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Person Details: Howard P. Glauert

Superfund Research Program

Howard P. Glauert

University of Kentucky
Graduate Center for Nutritional Sciences
222 Funkhouser Building
Lexington, Kentucky 40506-0054
Phone: 859-257-7789
Fax: 859-323-0061
Email: hglauert@uky.edu

Projects

Publications

2013

  • Ludewig G, Robertson LW, Glauert HP. 2013. Carcinogenicity and Mechanisms of Persistent Organic Pollutants. In: Effects of Persistent and Bioactive Organic Pollutants on Human Health. pp.57-100.

2011

  • Bunaciu RP, Tharappel JC, Lehmler H, Lee EY, Robertson LW, Bruckner GG, Spear BT, Glauert HP. 2011. Role of oil vehicle on hepatic cell proliferation in PCB-treated rats. J Environ Pathol Toxicol Oncol 30(4):273-282. PMID:22181977 PMCID:PMC3522147

2008

  • Glauert HP, Tharappel JC, Banerjee S, Chan NL, Kania-Korwel I, Lehmler H, Lee EY, Robertson LW, Spear BT. 2008. Inhibition of the promotion of hepatocarcinogenesis by 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) by the deletion of the p50 subunit of NF-kappa B in mice. Toxicol Appl Pharmacol 232(2):302-308. doi:10.1016/j.taap.2008.06.013 PMID:18644402 PMCID:PMC2583134
  • Glauert HP, Tharappel JC, Lu Z, Stemm DN, Banerjee S, Chan L, Lee EY, Lehmler H, Robertson LW, Spear BT. 2008. Role of oxidative stress in the promoting activities of pcbs. Environ Toxicol Pharmacol 25(2):247-250. doi:10.1016/j.etap.2007.10.025 PMID:19122744 PMCID:PMC2836878
  • Stemm DN, Tharappel JC, Lehmler H, Srinivasan C, Morris J, Spate VL, Robertson LW, Spear BT, Glauert HP. 2008. Effect of dietary selenium on the promotion of hepatocarcinogenesis by 3,3', 4,4'-tetrachlorobiphenyl and 2,2', 4,4', 5,5'-hexachlorobiphenyl. Exp Biol Med (Maywood) 233(3):366-376. doi:10.3181/0708-RM-211 PMID:18296742
  • Tharappel JC, Lehmler H, Srinivasan C, Robertson LW, Spear BT, Glauert HP. 2008. Effect of antioxidant phytochemicals on the hepatic tumor promoting activity of 3,3',4,4'-tetrachlorobiphenyl (PCB-77). Food Chem Toxicol 46(11):3467-3474. doi:10.1016/j.fct.2008.08.023 PMID:18796325 PMCID:PMC2597727

2007

  • Bunaciu RP, Tharappel JC, Lehmler H, Kania-Korwel I, Robertson LW, Srinivasan C, Spear BT, Glauert HP. 2007. The effect of dietary glycine on the hepatic tumor promoting activity of polychlorinated biphenyls (PCBs) in rats. Toxicology 239(3):147-55. PMID:17703865
  • Robertson LW, Berberian I, Borges T, Chen L, Chow CK, Glauert HP, Filser J, Thomas H. 2007. Suppression of peroxisomal enzyme activities and cytochrome P450 4A isozyme expression by congeneric polybrominated and polychlorinated biphenyls. PPAR Res 2007:15481. doi:10.1155/2007/15481 PMID:18274624 PMCID:PMC2220027
  • Strathmann J, Paal K, Ittrich C, Appel KE, Glauert HP, Buchmann A, Schwarz M, Krause E. 2007. Proteome analysis of chemically induced mouse liver tumors with different genotype. Proteomics 7(18):3318-31. PMID:17722141

2006

  • Strathmann J, Schwarz M, Tharappel JC, Glauert HP, Spear BT, Robertson LW, Appel KE, Buchmann A. 2006. PCB 153, a non-dioxin-like tumor promoter, selects for beta-catenin (Catnb)-mutated mouse liver tumors. Toxicol Sci 93(1):34-40. doi:10.1093/toxsci/kfl041 PMID:16782779

