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Person Details: Terrance J. Kavanagh

Superfund Research Program

Terrance J. Kavanagh

University of Washington
Department of Environmental and Occupational Health Sciences
4225 Roosevelt Way NE #100
Box 354695
Seattle, Washington 98105-6099
Phone: 206-685-8479
Fax: 206-685-4696




  • Steele WB, Kristofco LA, Corrales J, Saari GN, Corcoran EJ, Hill BN, Mills MG, Gallagher EP, Kavanagh TJ, Melnikov F, Zimmerman JB, Voutchkova-Kostal A, Anastas P, Kostal J, Brooks BW. 2020. Toward less hazardous industrial compounds: Coupling quantum mechanical computations, biomarker responses, and behavioral profiles to identify bioactivity of S(N)2 electrophiles in alternative vertebrate models. Chem Res Toxicol 33(2):367-380. doi:10.1021/acs.chemrestox.9b00290 PMID:31789507


  • Melnikov F, Botta D, White CC, Schmuck S, Winfough M, Schaupp C, Gallagher EP, Brooks BW, Williams E, Coish P, Anastas P, Voutchkova-Kostal A, Kostal J, Kavanagh TJ. 2019. Kinetics of Glutathione Depletion and Antioxidant Gene Expression as Indicators of Chemical Modes of Action Assessed in vitro in Mouse Hepatocytes with Enhanced Glutathione Synthesis. Chem Res Toxicol 32(3):421-436. doi:10.1021/acs.chemrestox.8b00259
  • Mills MG, Ramsden R, Ma EY, Corrales J, Kristofco LA, Steele WB, Saari GN, Melnikov F, Kostal J, Kavanagh TJ, Zimmerman JB, Voutchkova-Kostal A, Brooks BW, Coish P, Anastas P, Gallagher EP. 2019. CRISPR-generated Nrf2a loss- and gain-of-function mutants facilitate mechanistic analysis of chemical oxidative stress-mediated toxicity in zebrafish. Chem Res Toxicol doi:10.1021/acs.chemrestox.9b00346


  • Steele WB, Kristofco LA, Corrales J, Saari GN, Haddad SP, Gallagher EP, Kavanagh TJ, Kostal J, Zimmerman JB, Voutchkova-Kostal A, Anastas P, Brooks BW. 2018. Comparative behavioral toxicology with two common larval fish models: exploring relationships among modes of action and locomotor responses. Sci Total Environ 640-641:1587-1600. doi:10.1016/j.scitotenv.2018.05.402 PMID:30021323






  • Beyer RP, Lasarev MR, Meira LB, Palmer VS, Ross PK, Bammler TK, Bradford BU, Cunningham ML, Higgins G, Hurban P, Kayton RJ, Kosyk O, Vliet PA, Wolfinger R, Woods CG, Freedman JH, Linney EA, Kaufmann WK, Kavanagh TJ, Rusyn I, Samson LD, Spencer PS, Suk WA, Zarbl HF. 2007. Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses. Toxicol Sci 99(1):326-337. PMID:17562736
  • Giordano G, Afsharinejad Z, Guizzetti M, Vitalone A, Kavanagh TJ, Costa LG. 2007. Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency. Toxicol Appl Pharmacol 219(2-3):181-189. PMID:17084875


  • Bekris LM, Viernes HA, Farin FM, Maier LA, Kavanagh TJ, Takaro TK. 2006. Chronic beryllium disease and glutathione biosynthesis genes. J Occup Environ Med 48(6):599-606. PMID:16766924
  • Botta D, Shi S, White CC, Dabrowski MJ, Keener CL, Srinouanprachanh SL, Farin FM, Ware CB, Ladiges WC, Pierce RH, Fausto N, Kavanagh TJ. 2006. Acetaminophen-induced liver injury is attenuated in male glutamate-cysteine ligase transgenic mice. J Biol Chem 281(39):28865-28875. PMID:16840778


