteltaub KW, Bench G. 1998. Quantitative imaging microscopy for the sensitive detection of administered metal containing drugs in single cells and tissue slices - a demonstration using platinum based chemotherapeutic agents. J Pharm Biomed Anal 17(4-5):651-663. PMID:9682148
  • Turteltaub KW, Mani C, Dingley KH, Bench G, Mauthe RJ. 1998. DNA Adducts Using Accelerator Mass Spectrometry. In: Biomarkers: Medical and Workplace Applications. Joseph Henry Press, Washington, DC. pp.99-114.
  • Vogel JS, Turteltaub KW. 1998. Accelerator mass spectrometry as a bioanalytical tool for nutritional research. Advances in Experimental Medicine and Biology 445:397-410. PMID:9781403

1997

  • Creek MR, Mani C, Vogel JS, Turteltaub KW. 1997. Tissue distribution and macromolecular binding of extremely low doses of [14C]-benzene in B6C3F1 mice. Carcinogenesis 18(12):2421-2427. PMID:9450490
  • Kautiainen A, Vogel JS, Turteltaub KW. 1997. Dose-dependent binding of trichloroethylene to hepatic DNA and protein at low doses in mice. Chem Biol Interact 106(2):109-121. PMID:9366897

1995

  • Frantz CE, Bangerter C, Fultz E, Mayer KM, Vogel JS, Turteltaub KW. 1995. Dose-response studies of MeIQx in rat liver and liver DNA at low doses. Carcinogenesis 16(2):367-373. PMID:7859370
  • Macgregor JT, Farr S, Tucker JD, Heddle JA, Tice RR, Turteltaub KW. 1995. New molecular endpoints and methods for routine toxicity testing. Fundam Appl Toxicol 26(2):156-173. PMID:7589905
  • Titenko-Holland N, Turteltaub KW, Wyrobek AJ, Smith MT. 1995. Acrylamide induces DNA adducts in male germ cells and causes preimplantation abnormalities and dominant lethal mutations in mice. Environ Health Perspect 15(1):167.
  • Vogel JS, Turteltaub KW, Finkel R, Nelson DE. 1995. Accelerator mass spectrometry: isotope identification at attomole sensitivity. Anal Chem 67(11):353A-359A.
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