2005

  • Bunaciu RP, Spear BT, Glauert HP. 2005. The effect of Kupffer cell inhibition on hepatocyte cell proliferation in rats administered PCB-77 or PCB-153. FASEB J 17:A1165:
  • Espandiari P, Robertson LW, Srinivasan C, Glauert HP. 2005. Comparison of different initiation protocols in the resistant hepatocyte model. Toxicology 206(3):373-381. PMID:15588927
  • Glauert HP, Lu Z, Kumar A, Bunaciu RP, Patel S, Tharappel JC, Stemm DN, Lehmler H, Lee EY, Robertson LW, Spear BT. 2005. Dietary vitamin E does not inhibit the promotion of liver carcinogenesis by polychlorinated biphenyls in rats. J Nutr 135(2):283-286. PMID:15671227

2004

  • Espandiari P, Glauert HP, Lehmler H, Lee EY, Srinivasan C, Robertson LW. 2004. Initiating activity of 4-chlorobiphenyl metabolites in the resistant hepatocyte model. Toxicol Sci 79(1):41-46. PMID:14976334
  • Lu Z, Lee EY, Robertson LW, Glauert HP, Spear BT. 2004. Effect of 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB-153) on Hepatocyte Proliferation and Apoptosis in Mice Deficient in the p50 Subunit of the Transcription Factor NF-B. Toxicol Sci 81(1):35-42.
  • Stemm DN, Robertson LW, Tharappel JC, Glauert HP. 2004. Effects of 3,3',4,4'-tetrachlorobiphenyl (PCB 77) on the distribution and metabolism of selenium in rats. In: Proceedings of the 43rd Annual Meeting of the Society of Toxicology (SOT), March 21-25, 2004. Baltimore, MD.

2003

  • Bunaciu RP, Robertson LW, Spear BT, Glauert HP. 2003. Effect of inhibition of Kupffer cell activation by dietary glycine on hepatic cell proliferation in rats. FASEB J 17(5):A1165Part2Suppl.S.
  • Espandiari P, Glauert HP, Lehmler H, Lee EY, Srinivasan C, Robertson LW. 2003. Polychlorinated biphenyls (PCBs) as initiators in liver carcinogensis: resistant hepatocyte model. Toxicol Appl Pharmacol 186(1):55-62. PMID:12583993
  • Espandiari P, Lehmler H, Stemm DN, Glauert HP, Robertson LW. 2003. PCB metabolites as initiating agents in hepatocarcinogenesis. Toxicol Sci 72(S-1):1145.
  • Espandiari P, Lehmler H, Stemm DN, Glauert HP, Robertson LW. 2003. PCB metabolites as initiating agents in hepatocarcinogenesis. In: Proceedings of the 42nd Annual Meeting of the Society of Toxicology (SOT), March 9-13, 2003. Salt Lake City, UT.
  • Fadhel ZA, Bunaciu RP, Glauert HP, Robertson LW, Ludewig G. 2003. Lipid peroxidation and antioxidant enzymes in testes of rats treated with 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) and effects of corn oil, medium-chain triglyceride (MCT) oil and olive oil. Toxicol Sci 72(1):1771Suppl.S.
  • Fadhel ZA, Bunaciu RP, Glauert HP, Robertson LW, Ludewig G. 2003. Lipid peroxidation and antioxidant enzymes in testes of rats treated with 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) and effects of corn oil, medium-chain triglyceride (MCT) oil and olive oil. In: Proceedings of the 42nd Annual Meeting of the Society of Toxicology (SOT), March 9-13, 2003. Salt Lake City, UT.
  • Harp C, Stafine N, Bunaciu RP, Lu Z, Tharappel JC, Robertson LW, Spear BT, Glauert HP. 2003. Influence of purified diets on the induction of cell proliferation by the hepatic tumor promoters 2,2',4,4'5,5'-hexachlorobiphenyl (PCB-153) and the peroxisome proliferator ciprofibrate. FASEB J 17(5):A1155Suppl.S.
  • Lu Z, Robertson LW, Spear BT, Glauert HP. 2003. Effect of 2,2', 4,4', 5,5' -hexachlorobiphenyl (PCB153) on gene expression in mice deficient in the P50 subunit of NF-kappa B. In: Proceedings of the 42nd Annual Meeting of the Society of Toxicology (SOT), March 9-13, 2003. Salt Lake City, UT.
  • Lu Z, Tharappel JC, Lee EY, Robertson LW, Spear BT, Glauert HP. 2003. Effect of a single dose of polychlorinated biphenyls on hepatic cell proliferation and the DNA binding activity of NF-kappaB and AP-1 in rats. Mol Carcinog 37(4):171-180. doi:10.1002/mc.10135 PMID:12891626
  • Tharappel JC, Glauert HP, Spear BT. 2003. The effect of phenobarbital on cell proliferation in mice deficient in the p50 subunit of NF-kappa B. Toxicol Sci 72(S-1):1160.