  • Bammler TK, Beyer RP, Bhattacharya S, Boorman GA, Boyles A, Bradford BU, Bumgarner RE, Bushel PR, Chaturvedi K, Choi D, Cunningham ML, Deng S, Dressman HK, Fannin RD, Farin FM, Freedman JH, Fry RC, Harper A, Humble MC, Hurban P, Kavanagh TJ, Kaufmann WK, Kerr KF, Jing L, Lapidus JA, Lasarev MR, Li J, Li Y, Lobenhofer EK, Lu X, Malek RL, Milton S, Nagalla SR, O'Malley JP, Palmer VS, Pattee P, Paules RS, Perou CM, Phillips K, Qin L, Qiu Y, Quigley SD, Rodland M, Rusyn I, Samson LD, Schwartz DA, Shi Y, Shin J, Sieber SO, Slifer S, Speer MC, Spencer PS, Sproles DI, Swenberg JA, Suk WA, Sullivan RC, Tian R, Tennant RW, Todd SA, Tucker CJ, Van Houten B, Weis BK, Xuan S, Zarbl HF. 2005. Standardizing global gene expression analysis between laboratories and across platforms. Nat Methods 2(5):351-6. PMID:15846362


  • Botta D, Franklin CC, White CC, Krejsa CM, Dabrowski MJ, Pierce RH, Fausto N, Kavanagh TJ. 2004. Glutamate-cysteine ligase attenuates TNF-induced mitochondrial injury and apoptosis. Free Radic Biol Med 37(5):632-642. PMID:15288121
  • Diaz D, Krejsa CM, White CC, Charleston JS, Kavanagh TJ. 2004. Effect of methylmercury on glutamate-cysteine ligase expression in the placenta and yolk sac during mouse development. Reprod Toxicol 19(1):117-129. PMID:15336720
  • Kevil CG, Pruitt HM, Kavanagh TJ, Wilkerson J, Farin FM, Moellering D, Darley-Usmar VM, Bullard DC, Patel RP. 2004. Regulation of endothelial glutathione by ICAM-1: implications for inflammation. FASEB J 18(11):1321-3. PMID:15180961
  • Krzywanski DM, Dickinson DA, Iles KE, Wigley AF, Franklin CC, Liu R, Kavanagh TJ, Forman HJ. 2004. Variable regulation of glutamate cysteine ligase subunit proteins affects glutathione biosynthesis in response to oxidative stress. Arch Biochem Biophys 423(1):116-125. PMID:14871475
  • Tran PT, Parker SM, LeRoy E, Franklin CC, Kavanagh TJ, Zhang T, Zhou H, Vliet PA, Oseid E, Harmon JS, Robertson RP. 2004. Adenoviral overexpression of the glutamylcysteine ligase catalytic subunit protects pancreatic islets against oxidative stress. J Biol Chem 279(52):53988-53993. PMID:15485876


