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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Person Details: Federico M. Farin

Superfund Research Program

Federico M. Farin

University of Washington
Box 354695
Seattle, Washington 98105
Phone: 206-685-7285
Fax: 206-685-4696
Email: freddy@u.washington.edu

Projects

Publications

2015

2014

  • Ahmed I, Lee P, Lill CM, Nielsen SS, Artaud F, Gallagher LG, Loriot M, Mulot C, Nacfer M, Liu T, Biernacka JM, Armasu S, Anderson K, Farin FM, Lassen CF, Hansen J, Olsen JH, Bertram L, Maraganore DM, Checkoway H, Ritz B, Elbaz A. 2014. Lack of replication of the GRIN2A-by-coffee interaction in Parkinson disease. PLoS Genet 10(11):e1004788. doi:10.1371/journal.pgen.1004788 PMID:25412286 PMCID:PMC4238979
  • Cole TB, Li WF, Co AL, Hay AM, MacDonald JW, Bammler TK, Farin FM, Costa LG, Furlong CE. 2014. Repeated gestational exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1) modulated effects in maternal and fetal tissues. Toxicol Sci 141(2):409-422. doi:10.1093/toxsci/kfu144 PMID:25070982 PMCID:PMC4271046
  • Woods JS, Heyer NJ, Russo JE, Martin MD, Pillai PB, Bammler TK, Farin FM. 2014. Genetic polymorphisms of catechol-O-methyltransferase modify the neurobehavioral effects of mercury in children. J Toxicol Environ Health A 77(6):293-312. doi:10.1080/15287394.2014.867210 PMID:24593143 PMCID:PMC3967503

2012

  • Mata IF, Checkoway H, Hutter CM, Samii A, Roberts JW, Kim H, Alvarez V, Ribacoba R, Pastor P, Lorenzo-Betancor O, Infante J, Sierra M, Gomez-Garre P, Mir P, Ritz B, Rhodes SL, Colcher A, Van Deerlin V, Chung KA, Quinn JF, Yearout D, Martizez E, Farin FM, Wan JY, Edwards KL, Zabetian CP. 2012. Common variation in the LRRK2 gene is a risk factor for Parkinson's disease. Movement Disorders 27(14):1823-1826. doi:10.1002/mds.25226 PMID:23115130 PMCID:PMC3536918
  • Nielsen SS, Checkoway H, Butler RA, Nelson HH, Farin FM, Longstreth WT, Franklin GM, Swanson PD, Kelsey KT. 2012. LINE-1 DNA methylation, smoking and risk of Parkinson's disease. J Parkinsons Dis 2(4):303-308. doi:10.3233/JPD-012129 PMID:23938260 PMCID:PMC3962286
  • Woods JS, Heyer NJ, Echeverria D, Russo JE, Martin MD, Bernardo MF, Luis HS, Vaz L, Farin FM. 2012. Modification of neurobehavioral effects of mercury by a genetic polymorphism of coproporphyrinogen oxidase in children. Neurotoxicol Teratol 34(5):513-521. doi:10.1016/j.ntt.2012.06.004 PMID:22765978 PMCID:PMC3462250

2011

  • Cole TB, Beyer RP, Bammler TK, Park SS, Farin FM, Costa LG, Furlong CE. 2011. Repeated developmental exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1)-modulated effects on cerebellar gene expression. Toxicol Sci 123:155-169. doi:10.1093/toxsci/kfr157 PMID:21673326 PMCID:PMC3164442

2010

  • Echeverria D, Woods JS, Heyer NJ, Martin MD, Rohlman D, Farin FM, Li T. 2010. The association between serotonin transporter gene promotor polymorphism (5-HTTLPR) and elemental mercury exposure on mood and behavior in humans. J Toxicol Environ Health A 73(15):1003-1020. doi:10.1080/15287390903566591 PMID:20526950 PMCID:PMC2882654
  • Hofmann JN, Keifer M, Checkoway H, De Roos AJ, Farin FM, Fenske RA, Richter RJ, van Belle G, Furlong CE. 2010. Biomarkers of sensitivity and exposure in Washington state pesticide handlers. Advances in Experimental Medicine and Biology 660:19-27. doi:10.1007/978-1-60761-350-3_3 PMID:20221867 PMCID:PMC3041670
  • Kang J, Wilkerson H, Farin FM, Bammler TK, Beyer RP, Strand SE, Doty SL. 2010. Mammalian cytochrome CYP2E1 triggered differential gene regulation in response to trichloroethylene (TCE) in a transgenic poplar. Funct Integr Genomics 10(3):417-424. doi:10.1007/s10142-010-0165-4 PMID:20213342 PMCID:PMC3050643