2002

  • Espandiari P, Glauert HP, Robertson LW. 2002. Replacement of partial hepatectomy with fasting/refeeding or the use of neonatal animals in the resistant hepatocyte model. Toxicol Sci 66:310.
  • Fadhel ZA, Lu Z, Robertson LW, Glauert HP. 2002. Effect of 3,3',4,4'-tetrachlorobiphenyl and 2,2',4,4',5,5'-hexachlorobiphenyl on the induction of hepatic lipid peroxidation and cytochrome P-450 associated enzyme activities in rats. Toxicology 175(1-3):15-25. PMID:12049832
  • Fadhel ZA, Stafine N, Glauert HP, Robertson LW, Ludewig G. 2002. The effects of purified vs. unrefined diets on lipid peroxidation and antioxidant enzymes in tests of PCB-153 treated rats. Toxicol Sci 66:349.
  • Hansen LA, Machala M, James MO, Hennig B, Glauert HP, Narbonne J, van Bree L, Schultz T, Grevatt P, Suk WA, Holoubek I, Robertson LW. 2002. Research needs identified. In: Proceedings of the 2nd PCB Workshop: Recent Advances in the Environmental Toxicology and Health Effects of PCBs (polychlorinated biphenyls), 2002. Brno, Czech Republic.
  • Hansen LG, Machala M, Fischer L, James MO, Hennig B, Glauert HP, Narbonne J, van Bree L, Schultz T, Grevett P, Suk WA, Holoubek I, Robertson LW. 2002. Research needs identified at the second PCB Workshop in Brno, Czech Republic. Toxicol Sci 87(3):261-265. doi:10.1080/02772240500079011
  • Lu Z, Robertson LW, Spear BT, Glauert HP. 2002. Effect of 2,2', 4,4', 5,5' -hexachlorobiphenyl (PCB153) on gene expression in mice deficient in the P50 subunit of NF-kappa B. In: Proceedings of the Superfund Basic Research Program Annual Meeting, November 3-6, 2002. Tucson, AZ.
  • Tharappel JC, Lee EY, Robertson LW, Spear BT, Glauert HP. 2002. Regulation of cell proliferation, apoptosis, and transcription factor activities during the promotion of liver carcinogenesis by Polychlorinated Biphenyls. Toxicol Appl Pharmacol 179(3):172-184. PMID:11906247