  • Barrus H, Srinouanprachanh SL, Hooper MJ, Cobb GP, Kavanagh TJ. 2003. Metallothionein and glutamate-cysteine ligase gene expression in metal-exposed small mammals. In: Proceedings of the 42nd Annual Meeting of the Society of Toxicology (SOT), March 9-13, 2003. Salt Lake City, UT.
  • Bea F, Hudson FN, Chait A, Kavanagh TJ, Rosenfeld ME. 2003. Induction of glutathione synthesis in macrophages by oxidized low-density lipoproteins is mediated by consensus antioxidant response elements. Circ Res 92(4):386-393. PMID:12600891
  • Bekris LM, Shephard C, Zarghami M, Griffith WC, Kavanagh TJ, Lernmark A. 2003. Glutamate cysteine ligase catalytic subunit trinucleotide repeat polymorphism and type I diabetes. Toxicol Sci 72(1):480Suppl.S. PMID:17479437
  • Franklin CC, Rosenfeld-Franklin ME, White CC, Kavanagh TJ, Fausto N. 2003. TGF beta 1-induced suppression of glutathione antioxidant defenses in hepatocytes: caspase-dependent posttranslational and caspase-independent transcriptional regulatory mechanisms. FASEB J 17(11):1535-1537. PMID:12824300
  • Garry MR, Sidhu JS, Kavanagh TJ, Faustman EM. 2003. Differential modulation of stress and ubiquitination signaling pathways by cadmium, H202, and serum withdrawal in cultured mouse fibroblasts. Society of Toxicology 42nd annual Meeting in Salt Lake City, Utah, March 2003. Toxicol Sci 72(1):311Suppl.S.
  • Kavanagh TJ, Shi S, Botta D, White CC, Dabrowski MJ, Shephard C, Quigley SD, Farin FM, Beyer RP, Pierce RH, Franklin CC, Zarbl HF, Bammler TK. 2003. Using toxicogenomic analysis to assess the protective effects of enhanced glutathione synthesis in glutamate cysteine ligase transgenic mice. Toxicol Sci 72(1):805Suppl.S.
  • Luderer U, Diaz D, Faustman EM, Kavanagh TJ. 2003. Localization of glutamate cysteine ligase subunit mRNA within the rat ovary and relationship to follicular apoptosis. Mol Reprod Dev 65(3):254-261. PMID:12784246
  • Shao J, McKone EF, Keener CL, Shephard C, Farin FM, Aitken ML, Kavanagh TJ. 2003. The modification of cystic fibrosis lung disease by a polymorphism in a glutamate cysteine ligase gene. Toxicol Sci 72(1):487Suppl.S.
  • Shi S, Botta D, White CC, Dabrowski MJ, Shephard C, Quigley SD, Farin FM, Beyer RP, Pierce RH, Franklin CC, Zarbl HF, Bammler TK, Kavanagh TJ. 2003. Effects of enhanced glutathione synthesis on carbon tetracholoride-induced differential gene expression in glutamate-cysteine ligase transgenic mice livers. Free Radic Biol Med 35(1):227Suppl.S.
  • Shi S, Hendsch MB, Ogburn CE, Rabinovitch PS, Martin GM, Kavanagh TJ. 2003. Female mice transgenic for mitochondrial directed catalase have altered glutathione redox cycle enzyme activities coincident with tissue specific catalase expression. Toxicol Sci 72(1):394Suppl.S.
  • Thompson JA, Kavanagh TJ, White CC, Fausto N, Franklin CC. 2003. Distinct molecular mechanisms mediate AS3+-induced glutamate-cysteine ligase subunit gene expression in murine hepatocytes. Free Radical Biology and Medicine Annual Meeting, Seattle, WA, November 2003. Free Radic Biol Med 35:188Suppl.1.
  • White CC, Viernes HA, Krejsa CM, Botta D, Kavanagh TJ. 2003. Fluorescence-based microtiter plate assay for glutamate-cysteine ligase activity. Anal Biochem 318(2):175-180. PMID:12814619


  • Diaz D, Krejsa CM, Kavanagh TJ. 2002. Expression of glutamate-cysteine ligase during mouse development. Mol Reprod Dev 62:83-91. PMID:11933164
  • Faustman EM, Ponce RA, Ou YC, Mendoza MC, Lewandowski TA, Kavanagh TJ. 2002. Investigations of methylmercury-induced alterations in neurogenesis. Environ Health Perspect 110(Supp5):859-864. PMID:12426147
  • Franklin CC, Krejsa CM, Pierce RH, White CC, Fausto N, Kavanagh TJ. 2002. Caspase-3-dependent cleavage of the glutamate-L-cysteine ligase catalytic subunit during apoptotic cell death. Am J Pathol 160(5):1887-1894. PMID:12000740


  • Adams ML, Pierce RH, Vail ME, White CC, Tonge RP, Kavanagh TJ, Fausto N, Nelson SD, Bruschi SA. 2001. Enhanced acetaminophen hepatotoxicity in transgenic mice overexpressing BCL-2. Mol Pharmacol 60(5):907-915. PMID:11641418
  • Diaz D, Krejsa CM, Kavanagh TJ. 2001. Localization of glutamate-cysteine ligase mRNA and protein in mouse kidney and induction with methylmercury. Toxicol Lett 123(1):33-41. PMID:11514103
  • Diaz D, Krejsa CM, White CC, Keener CL, Farin FM, Kavanagh TJ. 2001. Tissue specific changes in the expression of glutamate-cysteine ligase mRNAs in mice exposed to methylmercury. Toxicol Lett 122(2):119-129. PMID:11439218
  • Luderer U, Kavanagh TJ, White CC, Faustman EM. 2001. Gonadotropin regulation of glutathione synthesis in the rat ovary. Reprod Toxicol 15:495-504. PMID:11780957
  • Rosato MT, Jabbour AJ, Ponce RA, Kavanagh TJ, Takaro TK, Hill JP, Poot M, Rabinovitch PS, Faustman EM. 2001. Simultaneous analysis of surface marker expression and cell cycle progression in human peripheral blood mononuclear cells. J Immunol Methods 256(1-2):35-46. PMID:11516753