2009

  • Heyer NJ, Echeverria D, Martin MD, Farin FM, Woods JS. 2009. Catechol O-methyltransferase (COMT) VAL158MET functional polymorphism, dental mercury exposure, and self-reported symptoms and mood. J Toxicol Environ Health A 72(9):599-609. doi:10.1080/15287390802706405 PMID:19296409 PMCID:PMC2866512
  • Hofmann JN, Keifer M, Furlong CE, De Roos AJ, Farin FM, Fenske RA, van Belle G, Checkoway H. 2009. Serum cholinesterase inhibition in relation to paraoxonase-1 (PON1) status among organophosphate-exposed agricultural pesticide handlers. Environ Health Perspect 117:1402-1408. PMID:19750105
  • Lefebvre KA, Tilton SC, Bammler TK, Beyer RP, Srinouanprachanh SL, Stapleton PL, Farin FM, Gallagher EP. 2009. Gene expression profiles in zebrafish brain after acute exposure to domoic acid at symptomatic and asymptomatic doses. Toxicol Sci 107(1):65-77. doi:10.1093/toxsci/kfn207 PMID:18936300 PMCID:PMC2735419

2008

  • Echeverria D, Woods JS, Heyer NJ, Martin MD, Rholman D, Farin FM, Li T. 2008. The association between serotonin transporter gene promoter polymorphism (5-HTTLPR), self-reported symptoms, and dental mercury exposure. J Toxicol Environ Health A 71(19):1318-1326. doi:10.1080/15287390802240850 PMID:18686203 PMCID:PMC2612706
  • Gallagher EP, Stapleton PL, Bammler TK, Beyer RP, Farin FM, LaVire HM. 2008. Hepatic expression profiling in smolting and adult coho salmon (Onchorhynchus kisutch). Environ Res 106(3):365-378. doi:10.1016/j.envres.2007.10.001 PMID:18241857 PMCID:PMC3321376
  • Tilton F, Tilton SC, Bammler TK, Beyer RP, Farin FM, Stapleton PL, Gallagher EP. 2008. Transcriptional biomarkers and mechanisms of copper-induced olfactory injury in zebrafish. Environ Sci Technol 42(24):9404-11. doi:10.1021/es801636v PMID:19174923

2007

  • Doty SL, James CA, Moore AL, Vajzovic A, Singleton GL, Ma C, Khan Z, Xin G, Kang J, Park J, Meilan R, Strauss SH, Wilkerson J, Farin FM, Strand SE. 2007. Enhanced phytoremediation of volatile environmental pollutants with transgenic trees. Proc Natl Acad Sci U S A 104(43):16816-16821. doi:10.1073/pnas.0703276104 PMID:17940038 PMCID:PMC2040402

2006

  • Bekris LM, Viernes HA, Farin FM, Maier LA, Kavanagh TJ, Takaro TK. 2006. Chronic beryllium disease and glutathione biosynthesis genes. J Occup Environ Med 48(6):599-606. PMID:16766924
  • Botta D, Shi S, White CC, Dabrowski MJ, Keener CL, Srinouanprachanh SL, Farin FM, Ware CB, Ladiges WC, Pierce RH, Fausto N, Kavanagh TJ. 2006. Acetaminophen-induced liver injury is attenuated in male glutamate-cysteine ligase transgenic mice. J Biol Chem 281(39):28865-28875. PMID:16840778
  • Echeverria D, Woods JS, Heyer NJ, Rohlman D, Farin FM, Li T, Garabedian CC. 2006. The association between a genetic polymorphism of coproporphyrinogen oxidase, dental mercury exposure and neurobehavioral response in humans. Neurotoxicol Teratol 28(1):39-48. PMID:16343843