2001

  • Calfee-Mason K, Spear BT, Glauert HP. 2001. Effect of dietary vitamin E on other cellular antioxidant defense systems in phenobarbital-treated rats. In: Recent Advances in the Environmental Toxicology and Health Effects of PCBs. University of Kentucky Press, Lexington, KY. pp.321-322.
  • Espandiari P, Glauert HP, Robertson LW. 2001. Replacement of partial hepatectomy with fasting/refeeding or the use of neonatal animals in the resistant hepatocyte model. In: Proceedings of the Superfund Basic Research Program Annual Meeting: Assessing Risks of Hormonally Active Agents, December 10-12, 2001. University of Florida Conference Center, Gainsville, FL.
  • Espandiari P, Twaroski TP, Festag M, Lee EY, Glauert HP, Robertson LW. 2001. Effect of 4-chlorobiphenyl as an initiator of rat liver carcinogenisis. In: PCBs: Recent Advances in Environmental Toxicology and Health Effects. University Kentucky Press, Lexington, KY. pp.399-401.
  • Espandiari P, Twaroski TP, Festag M, Lee EY, Glauert HP, Robertson LW. 2001. Effect of 4-chlorobiphenyl as initiator of rat liver carcinogenisis. In: PCBs: Recent Advances in Environmental Toxicology and Health Effects. University Kentucky Press, Lexington, KY. pp.399-402.
  • Glauert HP, Calfee-Mason K, Li Y, Lu Z, Nilakantan V, O'Brien ML, Tharappel JC, Lee EY, Robertson LW, Spear BT. 2001. Effect of dietary vitamin E on the promotion of altered hepatic foci by 3,3',4,4'-tetrachlorobiphenyl (PCB-77) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) in rats initiated with diethylnitrosamine. In: Proceedings of the 44th Annual Meeting of the Polish Chemical Society, September 9-13, 2001. Katowice, Poland.
  • Glauert HP, Calfee-Mason K, Li Y, Lu Z, Nilakantan V, O'Brien ML, Tharappel JC, Lee EY, Robertson LW, Spear BT. 2001. Role of oxidative stress in the promotion of hepatocarcinogenesis by environmental chemicals 44th Annual Meeting of the Polish Chemical Society in Katowice, Poland, September 9-13, 2001. Cent Eur J Public Health 105.
  • Glauert HP, Silberhorn EM, Robertson LW. 2001. PCBs and tumor promotion. In: PCBs: Recent Advances in Environmental Toxicology and Health Effects. University Kentucky Press, Lexington, KY. pp.355-371.
  • Lu Z, Lee EY, Robertson LW, Spear BT, Glauert HP. 2001. Effect of dietary vitamin E on the promotion of altered hepatic foci by 3,3',4,4'-tetrachlorobiphenyl (PCB-77) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) in rats initiated with diethylnitrosamine. In: Proceedings of the 40th Annual Meeting of the Society of Toxicology (SOT), March 25-29, 2001. San Franciso, CA.
  • Lu Z, Lee EY, Robertson LW, Spear BT, Glauert HP. 2001. Effect of dietary vitamin E on the promotion of altered hepatic foci by 3,3',4,4'-tetrachlorobiphenyl (PCB-77) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) in rats initiated with diethylnitrosamine. Toxicol Sci 60:161.
  • Lu Z, Spear BT, Lee EY, Robertson LW, Glauert HP. 2001. Activation of Rat Hepatic Transcription Factor NF-kB by PCBs. In: PCBs: Recent Advances in Environmental Toxicology and Health Effects. University Kentucky Press, Lexington, KY. pp.419-420.
  • Tharappel JC, Robertson LW, Lee EY, Spear BT, Glauert HP. 2001. Effect Of 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB-153) And 3,3',4,4'-Tetrachlorobiphenyl (PCB-77) On NF-kB And AP-1 Activation, Altered Hepatic Foci Formation, Cell Proliferation, And Apoptosis In Rats. In: PCBs: Recent Advances in Environmental Toxicology and Health Effects. University Kentucky Press, Lexington, KY. pp.417-418.
  • Twaroski TP, O'Brien ML, Larmonier N, Glauert HP, Robertson LW. 2001. Polychlorinated biphenyl-induced effects on metabolic enzymes, AP-1 binding, vitamin E and oxidative stress in the rat liver. Toxicol Appl Pharmacol 171(2):85-93. PMID:11222084

