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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Person Details: Avram Gold

Superfund Research Program

Avram Gold

University of North Carolina-Chapel Hill
Department of Environmental Sciences and Engineering
CB #7431, 157 Rosenau Hall
Chapel Hill, North Carolina 27599-7431
Phone: 919-966-7304
Fax: 919-966-7911
Email: avram_gold@unc.edu

Projects

Publications

2022

  • Frauenheim M, Offenberg J, Zhang Z, Surratt JD, Gold A. 2022. The C5-alkene triol conundrum: structural characterization and quantitation of isoprene-derived C5H10O3 reactive uptake products. Environ Sci Technol Lett 9(10):829-836. doi:10.1021/acs.estlett.2c00548

2017

  • Gao L, Mutlu E, Collins LB, Walker N, Hartwell HJ, Olson J, Sun W, Gold A, Ball LM, Swenberg JA. 2017. DNA product formation in female Sprague-Dawley rats following polyhalogenated aromatic hydrocarbon (PHAH) exposure. Chem Res Toxicol 30(3):794-803. doi:10.1021/acs.chemrestox.6b00368 PMID:28207250 PMCID:PMC5363288
  • Nakamura J, Shimomoto T, Collins LB, Holley DW, Zhang Z, Barbee JM, Sharma V, Tian X, Kondo T, Uchida K, Yi X, Perkins DO, Willis MS, Gold A, Bultman SJ. 2017. Evidence that endogenous formaldehyde produces immunogenic and atherogenic adduct epitopes. Sci Rep 7:12. doi:10.1038/s41598-017-11289-8 PMID:28883613 PMCID:PMC5589919
  • Shimomoto T, Collins LB, Yi X, Holley DW, Zhang Z, Tian X, Uchida K, Wang C, Horkko S, Bultman SJ, Willis MS, Gold A, Nakamura J. 2017. A purified MAA-based ELISA is a useful tool for determining anti-MAA antibody titer with high sensitivity. PLoS One 12(2):e0172172. doi:10.1371/journal.pone.0172172 PMID:28222187 PMCID:PMC5319763
  • Tian Z, Gold A, Nakamura J, Zhang Z, Vila J, Singleton D, Collins LB, Aitken MD. 2017. Nontarget Analysis Reveals a Bacterial Metabolite of Pyrene Implicated in the Genotoxicity of Contaminated Soil after Bioremediation. Environ Sci Technol 51(12):7091-7100. doi:10.1021/acs.est.7b01172 PMID:28510420 PMCID:PMC6309544
  • Venkatratnam A, Furuya S, Kosyk O, Gold A, Bodnar WM, Konganti K, Threadgill DW, Gillespie DA, Aylor DL, Wright FA, Chiu WA, Rusyn I. 2017. Editor's Highlight: Collaborative Cross mouse population enables refinements to characterization of the variability in toxicokinetics of trichloroethylene and provides genetic evidence for the role of PPAR pathway in its oxidative metabolism. Toxicol Sci 158(1):48-62. doi:10.1093/toxsci/kfx065 PMID:28369613

2016

2015

  • Rodgers-Vieira EA, Zhang Z, Adrion AC, Gold A, Aitken MD. 2015. Identification of anthraquinone-degrading bacteria in soil contaminated with polycyclic aromatic hydrocarbons. Appl Environ Microbiol 81(11):3775-3781. doi:10.1128/AEM.00033-15 PMID:25819957 PMCID:PMC4421061
  • Yoo HS, Bradford BU, Kosyk O, Shymonyak S, Uehara T, Collins LB, Bodnar WM, Ball LM, Gold A, Rusyn I. 2015. Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: liver effects. J Toxicol Environ Health A 78(1):15-31. doi:10.1080/15287394.2015.958417 PMID:25424544 PMCID:PMC4281929
  • Yoo HS, Bradford BU, Kosyk O, Uehara T, Shymonyak S, Collins LB, Bodnar WM, Ball LM, Gold A, Rusyn I. 2015. Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: kidney effects. J Toxicol Environ Health A 78(1):32-49. doi:10.1080/15287394.2015.958418 PMID:25424545 PMCID:PMC4281933

2014

2011

  • Zhang Z, Sangaiah R, Gold A, Ball LM. 2011. Synthesis of uniformly 13C-labeled polycyclic aromatic hydrocarbons. Org Biomol Chem 9:5431-5435. doi:10.1039/C0OB01107J PMID:21670806

2010

  • Lu K, Ye W, Zhou L, Collins LB, Chen X, Gold A, Ball LM, Swenberg JA. 2010. Structural characterization of formaldehyde-induced cross-links between amino acids and deoxynucleosides and their oligomers. J Am Chem Soc 132(10):3388-3399. doi:10.1021/ja908282f PMID:20178313 PMCID:PMC2866014

2009

  • Kim S, Boysen G, Swenberg JA, Gold A, Ball LM, Bradford BU, Rusyn I, Collins LB. 2009. Liquid chromatography electrospray ionization tandem mass spectrometry analysis method for simultaneous detection of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine. Toxicology 262(3):230-238. doi:10.1016/j.tox.2009.06.013 PMID:19549554 PMCID:PMC2765814
  • Ye W, Gold A, Ball LM, Swenberg JA, Lu K. 2009. Formation of S-[1-(N2-deoxyguanosinyl)methyl]glutathione between glutathione and DNA induced by formaldehyde. J Am Chem Soc 131(10):3414-3415. doi:10.1021/ja808048c PMID:19239220 PMCID:PMC3277947

