Superfund Research Program

Aikseng Ooi

University of Arizona
PO Box 210207
Pharmacy, Rm. 132
Tucson, Arizona 85721
Phone: 520-626-2823
Email: ooi@pharmacy.arizona.edu

Projects

• University of Arizona: Data Management and Analysis Core (2020-2025)

Publications

2023

• Anandhan A, Dodson M, Shakya A, Chen J, Liu P, Wei Y, Tan H, Wang Q, Jiang Z, Yang K, Garcia JG, Chambers SK, Chapman E, Ooi A, Yang-Hartwich Y, Stockwell BR, Zhang DD. 2023. NRF2 controls iron homeostasis and ferroptosis through HERC2 and VAMP8. Sci Adv 9(5):doi:10.1126/sciadv.ade9585 PMID:36724221 PMCID:PMC9891695

2022

• Dodson M, Dai W, Anandhan A, Schmidlin CJ, Liu P, Wilson NC, Wei Y, Kitamura N, Galligan JJ, Ooi A, Chapman E, Zhang DD. 2022. CHML is an NRF2 target gene that regulates mTOR function. Mol Oncol 16:1714-1727. doi:10.1002/1878-0261.13194 PMID:35184380 PMCID:PMC9019883
• Kerimoglu B, Lamb C, McPherson RD, Ergen E, Stone EM, Ooi A. 2022. Cyst(e)inase-rapamycin combination induces ferroptosis in both in vitro and in vivo models of hereditary leiomyomatosis and renal cell cancer. Mol Cancer Ther 21(3):doi:10.1158/1535-7163.MCT-21-0661 PMID:35086957 PMCID:PMC8898288
• Liu P, Anandhan A, Chen J, Shakya A, Dodson M, Ooi A, Chapman E, White E, Garcia JG, Zhang DD. 2022. Decreased autophagosome biogenesis, reduced NRF2, and enhanced ferroptotic cell death are underlying molecular mechanisms of non-alcoholic fatty liver disease. Redox Biol 59:102570. doi:10.1016/j.redox.2022.102570 PMID:36495698 PMCID:PMC9731892

2021

• Liu P, Dodson M, Li H, Schmidlin C, Shakya A, Wei Y, Garcia JG, Chapman E, Kiela PR, Zhang Q, White E, Ding X, Ooi A, Zhang DD. 2021. Non-canonical NRF2 activation promotes a pro-diabetic shift in hepatic glucose metabolism. Mol Metab 51:101243. doi:10.1016/j.molmet.2021.101243 PMID:33933676 PMCID:PMC8164084
• Liu P, Luo G, Dodson M, Schmidlin C, Wei Y, Kerimoglu B, Ooi A, Chapman E, Garcia JG, Zhang DD. 2021. The NRF2-LOC344887 signaling axis suppresses pulmonary fibrosis. Redox Biol 38:101766. doi:10.1016/j.redox.2020.101766 PMID:33126057 PMCID:PMC7573654

2019

• Kerins M, Liu P, Tian W, Mannheim W, Zhang DD, Ooi A. 2019. Genome-wide CRISPR screen reveals autophagy disruption as the convergence mechanism that regulates the NRF2 transcription factor. Mol Cell Biol 39(13):e00037-19. doi:10.1128/MCB.00037-19 PMID:31010806 PMCID:PMC6580702
• Pengfei L, Kerins M, Tian W, Neupane D, Zhang DD, Ooi A. 2019. Differential and overlapping targets of the transcriptional regulators NRF1, NRF2, and NRF3 in human cells. J Biol Chem 294:18131-18149. doi:10.1074/jbc.RA119.009591 PMID:31628195 PMCID:PMC6885608

2018

• Liu P, de la Vega MR, Sammani S, Mascarenhas JB, Kerins M, Dodson M, Sun X, Wang T, Ooi A, Garcia JG, Zhang DD. 2018. RPA1 binding to NRF2 switches ARE-dependent transcriptional activation to ARE-NRE-dependent repression. Proc Natl Acad Sci U S A 115(44):E10352-E10361. doi:10.1073/pnas.1812125115 PMID:30309964 PMCID:PMC6217430