2000

  • Calfee-Mason K, Spear BT, Glauert HP. 2000. Effect of dietary vitamin E on other cellular antioxidant defense systems in phenobarbital-treated rats. Toxicol Sci 54(1):946.
  • Fadhel ZA, Lu Z, Robertson LW, Glauert HP. 2000. Role of cytochrome P-450 induction and lipid peroxidation in 3,3',4,4'-tetrachlorobiphenyl (PCB-77)- and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153)-induced toxicity in liver of male rats. In: Proceedings of the 39th Annual Meeting of the Society of Toxicology (SOT), March 19-23, 2000. Philadelphia, PA.
  • Fadhel ZA, Lu Z, Robertson LW, Glauert HP. 2000. Role of cytochrome P-450 induction and lipid peroxidation in 3,3',4,4'-tetrachlorobiphenyl (PCB-77)- and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153)-induced toxicity in liver of male rats. Toxicol Sci 54:78.
  • Glauert HP, Tharappel JC, Lee EY, Robertson LW, Spear BT. 2000. Effect of PCBs on the activation of the transcription factors AP-1 and NF-kB. Cent Eur J Public Health 8Suppl::17-18. PMID:10943439
  • Lu Z, Spear BT, Robertson LW, Glauert HP. 2000. Activation of hepatic hepatic NF-kB by polychlorinated biphenyls (PCBs) in vivo and in cultured rat hepatocytes. Toxicol Sci 54:254.
  • Lu Z, Spear BT, Robertson LW, Glauert HP. 2000. Activation of hepatic hepatic NF-kB by polychlorinated biphenyls (PCBs) in vivo and in cultured rat hepatocytes. In: Proceedings of the 39th Annual Meeting of the Society of Toxicology (SOT), March 19-23, 2000. Philadelphia, PA.
  • Robertson LW, Espandiari P, Lehmler H, Pereg D, Srinivasan A, Tampal N, Twaroski TP, Ludewig G, Glauert HP, Arif JM, Gupta RC. 2000. Metabolism and activation of polychlorinated biphenyls (PCBs). Cent Eur J Public Health 8Suppl:14-15. PMID:10943437
  • Tharappel JC, Robertson LW, Lee EY, Spear BT, Glauert HP. 2000. Effect of 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) and 3,3',4,4'-tetrachlorobiphenyl (PCB-77) on NF-kB and AP-1 activation, altered hepatic foci formation, cell proliferation, and apoptosis in rats. Toxicol Sci 54:271.
  • Twaroski TP, Larmonier N, O'Brien ML, Glauert HP, Robertson LW. 2000. PCB-induced effects on cytochrome P-450 1A1, DT-diaphorase, AP-1 binding and oxidative stress in the rat liver. Chapter 41in: Proceedings of the 91st Annual Meeting of American Association for Cancer Research Annual Meeting, 2000. San Diego, CA. pp.507.

1999

  • Lu Z, Spear BT, Lee EY, Robertson LW, Glauert HP. 1999. Activation of hepatic NF-ÇB by a single dose of Polychlorinated Biphenyls (PCBs). FASEB J 13:681.10.
  • Tharappel JC, Robertson LW, Lee EY, Spear BT, Glauert HP. 1999. Effect of the PCBs 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) and 3,3',4,4'-tetrachlorobiphenyl (PCB-77) on cell proliferation and the activation of the transcription factors NF-ÇB and AP-1 in rats treated with diethylnitrosamine (DEN). FASEB J 13:162.3.

1998

  • Arif JM, Gairola CG, Glauert HP, Kelloff GJ, Lubet RA, Gupta RC. 1998. Inhibition of cigarette smoke-related lipophilic DNA adducts in rat tissues by dietary oltipraz. Carcinogenesis 19(8):1515-1517. PMID:9744551
  • Boissonneault GA, Hardwick TA, Bogardus SL, Chan WK, Tatum V, Glauert HP, Chow CK, Decker EA. 1998. Interactions between carnosine and vitamin E in mammary cancer risk determination. Nutr Res 18:723-733.
  • Espandiari P, Ludewig G, Glauert HP, Robertson LW. 1998. Activation of hepatic NF-ÇB by the herbicide Dicamba (2-methoxy-3,6-dichlorobenzoic acid) in female and male rats. J Biochem Mol Toxicol 12:339-344. PMID:9736482
  • Glauert HP, Li Y, Nilakantan V, Tharappel JC, Calfee KG, Lu Z, Robertson LW, Spear BT. 1998. Role of NF-ÇB in the promotion of hepatocarcinogenesis. Pol J Pharmacol 50:80-81.
  • Glauert HP, Lu Z, Al-bayati Z, Lee EY, Robertson LW. 1998. Effects of PCBs on hepatic lipid peroxidation and transcription factor activation in rats. In: Proceedings of the Superfund Basic Research Program (SBRP) Conference, 1998. Boston, MA. pp.9.
  • Leung LK, Glauert HP. 1998. Effect of the peroxisome proliferator ciprofibrate on hepatic cyclooxygenase and phospholipase A2 in rats. Toxicology 126(1):65-73. PMID:9585093
  • Nilakantan V, Spear BT, Glauert HP. 1998. Effect of the peroxisome proliferator ciprofibrate on lipid peroxidation and 8-hydroxydeoxyguanosine formation in transgenic mice with elevated hepatic catalase activity. Free Radic Biol Med 24:1430-1436. PMID:9641260
  • Nilakantan V, Spear BT, Glauert HP. 1998. Liver-specific catalase expression in transgenic mice inhibits NF-χB Activation and DNA synthesis induced by the peroxisome proliferator ciprofibrate. Carcinogenesis 19:631-637.