2008

  • Kang-Sickel JC, Nam T, Jayaraj K, Ball LM, French JE, Klapper DG, Gold A, Nylander-French LA. 2008. S-arylcysteine-keratin adducts as biomarkers of human dermal exposure to aromatic hydrocarbons. Chem Res Toxicol 21(4):852-858. doi:10.1021/tx7003773 PMID:18361511

2006

  • Kang-Sickel JC, Gold A, Ball LM, Karupiah J, Nylander-French LA, Parron V, Klapper DG, French JE. 2006. Detection of naphthalene keratin adducts in human skin using ELISA. J Mol Biol 38(Suppl.2):67-68.
  • Singleton D, Sangaiah R, Gold A, Ball LM, Aitken MD. 2006. Identification and quantification of uncultivated Proteobacteria associated with pyrene degradation in a bioreactor treating PAH-contaminated soil. Environ Microbiol 8(10):1736-1745. doi:10.1111/j.1462-2920.2006.01112.x PMID:16958754
  • Ye W, Sangaiah R, Degen DE, Gold A, Jayaraj K, Koshlap KM, Boysen G, Williams J, Tomer KB, Ball LM. 2006. A 2-iminohydantoin from the oxidation of guanine. Chem Res Toxicol 19(4):506-10. PMID:16608161

2005

  • Jeong Y, Sangaiah R, Nakamura J, Pachkowski BF, Ranasinghe A, Gold A, Ball LM, Swenberg JA. 2005. Analysis of M(1)G-dR in DNA by aldehyde reactive probe labeling and liquid chromatography tandem mass spectrometry. Chem Res Toxicol 18(1):51-60. PMID:15651849
  • Singleton D, Powell SN, Sangaiah R, Gold A, Ball LM, Aitken MD. 2005. Stable-isotope probing of bacteria capable of degrading salicylate, naphthalene, or phenanthrene in a bioreactor treating contaminated soil. Appl Environ Microbiol 71(3):1202-1209. doi:10.1128/AEM.71.3.1202-1209.2005 PMID:15746319 PMCID:PMC1065189
  • Ye W, Sangaiah R, Degen DE, Gold A, Jayaraj K, Koshlap KM, Boysen G, Ball LM. 2005. A 2-Iminohydantoin is the major product from DMDO oxidation of Guanine. In: Superfund Basic Research Program Annual Meeting, January 12-13. New York Academy of Medicine, New York, NY.

2004

  • Casteel MJ, Jayaraj K, Gold A, Ball LM, Sobsey MD. 2004. Photoinactivation of hepatitis A virus by synthetic porphyrins. Photochemistry and Photobiology 80(2):294-300. PMID:15362943
  • Lin P, Sangaiah R, Ranasinghe A, Ball LM, Swenberg JA, Gold A. 2004. Synthesis of chlorinated and non-chlorinated biphenyl-2,3-and 3,4-catechols and their [H-2(3)]-isotopomers. Org Biomol Chem 2(18):2624-2629. PMID:15351827

2003

  • Gold A, Nam T, Jayaraj K, Sangaiah R, Klapper DG, Ball LM, French JE, Nylander-French LA. 2003. Synthesis of S-aryl-D,L-cysteines and incorporation into keratin sequences. Organic Preparations and Procedures International 35(4):375-382.
  • Pachkowski BF, Nakamura J, Li Y, Sangaiah R, Gold A, Swenberg JA. 2003. An LC/MS Approach to the Differentiation of Aldehydic Deoxyribose Lesions. In: Proceedings of the American Association for Cancer Research Annual Meeting, 2003.

2002

  • Nam T, Sangaiah R, Gold A, Lacks GD, Nylander-French LA, French JE. 2002. Synthesis of FMOC-protected S-arylcysteines and modified keratin sequence peptides as specific epitopes as immunogens. Polycyclic Aromatic Compounds 22(3-4):239-248.

2001

  • Kazunga C, Aitken MD, Gold A, Sangaiah R. 2001. Fluoranthene-2,3- and -1,5-diones are novel products from the bacterial transformation of fluoranthene. Environ Sci Technol 35(5):917-922. PMID:11351535
  • Nam T, Sangaiah R, Gold A, Lacks GD, Nylander-French LA, French JE. 2001. Synthesis of FMOC-protected S-aryclysteines and modified keratin sequence peptides as specific epitopes as immunogens. In: Proceedings of the 18th International Symposiium on Polycyclic Aromatic Compounds, Sept 9-13. Cincinnati, OH.

2000

  • Lin P, Sangaiah R, Ranasinghe A, Upton PB, La DK, Gold A, Swenberg JA. 2000. Formation of quinonoid-derived protein adducts in the liver and brain of Sprague-Dawley rats treated with 2,2',5,5'-tetrachlorobiphenyl. Chem Res Toxicol 13(8):710-718. PMID:10956058

1999

  • Kazunga C, Aitken MD, Gold A. 1999. Primary product of the horseradish peroxidase-catalyzed oxidation of pentachlorophenol. Environ Sci Technol 33:1408-1412.

1998

  • Yen T, Holt S, Sangaiah R, Gold A, Swenberg JA. 1998. Quantitation of 1,N6 ethenoadenine in rat urine by immunoaffinity extraction combined with liquid chromatography/electrospray ionization mass spectrometry. Chem Res Toxicol 11(7):810-815. PMID:9671544

1995

  • Scheller NA, Sangaiah R, Ranasinghe A, Amarnath V, Gold A, Swenberg JA. 1995. Synthesis of [4,5,6,8-13C4]guanine, a reagent for the production of internal standards of guanyl DNA adducts. Chem Res Toxicol 8(3):333-337. PMID:7578918
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