2005

  • Bammler TK, Beyer RP, Bhattacharya S, Boorman GA, Boyles A, Bradford BU, Bumgarner RE, Bushel PR, Chaturvedi K, Choi D, Cunningham ML, Deng S, Dressman HK, Fannin RD, Farin FM, Freedman JH, Fry RC, Harper A, Humble MC, Hurban P, Kavanagh TJ, Kaufmann WK, Kerr KF, Jing L, Lapidus JA, Lasarev MR, Li J, Li Y, Lobenhofer EK, Lu X, Malek RL, Milton S, Nagalla SR, O'Malley JP, Palmer VS, Pattee P, Paules RS, Perou CM, Phillips K, Qin L, Qiu Y, Quigley SD, Rodland M, Rusyn I, Samson LD, Schwartz DA, Shi Y, Shin J, Sieber SO, Slifer S, Speer MC, Spencer PS, Sproles DI, Swenberg JA, Suk WA, Sullivan RC, Tian R, Tennant RW, Todd SA, Tucker CJ, Van Houten B, Weis BK, Xuan S, Zarbl HF. 2005. Standardizing global gene expression analysis between laboratories and across platforms. Nat Methods 2(5):351-6. PMID:15846362
  • Okada S, Farin FM, Stapleton PL, Viernes HA, Quigley SD, Powers KM, Smith-Weller T, Franklin GM, Longstreth WT, Swanson PD, Checkoway H. 2005. No associations between Parkinson's disease and polymorphisms of the quinone oxidoreductase (NQO1, NQO2) genes. Neurosci Lett 375(3):178-180. PMID:15694256
  • Woods JS, Echeverria D, Heyer NJ, Simmonds PL, Wilkerson J, Farin FM. 2005. The association between genetic polymorphisms of coproporphyrinogen oxidase and an atypical porphyrinogenic response to mercury exposure in humans. Toxicol Appl Pharmacol 206(2):113-120. PMID:15967199

2004

  • Costa LG, Kelada SN, Costa-Mallen P, Farin FM, Viernes HA, Smith-Weller T, Franklin GM, Longstreth WT, Swanson PD, Checkoway H, Furlong CE. 2004. Paraoxonase 2 (PON2) polymorphisms and Parkinson's disease. Neurosci Res Commun 34(3):130-135.
  • Costa-Mallen P, Afsharinejad Z, Kelada SN, Costa LG, Franklin GM, Swanson PD, Longstreth WT, Viernes HA, Farin FM, Smith-Weller T, Checkoway H. 2004. DNA sequence analysis of monoamine oxidase B gene coding and promoter regions in Parkinson's disease cases and unrelated controls. Movement Disorders 19(1):76-83. PMID:14743364
  • Heyer NJ, Echeverria D, Bittner AC, Farin FM, Garabedian CC, Woods JS. 2004. Chronic low-level mercury exposure, BDNF polymorphism, and associations with self-reported symptoms and mood. Toxicol Sci 81(2):354-363. PMID:15254338
  • Kevil CG, Pruitt HM, Kavanagh TJ, Wilkerson J, Farin FM, Moellering D, Darley-Usmar VM, Bullard DC, Patel RP. 2004. Regulation of endothelial glutathione by ICAM-1: implications for inflammation. FASEB J 18(11):1321-3. PMID:15180961

2003

  • Kavanagh TJ, Shi S, Botta D, White CC, Dabrowski MJ, Shephard C, Quigley SD, Farin FM, Beyer RP, Pierce RH, Franklin CC, Zarbl HF, Bammler TK. 2003. Using toxicogenomic analysis to assess the protective effects of enhanced glutathione synthesis in glutamate cysteine ligase transgenic mice. Toxicol Sci 72(1):805Suppl.S.
  • Kelada SN, Costa-Mallen P, Checkoway H, Viernes HA, Farin FM, Costa LG, Longstreth WT, Furlong CE, Jarvik GP, Swanson PD. 2003. Paraoxonase 1 promoter and coding region polymorphisms in Parkinson's disease. Journal of Neurology, Neurosurgery & Psychiatry 74(4):546-547. PMID:12640090
  • Kelada SN, Stapleton PL, Farin FM, Bammler TK, Eaton DL, Smith-Weller T, Franklin GM, Swanson PD, Longstreth WT, Checkoway H. 2003. Glutathione S-transferase M1, T1, and P1 polymorphisms and Parkinson's disease. Neurosci Lett 337(1):5-8. PMID:12524158
  • Shao J, McKone EF, Keener CL, Shephard C, Farin FM, Aitken ML, Kavanagh TJ. 2003. The modification of cystic fibrosis lung disease by a polymorphism in a glutamate cysteine ligase gene. Toxicol Sci 72(1):487Suppl.S.
  • Shi S, Botta D, White CC, Dabrowski MJ, Shephard C, Quigley SD, Farin FM, Beyer RP, Pierce RH, Franklin CC, Zarbl HF, Bammler TK, Kavanagh TJ. 2003. Effects of enhanced glutathione synthesis on carbon tetracholoride-induced differential gene expression in glutamate-cysteine ligase transgenic mice livers. Free Radic Biol Med 35(1):227Suppl.S.