1997

  • Arif JM, Gairola CG, Glauert HP, Kelloff GJ, Lubet RA, Gupta RC. 1997. Effects of dietary supplementation of N-acetylcysteine on cigarette smoke-related DNA adducts in rat tissues. Int J Oncol 11:1227-1233. PMID:21528327
  • Leung LK, Glauert HP. 1997. Lack of correlation between hepatic prostaglandin concentrations and DNA synthesis after the administration of phenobarbital and the peroxisome proliferator ciprofibrate in rats. Toxicology 123:101-109. PMID:9347925
  • Leung LK, Johnson M, Glauert HP. 1997. Effect of gadolinium chloride-induced Kupffer cell inactivation on liver regeneration in rats. Environment & Nutrition Interactions 1:13-22.
  • Peebles RS, Glauert HP. 1997. Effect of phenobarbital on hepatic eicosanoid concentrations in rats. Arch Toxicol 71(10):646-650. PMID:9332702

1996

  • Hong JT, Glauert HP. 1996. Comitogenicity of eicosanoids and the peroxisome proliferator ciprofibrate in cultured rat hepatocytes. Journal of Cellular Physiology 169:309-319. PMID:8908198
  • Leung LK, Glauert HP. 1996. Reduction of the concentrations of prostaglandins E2 and F, and thromboxane b2 in cultured rat hepatocytes treated with the peroxisome proliferator ciprofibrate. Toxicol Lett 85(3):143-149.
  • Li Y, Leung LK, Glauert HP, Spear BT. 1996. Activation of hepatic NF-ÇB by phenobarbital in rats. Biochem Biophys Res Commun 229(3):982-989.
  • Li Y, Leung LK, Glauert HP, Spear BT. 1996. Treatment of rats with the peroxisome proliferator ciprofibrate results in increased liver NF-ÇB activity. Carcinogenesis 17(11):2305-2309. PMID:8968042
  • Nilakantan V, Li Y, Glauert HP, Spear BT. 1996. Increased liver-specific catalase activity in transgenic mice. DNA Cell Biol 15:625-630. PMID:8769564

1995

  • Berberian I, Chen L, Robinson FR, Glauert HP, Chow CK, Robertson LW. 1995. Effect of dietary retinyl palmitate on the promotion of altered hepatic foci by 3,3',4,4'-tetrachlorobiphenyl and 2,2',4,4',5,5'-hexachlorobiphenyl in rats initiated with diethylnitrosamine. Carcinogenesis 16(2):393-398. PMID:7859372
  • Espandiari P, Thomas VA, Glauert HP, O'Brien ML, Noonan D, Robertson LW. 1995. The herbicide Dicamba (2-methoxy-3,6-dichlorobenzoic acid) is a peroxisome proliferator in rats. Fundam Appl Toxicol 26(1):85-90. PMID:7657066
  • Hong JT, Wilson MW, Glauert HP. 1995. Effect of phenobarbital and the peroxisome proliferator ciprofibrate on gamma-Glutamyltranspeptidase activity and leukotriene C4 concentration in cultured rat hepatocytes. J Biochem Toxicol 10(5):239-243. PMID:8847705
  • Wilson MW, Lay LT, Chow CK, Tai H, Robertson LW, Glauert HP. 1995. Altered hepatic eicosanoid concentrations in rats treated with the peroxisome proliferators ciprofibrate and perfluorodecanoic acid. Arch Toxicol 69(7):491-497. PMID:8526745
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