  • Hudson FN, Kavanagh TJ. 2000. Cloning and characterization of the proximal promoter region of the mouse glutamate-L-cysteine ligase regulatory subunit gene. Biochim Biophys Acta 1492:447-451. PMID:10899580
  • Jarvinen K, Pietarinen-Runtti P, Linnainmaa K, Raivio KO, Krejsa CM, Kavanagh TJ, Kinnula VL. 2000. Antioxidant defense mechanisms of human mesothelioma and lung adenocarcinoma cells. Am J Physiol 278(4):L696-702. PMID:10749746
  • Kirlin WG, Cai J, Thompson SA, Diaz D, Kavanagh TJ, Jones DP. 2000. Glutathione redox potential in response to differentiation and enzyme inducers. Free Radic Biol Med 27(11-12):1208-1218. PMID:10641713
  • Pierce RH, Campbell JS, Stephenson AB, Franklin CC, Chaisson M, Poot M, Kavanagh TJ, Rabinovitch PS, Fausto N. 2000. Disruption of redox homeostasis in tumor necrosis factor-induced apoptosis in a murine hepatocyte cell line. Am J Pathol 157(1):221-36. PMID:10880392
  • Thompson SA, White CC, Krejsa CM, Eaton DL, Kavanagh TJ. 2000. Modulation of glutathione and glutamate-L-cysteine ligase by methylmercury during mouse development. Toxicol Sci 57:141-6. PMID:10966520


  • Nelson KC, Carlson JL, Newman ML, Sternberg P, Jones DP, Kavanagh TJ, Diaz D, Cai J, Wu M. 1999. Effect of dietary inducer dimethylfumarate on glutathione in cultured human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 40(9):1927-1935. PMID:10440245
  • Ou YC, Thompson SA, Ponce RA, Schroeder JI, Kavanagh TJ, Faustman EM. 1999. Induction of the cell cycle regulatory gene p21 (Waf1, Cip1) following methylmercury exposure in vitro and in vivo. Toxicol Appl Pharmacol 157:203-212. PMID:10373404
  • Ou YC, White CC, Krejsa CM, Ponce RA, Kavanagh TJ, Faustman EM. 1999. The Role of intracellular glutathione in methylmercury-induced toxicity in embryonic neuronal cells. Neurotoxicology 20:784-793. PMID:10591515
  • Siitonen T, Alaruikka P, Mantymaa P, Savolainen ER, Kavanagh TJ, Krejsa CM, Franklin CC, Kinnula VL, Koistinen P. 1999. Protection of acute myeloblastic leukemia cells against apoptotic cell death by high glutathione and gamma-glutamylcysteine synthetase levels during etoposide-induced oxidative stress. Annals of Oncology 10(11):1361-1367. PMID:10631466
  • Thompson SA, White CC, Krejsa CM, Diaz D, Woods JS, Kavanagh TJ. 1999. Induction of glutamate-cysteine ligase in the brains of adult female mice sub-chronically exposed to methylmercury. Toxicol Lett 110:1-10. PMID:10593589
  • Woods JS, Kavanagh TJ, Corral J, Reese AW, Diaz D, Ellis ME. 1999. The role of glutathione in chronic adaptation to oxidative stress: studies in a normal rat kidney epithelial (NRK52E) cell model of sustained upregulation of glutathione biosynthesis. Toxicol Appl Pharmacol 160(3):207-216. PMID:10544055


  • Broudy VC, Lin NL, Buhring H, Komatsu N, Kavanagh TJ. 1998. Analysis of c-Kit receptor dimerization by fluorescence resonance energy transfer. Blood 91:898-906. PMID:9446650
  • Calverley DC, Kavanagh TJ, Roth GJ. 1998. Human signaling protein 14-3-3 zeta interacts with platelet glycoprotein Ib subunits Ib alpha and Ib beta. Blood 91(4):1295-1303. PMID:9454760
  • Ponce RA, Bartell SM, Kavanagh TJ, Woods JS, Lee RC, Takaro TK, Faustman EM. 1998. Uncertainty analysis methods for comparing predictive models and biomarkers: A case study of dietary methylmercury exposures. Regul Toxicol Pharmacol 28(2):96-105.
  • Thompson SA, Roellich KL, Grossmann A, Gilbert SG, Kavanagh TJ. 1998. Alterations in immune parameters associated with low level methylmercury exposure in mice. Immunopharmacol Immunotoxicol 20(2):299-314. PMID:9653674