2002

  • Costa-Mallen P, Kelada SN, Viernes HA, Srinouanprachanh SL, Farin FM, Costa LG, Checkoway H. 2002. DNA sequencing analysis of the monoamine oxidase B gene coding region in Parkinson's disease cases and controls. In: Proceedings of the Tenth International Aamine Oxidases Workshop, August. Istanbul, Turkey.
  • Higashi MK, Veenstra DL, Kondo LM, Wittkowsky AK, Srinouanprachanh SL, Farin FM, Rettie AE. 2002. Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapy. JAMA - Journal of the American Medical Association 287(13):1690-1698. PMID:11926893

2001

  • Diaz D, Krejsa CM, White CC, Keener CL, Farin FM, Kavanagh TJ. 2001. Tissue specific changes in the expression of glutamate-cysteine ligase mRNAs in mice exposed to methylmercury. Toxicol Lett 122(2):119-129. PMID:11439218
  • Farin FM, Hitosis Y, Hallagan SE, Kushleika JV, Woods JS, Janssen P, Smith-Weller T, Franklin GM, Swanson PD, Checkoway H. 2001. Genetic polymorphisms of superoxide dismutase in Parkinson's disease. Movement Disorders 16(4):705-707. PMID:11481695
  • Farin FM, Janssen P, Quigley SD, Abbott D, Hassett C, Smith-Weller T, Franklin GM, Swanson PD, Longstreth WT, Omiecinski CJ, Checkoway H. 2001. Genetic polymorphisms of microsomal and soluble epoxide hydrolase and the risk of Parkinson's disease. Pharmacogenet Genomics 11(8):703-708. PMID:11692079
  • Kim HS, Newcomb PA, Ulrich CM, Keener CL, Farin FM, Bostick RM, Potter JD. 2001. Vitamin D receptor polymorphisms and the risk of colorectal adenomas: evidence of interaction with dietary vitamin D and calcium. Cancer Epidemiol Biomarkers Prev 10(8):869-874. PMID:11489753
  • Ulrich CM, Yasui Y, Storb RF, Schubert MM, Wagner JL, Bigler J, Ariail KS, Keener CL, Li S, Liu H, Farin FM, Potter JD. 2001. Pharmacogenetics of methotrexate: toxicity among marrow transplantation patients varies with the methylenetetrahydrofolate reductase C677T polymorphism. Blood 98(1):231-234. PMID:11418485
  • Winterton DL, Kaufman JD, Keener CL, Quigley SD, Farin FM, Williams PV, Koenig JQ. 2001. Genetic polymorphisms as biomarkers of sensitivity to inhaled sulfur dioxide in subjects with asthma. Ann Allergy Asthma Immunol 86(2):232-238. doi:10.1016/S1081-1206(10)62697-X PMID:11258696

2000

  • Kirchner SC, Hallagan SE, Farin FM, Dilley J, Costa-Mallen P, Smith-Weller T, Franklin GM, Swanson PD, Checkoway H. 2000. Mitochondrial Complex I (ND1 subunit) sequence analysis and association of the T4216C mutation with Parkinson's disease. Neurotoxicology 21:441-446. PMID:11022854
  • Ulrich CM, Bigler J, Velicer CM, Greene EA, Farin FM, Potter JD. 2000. Searching expressed sequence tag (EST) databases: discovery and confirmation of a common polymorphism in the thymidylate synthase gene. Cancer Epidemiol Biomarkers Prev 9(12):1381-1385. PMID:11142426

1998

  • Andersen MR, Farin FM, Omiecinski CJ. 1998. Quantification of multiple human cytochrome P450 mRNA molecules using competitive RT-PCR. DNA Cell Biol 17(3):231-238. PMID:9539103
  • Checkoway H, Farin FM, Costa-Mallen P, Kirchner SC, Costa LG. 1998. Genetic polymorphisms in Parkinson's disease. Neurotoxicology 19:635-643. PMID:9745923

1997

  • Villaroman C, Farin FM, Sidhu JS, Oda D, Omiecinski CJ. 1997. Detection of cytochrome P450 mRNA in tissue sections and cell lines using enzyme-linked fluorescence in situ hybridization. In Vitr Mol Toxicol 10:295-308.

1996

  • Heinonen JT, Sidhu JS, Reilly MT, Farin FM, Omiecinski CJ, Eaton DL, Kavanagh TJ. 1996. Assessment of regional cytochrome P450 activities in rat liver slices using resorufin substrates and fluorescence confocal laser cytometry. Environ Health Perspect 104(5):535-543. PMID:8743442

1995

  • Farin FM, Bigler LG, Oda D, McDougall JK, Omiecinski CJ. 1995. Expression of cytochrome P450 and microsomal epoxide hydrolase in cervical and oral epithelial cells immortalized by human papillomavirus type 16 E6/E7 genes. Carcinogenesis 16(6):1391-1401. PMID:7788860
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