  • Krejsa CM, Nadler SG, Esselstyn JM, Kavanagh TJ, Ledbetter JA, Schieven GL. 1997. Role of oxidative stress in the action of vanadium phosphotyrosine phosphotase inhibitors: Redox independent activation of NF-ÇB. J Biol Chem 272(17):11541-11549.
  • Ou YC, Thompson SA, Kirchner SC, Kavanagh TJ, Faustman EM. 1997. Induction of growth arrest and DNA damage-inducible genes Gadd45 and Gadd153 in primary rodent embryonic cells following exposure to methylmercury. Toxicol Appl Pharmacol 147:31-38. PMID:9356304
  • Potter AJ, Grossmann A, Rabinovitch PS, Eaton DL, Kavanagh TJ. 1997. The effect of in vitro phorone exposure on glutathione content and T-cell antigen receptor stimulated calcium mobilization in murine splenic T lymphocytes. In Vitr Mol Toxicol 11(4):355-363. PMID:20654322
  • Reid LL, Botta D, Lu Y, Gallagher EP, Kavanagh TJ. 1997. Molecular cloning and sequencing of the cDNA encoding the catalytic subunit of mouse glutamate-cysteine ligase. Biochim Biophys Acta 1352(3):233-237. PMID:9224945
  • Reid LL, Botta D, Shao J, Hudson FN, Kavanagh TJ. 1997. Molecular cloning and sequencing of the cDNA encoding mouse glutamate-cysteine ligase regulatory subunit. Biochim Biophys Acta 1353(2):107-110. PMID:9294003


  • Heinonen JT, Sidhu JS, Reilly MT, Farin FM, Omiecinski CJ, Eaton DL, Kavanagh TJ. 1996. Assessment of regional cytochrome P450 activities in rat liver slices using resorufin substrates and fluorescence confocal laser cytometry. Environ Health Perspect 104(5):535-543. PMID:8743442
  • Krejsa CM, Nadler SG, Esselstyn JM, Kavanagh TJ, Ledbetter JA, Schieven GL. 1996. The differenetial role of oxidative stress in the activation of protein tyrosine kinases, MAP kinase, and NF-χB by vanadium phosphotyrosine phosphatase inhibitors. FASEB J 10(6):P10.
  • Li S, Thompson SA, Kavanagh TJ, Woods JS. 1996. Localization by in situ hybridizatioin of glutamylcysteine synthetase mRNA expression in rat kidney following acute methylmercury treatment. Toxicol Appl Pharmacol 141:59-67. PMID:8917676
  • Poot M, Hudson FN, Grossmann A, Rabinovitch PS, Kavanagh TJ. 1996. Probenicid inhibition of fluorescence extrusion after MCB-staining of rat-1 fibroblasts. Cytometry Part A 23(1):78-81. PMID:14650445


  • Grossmann A, Rabinovitch PS, Kavanagh TJ, Jinneman JC, Gilliland LK, Ledbetter JA, Kanner SB. 1995. Activation of murine T-cells via phospholipase-Cg1-associated protein tyrosine phosphorylation is reduced with aging. J Gerontol 50(4):B205-B212. PMID:7614232
  • Krejsa CM, Ledbetter JA, Kavanagh TJ. 1995. Oxidant induced changes in red autofluorescence in lymphocytes and lymphoblastoid cell lines correlates with decreased glutathione. Environ Health Perspect 15:158a.
  • Poot M, Teubert H, Rabinovitch PS, Kavanagh TJ. 1995. De novo synthesis of glutathione is required for both entry into and progression through the cell cycle. Journal of Cellular Physiology 163(3):555-560. PMID:7539813
  • Reid LL, Kavanagh TJ. 1995. Cloning and sequencing of the mouse cDNAs encoding the light and heavy subunits of g-glutamylcysteine synthetase. Environ Health Perspect 15:1613a.
  • Thompson SA, Grossmann A, White CC, Eaton DL, Gilbert SG, Kavanagh TJ. 1995. Strain specific effects of sub-chronic, low level methylmercury exposure on GSH levels in mice. Environ Health Perspect 15:1616a.
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